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What is the main use of this product 1h - pyrrolo [2,3 - b] pyridine, 4 - chloro - 2 - iodo -
This substance 1H-pyrrolido [2,3-b] pyridine, 4-chloro-2-iodine, its main use in "Tiangong Kaiwu" Although there is no direct corresponding record, it can be deduced according to the application of ancient and modern chemical substances.
In ancient times, although there was no clear understanding of this specific structural compound, it contained chlorine, iodine and nitrogen-containing heterocyclic substances or had similar uses. Chlorine was used in some disinfection and cleaning in the past. Ancient healers used chlorine-containing substances to clean wounds and prevent infection. And iodine was also known in ancient times for its effect on injuries and diseases. For example, applying iodine-containing herbs to boils can relieve swelling and pain.
Nitrogen-containing heterocyclic compounds, often with special chemical activities. In ancient times, alchemy, pharmaceuticals, etc., or used to catalyze reactions to change chemical processes to make medicinal pills and pharmaceuticals. This 1H-pyrrolido [2,3-b] pyridine structure, due to its unique conjugate system, or can be used to stabilize reaction intermediates, making the reaction more prone to occur.
At present, such substances are often used in the field of medicinal chemistry as key intermediates for the synthesis of drugs. With their special structure, molecules with specific pharmacological activities can be designed and synthesized to treat various diseases. In materials science, because of its unique electronic structure, it can be used to prepare optoelectronic materials, giving materials special optical and electrical properties. Although "Tiangong Kaiwu" does not describe this substance in detail, the origin of its use is also related to ancient chemical practice.
What are the synthesis methods of 1h - pyrrolo [2,3 - b] pyridine, 4 - chloro - 2 - iodo -
The synthesis method of 4-chloro-2-iodine-1H-pyrrolido [2,3-b] pyridine is described in ancient words.
To prepare this substance, one of the methods can be to use pyrrolido [2,3-b] pyridine as the base to find an appropriate halogenating reagent. If you want to introduce iodine atoms at the 2 position, you can choose an iodine substitution reagent, such as an iodine elemental substance, which is mixed with an appropriate oxidizing agent, so that under mild reaction conditions, the electrophilic substitution reaction is carried out, and the iodine atom is obtained in the 2 position.
As for the introduction of the 4-position chlorine atom, a suitable chlorine substitution reagent can be selected at an appropriate time. If a chlorine-containing halogenating agent is used in a specific reaction medium, with the help of a catalyst, it will interact with the substrate, and the chlorine atom will enter the 4-position position. During the reaction, attention must be paid to the reaction temperature, time and dosage of reagents to ensure that the reaction goes smoothly and the purity of the product is guaranteed.
There are other ways to construct a pyridine ring first, and introduce chlorine and iodine atoms in an orderly manner before or after the formation of the pyrrole ring. For example, a chlorine-containing pyridine derivative is prepared first, and then a pyrrole ring is combined with it through an ingenious reaction path, and then iodine atoms are introduced at the 2-position of the pyrrole ring. The key lies in the precise control of the reaction conditions at each step, and the choice of solvent is also a priority. The appropriate solvent can promote the rate of reaction and increase the yield of the product.
The process of synthesis is often tortuous, and each step must be carefully considered and carefully operated to obtain the target product of 4-chloro-2-iodine-1H-pyrrolido [2,3-b] pyridine.
1H - pyrrolo [2,3 - b] pyridine, 4 - chloro - 2 - iodo - what is the price range in the market
1h+-+pyrrolo%5B2%2C3+-+b%5Dpyridine%2C+4+-+chloro+-+2+-+iodo is 4-chloro-2-iodine-1H-pyrrolido [2,3-b] pyridine, which is an organic compound. However, it is difficult to determine the price range above the market. Because the price of organic compounds is often affected by many factors.
First, the difficulty of preparation is the key factor. If the preparation process of this compound is complicated, it needs to go through multiple steps of reaction, and the yield of each step is not high, or special reagents, catalysts and reaction conditions are required, such as harsh temperature, pressure and anhydrous and anaerobic environment, the production cost will increase greatly, which will then increase the market price.
Second, the market demand situation also affects the price. If this compound has extensive demand in the fields of medicine, materials science, etc., if it is an intermediate for the synthesis of a specific drug, the demand is strong and the supply is limited, the price will rise; on the contrary, if the demand is very small, there are few manufacturers, and the price may be relatively low.
Third, the cost of raw materials is also related to the price. The starting materials and reagents required for its synthesis, if the raw materials are scarce or the acquisition cost is high, will also push up the price of the product.
Fourth, the scale of production also has a great impact on the price. In large-scale production, due to the scale effect, the unit production cost may be reduced, and the price may also be lowered; in small-scale production, the cost is difficult to reduce, and the price may be higher.
Fifth, the market competition situation cannot be ignored. If there are many manufacturers producing this compound and the competition is fierce, the manufacturers may appropriately lower the price in order to occupy the market share; if only a few manufacturers can produce it, they are in a monopoly or oligopoly position, and the price may remain at a high level.
In summary, due to the lack of detailed information on the preparation process, market demand, raw material costs, production scale and competition situation of this compound, it is difficult to give the exact market price range of 4-chloro-2-iodine-1H-pyrrolido [2,3-b] pyridine. To know the exact price, you can consult professional chemical product suppliers, relevant industry research institutions, or consult the chemical product trading platform for reference.
What are the physicochemical properties of 1h - pyrrolo [2,3 - b] pyridine, 4 - chloro - 2 - iodo -
4-Chloro-2-iodine-1H-pyrrolido [2,3-b] pyridine is also an organic compound. Its physical and chemical properties are quite important, and it is related to many properties of this compound.
In terms of physical properties, the color state is at room temperature, or in the state of a crystalline solid, with a white color, just like the first snow in winter, pure and clear. Due to the intermolecular forces, the molecules are arranged in an orderly manner to form a crystalline structure. The melting point is also a key physical property. Its melting point has been determined, or it is in a specific temperature range, such as about 150-160 ° C. This temperature reflects the strength of the interaction between molecules. When the temperature rises to the melting point, the molecule is energized enough to overcome part of the interaction force, the lattice structure disintegrates, and the substance changes from solid to liquid.
The solubility cannot be ignored. In organic solvents, such as dichloromethane and chloroform, it exhibits a certain solubility. This is because the molecular structure of the compound contains specific functional groups, which can form interactions such as van der Waals force and hydrogen bonds with organic solvent molecules, so that it can be integrated into the solvent.
As for the chemical properties, because it contains halogen atoms such as chlorine and iodine, it is chemically active. Both chlorine atoms and iodine atoms can participate in nucleophilic substitution reactions. In case of nucleophilic reagents, halogen atoms can be replaced to form new compounds. Under suitable conditions, pyridine ring and pyrrole ring can also participate in the reaction, or due to the characteristic of electron cloud distribution on the ring, electrophilic substitution reaction is prone to occur, and other functional groups are introduced at specific positions on the ring. In addition, the nitrogen atom of this compound has lone pairs of electrons, which can be used as a Lewis base to react with Lewis acid, showing a unique chemical behavior.
1H - pyrrolo [2,3 - b] pyridine, 4 - chloro - 2 - iodo - what are the relevant safety precautions
4-Chloro-2-iodine-1H-pyrrolido [2,3-b] pyridine This substance is related to safety and needs to be paid attention to many matters. It is a chemical substance, and it is the first protection during operation. Suitable protective equipment, such as protective clothing, gloves and goggles, must be worn to prevent it from touching the skin and eyes, because it may be corrosive and irritating, and contact can cause damage.
Furthermore, when the operation is in a well-ventilated place, it is best to carry out it in a fume hood. This substance may evaporate harmful gases. Good ventilation can reduce the concentration of harmful substances in the air, prevent the operator from inhaling, and prevent respiratory damage and other health problems.
Storage is also exquisite. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Because of its flammability, it may encounter open flames, hot topics or cause combustion or even explosion. And it should be stored separately from oxidizers, acids, etc., to avoid reactions.
During transportation, it is also necessary to strictly abide by relevant regulations and properly pack it to ensure its stability. Avoid package damage caused by collision and vibration, and material leakage.
In addition, operators should be professionally trained and familiar with the characteristics of this object, safe operation procedures and emergency treatment methods. In the event of an accident such as leakage, they should be able to respond quickly and correctly. If they are accidentally contacted, they need to be dealt with immediately according to the relevant emergency measures, and in severe cases, they should be sent to the hospital immediately.