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What are the chemical properties of 2-amino-4-bromo-3-fluoro-5-iodobenzoic Acid?
2-Amino-4-bromo-3-fluoro-5-iodobenzoic acid is an organic compound with unique chemical properties and considerable research value.
From an acidic point of view, it contains carboxyl groups, which are acidic and can neutralize with bases, just like common carboxylic acids. When encountering bases such as sodium hydroxide, corresponding carboxylic salts and water will be formed.
In terms of the characteristics of substituents, amino groups are the power supply groups, which can increase the electron cloud density of the benzene ring and make the benzene ring more prone to electrophilic substitution. The halogen atoms of bromine, fluorine and iodine, although they are electron-withdrawing groups, can conjugate with the benzene ring by their lone pairs of electrons, which affects the reactivity and selectivity of the benzene ring to a
In electrophilic substitution reactions, the positioning effect of amino groups will cause new substituents to mainly enter their adjacent and para-sites. However, due to the steric resistance of bromine, fluorine, and iodine atoms and electronic effects, the regioselectivity of the actual reaction will be more complicated.
The halogen atoms in this compound can participate in many reactions, such as nucleophilic substitution reactions. Under suitable conditions, bromine and iodine atoms can be replaced by nucleophiles, resulting in a variety of organic synthesis pathways.
In addition, in view of the fact that it contains a variety of different atoms, the compound will have unique spectral properties. In infrared spectroscopy, nuclear magnetic resonance spectroscopy and other analytical methods, each atom or group will show a characteristic absorption peak or signal, which is helpful for the accurate determination and analysis of the structure.
In short, 2-amino-4-bromo-3-fluoro-5-iodobenzoic acid has rich and diverse chemical properties due to the interaction between functional groups and atoms, and has potential applications in organic synthesis, medicinal chemistry and other fields.
What are the synthetic methods of 2-amino-4-bromo-3-fluoro-5-iodobenzoic Acid?
For the synthesis of 2-amino-4-bromo-3-fluoro-5-iodobenzoic acid, please refer to the following.
First take suitable starting materials, often benzoic acid derivatives are preferred. Because the target product has a variety of halogen atoms and amino groups on the benzene ring, the reaction sequence needs to be carefully planned according to the characteristics of each group during synthesis.
To introduce bromine atoms, a suitable brominating reagent, such as N-bromosuccinimide (NBS), can be selected under suitable reaction conditions, such as in an organic solvent, under the action of light or initiator, to achieve bromination reaction at a specific position of the benzene ring. This step requires precise control of the reaction conditions to prevent excessive bromination.
The introduction of fluorine atoms is usually carried out by nucleophilic substitution in the presence of fluorinated reagents, such as potassium fluoride, in the presence of a phase transfer catalyst. This reaction requires strict reaction temperature and solvent properties, and careful regulation is required to accurately replace fluorine atoms to the target position.
The introduction of iodine atoms can be achieved by oxidative iodization with the assistance of appropriate oxidants using iodizing reagents, such as sodium iodide. In this process, the amount of oxidant and reaction time are key factors, which affect the efficiency and selectivity of the iodine substitution reaction.
As for the introduction of amino groups, nitro groups can be introduced into the benzene ring first, and then converted into amino groups through reduction reaction. The introduction of nitro groups is often treated with mixed acid (concentrated sulfuric acid mixed with concentrated nitric acid) to treat the benzene ring, and a nitrification reaction occurs. To reduce nitro groups to amino groups, iron powder and hydrochloric acid system can be selected, or catalytic hydrogenation methods can be used, depending on the actual situation.
After each step of the reaction is completed, it needs to be separated and purified, such as column chromatography, recrystallization, etc., to obtain high-purity 2-amino-4-bromo-3-fluoro-5-iodobenzoic acid. Each step of the reaction needs to be carefully controlled to enable the synthesis to proceed smoothly and obtain the target product.
What are the applications of 2-amino-4-bromo-3-fluoro-5-iodobenzoic Acid?
2-Amino-4-bromo-3-fluoro-5-iodobenzoic acid, this compound is used in medicine, materials science, chemical synthesis and other fields.
In the field of medicine, it can be used as a key intermediate for the creation of new special drugs. Because the molecule is rich in halogen atoms, amino groups, carboxyl groups and other active groups, it can be skillfully spliced with other molecules through various chemical reactions, and then synthesized compounds with exquisite structures and unique biological activities. Taking the development of anti-cancer drugs as an example, researchers may be able to use this compound to precisely modify drug molecules, improve the targeting and affinity of drugs to cancer cells, enhance the anti-cancer efficacy, and reduce the damage to normal cells. Another example is the development of antibacterial drugs. By rationally modifying the structure of this compound, high-efficiency antibacterial agents for specific drug-resistant bacteria may be developed to solve the problem of drug resistance.
In the field of materials science, 2-amino-4-bromo-3-fluoro-5-iodobenzoic acid can participate in the preparation of materials with unique functions. Because of its halogen atoms and polar groups, it can affect the electron cloud distribution and intermolecular forces of materials, thus endowing materials with special electrical, optical or thermal properties. For example, in organic optoelectronic materials, the introduction of this compound may optimize the charge transfer efficiency and luminescence properties of materials, providing new opportunities for the manufacture of high-resolution displays, high-efficiency solar cells, etc. In terms of intelligent responsive materials, the special structure of the compound may make it have a unique response to external stimuli such as temperature, pH value, and specific ions, which is expected to develop new functional materials such as intelligent discoloration and intelligent adsorption.
In the field of chemical synthesis, as an important synthetic block, with its rich activity check points, it can participate in many classic organic reactions, such as nucleophilic substitution, coupling reactions, etc., to construct complex and diverse organic molecular structures. Chemists can use this as a basis to ingeniously design reaction routes and synthesize organic compounds with specific spatial configurations and functional group arrangements, injecting new vitality into the development of organic synthetic chemistry, helping to synthesize more organic compounds with novel structures and excellent properties, and promoting the continuous development of chemistry.
2-amino-4-bromo-3-fluoro-5-iodobenzoic the market price of Acid
Today, I have asked what the market price of 2 - amino - 4 - bromo - 3 - fluoro - 5 - iodobenzoic Acid is. This is a fine chemical, and its price varies depending on many factors.
First, the complexity of the production process is related to the cost, which in turn affects the price. If the synthesis of this compound requires multiple steps of reaction, and each step requires strict conditions, such as precise temperature, pressure control, and special catalyst use, the production cost will be high, and the price will also rise.
Second, the purity is the key factor. High purity, less impurities, suitable for high-end scientific research, pharmaceutical research and development and other fields, the price is more expensive than low purity. For example, high-purity products used in drug synthesis have extremely strict restrictions on the content of impurities, are difficult to produce, and are expensive.
Third, the market supply and demand situation has a great impact. If the market demand for it is strong, such as a new drug research and development needs a lot, but the supply is limited, the price will rise; conversely, if the demand is low and the supply is sufficient, the price will fall.
Fourth, the cost of raw materials also affects the price. The price fluctuations of raw materials such as bromine, fluorine, and iodine directly affect the production cost of the compound. If raw materials are scarce or the price fluctuates greatly, the price of the product will also fluctuate.
Due to the lack of specific market survey data, it is difficult to determine its price. However, to learn more, you can consult chemical product suppliers, consult professional chemical market reports, or communicate at relevant industry forums to obtain the latest and accurate price information.
What are the storage conditions for 2-amino-4-bromo-3-fluoro-5-iodobenzoic Acid?
2-Amino-4-bromo-3-fluoro-5-iodobenzoic acid, this substance is very rare, and its storage is important, which is related to many aspects.
First, the control of temperature. When it is appropriate to be in a cool place, it must not be placed in a high temperature place. High temperature is like a fire, which is easy to make the properties of this substance change. If the temperature is too high, or its chemical structure is shaken, the efficacy or characteristics are affected. Therefore, the storage place should be kept at a temperature near room temperature, not higher than 30 degrees Celsius, so as to keep it stable.
Second, the control of humidity. It needs to be placed in a dry place to avoid moisture. The damp and moist gas is like a hidden enemy, slowly eroding. Once it gets damp, or causes it to undergo hydrolysis and other changes, the quality will drop significantly. Therefore, when using a sealed device or a desiccant to make the humidity of the environment constant at a lower level, in order to ensure its quality as before.
Third, prevent light. This object is afraid of light. Under strong light, it is like being exposed to the hot sun, and it is prone to photochemical reactions. Therefore, when hiding in the dark, or using a shading device to protect it from light damage.
Fourth, the weight of isolation. Do not mix with other objects, especially those with strong oxidizing and reducing properties, or acids and alkalis. If these substances come into contact with it, such as a dragon or tiger, they will react violently and cause their destruction. Therefore, when stored separately, and in the storage place, its characteristics should be clearly stated to warn everyone.
Store 2-amino-4-bromo-3-fluoro-5-iodobenzoic acid, and observe the requirements of temperature, humidity, light, and isolation. In this way, its quality can be maintained for a long time, so that it can be used as before when needed.
