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What is the chemical structure of 2- (acetylamino) -3- (4-hydroxy-3,5-diiodophenyl) propanoic Acid?
2-%28acetylamino%29-3-%284-hydroxy-3%2C5-diiodophenyl%29propanoic Acid, it is an organic compound. In modern chemical representation, its chemical formula can be detailed as follows:
In this compound, it contains acetylamino, which is formed by connecting acetyl group (-COCH) with amino group (-NH2O), i.e. -NHCOCH. Furthermore, it also contains 4-hydroxy-3,5-diiodophenyl (4-hydroxy-3,5-diiodophenyl), which has a hydroxyl group (-OH) at the 4th position and an iodine atom (-I) at the 3rd and 5th positions. In addition, this compound contains propanoic acid (propanoic acid) structure, the basic structure of propionic acid is CH 🥰 CH 🥰 COOH, in this compound, the 2 position of propionic acid is connected to acetamide group, and the 3 position is connected to 4-hydroxy-3,5-diiodophenyl group.
Therefore, its chemical structure is roughly: CH 🥰 CONH - CH (COOH) - CH 🥰 - C 🥰 H 🥰 (OH) I. In this way, the groups are connected in sequence to form this specific chemical structure. In this structure, different groups interact, endowing the compound with unique chemical and physical properties. Due to its special structure, it may have unique reactivity and application possibilities in chemical research and related fields.
What are the main uses of 2- (acetylamino) -3- (4-hydroxy-3,5-diiodophenyl) propanoic Acid?
2- (Acetamido) -3- (4-hydroxy-3,5-diiodophenyl) propionic acid, this substance is a key raw material for organic synthesis and is widely used in the field of medicinal chemistry.
In the field of drug research and development, its role is crucial. Many anti-inflammatory drugs and analgesics are prepared based on it. Because of its special chemical structure, it can participate in complex chemical reactions and undergo multiple steps of transformation to generate compounds with specific pharmacological activities. For example, in the synthesis process of some drugs targeting inflammatory diseases such as arthritis, this substance can be used as a key intermediate to play a key role in building the core structure of drug activity.
In the field of organic synthetic chemistry, it is also an extremely important synthetic building block. With multiple activity check points in its structure, it can react with different reagents to achieve diverse modifications of molecular structures. Chemists can use it to react with various halogens, amine compounds, etc. according to specific design requirements to construct complex and functional organic molecules, providing the possibility for the creation of new materials and functional molecules.
In addition, in biochemical research, it also has important uses. Because of its structural similarity to naturally occurring compounds in some organisms, it can be used as a probe molecule to study specific biochemical reaction processes and metabolic pathways in organisms, helping scientists to deeply understand the chemical nature of life activities.
What are the physical properties of 2- (acetylamino) -3- (4-hydroxy-3,5-diiodophenyl) propanoic Acid?
2-%28acetylamino%29-3-%284-hydroxy-3%2C5-diiodophenyl%29propanoic Acid is 2- (acetamido) -3- (4-hydroxy-3,5-diiodophenyl) propionic acid, often referred to as iodohexanol impurities, its physical properties are as follows:
This substance is usually white to off-white crystalline powder state. Looking at its color, pure is white and uniform, if it contains impurities, or has a slight color change. Its texture is delicate, and it feels smooth to the touch.
In terms of solubility, it can show a certain solubility in water, but the solubility is not very high, and the degree of solubility may increase with increasing temperature. In organic solvents, such as ethanol, acetone, etc., there are also different solubility behaviors. It is slightly better in ethanol and slightly less soluble in acetone. This is because there are both polar groups in the molecular structure, such as carboxyl, hydroxyl and acetamide, which give it a certain hydrophilicity. It also contains non-polar benzene rings and iodine atoms, which affect its solubility balance in water and organic solvents.
Its melting point is in a specific temperature range, roughly around [X] ° C. This characteristic is of great significance for material identification and purity judgment. When heated to this temperature, the material gradually melts from solid to liquid. This process is smooth and the temperature range is narrow. If the purity is not good, the melting point may be reduced, and the melting range will also be widened.
In addition, the density of this substance is also an inherent physical property, about [X] g/cm ³, reflecting the unit volume mass of the substance. It is crucial for accurate measurement and mixing operations in the process of substance separation and preparation. Its stability is good at room temperature and pressure. In case of high temperature, strong light or specific chemical environment, the structure may change, which affects its quality and performance.
What are the synthesis methods of 2- (acetylamino) -3- (4-hydroxy-3,5-diiodophenyl) propanoic Acid?
2-%28acetylamino%29-3-%284-hydroxy-3%2C5-diiodophenyl%29propanoic Acid is 2- (acetamido) -3- (4-hydroxy-3,5-diiodophenyl) propionic acid, which is an organic compound. The common synthesis method is covered with the following numbers:
First, it is based on iodobenzene derivatives. First, find 4-hydroxy-3,5-diiodobenzaldehyde and other substances, and make it and diethyl malonate in an alkaline environment, such as ethanol solution of sodium ethyl alcohol, Knoevenagel condensation reaction. This reaction can form a trans-cinnamate derivative. After reducing the ester group to an alcohol with a reducing agent such as lithium aluminum hydride, it is oxidized, such as PCC (pyridinium chlorochromate salt), to obtain the corresponding aldehyde. Next, acetamide is used as the acetamide donor, and in the presence of a suitable catalyst, such as p-toluenesulfonic acid, it is condensed with the aldehyde, and then hydrolyzed to obtain the target product.
Second, starting from halogenated benzene. Select 3,5-dihalo-4-hydroxybenzene as the raw material, and first use an acetamide reagent, such as acetyl chloride, to react with anhydrous aluminum trichloride to introduce acetamide. After that, after the iodine substitution reaction, iodine and appropriate oxidants, such as hydrogen peroxide, sodium periodate, etc., are usually used in a suitable solvent, such as glacial acetic acid, to replace the halogen atom on the benzene ring with iodine. Finally, the propionic acid structure is constructed by the malonate ester method. Similar to the previous method, the ester is formed first, and then it is reduced, oxidized, condensed, and hydrolyzed to obtain 2- (acetamido) -3- (4-hydroxy-3,5-diiodophenyl) propionic acid.
Third, aminophenol is used as the starting material. Take 4-aminophenol, acetylate the protective amino group first, and then iodide to obtain 4- (acetamino) -3,5-diiodophenol. After reacting with halogenated propionate, under alkaline conditions, the phenolic hydroxyl group and halogenated propionate undergo nucleophilic substitution. Finally, hydrolyze the ester group to obtain the target compound.
When synthesizing, it is necessary to pay attention to the precise control of the reaction conditions. The solvent, temperature, and catalyst dosage are all related to the success or failure of the reaction and the purity of the product. And the products of each step often need to be finely separated and purified, such as column chromatography, recrystallization and other means to remove impurities and obtain high-purity 2- (acetamido) -3- (4-hydroxy-3,5-diiodophenyl) propionic acid.
2- (acetylamino) -3- (4-hydroxy-3,5-diiodophenyl) propanoic Acid What are the precautions during use?
2-%28acetylamino%29-3-%284-hydroxy-3%2C5-diiodophenyl%29propanoic Acid is 2- (acetamido) -3- (4-hydroxy-3,5-diiodophenyl) propionic acid, which is an organic compound. During use, pay attention to the following ends:
First, it is related to safety protection. Because it has certain chemical activity, it is necessary to take protective measures when contacting. When operating, you need to wear laboratory clothes, gloves and goggles to prevent the substance from contacting the skin and eyes. In case of inadvertent contact, you should immediately rinse with plenty of water. If symptoms persist, you must seek medical attention in time.
Second, about storage conditions. Store it in a dry, cool and well-ventilated place, away from fire and heat sources. At the same time, it needs to be stored separately from oxidants, acids, bases, etc., to avoid chemical reactions caused by mixed storage, resulting in deterioration or danger.
Third, accurately control the dosage when using. According to specific experimental or production needs, obtain the right amount of the substance by accurate weighing. Too much or too little dosage may affect the experimental results or product quality. For example, in a chemical synthesis reaction, improper dosage may lead to incomplete reaction or formation of impurities.
Fourth, be familiar with its physical and chemical properties. Understand its solubility, stability and other properties so that it can be properly handled during use. For example, know which solvent it has good solubility in, which helps to choose the appropriate reaction medium or separation and purification method.
Fifth, the use environment should not be ignored. The operation should be carried out in a place with good ventilation equipment to prevent the accumulation of volatile gases in the air and cause harm to human health. At the same time, keep the operating environment clean and tidy to avoid impurities mixing affecting its performance.