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What are the main application fields of 1h-pyrazolo [3,4-b] pyridine, 4-iodo-
4-Iodine-1H-pyrazolo [3,4-b] pyridine, this compound is widely used in the field of medicinal chemistry. Because of its unique structure, it is often a key raw material when creating new drugs.
The research and development of anti-cancer drugs, first, in the exploration of anti-cancer drugs, this compound may serve as an important cornerstone. Because it can interact with specific targets in cancer cells, or can interfere with key processes such as cancer cell proliferation and metastasis, it is expected to become a new anti-cancer drug. Second, it also has potential in the development of drugs for neurological diseases. The etiology of neurological diseases is complex, and this compound can be used to modulate the transmission of neurotransmitters, affect nerve cell signaling pathways, or be a new way to treat diseases such as Alzheimer's disease and Parkinson's disease.
Furthermore, in the field of materials science, there are also areas that can be explored. Because 4-iodine-1H-pyrazolo [3,4-b] pyridine has specific electronic properties and spatial structure, or can participate in the preparation of special optoelectronic materials. For example, in organic Light Emitting Diode (OLED) materials, it may improve the luminous efficiency and stability of materials, contributing to the progress of display technology. And in the field of chemical sensors, with its specific binding ability with specific substances, high-sensitivity sensors can be designed for the detection of environmental pollutants, biomarkers, etc.
All in all, 4-iodine-1H-pyrazolo [3,4-b] pyridine has potential application value in many fields such as medicine and materials, providing many possibilities for scientific research and technological innovation.
What are the synthesis methods of 1h-pyrazolo [3,4-b] pyridine, 4-iodo-
The synthesis method of 1h - pyrazolo [3,4 - b] pyridine, 4 - iodo - is a very important topic in the field of organic chemistry. There are several common synthetic routes.
First, it can be started from a suitable pyridine derivative. First, a specific functionalization of the pyridine ring is carried out, and a suitable substituent is introduced to lay the foundation for the subsequent construction of the pyrazolo-pyridine structure. For example, using a pyridine with a specific substituent as a raw material, a group that can form a relevant intermediate with the pyrazole ring is introduced through a nucleophilic substitution reaction. After that, a cyclization reaction is used to promote the fusing of the pyrazole ring with the pyridine ring. In this process, it is necessary to precisely control the reaction conditions, such as temperature, reaction time and the catalyst used. If the temperature is too high or too low, it may affect the reaction process and product selectivity; if the reaction time is too long or too short, it will also have a significant impact on the yield. The type and amount of catalyst used also affect the rate and efficiency of the reaction.
Second, it can also start from pyrazole derivatives. First, the pyrazole ring is modified, and the active group related to the construction of the pyridine ring is introduced. Then, through a series of reactions, it is connected to the pyridine ring and cyclized. In this path, the sequence of reaction steps is extremely critical. Each step needs to be carefully planned according to the activity of the reactants and the requirements of the reaction conditions. For example, some reactions need to be carried out in an anhydrous and anaerobic environment to avoid oxidation or hydrolysis of the reactants, ensure the smooth progress of the reaction, and improve the purity and yield of the products.
Third, the reaction strategy of transition metal catalysis can also be used. Transition metal catalysts have unique advantages in building carbon-carbon bonds and carbon-heteroatomic bonds. Through rational selection of transition metal catalysts and ligands, precise regulation of the reaction check point and selectivity can be achieved. For example, using transition metal catalysts such as palladium and copper, in a suitable reaction system, the substrate is coupled to form the target 1h-pyrazolo [3,4-b] pyridine, 4-iodo-structure. However, this method requires harsh reaction conditions and the cost of the catalyst is relatively high, so it needs to be comprehensively considered in practical applications.
What are the physicochemical properties of 1h-pyrazolo [3,4-b] pyridine, 4-iodo-
1H-pyrazolo [3,4-b] pyridine-4-iodide, this is an organic compound. Its physical and chemical properties are unique, let me explain in detail.
Looking at its physical properties, under room temperature and pressure, it is mostly presented in solid form. Because the molecular structure contains iodine atoms, the atomic weight is large, so that its density is higher than that of ordinary organic small molecules. And the existence of iodine atoms also affects its melting point and boiling point, usually the melting point is higher. This is because the force between iodine atoms and surrounding atoms is strong, and more energy is required to change its state.
On its chemical properties, iodine atoms are active check points. The electronegativity of the iodine atom is moderate, so that the compound can undergo various chemical reactions under certain conditions. For example, in the nucleophilic substitution reaction, the iodine atom can be replaced by other nucleophilic reagents. Due to the good ability of iodine ion departure, it is easy to exchange with nucleophilic reagents. Under suitable catalyst and reaction conditions, it can react with compounds containing hydroxyl, amino and other nucleophilic groups to generate new organic compounds.
Furthermore, the structure of 1H-pyrazolo [3,4-b] pyridine endows the compound with certain aromaticity and stability. The nitrogen atom in this structure can participate in the formation of the conjugated system, which affects the electron cloud distribution of the compound, and then affects its chemical activity. The solitary pair electrons of nitrogen atoms can coordinate with metal ions to form complexes, which may have potential applications in catalysis, materials science and other fields.
Its solubility is also worth mentioning. Due to the hydrophobic structure of iodine-containing atoms and pyrazolopyridine, the solubility in water is not good. However, in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide, etc., there may be a certain solubility, which is convenient for the selection of suitable solvents in the process of organic synthesis and separation and purification.
In summary, 1H-pyrazolo [3,4-b] pyridine-4-iodide has the above physical and chemical properties due to its unique structure, which lays the foundation for organic chemistry research and related applications.
What is the price range of 1h-pyrazolo [3,4-b] pyridine, 4-iodo in the market?
I have not obtained the exact price of 1H-pyrazolo [3,4-b] pyridine-4-iodide in the market. The price of this product often changes due to changes in quality, quantity, seller and market conditions.
If you want to know the price, you can follow several ways. First, visit the website of the chemical reagent supplier, or have its price list. These suppliers often supply a variety of chemicals, and you can get corresponding quotations according to the quality and quantity of the required products. Second, write to the reagent supplier, detailing the quantity and specifications of the required materials, and they should quote the exact price. Third, ask in chemical related forums or communities, and people in the industry may give an approximate price range based on experience.
Although it is difficult to determine its exact price, the price of rare and difficult to synthesize chemicals must be high. If the synthesis of 4-iodine-1H-pyrazolo [3,4-b] pyridine is complicated, the raw materials are rare and expensive, and the price is not cheap; if the preparation is easy and the raw materials are wide, the price is relatively easy. The amount is also dependent on the price, and the unit price is lower than the amount.
If you want to know the market price of 1H-pyrazolo [3,4-b] pyridine-4-iodide, you should consult the supplier in person or the industry community to obtain a more accurate price.
What are the manufacturers of 1h-pyrazolo [3,4-b] pyridine, 4-iodo-?
1H - pyrazolo [3,4 - b] pyridine, 4 - iodo - that is, 4 - iodine - 1H - pyrazolo [3,4 - b] pyridine, there are many manufacturers of this product in today's world.
Guaner Sigma - Aldrich is a giant of chemical reagents. It is rigorous and has profound attainments in the preparation of various chemical products. The 4 - iodine - 1H - pyrazolo [3,4 - b] pyridine produced is of high quality and is widely recognized in scientific research and industrial fields. The process is exquisite, the control is strict, and the product purity is quite high, which can meet the needs of all parties.
And TCI (Tokyo Chemical Industry Co., Ltd.) is also a leader in the industry. He focuses on the development of special chemicals, 4-iodine-1H-pyrazolo [3,4-b] pyridine is one of its key products. His R & D team is quite talented, with advanced technology and concepts, so that the products have advantages in quality and performance. In the global market, TCI's products have a good reputation, and many customers are favored by their products for their excellent performance.
Other manufacturers such as AstaTech are also involved in the production of 4-iodine-1H-pyrazolo [3,4-b] pyridine. AstaTech has made a lot of achievements in the field of organic synthetic chemicals, and its production of this product focuses on innovation and efficiency. With a unique process path, it not only guarantees product quality, but also has advantages in cost control, providing a cost-effective choice for the market.
These manufacturers play a key role in the production and supply of 4-iodine-1H-pyrazolo [3,4-b] pyridine, promoting the development of related fields.