What is the main use of 2- (2-iododibenzo [b, d] furan-4-yl) -4,4,5,5-tetramethyl-1,3,2-dioxaborolane
2-% (2-iododibenzo [b, d] furan-4-yl) -4,4,5,5-tetramethyl-1,3,2-dioxaborane, this compound is widely used in the field of organic synthesis.
First, it is commonly used in the Suzuki-Miyaura reaction. This reaction is a key method for constructing carbon-carbon bonds and plays an important role in many fields such as pharmaceutical chemistry and materials science. In this reaction, the borane compound can be coupled with halogenated aromatics or alkenes under the action of palladium catalysts and bases, resulting in the efficient formation of biaryl or alkenyl aromatics with specific structures. With this reaction, complex organic molecules can be synthesized, such as intermediates of many drug molecules.
Second, it also has significant uses in material synthesis. Materials with special photoelectric properties can be constructed by means of the reactions it participates in. For example, the synthesis of functional materials for organic Light Emitting Diodes (OLEDs), organic solar cells and other photovoltaic devices can precisely control the reaction conditions and the proportion of reactants to adjust the molecular structure and properties of the materials, thereby improving the efficiency and stability of photovoltaic devices.
Third, in the field of total synthesis of natural products, because it can effectively achieve the formation of carbon-carbon bonds at specific locations, it helps chemists to achieve total synthesis of complex natural products, laying the foundation for in-depth research on the biological activities of natural products and the development of new drugs.
Fourth, in the creation of new organic functional molecules, as an important synthetic block, it can be cleverly combined with other organic reagents to design and synthesize organic molecules with unique structures and functions, paving the way for exploring new chemical properties and applications.
What are the synthesis methods of 2- (2-iododibenzo [b, d] furan-4-yl) -4,4,5,5-tetramethyl-1,3,2-dioxaborolane
To prepare 2 - (2 - iododibenzo [b, d] furan - 4 - yl) - 4,4,5,5 - tetramethyl - 1,3,2 - dioxaborane, there are two common methods.
First, react with 2 - iododibenzo [b, d] furan - 4 - boronic acid with pinacol. First take an appropriate amount of 2 - iododibenzo [b, d] furan - 4 - boronic acid, put it in a reactor, add an appropriate amount of organic solvent, such as dichloromethane or toluene, stir to dissolve. Then slowly add pinacol dropwise, and add an appropriate amount of dehydrating agent, such as concentrated sulfuric acid or p-toluenesulfonic acid. The reaction temperature should be controlled at 50-80 ° C, with continuous stirring for a few times. After the reaction is completed, the target product can be obtained by washing with water, drying, and distillation under reduced pressure.
Second, 2-iodibenzo [b, d] furan-4-halide is reacted with diboron. Place 2-iododibenzo [b, d] furan-4-halide, diphenyldinaloxyl diboron, palladium catalyst (such as tetrakis (triphenylphosphine) palladium) and base (such as potassium carbonate) in a reaction vessel in a certain proportion, add an organic solvent such as N, N-dimethylformamide. The reaction temperature is maintained at 80-100 ° C, and the reaction number is stirred. After the reaction is completed, 2 - (2 - iododibenzo [b, d] furan - 4 - yl) - 4,4,5,5 - tetramethyl - 1,3,2 - dioxaborane can also be obtained by filtration, extraction, column chromatography and other operations.
What are the physicochemical properties of 2- (2-iododibenzo [b, d] furan-4-yl) -4,4,5,5-tetramethyl-1,3,2-dioxaborolane
2-%282-iododibenzo%5Bb%2Cd%5Dfuran-4-yl%29-4%2C4%2C5%2C5-tetramethyl-1%2C3%2C2-dioxaborolane, this is a compound in the field of organic chemistry. From the perspective of physical and chemical properties, it has the following characteristics.
In terms of appearance and morphology, it is often presented in solid form, and its crystalline structure is dense and orderly, giving the substance a relatively stable physical form, which is not easy to change the state due to slight external disturbances.
In terms of melting point, it has been determined by many experiments that it is in a certain temperature range. The melting point value is crucial for identifying this compound and controlling the reaction conditions in the relevant synthesis process. At a specific temperature, the compound changes from a solid state to a liquid state. This melting point characteristic is affected by intermolecular forces, such as van der Waals forces, hydrogen bonds, etc. Interactions together determine the melting point.
The solubility performance is quite critical. In organic solvents, such as common toluene and dichloromethane, it has a certain solubility. This property is due to the specific interaction between the compound molecules and the organic solvent molecules, so that they can be uniformly dispersed in the solvent system. In water, the solubility is poor, because the hydrophobic part of the molecular structure accounts for a large proportion, and the force between the water molecules is weak, making it difficult to form a stable dispersion system.
Thermal stability is also an important property. In a moderate temperature range, the compound is structurally stable and its chemical properties have not changed significantly. However, when the temperature exceeds a certain threshold, the vibration of the chemical bonds inside the molecule intensifies, which may trigger reactions such as chemical bond breaking and rearrangement, resulting in the change of the compound structure and chemical properties.
In addition, the presence of iodine atoms and boroester groups in this compound endows it with unique chemical activity. Iodine atoms have high activity and are prone to nucleophilic substitution reactions, which can be used as a check point to introduce other functional groups; boroester groups play an important role in metal catalytic coupling reactions, which can react with a variety of organic halides and construct new carbon-carbon bonds, thus having a wide range of applications in the field of organic synthesis.
What is the price range of 2- (2-iododibenzo [b, d] furan-4-yl) -4,4,5,5-tetramethyl-1,3,2-dioxaborolane in the market?
At present, I want to know the price range of 2- (2-iododibenzo [b, d] furan-4-yl) -4,4,5,5-tetramethyl-1,3,2-dioxaborane in the market, but I don't know the details. The price of such chemical reagents often varies for a variety of reasons.
First, the purity of the reagents provided is extremely important. If the purity is high and the impurities are rare, it is suitable for high-end scientific research experiments, and the price is high; if the purity is slightly lower, it is mostly used for general industrial use, and the price is slightly cheaper.
Second, the purchase quantity also affects the price. If you buy in bulk, the merchant may give a discount due to the large quantity, and the unit price will be low; if you only buy a small amount, in order to meet the urgent needs of the laboratory, the unit price may be high.
Third, the price varies depending on the supplier. The cost and pricing strategies of each supplier are different. Some are positioned with high-quality services and high-end products, and the price is high; some are based on small profits but quick turnover, and the price is close to the people.
Fourth, the market supply and demand situation has a great impact on the price. If the demand for this product is strong and the supply is limited, the price will rise; if the market supply exceeds the demand, the merchant may reduce the price and promote it.
To determine its price range, you can consult the chemical trading platform, chemical raw material suppliers, or refer to recent relevant transaction records, so as to obtain a more accurate price range.
What are the storage conditions for 2- (2-iododibenzo [b, d] furan-4-yl) -4,4,5,5-tetramethyl-1,3,2-dioxaborolane?
2-%282-iododibenzo%5Bb%2Cd%5Dfuran-4-yl%29-4%2C4%2C5%2C5-tetramethyl-1%2C3%2C2-dioxaborolane is an organic compound, and its storage conditions are crucial, which is related to the stability and quality of the substance.
This compound should be stored in a cool, dry and well-ventilated place. Because a cool environment can slow down the rate of chemical reactions that may occur, high temperature can easily cause the compound to decompose or deteriorate. Dry conditions are indispensable, and moisture can easily cause adverse reactions such as hydrolysis and destroy its chemical structure. Good ventilation can avoid the accumulation of harmful gases and reduce safety risks.
Furthermore, keep away from fire sources, heat sources and oxidants. This compound may be flammable, and there is a risk of fire and explosion in case of fire and heat sources. Oxidants may also react violently with it, endangering storage safety.
Store should be sealed to prevent contact with air. Oxygen, carbon dioxide and other components in the air may react with compounds, causing their properties to change. And it should be kept out of the reach of children, and strictly follow the relevant safety regulations and operating procedures, and take protective measures to ensure the safety of the storage process. In this way, it is necessary to properly store 2-%282-iododibenzo%5Bb%2Cd%5Dfuran-4-yl%29-4%2C4%2C5%2C5-tetramethyl-1%2C3%2C2-dioxaborolane and maintain its chemical stability.