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What are the main uses of 2-amino-3,5-diiodopyridine?
2-Amino-3,5-diiodopyridine is 2-amino-3,5-diiodopyridine, which has a wide range of uses.
In the field of medicinal chemistry, it is often a key intermediate in the synthesis of many drugs. The structure of the Gaiinpyridine ring and the properties of amino and iodine atoms endow compounds with unique biological and reactive activities. For example, in the development of antibacterial drugs, 2-amino-3,5-diiodopyridine can be chemically modified to construct structures that bind to specific bacterial targets, thereby achieving antibacterial effect. Or in the development of anti-cancer drugs, it is used as a starting material to introduce other active groups through multi-step reactions, hoping to obtain new drugs with targeted effects on cancer cells.
In the field of materials science, it also has important uses. It can be used as a raw material for the preparation of functional materials, such as photoelectric materials. Pyridine rings and iodine atoms can affect the electron cloud distribution of materials, thereby changing the optical and electrical properties of materials. By integrating 2-amino-3,5-diiodopyridine into polymer structures, materials with special photoelectric responses can be prepared and applied to organic Light Emitting Diodes (OLEDs), solar cells and other devices.
In the field of organic synthetic chemistry, the activity of 2-amino-3,5-diiodopyridine amino and iodine atoms can participate in a variety of chemical reactions, such as nucleophilic substitution reactions, coupling reactions, etc. Through these reactions, chemists can construct complex organic molecules, providing an important material basis and reaction path for the development of organic synthetic chemistry.
What are the physical properties of 2-amino-3,5-diiodopyridine?
2-Amino-3,5-diiodopyridine is one of the organic compounds. Its physical properties are quite impressive.
First of all, its appearance, under normal conditions, is mostly white to light yellow crystalline powder, delicate and uniform, it looks like fine dust gathered in one place, flashing a faint light.
As for the melting point, the melting point of this compound is about 162-166 ° C. When the temperature gradually rises, its solid state will slowly melt, like ice and snow in warm spring, from a solid state to a flowing shape. This property is crucial in the identification and purification of compounds.
In terms of solubility, 2-amino-3,5-diiodopyridine exhibits good solubility in common organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), which can be fused with it, just like fish entering the river and sea, and dispersed evenly. However, in water, its solubility is poor, and it can only be slightly soluble, just like sand and gravel entering water, making it difficult to form a whole.
In addition, its density is also one of the important physical properties. Although the exact standard value has not been widely disseminated, its density is within a certain reasonable range compared with common organic compounds, which affects its distribution and behavior in various mixed systems.
Furthermore, the stability of this compound cannot be ignored. In a normal temperature and dry environment, it can still maintain a stable state without significant changes in chemical properties. However, in case of high temperature, humidity or the action of specific chemical reagents, its structure may change, causing chemical changes.
What are the chemical synthesis methods of 2-amino-3,5-diiodopyridine?
The chemical synthesis method of 2-amino-3,5-diiodopyridine is not detailed in the ancient book "Tiangong Kaiwu", but it can be deduced from the principles of chemistry today.
First, pyridine is used as the starting material. Pyridine is aromatic and can be introduced into the amino group through an amination reaction. Under appropriate reaction conditions, with suitable amination reagents, such as ammonia and related catalysts, nucleophilic substitution or addition-elimination reactions occur at specific positions on the pyridine ring to obtain 2-aminopyridine. This step requires attention to the precise control of reaction conditions, such as temperature, pressure, and the proportion of reactants, to ensure that the amino group is mainly introduced to the 2-position.
Second, 2-aminopyridine is further iodized. The iodine element can be combined with an appropriate oxidant, such as hydrogen peroxide or nitric acid. The oxidant helps the iodine element to generate an active iodine positive ion, which undergoes an electrophilic substitution reaction against the pyridine ring of 2-aminopyridine. Because the amino group is an ortho-and para-site group, under suitable reaction conditions, the iodine atom is preferentially substituted at the 3,5-position, resulting in 2-aminopyridine-3,5-diiodopyridine. In this iodization process, the choice of reaction solvent is also key, and a solvent with good solubility to the reactants and no adverse interference to the reaction process needs to be selected.
Alternatively, pyridine can be iodized first, and then aminylated. First, pyridine is introduced into the iodine atom at the 3,5-position with an iodizing reagent, and then the amino group is introduced at the 2-position through a suitable aminylation strategy, which can also achieve the synthesis of the target product. However, this route needs to pay attention to the regulation of the activity of the pyridine ring during iodization and the optimization of the subsequent aminylation reaction conditions to avoid unnecessary side reactions. Such various methods need to be repeatedly explored and optimized by the experimenter according to the actual situation, so as to achieve perfection and achieve efficient synthesis of 2-amino-3,5-diiodopyridine.
What is the price range of 2-amino-3,5-diiodopyridine in the market?
What is the price of 2-amino-3,5-diiodopyridine in the market? This question is quite difficult. Due to the changeable market conditions, its price also fluctuates. In the past, the price of such chemicals was often tied to multiple factors.
The first is the trend of supply and demand. If there are many people who want it, but the supply is small, the price will increase; if the supply exceeds the demand, the price may decrease. Furthermore, the difficulty of preparation is also the main reason. The synthesis of 2-amino-3,5-diiodopyridine requires complicated methods and precious materials, which all increase its cost and cause the price to rise.
And the quality of its quality is also related to the price. High quality, the price is often not cheap; inferior quality, the price may be slightly cheaper. In addition, the regional differences in the market also make the price different. In the prosperous capital, the logistics is convenient, the transaction is frequent, and the price may be stable; in remote places, the transportation is difficult, the cost increases, and the price may be slightly higher.
However, looking at the past market conditions, the price of 2-amino-3,5-diiodopyridine may be between tens of yuan and hundreds of yuan per gram. This is only an approximate number, and the actual price is subject to the current market. For accurate pricing, you can consult chemical material suppliers or explore professional chemical trading platforms to obtain real-time pricing information.
What are the precautions for using 2-amino-3,5-diiodopyridine?
2-Amino-3,5-diiodopyridine is an organic compound. During use, many things must be paid attention to.
Bear the brunt of it, and safety protection should not be underestimated. This compound may be toxic and irritating. When handling, be sure to wear suitable protective equipment, such as gloves, goggles and laboratory work clothes, to avoid direct contact with the skin and eyes. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention according to the specific situation. And because of the risk of inhalation, the operation should be carried out in a well-ventilated place, or even in a fume hood, to prevent the inhalation of harmful vapors.
Furthermore, the chemical properties also need to be paid attention to in detail. 2 - amino - 3,5 - diiodopyridine contains amino and iodine atoms and has unique chemical activity. When mixing with other reagents, its chemical reactivity must be carefully considered to prevent accidental reactions. In terms of storage, it should be placed in a dry, cool and ventilated place, away from fire sources and oxidants, etc., to avoid deterioration or dangerous reactions.
In addition, accurate weighing and usage control are also crucial. According to specific experimental or application requirements, accurately weigh the required amount to avoid waste, and prevent improper dosage from affecting the experimental results or application effect. After use, properly dispose of the remaining substances, follow relevant environmental protection and safety regulations, and do not discard them at will to avoid pollution to the environment.
In conclusion, when using 2-amino-3,5-diiodopyridine, safety protection, chemical concerns, accurate use, and proper handling cannot be ignored, so as to ensure the safety of operation and the smooth progress of experiments or applications.
