2 Amino 3 Iodopyridine

2-Amino-3-iodopyridine, Chinese name 2-amino-3-iodopyridine, is widely used and can be regarded as a key organic synthesis intermediate in the field of medicinal chemistry.
Looking at the road of drug development, it can undergo multiple chemical transformations to build a complex molecular structure with specific pharmacological activities. For example, through specific chemical reactions, it can be connected with other organic molecules to create new anti-malarial drugs. Malaria is a serious infectious disease that threatens human health and infects a large number of people worldwide every year. 2-Amino-3-iodopyridine is involved in the synthesis of new antimalarial drugs, which may open up new avenues for malaria treatment. With its unique chemical structure, it precisely acts on specific targets of malaria parasites, interferes with their physiological and metabolic processes, inhibits the growth and reproduction of malaria parasites, and brings good news to many malaria patients.
In the field of materials science, 2-amino-3-iodopyridine also has good performance. When preparing some functional materials, it can be introduced into the polymer structure. For example, the preparation of materials with special optoelectronic properties, when 2-amino-3-iodopyridine is integrated into the polymer system, due to the amino and iodine atoms it contains, it may change the intermolecular force and electron cloud distribution of the material, giving the material unique optoelectronic properties, such as excellent fluorescence properties or good semiconductor properties. Such materials are very useful in frontier fields such as organic Light Emitting Diode (OLED) and solar cells. OLED displays are favored for their self-luminous, high contrast, wide viewing angle and other advantages. The materials synthesized by 2-amino-3-iodopyridine may further improve the performance of OLED and promote the development of display technology.
Furthermore, in the field of pesticide chemistry, 2-amino-3-iodopyridine can be used as an important starting material for the synthesis of new pesticides. Through a series of reactions, pesticides with high-efficiency killing effect on specific pests and environmental friendliness can be synthesized. At present, agricultural production has an urgent need for high-efficiency and low-toxicity pesticides. This compound participates in the synthesis of pesticides, which may be able to precisely target pests, reduce non-target organisms and environmental hazards, and achieve sustainable agricultural development.

2-Amino-3-iodopyridine is also an important compound in the field of organic synthesis. There are many synthesis methods, each with its own beauty, which will be described in detail today.
One is halogenation. First, 2-aminopyridine is used as the starting material, and iodine atoms are introduced under appropriate reaction conditions. Often iodine elemental or iodine-containing reagents are used with appropriate catalysts and reaction solvents. For example, iodine elemental and 2-aminopyridine react in polar solvents such as dimethyl sulfoxide (DMSO) or N, N-dimethylformamide (DMF) in the presence of oxidants such as hydrogen peroxide or periodate. This oxidant can promote the electrophilic substitution reaction of iodine atoms to specific positions on the pyridine ring, so that the iodine atoms are selectively connected to the 3-position, thereby obtaining 2-amino-3-iodine pyridine.
The second is the metal catalytic coupling method. 2-aminopyridine derivatives are often used as substrates to couple with iodine substitutes under the action of metal catalysts. If a palladium catalyst is used, 2-aminopyridine borate and iodine-substituted aromatics are reacted in an organic solvent in the presence of a base. The base can promote the reaction and adjust the pH of the reaction system. Palladium catalysts can effectively activate substrate molecules and promote the formation of carbon-iodine bonds. Through this reaction route, the target product 2-amino-3-iodopyridine can also be obtained.
The third is the guide group auxiliary method. A specific guide group is introduced into the 2-aminopyridine molecule to guide the iodine atom selectively into the 3-position. The guide group interacts with the nitrogen atom or amino group on the pyridine ring to change the electron cloud density distribution of the pyridine ring, so that the selectivity of the iodine generation reaction occurs at a specific location. After the reaction is completed, the guide group can be removed by an appropriate method to obtain pure 2-amino-3-iodopyridine.
These several synthesis methods have their own advantages and disadvantages. The halogenation method is relatively simple to operate, but the selectivity may require fine regulation; the metal catalytic coupling method has good selectivity, but the catalyst cost is higher; the guide group auxiliary method although the steps are slightly complicated, but the selectivity of the target product is excellent. Synthesizers should choose carefully according to actual needs and conditions.

2-Amino-3-iodopyridine is also an organic compound. It has specific physical properties, which are described in detail below.
When it comes to the melting point, the melting point of this compound is crucial for its state transition under different environments. The melting point is the temperature at which the substance changes from solid to liquid. The melting point of 2-amino-3-iodopyridine may vary depending on its purity and measurement conditions. However, in general, the accurately determined melting point can be an important basis for identification and purity determination.
As for the boiling point, the temperature at which the saturated vapor pressure of the liquid is equal to the external atmospheric pressure. The boiling point of 2-amino-3-iodopyridine reflects the ease of conversion from liquid to gaseous state when heated. The boiling point is related to the intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. The molecular structure of this compound determines its intermolecular forces, which in turn affect the boiling point.
Solubility is also one of the key physical properties. In common solvents, 2-amino-3-iodopyridine may have some solubility in organic solvents such as ethanol and dichloromethane. Its solubility depends on the interaction between the compound molecules and the solvent molecules. Those with similar polarities are miscible. This compound contains amino and iodine atoms, and its polar characteristics affect its solubility in different polar solvents.
In terms of appearance, 2-amino-3-iodopyridine is often in solid form, or crystalline, and the color varies from white to light yellow. This appearance feature is not only convenient for preliminary identification, but also related to the quality during production and storage.
Density is also a physical property that cannot be ignored. Density, the quality of a unit volume of material. The density of 2-amino-3-iodopyridine is a fixed value at a specific temperature and pressure. In the process of chemical production, separation and purification, the density data is of great significance for material measurement, phase separation and other operations.
In summary, the melting point, boiling point, solubility, appearance and density of 2-amino-3-iodopyridine are essential information in chemical research, chemical production and related fields.

I haven't found a solution for the 2-amino-3-iodopyridine market yet. However, if you want to know the solution, you can often ask for it from multiple sources.
One of them can be found at the top of the list of suppliers. Today's multi-product suppliers are all listed on the list of their products. Register for it, ask for it with 2-amino-3-iodopyridine, or you can get it. Different suppliers vary depending on the brand, size, and package size. Such as Sigma-Aldrich, Alfa Aesar and other well-known suppliers, often have high-quality products, but they are expensive or expensive; while some local suppliers, if they can guarantee the quality of the product, can be expensive or more expensive.
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2-Amino-3-iodopyridine is an organic compound. When storing and transporting, pay attention to the following matters.
When storing, the first priority is the environment. Choose a cool, dry and well-ventilated place. This is because if it is in a high temperature or humid environment, it may cause changes in quality. High temperature may promote its chemical reaction to speed up, and humidity may cause it to deliquescent and damage its purity. Furthermore, be sure to keep away from fires and heat sources. This compound may be flammable, and in case of open flames, hot topics, it may cause fire or even explosion.
Storage place should also be separated from oxidants, acids, etc. Due to the active chemical properties of 2-amino-3-iodopyridine, contact with oxidants, or severe oxidation reactions; coexistence with acids, or chemical reactions occur, causing material deterioration, and or generating harmful gases.
As for transportation, it is necessary to ensure that the container is well sealed. If the container leaks, the compound leaks, which not only fouls the environment, but also poses a threat to the health of transporters. During transportation, drive steadily to avoid sharp bumps and vibrations. Rapid action or rupture of the container, material leakage.
Transport vehicles should also be equipped with corresponding fire equipment and leakage emergency treatment equipment. Once a leak occurs, it can be responded to in time to reduce the harm. And transportation personnel should be professionally trained, familiar with the characteristics of the compound and emergency treatment methods, and closely monitored during transportation to ensure safe transportation.