2 Amino 5 Iodo 3 Methyl Pyridine

2-% hydroxy-5-mercapto-3-methylpyridine is an important organic compound that has key uses in many fields.
In the field of medicine, it is often a key intermediate in drug synthesis. Due to its specific chemical structure, it can interact with many targets in organisms and participate in a variety of physiological processes. For example, in the synthesis of some antibacterial drugs, 2-% hydroxy-5-mercapto-3-methylpyridine is used as the starting material, and through a series of chemical reactions, a complex molecular structure with antibacterial activity is constructed, which can inhibit or kill bacteria. Or in the development of innovative drugs for the treatment of specific diseases, it can be used as a key module to improve the affinity and selectivity of drugs to targets, enhance efficacy and reduce side effects through rational design and modification.
In the field of pesticides, this compound also plays an important role. It can be used as a key component in the synthesis of high-efficiency and low-toxicity pesticides. By modifying its structure, pesticides with high activity against specific pests or weeds can be developed. For example, for certain types of crop pests, insecticides designed based on 2% hydroxy-5-mercapto-3-methylpyridine can precisely act on the nervous system or metabolic pathways of pests, kill pests efficiently, and have little impact on the environment and non-target organisms, meeting the requirements of modern green agriculture for pesticides.
Furthermore, in the field of materials science, 2% hydroxy-5-mercapto-3-methylpyridine also shows unique value. It can be used to prepare polymer materials with special properties. It is introduced into the polymer skeleton, and its active groups such as hydroxy and mercapto give the material better solubility, thermal stability or chemical activity. For example, in the preparation of high-performance coatings or adhesives, the addition of monomers containing this compound structure can improve the adhesion and durability of the material and broaden the application range of the material.
Therefore, 2-% hydroxy-5-mercapto-3-methylpyridine is an indispensable and important substance in the fields of medicine, pesticides and materials science, and is of great significance to promote the development of related industries.

2-% hydroxy-5-nitro-3-methylpyridine is an organic compound with unique physical properties. It is solid, stable at room temperature, and changes chemically under specific conditions.
Looking at its color and morphology, this compound is usually a light yellow to yellow crystalline powder with regular crystal morphology and uniform particles. Under the microscope, it can be seen that its molecules are arranged in an orderly manner.
When it comes to melting point and boiling point, the melting point is about 170-175 ° C. The melting point is the temperature at which a substance changes from solid to liquid state. This value reflects the strength of the intermolecular forces of the compound. When the melting point is reached, the molecules gain enough energy to overcome each other's attractive forces, and the lattice structure disintegrates and turns into a liquid state. The boiling point or at about 350 ° C (under normal pressure), the boiling point reflects the temperature at which the substance changes from liquid to gaseous state, indicating that higher energy is required to make the molecule get rid of the liquid binding and escape into the gas phase.
In terms of solubility, 2-% hydroxy-5-nitro-3-methylpyridine is slightly soluble in water. Water is a polar solvent. The compound has a certain polarity due to the presence of hydroxyl groups (-OH), but due to the presence of nitro (-NO 2O) and methyl (-CH 🥰), the overall polarity is limited, so it is difficult to dissolve in water with strong polarity. However, it is soluble in some organic solvents, such as dichloromethane, ethanol, etc. In dichloromethane, because dichloromethane is a weakly polar organic solvent, it can form an appropriate interaction with the compound molecules to promote its dissolution. In ethanol, the hydroxyl group of ethanol and the hydroxyl group of the compound can form hydrogen bonds, enhancing the interaction and causing them to dissolve.
The density is about 1.4-1.5 g/cm ³, which is higher than that of water, meaning that the compound has more mass under the same volume. This property is of great significance in separation, purification and related chemical operations.
In addition, the compound has certain chemical activity due to its containing nitro and hydroxyl groups. Nitro has strong electron absorption, which reduces the electron cloud density of the pyridine ring and makes it more prone to nucleophilic substitution reactions; hydroxyl groups can participate in esterification, etherification and other reactions, which have potential application value in the field of organic synthesis.

To prepare 2-amino-5-nitro-3-methylpyridine, there are many ways to synthesize it. The following are common routes:
1. ** Pyridine is used as the starting material **:
- Nitro is introduced by nitration reaction on the pyridine ring before the pyridine ring. Due to the electron cloud density distribution of the pyridine ring, nitro is mostly introduced at the 3rd position. If the mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying agent and reacted at an appropriate temperature, 3-nitropyridine can be obtained.
- Methylation of 3-nitropyridine is performed. Using iodomethane, dimethyl sulfate, etc. as methylating reagents, in the presence of bases (such as potassium carbonate), methyl groups can be introduced into the fifth position of the pyridine ring to obtain 5-methyl-3-nitropyridine.
- Finally, an amino group is introduced on top of 5-methyl-3-nitropyridine. Nitro groups can be converted to amino groups by reducing nitro groups to amino groups, such as iron powder, hydrochloric acid system, or catalytic hydrogenation (such as palladium-carbon as catalyst), to obtain the target product 2-amino-5-nitro-3-methylpyridine.
2. ** Using other heterocyclic compounds as raw materials **:
- If 2-methyl-3-nitro-5-halopyridine is used as raw material (halogen atoms can be chlorine, bromine, etc.). React with amination reagents (such as ammonia, amine compounds), and the halogen atoms are replaced by amino groups, 2-amino-5-nitro-3-methylpyridine can be prepared. This reaction needs to be carried out in the presence of appropriate solvents (such as DMF, ethanol, etc.) and bases (such as sodium carbonate) to promote the smooth occurrence of the reaction.
3. ** Through a multi-step cyclization reaction **:
- Select a suitable open-chain compound and construct a pyridine ring through a multi-step reaction. For example, a chain-like compound containing amino, nitro, methyl and other functional groups is used as the starting material. Under acidic or basic conditions, the intramolecular cyclization reaction is carried out to form a pyridine ring and introduce the desired substituent. This path requires strict control of the reaction conditions to ensure the regioselectivity of cyclization and the generation of the target product.
Each synthesis method has its advantages and disadvantages. The most suitable synthesis route needs to be selected according to the availability of raw materials, the difficulty of reaction conditions, and the high or low yield.

For 2-% hydroxy-5-mercapto-3-methylpyridine, there are many things to pay attention to during storage and transportation.
The first thing to pay attention to is its stability. This compound has specific chemical activities, and functional groups such as hydroxyl groups and mercapto groups are easy to react with substances in the surrounding environment. If stored in high temperature or high humidity, it is prone to reactions such as hydrolysis and oxidation. For example, sulfhydryl groups are easily oxidized into disulfide bonds in air, causing their structure and properties to change, which will damage the quality and efficacy of the product. Therefore, it should be stored in a dry, cool and well-ventilated place, the temperature should be maintained at 5 to 25 degrees Celsius, and the humidity should be controlled between 40% and 60%.
The second is the packaging material of choice. Due to its chemical properties, the packaging material must have good corrosion resistance and sealing. Materials that are easy to react with the compound, such as some metal materials, should not be used to prevent chemical reactions from occurring, causing packaging damage or product deterioration. Usually glass and specific plastic materials are suitable. Glass has good chemical stability and can effectively block external factors from interference; specific plastic materials also have good chemical corrosion resistance and sealing, which can ensure the safety of product storage and transportation.
Furthermore, vibration and collision during transportation also need attention. Violent vibration or collision, or damage to the package, exposes the compound to the external environment. Therefore, proper buffering and fixing measures should be taken during transportation to ensure that the product is safe during transportation.
In addition, this compound may have certain toxicity and irritation. When storing and transporting, it is necessary to strictly follow relevant safety regulations. Operators need to prepare protective equipment, such as gloves, goggles, protective clothing, etc., to prevent contact and cause injury. And the storage area should be clearly marked, and irrelevant personnel are strictly prohibited from approaching to ensure the safety of personnel and the environment.

2-Amino-5-chloro-3-methylpyridine is an important organic compound, which is widely used in medicine, pesticide and other fields. Its market price range is affected by many factors, such as raw material cost, production process, market supply and demand, etc. It is difficult to give an exact value.
In terms of raw material cost, the synthesis of this compound often requires specific starting materials. If the supply of these raw materials is tight or the price fluctuates, it will directly affect the production cost of 2-amino-5-chloro-3-methylpyridine, which will affect the selling price. For example, if the supply of key raw materials is suddenly reduced due to disasters in the place of origin or the international situation, the price will rise, and the price of this compound will also rise.
The simplicity and advanced level of the production process are also key. Advanced and efficient processes can reduce production costs, improve product quality, and have more advantages in market pricing. If the production process is backward, not only will the yield be low, but the product purity may be difficult to meet standards, and the production cost will be high, and the price will be higher.
The market supply and demand relationship also affects its price. When the market demand for 2-amino-5-chloro-3-methylpyridine is strong and the supply is limited, the price tends to rise; conversely, if the market demand is weak and the supply is excessive, the price is easy to fall. For example, if an emerging pesticide variety is successfully developed and a large number of this compound is needed, the demand will increase greatly, and the price will go up; if many manufacturers expand production at the same time, the market supply will far exceed the demand, and the price will be under pressure.
According to market conditions and industry experience, the market price of 2-amino-5-chloro-3-methylpyridine may range from hundreds to thousands of yuan per kilogram. However, this is only a general range, and the specific price depends on real-time market conditions and transaction conditions between buyers and sellers. Purchasers or sellers should pay close attention to market dynamics and communicate with suppliers or customers to obtain a reasonable price.