1H-Pyrazole-5-Carboxylic Acid, 4-Iodo-1-Methyl-

4-Iodine-1-methyl-1H-pyrazole-5-carboxylic acid, this physical property is also related to the shape, state, degree of melting and boiling, solubility in agents, etc.
Viewing its shape, under room temperature, it often appears solid state appearance, color or white or nearly white, carefully observed, or crystalline, body micro, shape and regular, shining under light.
Its melting degree, about a specific temperature, when heated to a certain value, begins to convert from solid to liquid, this value is often a measure of its purity. If the quality is pure, the melting range is narrow; if it contains impurities, the melting range is wide and the melting degree is lower.
As for the degree of boiling, it is difficult to measure at normal pressure, because it may decompose at high temperature. However, in the environment of decompression, the number of its degree of boiling may be obtained, which helps to analyze its thermal stability.
Solubility, in water, slightly soluble. Water is a polar agent, and the polarity of this substance is limited, so the solubility is not high. However, in polar organic solvents, such as dimethyl sulfoxide, N, N-dimethylformamide, it is easily soluble. This is because of the principle of "similar miscibility", and the polarity is close to each other. In some alcohol solvents, it also has a certain solubility, depending on the length of the carbon chain of the alcohol and the strength of the polarity. The density of
is heavier than that of water. If it is placed in water, it will sink to the bottom. Its intermolecular force and atomic weight cause its density to have this state.
This substance is sensitive to light and heat. Exposure to strong light, or excessive heating, the molecular structure may change, and the chemistry will also change. Therefore, when storing, it is appropriate to store it in a cool, dark place, and control its temperature to prevent deterioration.
4-Iodine-1-methyl-1H-pyrazole-5-carboxylic acid has such physical properties, which are the key to consideration in chemical synthesis, drug development and other fields. Those who use it must carefully observe its properties before making good use of it.

4-Iodine-1-methyl-1H-pyrazole-5-carboxylic acid, this is an organic compound. Looking at its chemical properties, it has various unique properties due to the specific functional groups such as pyrazole ring and carboxyl group, iodine atom and methyl group.
The pyrazole ring imparts certain aromaticity and stability to the compound. Its conjugate system reduces the molecular energy and stabilizes the structure. This stability affects the activity of the compound participating in various chemical reactions. In many reactions, the pyrazole ring can remain relatively stable and is not easy to break or rearrange under conventional conditions.
Carboxyl (-COOH) imparts acidity to the compound. In a suitable solvent, the carboxyl group can be ionized, releasing hydrogen ions and exhibiting acidic properties. With this acidic property, the compound can neutralize with bases to form corresponding carboxylic salts. For example, when reacted with sodium hydroxide, 4-iodine-1-methyl-1H-pyrazole-5-carboxylate sodium salt and water can be formed. At the same time, the carboxyl group is also an important reaction check point, which can participate in esterification reactions, and react with alcohols under acid catalysis to form ester compounds. This reaction is often used in organic synthesis to construct ester derivatives with specific functions. The introduction of
iodine atoms greatly increases the molecular weight and polarity of compounds. Iodine atoms have a large atomic radius and high electronegativity, which not only enhances the intermolecular force and affects the physical properties of the compound, such as the possible increase of melting point and boiling point, but also significantly enhances its activity in nucleophilic substitution reactions. Iodine atoms, as good leaving groups, are easily substituted when appropriate nucleophilic reagents exist, providing an effective way for compound structure modification and new compound synthesis. For example, nucleophilic substitution reactions can occur with nucleophilic reagents such as sulfur and nitrogen, and organic molecules with more complex structures can be constructed.
methyl (-CH 🥰), although relatively simple, has a profound impact on the properties of compounds. It has a donor electron effect, which can change the electron cloud density distribution on the pyrazole ring through induction and superconjugation effects, and indirectly affect the activities of other functional groups. At the same time, the steric hindrance effect of methyl groups may affect the reaction selectivity and rate in some reactions. For example, in a reaction involving a specific position of the pyrazole ring, the steric hindrance of methyl groups may prevent some larger reagents from approaching, thereby guiding the reaction in a specific direction.

The common synthesis methods of 4-iodine-1-methyl-1H-pyrazole-5-carboxylic acids are described below:
First, the corresponding pyrazole derivatives can be prepared by iodization and carboxylation reactions. Initially, 1-methyl-1H-pyrazole-5-carboxylic acid is used as raw material, and in a suitable reaction system, a suitable iodide reagent is selected, such as iodine elemental substance (I _ 2) with a suitable oxidizing agent, such as hydrogen peroxide (H _ 2O _) or sodium periodate (NaIO _). At the right temperature, reaction time and solvent environment, the iodine reagent interacts with 1-methyl-1H-pyrazole-5-carboxylic acid to cause iodine reaction at a specific position of the pyrazole ring, and then generates the target product 4-iodine-1-methyl-1H-pyrazole-5-carboxylic acid. In this path, the choice of solvent is quite critical. Common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), etc., their polarity and solubility affect the reaction process and product yield. The reaction temperature usually needs to be precisely regulated, depending on the activity of different reagents and substrates, either at room temperature or heated to a moderate temperature to ensure that the reaction is efficient and selective.
Second, it can also be obtained from the precursor containing iodine and methyl through cyclization and carboxyl group introduction steps. For example, the enaminone compounds containing iodine and methyl are selected to undergo intramolecular cyclization under acidic or basic catalytic conditions to construct a pyrazole ring structure. Subsequently, by carboxylation means, such as using carbon dioxide (CO 2) as the carboxyl source, the cyclization product is further carboxylated under the catalysis of transition metals, so as to obtain 4-iodine-1-methyl-1H-pyrazole-5-carboxylic acid. In this method, the choice of catalytic conditions for the cyclization reaction has a significant impact on the regioselectivity and yield of pyrazole ring formation. In basic catalysis, attention should be paid to the strength and dosage of bases to prevent overreaction or side reactions from occurring; the same is true for acidic catalysis. In the carboxylation step, the type and dosage of transition metal catalysts, such as palladium (Pd) and copper (Cu), are crucial to the smooth progress of the reaction and the efficiency of product generation.
In addition, 4-iodine-1-methyl-1H-pyrazole can also be considered as the starting material and reacted with a suitable carboxylation reagent. If halogenated carboxylic acid esters are used, under basic conditions, the halogen atom of the halogenated carboxylic acid ester undergoes nucleophilic substitution reaction with the appropriate position on the pyrazole ring, and an ester group is introduced, and then the ester group is converted into a carboxylic group through a hydrolysis step, and finally 4-iodine-1-methyl-1H-pyrazole-5-carboxylic acid is obtained. In this process, factors such as the intensity and amount of base in the nucleophilic substitution reaction, the structure of halocarboxylate and the reaction temperature will all affect the reaction process and product purity. During the hydrolysis step, the reaction conditions should be carefully controlled to avoid the destruction of the pyrazole ring structure.

4-Iodine-1-methyl-1H-pyrazole-5-carboxylic acid is useful in various fields such as medicine and materials.
In the field of medicine, it can be used as a key intermediate in organic synthesis to prepare compounds with specific biological activities. Geinpyrazole compounds have many biological activities, such as antibacterial, anti-inflammatory, and anti-tumor properties. The iodine atom and methyl group in this compound may affect the electron cloud distribution and spatial structure of the molecule, thereby affecting its interaction with biological targets. After chemical modification and modification, new and efficient drugs can be developed, such as antibacterial drugs, which can interfere with the metabolic process of bacteria and hinder their growth and reproduction; or they can be developed as anti-tumor drugs, which can induce tumor cell apoptosis by regulating the signal transduction pathway of tumor cells.
In the field of materials, it can be used to create functional materials. Because of the pyrazole ring structure, it may have unique photoelectric properties. For example, it can be introduced into polymer materials, and through molecular design and synthesis, special properties such as fluorescence and electrical conductivity can be given to materials. In this way, luminescent materials can be prepared for organic Light Emitting Diodes (OLEDs), which can emit light of a specific color and improve the display effect; or conductive materials with special electrical properties can be prepared, which can be used in the field of electronic devices, such as field effect transistors, etc., to promote the development of miniaturization and high performance of electronic devices.
In summary, 4-iodine-1-methyl-1H-pyrazole-5-carboxylic acids have great potential application value in the fields of medicine and materials. With the deepening of research, it may bring new opportunities for the development of related fields.

1-Hydrogen-pyrazole-5-carboxylic acid, 4-iodine-1-methyl, this product has considerable market prospects. In the field of chemical synthesis, many studies focus on novel and special compounds. The unique molecular structure of 1-hydrogen-pyrazole-5-carboxylic acid and 4-iodine-1-methyl gives many potential applications.
In the field of pharmaceutical research and development, the birth of many innovative drugs often stems from the exploration of compounds with special structures. The chemical properties of 1-hydrogen-pyrazole-5-carboxylic acid, 4-iodine-1-methyl may become a key raw material for the development of new drugs, which can be used to cure specific diseases or improve the efficacy of existing drugs. Therefore, the demand for it in the pharmaceutical industry is expected to grow.
In the field of materials science, this compound may participate in the synthesis of new functional materials. For example, in the field of optoelectronic materials, its unique structure may improve the photoelectric conversion performance of materials, injecting new energy into the progress of related fields. With the rapid development of science and technology, the demand for new materials continues to rise. 1-hydrogen-pyrazole-5-carboxylic acid, 4-iodine-1-methyl are potential key components in material synthesis, and the market prospect is broad.
Furthermore, the fine chemical industry also has a great demand for special structural compounds. 1-hydrogen-pyrazole-5-carboxylic acid, 4-iodine-1-methyl can be used as a key intermediate for fine chemical products. Through a series of reactions, a variety of high-value-added fine chemicals can be derived to meet the specific needs of different industries. In summary, 1-hydrogen-pyrazole-5-carboxylic acid, 4-iodine-1-methyl has a bright future based on the market, and is expected to shine in many fields and stimulate the new development of the industry.