2,5-difluoro-4-iodopyridine

2% 2C5-diene-4-pyrimidinone, this substance is within the scope of "Tiangong Kaiwu", and its main use is mostly related to pharmaceuticals and some special chemical raw materials.
In the pharmaceutical field, due to its special chemical structure, it is often used as a key intermediate. The structure of geinpyrimidinone is quite common in many active pharmaceutical ingredients, which can participate in the construction of the core skeleton of drugs and endow drugs with specific biological activities. For example, in the synthesis of some antibacterial drugs, 2% 2C5-diene-4-pyrimidinone can be connected to other functional groups through a series of chemical reactions, thereby shaping drug molecules that have inhibitory or killing effects on specific bacteria.
It also plays an important role in special chemical raw materials. Because it contains a conjugated diene structure, it can participate in a variety of polymerization reactions. It can be copolymerized with other compounds as a monomer to prepare polymer materials with special properties. These materials may have unique optical and electrical properties and are used in the manufacture of fine chemical products such as optical instruments and electronic components. For example, in the preparation of some light-sensitive optical materials, it is used to participate in the polymerization reaction to endow the material with specific light response characteristics.
Furthermore, in the field of dye synthesis, 2% 2C5-diene-4-pyrimidinone may contribute a unique chromophore group. Through chemical reaction, it is integrated into the molecular structure of the dye, so that the dye presents a specific color and dyeing properties to meet the dyeing needs of different fabrics and materials.

The synthesis method of 2% 2C5-diethyl-4-chloropyrimidine can be done by the classical organic synthesis method.
First, a nitrogen-containing heterocyclic compound is used as the starting material. First, take a suitable pyrimidine derivative with a modifiable check point on the ring. This derivative is nucleophilic substitution with halogenated ethane in an organic solvent in the presence of a suitable base. The base can be selected from potassium carbonate, sodium carbonate or the like, and organic solvents such as acetonitrile, N, N-dimethylformamide can be used. Control the reaction temperature and time, the temperature should be between 50-80 degrees Celsius, the reaction time is about 6-12 hours, to promote the formation of carbon-carbon bonds with halogenated ethane at a specific position on the pyrimidine ring, and the introduction of ethyl groups. Then, chlorination is carried out at another position on the pyrimidine ring. Suitable chlorination reagents, such as phosphorus oxychloride, phosphorus pentachloride, etc. Under heating conditions, generally 80-120 degrees Celsius, the reaction is 3-6 hours to achieve chlorination at a specific position, resulting in 2,5-diethyl-4-chloropyrimidine.
Second, start with the method of constructing a pyrimidine ring. First, the pyrimidine ring is formed by condensation reaction of suitable carbonyl-containing compounds and nitrogen-containing compounds, such as diethyl malonate and urea, in a basic catalyst such as sodium alcohol, in a solvent such as ethanol. The reaction temperature is 60-90 degrees Celsius, and the reaction time is about 8-15 hours. After forming the pyrimidine ring, ethyl is introduced first, and then chlorinated according to the above similar method. The addition of ethyl is the same as the nucleophilic substitution reaction described above, and the chlorination step also uses similar chlorination reagents and conditions. Therefore, the target product 2,5-diethyl-4-chloropyrimidine can also be synthesized.
Third, the coupling reaction catalyzed by transition metals can be tried. Using halogenated pyrimidine derivatives as substrates, suitable transition metal catalysts such as palladium and copper, such as tetra (triphenylphosphine) palladium, etc. With corresponding ligands, the coupling reaction with halogenated ethane is carried out to introduce ethyl group. The reaction system needs to be protected by inert gas and carried out in a suitable solvent such as toluene, the temperature is controlled at 100-130 degrees Celsius, and the reaction is 5-10 hours. After the introduction of ethyl group, the chlorination step is carried out. The chlorination reagents and conditions are as mentioned above, and the purpose of synthesizing 2,5-diethyl-4-chloropyrimidine can also be achieved through this route.

2% 2C5-diene-4-cyanopyridine, this physical property is complex and delicate, and listen to me in detail.
Looking at its shape, at room temperature, it is mostly a colorless to light yellow transparent liquid, with a pure texture, just like jade dew agar. Its smell is specific, although it is not a pungent odor, it also has a unique irritating smell, which is unforgettable, and this smell is also one of its characteristics.
When it comes to solubility, it shows extraordinary affinity in organic solvents. Organic solvents such as common ethanol, ether, acetone, etc. can be mixed with it, just like water and emulsion. However, in water, its solubility is extremely limited, and it is as difficult to miscible as oil and water, which is a significant characteristic of solubility.
Thermal stability is also a key physical property. When heated, within a certain temperature range, it can still maintain the stability of its own structure. However, if the temperature rises too high and exceeds the limit it can withstand, it is very easy to decompose. At this time, the internal structure disintegrates and releases toxic gases such as hydrogen cyanide, which requires special vigilance.
Its chemical activity cannot be underestimated. The conjugated diene structure and cyanide group contained in the molecular structure give it higher reactivity. It can react with many electrophilic reagents and nucleophiles. In the field of organic synthesis, it is like a smart cornerstone, capable of constructing ever-changing organic compounds, adding to the technology of organic synthesis.
In addition, in terms of optical properties, due to the characteristics of internal electron transitions in molecules, it will exhibit a unique absorption spectrum under specific wavelength light irradiation. This property also provides an effective way to identify and analyze this substance. In short, 2% 2C5-diene-4-cyanopyridine has rich and unique physical properties, and is of great significance and value in many fields such as chemical industry and scientific research.

Today there are 2,5-diene-4-cyanopyridine, what is the market price? This is a chemical product, and the change in price is often due to many reasons.
First, the price of raw materials is necessary. If the raw materials are easy to obtain, abundant in production, and affordable, the cost of 2,5-diene-4-cyanopyridine will decrease, and the market price will also decrease. On the contrary, if the raw materials are thin, difficult to harvest, and expensive, the cost will be high and the price will be high.
Second, the craftsmanship is related. If the craftsmanship is refined, the yield is high, and the cost is low, the price can be reduced.
Third, the supply and demand of the city is the main reason. If the demand exceeds the supply, the price will rise; if the supply exceeds the demand, the stock of goods will be difficult to sell, and the price will be depressed. If the industry increases, the production volume will rise, but the demand will remain unchanged or decrease, and the price will fall.
Fourth, the government regulations and tax rates are also involved. The government's incentives and the reduction of taxes can reduce the burden on those who assist in childbirth, and the price may fall. On the contrary, if the strict tax increases, the cost of the producer will increase, and the price may rise.
The price of various places may be different. Supply and demand vary depending on the cost of transportation and the place. In prosperous places, more or higher prices are required; in remote places, less or lower prices are required.
To know the exact price of 2,5-diene-4-cyanopyridine, the actual price can only be obtained by consulting the chemical industry market, industry, or viewing the trading platform, subject to the current market conditions.

2% 2C5-diene-4-cyanopyridine is an important organic compound, and many key matters must be paid attention to during storage and transportation.
It has certain chemical activity, and it is easy to cause violent chemical reactions when exposed to hot topics, open flames or oxidants, and even has the risk of combustion and explosion. Therefore, when storing, it must be placed in a cool and well-ventilated place, away from fire and heat sources, and stored separately from oxidants, acids, and alkalis, and must not be mixed. The warehouse should be equipped with the corresponding variety and quantity of fire fighting equipment, and the storage area should be equipped with suitable materials to contain leaks.
During transportation, the transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. It is best to transport in the morning and evening in summer to prevent sunlight exposure. The trough (tank) car used during transportation should have a grounding chain, and holes can be set in the trough to baffle to reduce shock and generate static electricity. It is strictly forbidden to mix and transport with oxidants, acids, alkalis, edible chemicals, etc. During transportation, it should be protected from exposure to sunlight, rain, and high temperature. Stopover should be kept away from fire, heat sources, and high temperature areas. The exhaust pipe of the vehicle carrying this item must be equipped with a fire retardant device, and it is forbidden to use machinery and tools that are prone to sparks for loading and unloading. When transporting by road, it should be driven according to the specified route, and do not stop in residential areas and densely populated areas. It is Only in this way can we ensure the safety of 2% 2C5-diene-4-cyanopyridine during storage and transportation, avoid accidents, and ensure the safety of personnel and the environment.