2,4-dichloro-3-iodopy-ridine

2% 2C4-dihydro-3-furanone, this substance has important uses in many fields.
In the field of fragrances, it is widely used in the preparation of various flavors by virtue of its unique aroma characteristics. Because it can give flavors a unique flavor, and the effect of enhancing and enhancing fragrance is significant, it frequently appears in flavor formulations in food, cosmetics and other industries. In the preparation of food flavors, it can create a fresh, sweet and unique aroma, greatly enhance the flavor quality of food, and play a key role in shaping the aroma of some high-end candies and beverages; in cosmetic flavors, it can give products a pleasant aroma and increase product attractiveness.
In the field of medicine, 2% 2C4-dihydro-3-furanone is an important pharmaceutical intermediate. Its special chemical structure provides a key starting material or reaction intermediate for the synthesis of many drugs. By modifying and transforming its structure, compounds with specific pharmacological activities can be prepared. Many drugs with antibacterial, anti-inflammatory, anti-tumor and other activities are prepared with 2% 2C4-dihydro-3-furanone as the basic raw material in the synthesis process and are prepared by multi-step chemical reaction, which is of great significance to promote the process of pharmaceutical research and development.
In the field of organic synthesis, it is an extremely useful synthetic block. Due to its unsaturated bonds and active groups such as carbonyl groups, it can participate in a variety of organic reactions, such as nucleophilic addition and cyclization reactions. With the help of these reactions, complex and diverse organic compounds can be constructed, providing a powerful tool for the development of organic synthetic chemistry, and are widely used in the synthesis of new materials, fine chemicals and other synthesis studies.

2% 2C4-difluoro-3-iodopyridine is a key intermediate in the field of organic synthesis, with the following physical properties:
- ** Appearance properties **: Under normal conditions, 2% 2C4-difluoro-3-iodopyridine is mostly colorless to light yellow liquid, with pure texture, translucent visual perception, and no obvious impurities. This appearance feature provides an intuitive basis for its observation and identification in actual operation. In the laboratory or industrial production scene, its purity and deterioration can be preliminarily determined by observing its color and state.
- ** Melting point and boiling point **: The melting point is about - 20 ° C, and the boiling point is between 180-182 ° C. The lower melting point means that the substance can be converted from solid to liquid in a relatively low temperature environment; while the boiling point is within a certain range, indicating that by precisely controlling the temperature, it can be converted from liquid to gaseous, and then distillation, separation, purification and other operations can be achieved, which is of great significance for its preparation and purification.
- ** Solubility **: 2% 2C4-difluoro-3-iodopyridine is soluble in a variety of common organic solvents, such as dichloromethane, chloroform, ether, tetrahydrofuran, etc., but it is difficult to dissolve in water. The good solubility in organic solvents makes it a reactant or intermediate in organic synthesis reactions, fully contacting and reacting with many compounds that are also soluble in organic solvents, greatly expanding its application in the field of organic synthesis. The property of insolubility in water also facilitates the separation of it from water-soluble substances, which can be effectively separated by simple liquid-liquid extraction operations.
- ** Density and vapor pressure **: The density is about 2.053 g/cm ³, which is relatively dense compared to water and will be in the lower layer in the reaction or separation process involving stratification. The vapor pressure will change with temperature changes. When the temperature increases, the vapor pressure increases, and the evaporation rate of the substance increases. Knowing the vapor pressure can help to take appropriate measures according to the ambient temperature during storage and use to avoid losses due to excessive volatilization or safety issues.
- ** Stability **: Under normal storage and use conditions, 2% 2C4-difluoro-3-iodopyridine has certain stability. However, due to the presence of iodine and fluorine atoms in its structure, it is more sensitive to light and heat. Light or high temperature environments may cause chemical bonds to break and initiate decomposition reactions, so it is usually necessary to store in a cool, dry and dark place, and away from substances that may initiate reactions such as ignition and oxidants.

2% 2C4-difluoro-3-iodopyridine, this is an organic compound. The stability of its chemical properties needs to be explored from multiple ends.
Structurally, the pyridine ring is aromatic, and the delocalization of its π electron cloud imparts certain stability to the molecule. The fluorine atom has a high electronegativity and is connected to the carbon atom to form a C-F bond. This bond energy is relatively large, about 485kJ/mol, which can enhance the stability of molecular structure. Although the electronegativity of iodine atom is inferior to that of fluorine, its atomic radius is large, which can disperse the electron cloud to a certain extent and is also beneficial to molecular stability.
However, this compound also has unstable factors. The nitrogen atom on the pyridine ring has a lone pair of electrons, which can participate in chemical reactions, such as nucleophilic substitution reactions. When encountering nucleophilic reagents, the atoms adjacent to or relative to the nitrogen atom on the pyridine ring can be replaced. Especially the iodine atom at the 3-position has a large tendency to leave the iodine atom. Under suitable conditions, nucleophilic substitution is prone to occur, resulting in molecular structure changes.
In addition, the stability of the compound to light and heat also needs to be considered. Light and heat can provide energy, which can lead to the breaking or rearrangement of chemical bonds in the molecule. In terms of thermal stability, although the C-F bond is relatively stable with the pyridine ring, excessive temperature may cause the C-I bond to break, triggering decomposition In terms of photostability, molecules or active intermediates are produced under light to induce subsequent reactions.
In summary, the stability of 2% 2C4-difluoro-3-iodopyridine is not absolute, and its structure may change under specific conditions. The stability is restricted by molecular structure, reaction conditions and external environment.

To prepare 2,4-difluoro-3-methoxy pyridine, there are many methods. The following are common synthesis paths:
First, pyridine is used as the starting material. First, pyridine interacts with halogenated reagents under specific conditions to introduce halogen atoms, and then uses nucleophilic substitution reaction to replace halogen with fluorine ions, and then through methoxylation reaction, methoxy is introduced into the corresponding position to obtain the target product. This path step is relatively complicated, and it is necessary to precisely control the reaction conditions of each step to ensure that the reaction proceeds in the expected direction to improve the yield and purity.
Second, the derivative containing pyridine ring is used as the starting material. After appropriate functional group conversion, the desired substituent is gradually constructed. For example, the specific position of the derivative is halogenated first, and then the fluorination and methoxylation operations are carried out. This approach needs to reasonably plan the reaction sequence and conditions according to the structural characteristics of the starting derivative, so as to achieve the purpose of efficient synthesis.
Third, the pyridine ring is constructed by cyclization reaction. The chain compound with suitable substituents is used as raw material, and under appropriate catalyst and reaction conditions, the intramolecular cyclization occurs to form a pyridine ring structure, and fluorine atoms and methoxy groups are introduced at the same time or later. The key to this method is to design suitable chain precursors to ensure the smooth occurrence of cyclization reactions and the precise introduction of target substituents.
In actual synthesis, it is necessary to comprehensively consider the availability of raw materials, cost, difficulty in controlling reaction conditions, yield and purity, and carefully select the optimal synthesis method. It is also necessary to continuously optimize the reaction conditions, improve the reaction efficiency and product quality to meet the needs of actual production or research.

2% 2C4-dihydro-3-furanaldehyde is on the market, and its price is about 100 gold. The method of preparing this substance may be complex or simple, and the price of raw materials also fluctuates, so its price changes. If it is made by ordinary methods, the required raw materials are easily available and the price is flat, the price is also stable and slightly lower; if the preparation method requires exquisite techniques, or the raw materials are rare, the price is high. And the supply and demand of the market also affect its price. Those who want it are many, and those who supply it are few, the price will rise; if the supply exceeds the demand, the price will drop. At present, this aldehyde is in the market, and the price per catty may be between eighty gold and one hundred and twenty gold. Buyers and sellers often negotiate according to the current market conditions and the quality.