What is the chemical structure of 2- ({3- (acetylamino) -5- [acetyl (methyl) amino] -2,4,6-triiodobenzoyl} amino) -2-deoxy-d-glucopyranose?

2-%28+%7B3-%28acetylamino%29-5-%5Bacetyl%28methyl%29amino%5D-2%2C4%2C6-triiodobenzoyl%7Damino%29-2-deoxy-d-glucopyranose is an organic compound. Its chemical structure is quite complex and consists of many parts.

Looking at its structure, it contains a 2-deoxy-D-glucopyranose unit, and the 2-position of this sugar unit is replaced by a specific group. This substituent group contains a benzoamide part. There are acetamide groups in 3 positions above the benzene ring, acetyl (methyl) amino groups in 5 positions, and iodine atoms in 2, 4, and 6 positions of the benzene ring.

From the perspective of chemical structure, the glucopyranose part provides the basic skeleton of carbohydrates, and the groups containing benzene rings and polyiodine substitutions connected to it endow the compound with unique chemical and physical properties. Polyiodine substitution may affect its density, polarity and activity in chemical reactions. Nitrogen-containing acetamide and acetyl (methyl) amino groups also affect the reactivity, solubility and interaction with other molecules of the compound.

The structural design of this compound may be important in the fields of organic synthesis, medicinal chemistry and other fields in order to achieve specific chemical or biological functions. Its complex structure also poses challenges for chemical research and synthesis, and requires delicate organic synthesis strategies to successfully prepare it.

What are the main uses of 2- ({3- (acetylamino) -5- [acetyl (methyl) amino] -2,4,6-triiodobenzoyl} amino) -2-deoxy-d-glucopyranose?

2-%28+%7B3-%28acetylamino%29-5-%5Bacetyl%28methyl%29amino%5D-2%2C4%2C6-triiodobenzoyl%7Damino%29-2-deoxy-d-glucopyranose is called iodoxanol, which is a non-ionic dimer iodine-containing contrast agent widely used in the field of medical imaging. Its main uses are as follows:
- ** X-ray angiography **: In cardiovascular angiography, iodoxanol is injected into the blood vessel. With its X-ray imaging characteristics, the doctor can clearly see the shape, running, stenosis or obstruction of the blood vessel. Such as coronary angiography, it can accurately determine whether there is atherosclerotic plaque in the coronary artery caused by lumen narrowing, which helps the doctor to accurately diagnose and evaluate the condition of coronary heart disease, and provides a key basis for subsequent treatment plans, such as drug therapy, interventional treatment or bypass surgery.
- ** CT Enhanced Scan **: During CT examination, the introduction of iodoxanol can improve the contrast between the diseased tissue and the normal tissue. For liver tumors, it may be difficult to clearly define the boundary and internal structure of the tumor on ordinary CT scan. After iodoxanol enhanced scan, the tumor tissue presents a specific enhancement pattern due to blood supply characteristics, which helps doctors to distinguish the benign and malignant tumors. Accurately determine the location, size and infiltration range of the tumor, which is of great significance to the stage and treatment planning of the tumor.
- ** Urography **: For the imaging of the urinary system, it can clearly display the morphology and structure of the renal pelvis, calyx, ureter and bladder. For the diagnosis of urinary system stones, tumors, congenital malformations and other diseases is of great value. For example, it can clarify the specific location of stones in the urinary system and provide detailed information for the selection of appropriate treatment methods, such as extracorporeal shock wave lithotripsy and ureteroscopy lithotripsy.

What are the physical properties of 2- ({3- (acetylamino) -5- [acetyl (methyl) amino] -2,4,6-triiodobenzoyl} amino) -2-deoxy-d-glucopyranose?

2-%28+%7B3-%28acetylamino%29-5-%5Bacetyl%28methyl%29amino%5D-2%2C4%2C6-triiodobenzoyl%7Damino%29-2-deoxy-d-glucopyranose is an organic compound. Its physical properties are as follows:

Looking at it, this compound is often in the state of white to off-white crystalline powder, with a fine texture and can be seen as uniform fine particles. This form is easy to store and transport, and is easy to handle in many experiments and production operations.

Smell, usually has no significant odor, or only a very weak special smell, which is almost imperceptible. This property makes it difficult to detect during use. This property does not disturb the experimenter or the surrounding environment due to strong odor.

Its solubility is quite important. In water, this compound has a certain solubility, but the solubility is not very high. In organic solvents, such as ethanol, acetone, etc., the solubility may vary. In ethanol, the solubility may be slightly better than that of water, and it can partially dissolve to form a uniform solution; in acetone, the solubility also has a specific performance, and the specific solubility will change due to temperature and other conditions.

Melting point is also one of the key physical properties. Its melting point has been determined to be in a specific temperature range, which is of great significance for the purity identification of the compound and related processing. When heated near the melting point, the compound will gradually transform from a solid state to a liquid state. This transition process provides an important reference for its processing in production and experimental applications.

In terms of density, the compound has a specific density value, which reflects its mass per unit volume. When mixing with other substances or performing separation operations, density characteristics can help to achieve separation by methods such as centrifugation and sedimentation according to the density difference of different substances.

In summary, the physical properties of 2-%28+%7B3-%28acetylamino%29-5-%5Bacetyl%28methyl%29amino%5D-2%2C4%2C6-triiodobenzoyl%7Damino%29-2-deoxy-d-glucopyranose, including appearance, odor, solubility, melting point and density, are of great value in chemical research, drug development and related industrial production, laying the foundation for their rational application and in-depth research.

What is the synthesis of 2- ({3- (acetylamino) -5- [acetyl (methyl) amino] -2,4,6-triiodobenzoyl} amino) -2-deoxy-d-glucopyranose?

To prepare 2 - {3 - (acetamido) -5 - [acetyl (methyl) amino] -2, 4, 6 - triiodobenzoyl} amino - 2 - deoxy - D - glucopyranose, the method is as follows:

First take an appropriate amount of 3 - amino - 5 - methylamino - 2,4,6 - triiodobenzoic acid, place it in a reactor, add an appropriate amount of acetic anhydride, and carry out the acetylation reaction at an appropriate temperature for a long time, so that the amino group is gradually converted into acetamido and acetyl (methyl) amino group, to obtain 3 - (acetamido) -5 - [acetyl (methyl) amino group The intermediate of -2,4,6-triiodobenzoic acid.

Take another 2-deoxy-D-glucopyranose and properly protect its hydroxyl group to avoid its gratuitous participation in the subsequent reaction. Then, the acetylated 3- (acetamido) -5 - [acetyl (methyl) amino] -2,4,6-triiodobenzoic acid and the protective hydroxyl group of 2-deoxy-D-glucopyranose are mixed in a suitable organic solvent, and a condensing agent, such as dicyclohexylcarbodiimide (DCC), is added to promote the condensation of the carboxyl group and the amino group of the two to form an amide bond to form a product containing the target structure, but at this time the hydroxyl group of the glucopyranose part is still in a protected state.

After the reaction is completed, the product is separated and purified, and impurities such as unreacted raw materials, condensing agents and their by-products are removed. After using suitable methods, such as using acid or base under specific conditions to remove the protective group on the hydroxyl group of glucose pyranose, carefully control the reaction conditions to ensure the structural integrity and purity of the target product, and finally obtain 2 - {3 - (acetamido) -5 - [acetyl (methyl) amino] -2,4,6 - triiodobenzoyl} amino - 2 - deoxy - D - glucopyranose. The whole process requires fine control of the reaction conditions and monitoring of the reaction process to achieve good yield and purity.

2- ({3- (acetylamino) -5- [acetyl (methyl) amino] -2,4,6-triiodobenzoyl} amino) -2-deoxy-d-glucopyranose What are the precautions during use?

2-%28+%7B3-%28acetylamino%29-5-%5Bacetyl%28methyl%29amino%5D-2%2C4%2C6-triiodobenzoyl%7Damino%29-2-deoxy-d-glucopyranose is a complex organic compound, in the process of use, the following things should be noted:

First, this material has a specific chemical structure and characteristics, and its operation must be cautious. Because it contains specific groups such as iodine atoms, or has specific chemical reactions with other substances. Before use, it is necessary to understand its chemical properties in detail, especially the interaction with various substances in the surrounding environment, in order to prevent adverse reactions or accidents.

Second, when taking the compound, accurate weighing is the key. Because in the reaction or application, the amount of dosage may have a significant impact on the result. When using precise weighing equipment, and strictly follow the dosage required by the experiment or production.

Third, the storage conditions should not be ignored. According to its characteristics, it should be stored in a suitable environment, such as under specific temperature and humidity conditions, and factors such as protection from light and moisture should be considered to ensure its stability and quality are not affected. If stored improperly, it may cause the compound to deteriorate, which in turn affects the use effect.

Fourth, during use, safety protection is indispensable. In view of the complexity of its chemical structure, or potential harm to the human body. Therefore, the operator should wear suitable protective equipment, such as gloves, goggles, protective clothing, etc., to prevent the compound from contacting the skin, eyes, etc., to ensure their own safety.

Fifth, the place where the compound is used should be well ventilated. In order to prevent the accumulation of gas generated by compound volatilization, avoid damage to the health of operators, and reduce potential safety risks.

In short, when using 2-%28+%7B3-%28acetylamino%29-5-%5Bacetyl%28methyl%29amino%5D-2%2C4%2C6-triiodobenzoyl%7Damino%29-2-deoxy-d-glucopyranose, its characteristics, operating specifications, safety protection and storage conditions should be carefully considered, and must not be taken lightly to ensure the smooth use process.