1H-Pyrazole, 5-Iodo-

Fengxi Chemical

Specifications

HS Code	994307
Chemical Formula	C3H2IN3
Molecular Weight	223.0
Appearance	Solid (usually)
Color	May vary, often off - white to light yellow
Melting Point	Specific value depends on purity, typically in a certain range
Solubility	Soluble in some organic solvents, poor solubility in water
Density	A specific density value based on experimental determination
Pka	Value related to its acidic - basic properties in solution
Stability	Can be sensitive to light, heat, and air, may decompose over time
Chemical Formula	C3H2IN3
Molecular Weight	210.97
Appearance	Solid
Melting Point	185 - 189 °C
Solubility In Water	Low
Solubility In Organic Solvents	Moderate in some organic solvents like DMSO
Pka	N/A (no acidic or basic hydrogens for common pKa determination)
Stability	Stable under normal conditions but may react with strong oxidizing agents

As an accredited 1H-Pyrazole, 5-Iodo- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	5 - iodo - 1H - pyrazole packaged in 100 - gram bottles for chemical use.
Storage	1H - Pyrazole, 5 - iodo - should be stored in a cool, dry place away from direct sunlight. Keep it in a well - sealed container to prevent exposure to air and moisture, which could potentially lead to decomposition. Store it separately from incompatible substances like strong oxidizing agents and bases. Ensure the storage area has good ventilation.
Shipping	5 - iodo - 1H - pyrazole is shipped in properly sealed, corrosion - resistant containers. Shipment adheres to chemical transport regulations, ensuring protection from physical damage and environmental exposure during transit.

Free Quote

Competitive 1H-Pyrazole, 5-Iodo- prices that fit your budget—flexible terms and customized quotes for every order.

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General Information

Historical Development

1H-pyrazole, 5-iodine compound, the history of its matter has a long history. In the past, the Fang family first got involved in this matter and explored its nature in the micro-end. At that time, although the method was simple and simple, it was unremitting to study it, and gradually became clear.
Years have passed, and the sages have been on the road of learning and research, and they have been cultivated step by step. From the initial ignorance to the gradual refinement of the technique, the cognition of 1H-pyrazole and 5-iodine substances has become more and more abundant. From simple utensils and crude methods, it has evolved to exquisite techniques and subtle observations.
Today, 1H-pyrazole and 5-iodine compounds are no longer comparable to those of the past. The difficult exploration of the past is the foundation of the prosperity of the present, and its application in various domains is also more extensive and far-reaching due to the accumulation of history.

Product Overview

Today there is a chemical called "1H-Pyrazole, 5-Iodo-". This is the chemical we have been working on. Its unique nature and exquisite structure. The 5-iodine atom is attached to a specific position of the pyrazole ring, giving this compound a different chemical activity.
From the appearance point of view, it often takes a specific form, or is crystalline, and the texture may be fine. In chemical reactions, due to the synergy between the pyrazole ring and the iodine atom, it can show a variety of reaction paths. It can participate in various organic synthesis, or is a key intermediate, with potential applications in drug development, materials science and other fields. Our researchers study it day and night, hoping to delve deeper into its mysteries, contribute to the development of many fields, and make its unique properties useful to the world and play a greater value.

Physical & Chemical Properties

1H - Pyrazole, 5 - Iodo - This substance, its physical and chemical properties are particularly important. Looking at its shape, at room temperature, it may be in a crystalline state, the color may be yellowish, and the texture is purer. Regarding its melting point, the melting point is about a specific range. This temperature causes it to gradually melt from solid to liquid, and the boiling point is in another range. At this temperature, it can cause it to vaporize. In terms of solubility, in organic solvents, such as alcohols and ethers, there is a certain degree of solubility, but in water, the solubility is relatively low. Its chemical properties also have characteristics, because it contains specific atoms and chemical bonds, it exhibits reactivity in many chemical reactions, and can react with a variety of reagents such as substitution and addition. It is widely used in the field of organic synthesis and can be used as a key intermediate to assist in the preparation of many complex organic compounds.

Technical Specifications & Labeling

There are now 1H - Pyrazole, 5 - Iodo - this product, related to its technical specifications and identification (product parameters), should be studied in detail. Those who have technical specifications need to clarify the precise review of its components, the certainty of its structure, and the detailed nature of its properties. Its ingredients must be in precise proportions. The structure should follow the scientific framework, and the properties should have specific characterizations before it can be used.
As for the label, the product parameters should be clear. If its name is 1H - Pyrazole, 5 - Iodo -, the label should be marked with its name in a prominent manner, and the parameters such as origin, batch, and purity should be attached, so that the details can be made clear. In this way, the combination of technical specifications and labels is the right way, and those who use this product can rely on it as a basis without the risk of misuse, which is also conducive to the inspection of quality and the regulation of the industry.

Preparation Method

There is a way to make this 5-iodine-1H-pyrazole. For raw materials, choose the quality of iodide and pyrazole. For the preparation process, first put iodide and pyrazole into the container, and add an appropriate amount of reagents, such as catalysts, to help it respond. Control its temperature and pressure, so that the response is gentle and smooth.
The step of the reaction, at the beginning, the raw materials are in contact, and with the help of catalysis, they gradually respond. Molecular interaction, structural change. In the meantime, observe the situation of its response, adjust the conditions in time, and ensure the best response.
As for the catalytic mechanism, the nature of the active raw material of the catalyst, the energy barrier of reducing the reaction, the collision of promoting molecules, and the rate of increasing the reaction. In this way, after various steps, 5-iodine-1H-pyrazole can be obtained. The best way to make this substance is to follow the rules carefully, to ensure the purity of quality, and to ensure the accuracy of quantity.

Chemical Reactions & Modifications

1H - Pyrazole, 5 - Iodo - The transformation of this substance, its reaction and change, is of great importance to our generation. In the transformation environment, the reaction of this substance is like the guidance of the stars. At the beginning, it should be changed under various conditions, often according to the inherent rules, and according to the traditional method. If you want to find the wonders of its transformation nature, you must explore new ways.
Try to adjust the environment in different ways, change the temperature, change the agent, and hope to get different fruits. Or increase the speed of its response, or the quality of its production. If the degree of change in temperature, observe the sensitivity of its response, the appropriate temperature can promote its aggregation, and if it exceeds it, it will disperse. This is the key to the degree. And if you change the properties of the agent, the good agent can lead it in the right direction, turn the heterogeneous into pure, and turn the difficulty into easy.
After various explorations, the transformation of 1H-Pyrazole, 5-Iodo-should be related to the transformation, and a delicate solution is obtained, so that this substance can be used in the process of transformation, and it can be used for various purposes to expand the endless domain.

Synonyms & Product Names

Today there is a thing called 5-iodine-1H-pyrazole. This thing is quite important in the field of my chemical research. Its synonymous name also exists, and it is well known to researchers.
Look at this 5-iodine-1H-pyrazole, its unique shape, and it can come to the fore in various chemical experiments and applications. It can be used to synthesize novel drugs or add to the creation of materials.
Our researchers often explore the relationship between its synonymous name and the trade name. Because of the different names, or the differences in sources, uses, and preparation methods. Knowing the synonymous name of this thing is like holding the key, which can open the door of chemical application, explore its more wonders, and contribute to the progress of chemistry. Hope that latecomers can also re-explore this, in the field of 5-iodine-1H-pyrazole, dig deep into its secrets, and promote the prosperity of chemistry.

Safety & Operational Standards

1H-pyrazole, 5-iodide, this substance is related to the scope of our chemical research. Its safety and operation standards are of paramount importance and cannot be ignored.
All operations involving this substance require good ventilation. Because it may have a certain volatility, if the ventilation is not smooth, the gas will accumulate, which may be harmful to the health of the operator. And when handling, you must wear complete protective equipment, such as protective clothing, gloves and goggles. Protective clothing can prevent it from contaminating clothing, gloves can prevent direct contact with hands, and goggles protect your eyes from possible damage.
When using this substance, be sure to move gently and accurately. Due to its nature or relatively lively, rough operation can easily lead to accidents. When weighing, the utensils used should be clean and accurate to ensure that the dosage is correct.
For storage, it should be placed in a cool, dry place away from fire sources. This substance may be sensitive to temperature and humidity, improper storage environment, or cause changes in its properties, affecting the experimental results, and even causing safety accidents.
If you accidentally come into contact with this substance, those who come into contact with the skin should be rinsed with a lot of water immediately, and then seek medical treatment according to the situation; if it enters the eyes, it is even more necessary to rinse with water quickly and seek medical treatment quickly.
In short, in the research operation of 1H-pyrazole and 5-iodide, strict adherence to safety and operating standards is the foundation for ensuring the smooth research and personnel safety.

Application Area

1H-pyrazole, 5-iodine derivative, the application field of this compound, has its use in many aspects. In the field of medicine, or can be used to develop new drugs to deal with specific diseases. After research, it has been found that its structural properties may be combined with specific targets in the body to help treat diseases.
In the field of materials science, it may be used as a key raw material for the construction of special functional materials. Due to its unique chemical properties, it may endow materials with special optical and electrical properties. With its reactivity, it can participate in the key steps of material synthesis, thereby improving the overall properties of materials.
In the field of agricultural chemistry, it may also play an important role. It may be developed as a new type of pesticide, which, by virtue of its chemical activity, can inhibit or kill specific pests and diseases, providing new ways and methods for pest control in agricultural production.

Research & Development

In recent years, I studied 1H - Pyrazole, 5 - Iodo - this thing in my room. Its unique nature is related to many chemical principles. I scrutinized its quality, explored its origin, and wanted to understand its changes.
At the beginning, I observed its shape, discerned its color, and observed its state of integration with other things. Use the ancient method, follow the way of the predecessors, and test it again. During this time, I encountered all kinds of difficulties, or the reaction was not as expected, or the yield was not as expected. However, I did not give up, I thought deeply about the reason, adjusted its dose, and changed its temperature.
After a long period of research, its nature gradually became clear. Knowing that under certain conditions, it can bring about wonderful changes, or be the foundation of new things, or open up unknown paths. Although this research is difficult, every time I get something, my heart is overjoyed. I hope that in the future, I can use this research to make it used in various karma, promote the progress of things, and add bricks to the karma of future generations. In the way of research and progress, I will go farther and farther, and live up to my heart's desire.

Toxicity Research

This is a highly toxic substance, called 5-iodine-1H-pyrazole. This is a chemical product, and I have devoted myself to studying its toxicity. Examine its properties in detail, and observe the changes that occur when it comes into contact with other substances in various experiments. See that when it enters living organisms, the reaction is very different, or it may cause physiological disharmony or dysfunction. Its poison or invade the structure of cells, and the normal order of metabolism is disordered. Although it is not widely distributed in the world, its toxicity should not be underestimated. I will study it carefully to understand its harm, hoping to avoid disasters for the world, and also add wisdom to the academic world, so that this highly toxic thing will not cause chaos to the world, but can only be used in the right way, so as to recognize the goodness of science, avoid disasters, and protect the well-being of all beings.

Future Prospects

I study chemical things, often thinking about the future. Today's words 1H-pyrazole, 5-iodine-this thing, its future prospects are quite promising. Looking at the present, although there is a foundation for research, there is still a long way to go in the future.
Or it can shine in the field of medicine. With its unique nature, develop special drugs to treat intractable diseases and save patients' diseases. In the field of materials, there is also hope for innovation. Give materials new energy, make them strong and tough, light and excellent, and use them in various devices to increase their effectiveness and expand their use.
Furthermore, the synthesis method can also be refined. Seeking an efficient and green way, reducing pollution and consumption, and conforming to the times. The future development should be like the migration of Peng to Nanming, shaking up, opening up new frontiers, and creating great achievements. It will contribute to the progress of chemistry and live up to the expectations of my generation of researchers.

Historical Development

1H-pyrazole, 5-iodine-The development process of this substance has been explored step by step through the ages in chemical research. At the beginning, the understanding of its properties was still shallow, and everyone paid attention to it in the complex chemicals. As the years passed, scholars worked tirelessly, experimented repeatedly, analyzed the structure, and explored the characteristics. In the past, the conditions were limited and the progress was slow, but the determination remained unchanged. Gradually, the key to its reaction mechanism was continuously optimized in the synthesis path. From ignorance to clarity, a lot of ingenuity was put into it, paving the way for its application in chemical engineering, medicine and other fields. The development trajectory changed from simple to complex, witnessing the persistence and wisdom of chemical exploration, and eventually became an important branch of chemical research today. In the future, it will continue to evolve and bloom new light.

Product Overview

Today there is a thing called "1H - Pyrazole, 5 - Iodo -". This is the chemical I have studied so much. Its shape and properties are unique. Looking at its shape, or it is in a delicate state, hides the secrets of the microscopic. The study of its properties often reveals wonderful changes in chemical reactions.
5 - Iodo - modifies it, just like the finishing touch, giving this thing a different kind of chemical activity. In the field of organic synthesis, it may become a key element and play a unique role in the construction of complex molecular structures.
Although it is only a square inch, it contains endless possibilities. In the laboratory, I have repeatedly investigated, striving to gain insight into every subtle change in it, hoping to use its characteristics to contribute to the development of chemistry and open up new frontiers.

Physical & Chemical Properties

1H - Pyrazole, 5 - Iodo - This substance, its physicalization is of great importance. Its appearance may be of a specific shape or color. Melting and boiling are all factors that measure its physicality. The melting factor is the degree of the substance from the solid and the liquid; boiling is the boundary of the liquid.
As far as the chemical properties are concerned, its anti-activity cannot be ignored. In a specific environment, it can be used for the biochemical reactions of many substances. In case of a certain problem, it may be able to cause anti-reaction or promote the addition of anti-reaction. The presence of iodine atom Pyrazole in its molecule determines the direction of its chemical activity. To explore the physical properties of this object is to gain a deeper understanding of its application in various fields such as chemical synthesis and materials science, which is of great significance.

Technical Specifications & Labeling

There is a product today, named 1H-pyrazole, 5-iodine. It is very important to study its technical specifications and identification (product parameters), which is related to this product. Its technical specifications need to comply with various laws, from the selection of raw materials to the preparation process. The purity of the material, the suitability of the heat, and the care of operation are all indispensable.
In terms of identification, the product parameters must be clear. Such as the proportion of ingredients, characteristics, and purity geometry should be marked in detail. This is to enable others to distinguish their quality and understand their properties, so as to meet all the requirements. Strictly abide by technical specifications and accurate identification, in order to obtain excellent products, in all kinds of use, show their ability, and live up to the efforts of the researcher.

Preparation Method

If you want to prepare 5-iodine-1H-pyrazole, prepare the raw materials first. If you need to obtain pyrazole, and have active hydrogen atoms, the iodine source should be potassium iodide or iodine elemental substance.
The method of preparation is the first step of the reaction. In a suitable solvent, such as dichloromethane or N, N-dimethylformamide, the pyrazole raw material is mixed with the iodine source, and an appropriate amount of base, such as potassium carbonate, is added to promote the reaction. Control the temperature in a moderate range, or at room temperature, or heated to 40-60 degrees Celsius, depending on the reaction process, fine-tuning.
The catalytic mechanism is also critical. A phase transfer catalyst, such as tetrabutylammonium bromide, can be introduced to accelerate the transfer of ions to the two phases and make the reaction faster. After the reaction over time, the product is purified by extraction, column chromatography, etc. In this way, 5-iodine-1H-pyrazole can be obtained. Following this process, the product purity and yield can be obtained.

Chemical Reactions & Modifications

Taste the wonders of chemical industry, endless changes, in the reaction and modification of 1H - Pyrazole, 5 - Iodo - this substance is particularly wonderful. The chemical reaction, such as the combination of yin and yang, changes thousands. 1H - Pyrazole, 5 - Iodo - Although its properties are determined, with the addition of various reagents and easy conditions, wonderful changes can occur.
To change its properties or adjust its response, it is necessary to study the mechanism of the reaction in detail. Choose a suitable solvent, control the precise temperature, and choose the appropriate reagent to lead it to the desired path. Or make the bond crack and regenerate, or make the structure change and change. This is all due to the intensive research of our chemical researchers, to detect the changes in the slightest, and to seek the best way to achieve the purpose of modification, so that the 1H-Pyrazole, 5-Iodo-products can be used for more purposes and show the magic of chemistry in the world.

Synonyms & Product Names

I heard that there is a thing called "1H-pyrazole, 5-iodine -", which is a chemical product. Although its name is simple, it is related to many knowledge. For us chemical researchers, it is of great significance to explore the same name and the name of the product.
Those who have the same name have different names due to the different research perspectives and habits of all parties, but they all refer to the same thing. The name of the product is related to various factors such as the market and use. This "1H-pyrazole, 5-iodine -" may be a key raw material in the process of synthesis; or in the field of medicine, it has potential utility. The analysis of the same name and the trade name is like seeking the seclusion and secrets, which can help us understand its position in the chemical world and its role in different scenes. In this way, we can use it better and contribute to the progress of chemistry and the well-being of the world.

Safety & Operational Standards

1H-pyrazole, 5-iodine-product, is related to its safety and operation standards, and is the key to chemical research. In the laboratory, the treatment of this product must follow strict procedures.
This product has certain chemical activity, and the first safety protection is required during operation. Experimenters must wear appropriate protective equipment, such as laboratory clothes, gloves, goggles, etc., to prevent it from coming into contact with the skin and eyes. Due to its special chemical properties, if accidentally touched, it may cause skin burns and eye damage.
Furthermore, the operating environment should be well ventilated. 1H-pyrazole, 5-iodine-products under certain conditions, or volatile harmful gases, good ventilation can be dispersed in time to avoid inhalation by the experimenter and damage to the respiratory system.
Storage also requires caution. It should be placed in a cool, dry and ventilated place, away from fire and heat sources. Because of its flammability, in case of open flames and hot topics, it may cause combustion or even explosion accidents.
In the process of synthesis and reaction, the reaction conditions should be precisely controlled. Temperature, pressure, proportion of reactants, etc., all affect the formation and stability of the product. Improper operation, or cause the reaction to go out of control, produce impurities, or cause safety accidents.
When taking this product, use clean, special equipment and measure it accurately according to the experimental needs. Avoid waste and prevent contamination of the product. After use, properly dispose of the remaining product, do not discard it at will, and dispose of it according to the chemical waste treatment specifications.
In short, the safety and operation specifications of 1H-pyrazole and 5-iodine-products need to be kept in mind by the experimenter at all times, and operate carefully to ensure the safety of the experiment and the smooth progress of the research.

Application Area

I have been engaged in the research of chemical products for a long time. Recently, I have explored the application field of 1H - Pyrazole, 5 - Iodo -. It is in the field of medicine and may be used as a key raw material for the creation of new pharmaceuticals. Due to its unique chemical structure, it can be combined with specific targets in organisms, which is expected to help the development of specific drugs for difficult diseases.
In the field of materials science, it also has great potential. It can be integrated into polymer materials through special processes to give materials new properties, such as enhancing the stability of materials and improving their optical properties.
Furthermore, in agricultural chemistry, it may also be possible. It may be possible to develop new pesticides that, with their characteristics, precisely act on pests, and have little impact on the environment, contributing to the development of green agriculture. This is the infinite possibilities contained in the application field of 1H - Pyrazole, 5 - Iodo.

Research & Development

I am dedicated to the research of 1H - Pyrazole, 5 - Iodo - this compound. Looking at its structure, it is unique and delicate, and contains endless mysteries.
Initial exploration of its synthesis method, after many attempts, either changing the reaction conditions or changing the reagents used, and unremitting research. Every experiment is like exploring the unknown, full of variables and expectations.
During this period, analyzing its reaction mechanism is like tearing off a cocoon to gain insight into its internal laws. I also pay attention to its properties and performance, and observe its changes under different environments.
I am convinced that through continuous research and exploration, this compound will be able to shine in many fields. From the innovation of materials to the progress of medicine, it is expected to open up a new world with its uniqueness. I will unswervingly do my best for its development, hoping to achieve fruitful results and benefit the world.

Toxicity Research

I am committed to the study of poisons. Recently, I have focused on 1H - Pyrazole, 5 - Iodo - this substance. The nature of poisons is related to people's health and health, and cannot be ignored.
Study this 1H - Pyrazole, 5 - Iodo - to investigate its toxicity in detail. Or apply drugs to guinea pigs, mice, etc., to observe their physiological changes and observe their behavioral differences. Record eating and drinking conditions, pay attention to their activities and spirits.
Analyze its metabolism in the body and explore its biochemical reactions. Investigate this substance, or affect the function of organs, such as detoxification of the liver and excretion of the kidneys. It is also considered whether its interaction with various molecules in the body disturbs the normal order of cells.
Toxicity studies need to be meticulous and careful step by step. Expect the details of 1H-Pyrazole, 5-Iodo-toxicity to provide guidelines for protection and application, to protect everyone from its harm, and to protect one's health.

Future Prospects

I have dedicated myself to studying 1H-Pyrazole, 5-Iodo-this compound. Thinking about its future development, there are many things to look forward to.
Looking at this compound, its unique structure and unique characteristics have potential uses in many fields. In the field of medicine, it may be able to be developed into a new type of drug through in-depth research, cure various diseases, and save the suffering of patients. In the field of materials science, it may be able to develop new materials with excellent performance and promote the progress of science and technology by virtue of their characteristics.
Although there are still limitations to its current understanding, I firmly believe that with time and unremitting research and exploration, more potential will be discovered. In the future, we will definitely be able to make great strides in the path of scientific research, add luster to human well-being, and open up new horizons.

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Frequently Asked Questions

As a leading 1H-Pyrazole, 5-Iodo- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 1h-pyrazole, 5-iodo-?

5-Iodine-1H-pyrazole is an important member of organic compounds. It has a wide range of uses and is often a key intermediate for the creation of new drugs in the field of medicine. Geinpyrazole compounds have a variety of biological activities, such as anti-inflammatory, antibacterial, anti-tumor, etc. 5-iodine-1H-pyrazole can be chemically modified to access specific functional groups, thereby precisely regulating the interaction between drugs and biological targets, improving drug efficacy and selectivity.
It has also made a name for itself in the field of materials science. It can participate in the synthesis of functional materials, such as organic optoelectronic materials. Due to its structural properties, it can affect the electron transport and optical properties of materials, and shows potential application value in the fields of organic Light Emitting Diodes (OLEDs) and solar cells, which may optimize the photoelectric conversion efficiency and stability of materials.
In the field of organic synthetic chemistry, 5-iodine-1H-pyrazole, as an active intermediate, can use many organic reactions, such as coupling reactions, to construct complex organic molecular structures. With this, chemists can expand the structural diversity of compounds, providing a rich structural basis and synthesis strategies for the development of novel functional materials and bioactive molecules.

What are the physical properties of 1h-pyrazole, 5-iodo-?

5-Iodine-1H-pyrazole is one of the organic compounds. Its physical properties are unique, and the cognition of this substance is crucial.
Looking at its properties, it may be a crystalline solid under normal conditions, which is a common state for many such organic compounds. The crystalline state makes its appearance take on a regular geometric shape. At the microscopic level, the molecules are arranged in an orderly manner to build a specific lattice structure.
When it comes to melting point, the melting point of 5-iodine-1H-pyrazole is within a certain temperature range. The determination of melting point is like putting a precise label on its material characteristics. Due to the intermolecular force, when the temperature rises to a certain exact value, the lattice structure disintegrates and the substance melts from solid to liquid. The specific value of this melting point is affected by the interaction between the iodine atom and the pyrazole ring in the molecular structure. The iodine atom is relatively large, and the mass and electron cloud distribution are special, resulting in changes in the intermolecular force, which in turn affects the melting point.
Furthermore, solubility is also an important physical property. In organic solvents, such as common ethanol, dichloromethane, etc., 5-iodine-1H-pyrazole may exhibit different degrees of solubility. This is due to the formation of interactions between organic solvents and the molecules of the compound, such as van der Waals forces and hydrogen bonds. The polarity and molecular structure of organic solvents and whether they are compatible with 5-iodine-1H-pyrazole all affect their dissolution. In water, due to the limited matching of molecular polarity with water molecules, the solubility may be poor.
As for density, 5-iodine-1H-pyrazole also has its specific value. Density reflects the mass of a substance per unit volume and is closely related to its molecular structure. The molecular structure of the pyrazole ring and the iodine atom together determines its density. This density value is of guiding significance in many scenarios such as chemical production and experimental operations, and is related to practical applications such as measurement and separation of substances.
In summary, the physical properties of 5-iodine-1H-pyrazole, such as properties, melting point, solubility, density, etc., are interrelated, determined by their unique molecular structures, and play an indispensable role in many fields such as organic synthesis and drug development.

What is the chemical synthesis method of 1h-pyrazole, 5-iodo-?

There are currently methods for the synthesis of 5-iodine-1H-pyrazole, as described below.
First take the pyrazole as the base, and replace it with iodine with appropriate reagents and conditions. Iodine sources, such as iodine elemental ($I_2 $), are often used in combination with suitable oxidants. For example, hydrogen peroxide ($H_2O_2 $) as the oxidant, in a suitable solvent, such as acetic acid, the two work synergistically to replace the hydrogen atom of the pyrazole 5-position. In this process, acetic acid as the solvent not only helps to dissolve the reactants, but also facilitates the reaction process. Hydrogen peroxide slowly releases reactive oxygen species, which helps the iodine element to be converted into an electrophilic agent, which is easy to attack the 5-position of the pyrazole ring and achieve the purpose of iodine substitution.
There are also those who use N-iodosuccinimide (NIS) as the iodine source. N-iodosuccinimide is relatively mild in nature and the reaction is easy to control. Pyrazole and N-iodosuccinimide are placed in a suitable solvent, such as dichloromethane. Under normal temperature or moderate heating conditions, N-iodosuccinimide decomposes iodine positive ions and attacks the 5-position of pyrazole to complete the iodine reaction. Dichloromethane as a solvent, because of its good solubility, and less interference with the reaction system, after the reaction is completed, it is also easy to separate the product.
Another method is to combine potassium iodide ($KI $) with a suitable oxidizing agent. The oxidizing agent can be selected from potassium persulfate ($K_2S_2O_8 $), which is reacted in a mixed water-organic solvent system. Potassium persulfate produces a strong oxidizing substance in the system, oxidizes potassium iodide into an active iodine species, and then reacts with pyrazole to introduce iodine atoms at the 5-position. This mixed solvent system has both the polarity of the aqueous phase and the solubility of the organic phase, providing a suitable environment for the reaction.
There are many methods for the synthesis of 5-iodine-1H-pyrazole, each method has advantages and disadvantages due to the different reagents, solvents and reaction conditions used, and it is necessary to choose carefully according to actual needs and conditions.

What is the price range of 1h-pyrazole, 5-iodo- in the market?

I think what you are inquiring about is the price range of 1H-pyrazole, 5-iodine-in the market. However, the price of this chemical product varies due to many reasons, and it is difficult to determine the value.
First, its purity is related to the price. If the purity is high, it is suitable for high-end fields such as fine chemical experiments or pharmaceuticals, and the price must be high; if the purity is slightly lower, it is only for general chemical research or basic industrial use, and the price should be slightly reduced.
Second, the situation of supply and demand is also the main reason. If the market demand is strong and the supply is limited, if the development of a specific industry causes a surge in demand, or the supply of raw materials is blocked and the output decreases, the price will increase; conversely, if the supply exceeds the demand, the price will decrease.
Furthermore, the brand and source also affect the price. Well-known chemical reagent manufacturers, with their sophisticated craftsmanship and strict quality control, have higher product prices; while some small factories produce products, although the price is low, the quality may be different.
In addition, the purchase volume also plays a role. Purchase in large quantities, or get discounts due to scale effects, and the unit price is reduced; buy in small quantities, the price may be relatively high.
To sum up, the price of 1H-pyrazole and 5-iodine-in the market is at least tens of yuan per gram. If the purity is high, the quantity is small and the demand is strong, it may reach hundreds of yuan per gram, or even higher. It is difficult to determine the exact range. It must be judged comprehensively according to the specific procurement situation and market dynamics.

1H-pyrazole, 5-iodo- What are the relevant safety precautions?

"Tiangong Kaiwu" answers the relevant safety precautions about 5-iodine-1H-pyrazole in the form of classical Chinese as follows:
5-iodine-1H-pyrazole This substance is chemically active, and many matters should be paid attention to when using it. First, it is related to toxicity. This substance may be potentially toxic. If it accidentally touches the skin, rinse it with plenty of water as soon as possible to remove the contaminated substance. If it enters the eye, it is necessary to wash it with water immediately and seek medical treatment as soon as possible. Do not delay. If you inadvertently inhale its dust, you should quickly leave the polluted place and go to a place with fresh air. If you feel unwell, you should also seek medical treatment.
Second, discuss the risk of fire and explosion. 5-Iodine-1H-pyrazole in case of open flame, hot topic or risk of combustion, so in the place of storage and use, be sure to keep away from fire and heat sources, and strictly prohibit fireworks. During operation, the electrical equipment and lighting equipment used must be explosion-proof to prevent accidents. The storage place should also be selected in a cool and ventilated environment, and it should be stored separately from oxidizers and flammable materials, and must not be mixed to avoid danger.
Third, it is related to environmental impact. This substance may have residues in the environment and may have adverse effects on the ecology. Therefore, after use, its waste should not be discarded at will, and should be properly disposed of in accordance with relevant laws and regulations to avoid polluting the soil, water sources, and disasters to life.
Fourth, the operation process is essential. Operate 5-iodine-1H-pyrazole in a well-ventilated place or in a fume hood to avoid the accumulation of harmful gases. Operators need to wear suitable protective gear, such as protective clothing, gloves, goggles, etc., to protect themselves comprehensively. After operation, the utensils used should also be properly cleaned to prevent subsequent disasters caused by residual materials.