2 Amino 5 Iodoanisole

2-Amino-5-chlorobenzamide is an extremely important organic synthesis intermediate, which has a wide range of uses in many fields such as medicine, pesticides, dyes, etc.
In the field of medicine, it is mainly used for the synthesis of various drugs. Due to its specific chemical structure, it can be used as a key structural fragment to participate in the construction of drug molecules. For example, in the synthesis of some anti-cancer drugs, 2-amino-5-chlorobenzamide can give drugs the ability to combine with tumor cell targets, thereby inhibiting the growth and proliferation of tumor cells. For example, in the development of antibacterial drugs, compounds synthesized from this raw material may have a unique antibacterial mechanism, which can effectively kill specific pathogens and provide new drug options for the treatment of bacterial infections.
In the field of pesticides, its role is also quite significant. It can be used as a key raw material for the synthesis of high-efficiency and low-toxicity pesticides. For example, some new insecticides, by introducing 2-amino-5-chlorobenzamide structures, enhance the interference effect of pesticides on the nervous system or physiological and metabolic processes of pests, thereby improving the insecticidal effect, and has little impact on the environment and non-target organisms, which is in line with the current trend of green pesticide development. In terms of herbicides, compounds containing this structure may precisely inhibit the specific physiological and biochemical processes of weeds, achieve good herbicide effect, and reduce the harm to crops.
In the field of dyes, 2-amino-5-chlorobenzamide can be used to synthesize dyes with special colors and properties. Because of the presence of amino and chlorine atoms in its structure, it can affect the electron cloud distribution and conjugation system of dye molecules, thereby changing the color, light resistance, washing resistance and other properties of dyes. It can prepare dyes with bright colors and excellent fastness, which are widely used in textile, printing and dyeing industries to meet the dyeing needs of different fabrics.

2-% hydroxy-5-nitroacetophenone, is a kind of organic compound. Its physical properties are as follows:
Looking at its appearance, at room temperature, it mostly shows a yellow needle-like crystalline state. This shape is clearly recognizable and exists stably in ordinary environments.
Talking about the melting point, it is between 72 ° C and 74 ° C. The melting point is the critical temperature at which a substance changes from solid to liquid. This specific melting point range provides a key basis for the identification and purification of the substance. When the temperature gradually rises, the lattice structure of the substance begins to disintegrate, and the molecular thermal motion intensifies, and then it gradually melts from solid to liquid.
Its solubility is also quite characteristic. It exhibits good solubility in organic solvents such as ethanol and ether. The molecular structures of ethanol and ether are similar to those of 2-% hydroxy-5-nitroacetophenone. According to the principle of "similarity and miscibility", they are easy to mix with each other. However, in water, their solubility is poor. Water has strong polarity and has a large difference in molecular forces with the compound, so it is difficult to dissolve with each other. This difference in solubility is of great significance for the separation, purification and choice of reaction medium of the substance in chemical experiments and industrial production.
As for the boiling point, although the relevant accurate data or the measurement conditions fluctuate, it is roughly in a certain temperature range. The boiling point characterizes the temperature required for the transformation of a substance from liquid to gas, which is crucial for the study of its behavior and application in high temperature environments. Knowing the boiling point of this substance allows for precise temperature control during distillation, rectification, and other operations to achieve effective separation from other substances.

2-% hydroxy-5-nitropyridyl acetic acid, this material is stable. In its structure, the hydroxyl group and the nitro group coexist in the pyridine ring, and the acetic acid group is connected, which has a unique structure, resulting in its stability.
From the perspective of the internal force of the molecule, the pyridine ring is aromatic, the conjugate system is large, and the electron cloud is evenly distributed, which makes the entire molecular skeleton stable. Although the hydroxyl group and the nitro group are polar groups, due to the conjugation effect of the pyridine ring, the charge can be dispersed, and the reaction will not be concentrated, just like the stars and the moon, and they are pinned and stable.
Furthermore, the hydrogen bond is also a stabilizing factor. Hydroxyl can form hydrogen bonds with electronegative atoms of surrounding molecules (such as nitro oxygen), acting as a bridge between molecules, strengthening the connection between each other, so that the molecules are arranged in an orderly manner and the system is stable.
In terms of chemical environment, 2-hydroxy-5-nitropyridyl acetic acid does not react significantly with common weak acids and bases under normal conditions. Although it can react with strong acids and bases, the required conditions are harsh, and the unusual environment can cause it. If it is in a neutral medium at room temperature and pressure, it can remain stable for a long time and is not easy to decompose or transform.
In summary, 2-hydroxy-5-nitropyridyl acetic acid is chemically stable due to its unique molecular structure, intramolecular forces and chemical environment.

To prepare 2-amino-5-chlorobenzamide, there are various methods.
First, start with 5-chloro-2-nitrobenzoic acid. First, it is heated with dichlorosulfoxide to obtain 5-chloro-2-nitrobenzoyl chloride. In this step, the dichlorosulfoxide reacts with the carboxyl group of the acid, and the chlorocarboxyl group forms an acid chloride, and sulfur dioxide and hydrogen chloride escape. Then it reacts with ammonia, and the acid chloride reacts with ammonia to form 5-chloro-2-nitrobenzamide. Finally, with a suitable reducing agent, such as iron and hydrochloric acid, or hydrogen and palladium carbon, the nitro group is reduced to an amino group to obtain 2-amino-5-chlorobenzamide.
Second, 2-aminobenzoic acid is used as the starting material. First, under suitable conditions, a suitable chlorination reagent, such as thionyl chloride or phosphorus oxychloride, is used to chlorinate the 5-position of the benzene ring to obtain 5-chloro-2-aminobenzoic acid. Then it interacts with dichlorosulfoxide to convert the carboxyl group into an acyl chloride to obtain 5-chloro-2-aminobenzoyl chloride. Finally, it reacts with ammonia to form 2-amino-5-chlorobenzamide.
Third, start with 2-nitro-5-chlorotoluene. First, oxidize the methyl to a carboxyl group with an oxidant such as potassium permanganate to obtain 2-nitro-5-chlorobenzoic acid. The subsequent steps are the same as the first method from 5-chloro-2-nitrobenzoic acid, that is, react with dichlorosulfoxide to obtain an acid chloride, then react with ammonia to obtain an amide, and finally reduce the nitro group to an amino group.
All methods have advantages and disadvantages. The first method starts from 5-chloro-2-nitrobenzoic acid, the starting material is easier to obtain, and the reaction step is relatively clear. However, the reduction of nitro groups requires attention to the reaction conditions to prevent side reactions. The second method starts with 2-aminobenzoic acid, which can better control the position of amino groups and chlorine. However, the chlorination step requires fine regulation of conditions to ensure selectivity. The third method starts from 2-nitro-5-chlorotoluene. Although the raw materials are common, the methyl oxidation step may have by-products, and the reaction conditions need to be optimized. In actual preparation, the choice should be carefully considered according to the availability, cost, yield and purity of the raw materials.

In today's world, the market is complex, there are many kinds of things, and the price is also changeable. It is not easy to know the price of 2-amino-5-chlorobenzamide in the market. The price often changes for various reasons, and it is difficult to have a fixed number.
Looking at the business conditions, the source of materials, the simplicity of production, and the amount of market demand all have a great impact on their price. If the material is easy to purchase, the production is simple, and the market demand is not prosperous, the price may be slightly cheaper. On the contrary, if the material is rare, the production is complicated, and the market is eager, the price will be expensive.
Gu Yun: "Rare things are expensive." If this thing is rare in the market, there are many people who want it and there are few people to supply it, the price will go up. If the rare goods can be lived in, the one who handles it can raise the price because of its scarcity. And if the work of production requires exquisite art, time-consuming and laborious, the cost will be high, and the price will also be higher.
However, if you want to get a definite price, you still need to study the cities and visit the people. The shops in the city are different, and the price may vary. The big ones may have different prices because of the wide purchase volume and the calculation of cost and profit; the shops of small merchants may have different prices because of the small purchase volume and the cost of operation. And in the four places, the terroir is different, and the price is also different.
Or: If you want to know the price, you can ask for it on the business network. Today's network is convenient, and all kinds of business are mostly concentrated here. However, the online price is not constant, or it rises and falls from time to time due to the season and the promotion of trade.
Therefore, if you want to know the price of 2-amino-5-chlorobenzamide in the city, you should widely observe the market conditions, study materials, production, supply and demand in detail, and visit the city shops and Jia people, and also look at the network business conditions. In summary, you can get a more accurate price.