What is the chemical structure of 2- (4- (2-cyclopropoxyethoxy) benzyl) -1-chloro-4-iodobenzene?
This is the naming of an organic compound. To know its chemical structure, it is necessary to analyze it according to the naming rules. "2- (4- (2-cyclopropoxyethoxy) benzyl) -1-chloro-4-iodobenzene", and see the step-by-step disassembly.
"Benzene" is a hexagonal aromatic hydrocarbon structure, which is the core skeleton of the compound. "1-chloro-4-iodobenzene" indicates that there are chlorine atoms at position 1 of the benzene ring and iodine atoms at position 4.
Look again at "2- (4- (2-cyclopropoxy ethoxy) benzyl) ". "Benzyl", that is, benzyl, is a benzene ring connected to a methylene (-CH ₂ -) 。“ 4- (2-cyclopropoxy ethoxy) "Modified benzyl group, is connected to a" 2-cyclopropoxy ethoxy "structure at position 4 of the benzyl phenyl ring." 2-Cyclopropoxyethoxy ", where" ethoxy "is ethyl (-C ² H) connected to the oxygen atom (-OC ² H), and" cyclopropoxy "is cyclopropane connected to the oxygen atom, and this cyclopropoxy is connected to the ethoxy at position 2.
In summary, the chemical structure of this compound is centered on the benzene ring, with a chlorine atom at position 1 and an iodine atom at position 4. There is a benzyl group with a specific substituent at position 2. The benzene ring at position 4 of this benzyl group is connected with a" 2-cyclopropoxyethoxy "structure. In this way, the chemical structure of the compound is immediately apparent.
What are the physical properties of 2- (4- (2-cyclopropoxyethoxy) benzyl) -1-chloro-4-iodobenzene?
2-%284-%282-cyclopropoxyethoxy%29benzyl%29-1-chloro-4-iodobenzene is an organic compound with unique physical properties. Its shape is either solid or liquid, depending on the surrounding temperature and pressure.
Looking at its melting point, it varies depending on the intermolecular force. If the intermolecular force is strong, more energy is required to break the lattice, and the melting point is high; otherwise, it is low. And the complexity of the molecular structure, polarity and other factors will also affect the melting point. The melting point of this compound may be in a specific range, but it is difficult to say precisely because there is no specific experimental data.
In terms of boiling point, it is affected by the intermolecular force and molecular weight. The larger the molecular weight, the stronger the intermolecular force. To make the molecule break free from the liquid phase and form a gas phase, the more energy is required, the higher the boiling point. In addition, if there are special intermolecular forces such as hydrogen bonds, the boiling point will also be significantly increased.
In terms of solubility, it follows the principle of "similar miscibility". Its molecular structure contains aromatic rings, halogen atoms and ether bonds. Aromatic rings and halogen atoms have certain hydrophobicity, while ether bonds have certain hydrophilicity. Therefore, in organic solvents such as toluene and dichloromethane, or due to similar structures, it has good solubility; in water, due to strong overall hydrophobicity, solubility or poor.
The density is related to the degree of molecular packing compactness and molecular weight. If it is tightly packed and has a large molecular weight, the density is high. However, the exact density value needs to be determined experimentally.
The physical properties of this compound are affected by the synergistic effect of various groups in the molecular structure. Although there is no specific value, the range and trend of physical properties can be roughly inferred by comparing chemical principles with similar structural compounds.
What are the synthesis methods of 2- (4- (2-cyclopropoxyethoxy) benzyl) -1-chloro-4-iodobenzene?
To prepare 2 - (4 - (2 - cyclopropoxyethoxy) benzyl) - 1 - chloro - 4 - iodobenzene, the method of synthesis can be obtained in many ways.
First Cox starts with halogenated aromatics. First take the appropriate chloroiodobenzene and find its activity check point. Among them, 1 - chloro - 4 - iodobenzene can react with benzyl derivatives with suitable functional groups. If a benzyl halide containing 2 - cyclopropoxyethoxy ethoxy is obtained, with the aid of a base and in a suitable solvent, the two can be nucleophilic substituted. Alkalis, such as potassium carbonate, can capture the active hydrogen of halogenated aromatic hydrocarbons to form carbon anions, and then attack the carbon-halogen bond of benzyl halide, so as to form a carbon-carbon bond, together with these two parts.
can start from the construction of cyclopropoxy ethoxy. First, 2-cyclopropoxy ethanol is prepared. After properly protecting the hydroxyl group, it reacts with halogenated benzyl benzene, then deprotects, and then halogenates to introduce chlorine and iodine atoms. If a halogenating agent such as phosphorus tribromide is used, the hydroxyl group can be converted into a halogen atom at a low temperature and in an anhydrous environment to obtain the desired halogen.
Furthermore, the method of transition metal catalysis can be Using metals such as palladium and copper as catalysts, the biarylation reaction may be able to achieve this synthesis. Select appropriate ligands to coordinate metals with substrates to regulate reaction activity and selectivity. For example, using bisphosphine ligands with palladium to catalyze 1-chloro-4-iodobenzene and benzyl derivatives containing 2-cyclopropoxyethoxy. Under mild conditions, the target product can be obtained through oxidative addition, migration insertion, reduction and elimination. All methods need to carefully consider the reaction conditions, temperature control, timing control, and agent selection to obtain the product with good yield.
What are the application fields of 2- (4- (2-cyclopropoxyethoxy) benzyl) -1-chloro-4-iodobenzene?
2-%284-%282-cyclopropoxyethoxy%29benzyl%29-1-chloro-4-iodobenzene is an organic compound with a unique chemical structure composed of a benzene ring and a specific substituent. This compound has potential applications in many fields, as detailed below:
- ** Medicinal Chemistry **: In drug development, benzene rings and halogen atoms are often key pharmacophore groups that can interact with biological targets. For example, chlorine and iodine atoms can change the lipid solubility and electron cloud distribution of compounds, enhancing the ability to bind to receptors. The ether bond and cyclopropyl part in its structure can affect molecular flexibility and spatial orientation, which is conducive to the design of drugs with high affinity and selectivity for specific disease-related targets. If the inhibitor design for certain receptors or enzymes, the compound structure may provide a unique binding mode, which is expected to be used in the development of anti-cancer, anti-inflammatory and neurological diseases therapeutic drugs.
- ** Materials Science Field **: Because of its halogen atom and aromatic structure, or with special optoelectronic properties. In organic semiconductor materials, benzene rings can form a conjugated system, which is conducive to electron transport; chlorine and iodine atoms can adjust the energy band structure and change the electrical properties of materials. Or can be used to prepare organic Light Emitting Diode (OLED), organic solar cells and other optoelectronic devices, providing the possibility for the development of high-performance, low-cost organic optoelectronic materials.
- ** Organic Synthetic Chemistry Field **: As a complex organic molecule, its structure can be used as an intermediate in organic synthesis. With the help of its different substituents, structural modification and derivatization can be carried out through various organic reactions, and more complex and diverse organic compounds can be synthesized, expanding the scope of organic synthesis chemistry research, and providing an effective way for the construction of new organic frameworks and functional molecules.
What is the market outlook for 2- (4- (2-cyclopropoxyethoxy) benzyl) -1-chloro-4-iodobenzene?
2-%284-%282-cyclopropoxyethoxy%29benzyl%29-1-chloro-4-iodobenzene, this is an organic compound. Looking at its current market prospects, it is quite impressive.
Due to the rapid development of the field of organic synthesis, there is a growing demand for organic compounds with characteristic structures in the development of many new materials and drugs. The unique chemical structure of this compound contains groups such as chlorine, iodine and cyclopropoxyethoxylbenzyl, which endow it with diverse reactivity and special physical and chemical properties.
In the field of materials science, it may be used to create new photoelectric materials. The conjugated system of halogen atoms and benzene rings in its structure may affect the distribution of molecular electron clouds and improve the photoelectric properties of materials, such as improving fluorescence efficiency and optimizing carrier transport. Due to the potential application value in frontier fields such as organic Light Emitting Diode (OLED) and solar cells, material research and development enterprises and scientific research institutions have paid high attention to similar structural compounds, and the market demand may gradually increase.
In the field of pharmaceutical chemistry, its structure may fit some drug targets. Through reasonable modification and modification, new therapeutic drugs may be developed. For example, with its special structure and activity, or inhibitors for specific disease-related proteins can be designed, providing novel opportunities for innovative drug development. At present, the competition for new drug development is intense, and there is an urgent need for compounds with unique structures and potential biological activities. This compound is expected to gain a place in the drug development market by virtue of its own characteristics.
In addition, with the deepening of the concept of green chemistry, the demand for efficient and green methods for synthesizing this compound is also growing. If an environmentally friendly and economically viable synthesis route can be developed, it will further expand its market application scope and enhance market competitiveness.
Overall, 2-%284-%282-cyclopropoxyethoxy%29benzyl%29-1-chloro-4-iodobenzene has shown good market prospects in many fields such as materials science and medicinal chemistry with its unique structure, and is expected to play an important role in the development of related industries in the future.