2 Amino 5 Iodobenzoic Acid

2-Amino-5-iodobenzoic acid, which has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of many drugs. Because of its amino and carboxyl groups, it has active chemical properties and can be combined with other compounds through various chemical reactions to form complex drug molecules. For example, it can be used for condensation reactions to react with compounds containing specific functional groups to prepare drugs with specific pharmacological activities, or to develop antibacterial and anti-inflammatory drugs to treat related diseases.
In the field of materials science, it also has important uses. Due to its special structure, it may participate in material synthesis, giving materials unique properties. For example, in the synthesis of some organic optoelectronic materials, introducing it into the material structure can change the electron cloud distribution of the material, which in turn affects the optical and electrical properties of the material, making the material suitable for devices such as Light Emitting Diode and solar cells.
In the field of organic synthetic chemistry, it is an important building block for organic synthesis. With the reactivity of amino and carboxyl groups, it can participate in various classic organic reactions such as esterification and amidation to construct complex organic molecular structures, providing an effective way for the synthesis of new organic compounds and promoting the development and innovation of organic synthetic chemistry. In short, 2-amino-5-iodobenzoic acid plays an indispensable role in many fields and is of great significance for promoting progress in related fields.

2-Amino-5-iodobenzoic acid, this is an organic compound. Looking at its physical properties, at room temperature, it is mostly in a solid state, but its specific appearance may vary slightly due to differences in purity and crystal form, or it is a white to light yellow crystalline powder.
Its melting point is related to the intermolecular force and lattice structure. It has been determined by many experiments that it is roughly in a specific temperature range. This temperature range is the critical temperature for the compound to melt from solid to liquid, which is of great significance for its identification and purity judgment.
In terms of solubility, the degree of solubility in water is limited. Although the molecule contains carboxyl groups and amino groups, it can form hydrogen bonds with water. However, the introduction of iodine atoms increases the hydrophobicity of the molecule. However, in polar organic solvents such as ethanol and dimethyl sulfoxide, the solubility is relatively high. This solubility characteristic is a key consideration in the selection of reaction solvents for organic synthesis, as well as in the design of separation and purification processes for compounds.
Its density is also an important physical property, reflecting the tightness of molecular stacking, which is related to other physical properties and affects the behavior of compounds in different media, such as the distribution in mixed solvents.
In addition, its odor is weak, and if there are no special impurities mixed in, it usually has no strong pungent or special odor. This property is related to the experimental environment and the operator's experience when handling and using the compound.

To prepare 2-amino-5-iodobenzoic acid, the following method can be followed.
First, 5-iodosalicylic acid is used as the starting material. This salicylic acid derivative is first reacted with thionyl chloride in a specific reaction environment. Sulfuryl chloride is a commonly used chlorination reagent. It interacts with the carboxyl group of 5-iodosalicylic acid to convert the carboxyl group into an acyl chloride group to obtain 5-iodosalicylic acid chloride. This reaction needs to be carried out at a suitable temperature and duration of the reaction, and attention should be paid to the anhydrous environment of the reaction system to prevent hydrolysis of acyl chloride.
After 5-iodosalicylic acid chloride is obtained, it is reacted with ammonia gas. Ammonia gas can be aminolyzed with acyl chloride to form 5-iodosalicylamide. In this step, attention should be paid to the regulation of the amount of ammonia gas and the reaction temperature. Too high temperature or too much ammonia gas may cause side reactions.
5-iodosalicylamide is then degraded by Hoffman. In this reaction, the amide undergoes a series of complex rearrangements and reaction steps based on the action of bromine and sodium hydroxide, and finally converts to amino groups to obtain 2-amino-5-iodobenzoic acid. This reaction step requires strict control of the reaction conditions, such as the amount of bromine, the concentration of sodium hydroxide, and the reaction temperature and time, all of which have a significant impact on the purity and yield of the product.
Another way can be started from 2-aminobenzoic acid. The iodization reaction of 2-aminobenzoic acid is carried out first. The iodization reagent can be selected from iodine elemental substance and appropriate oxidant, such as hydrogen peroxide. Under suitable solvents and reaction conditions, iodine atoms can selectively replace hydrogen atoms at specific positions on the benzene ring to generate 2-amino-5-iodobenzoic acid. This iodization reaction requires fine regulation of the reaction conditions to ensure that the iodine atoms are mainly replaced at the 5 position, and at the same time reduce the possibility of side reactions to generate iodized products at other positions. The choice of solvent, the proportion of reagents, and the control of reaction temperature and time are all key factors in the reaction, which affect the purity and yield of the product.

2-Amino-5-iodobenzoic acid, in the market, its price range is difficult to determine. This compound is used in the field of chemical raw materials, and its application may involve medicine, dyes, and organic synthesis. The change in its price is related to many factors.
First of all, the purity, high purity, high quality and high price. If it is used for scientific research, it needs extremely high purity, and there are almost no impurities, its price must be expensive, tens or even hundreds of yuan per gram. If the purity is slightly lower, it is used in general industrial synthesis, and the price should be slightly reduced.
The second is supply and demand. If there are many people in the market, but the amount produced is small, the price will rise. If there is a sudden demand for this product in the field of pharmaceutical research and development, when the supply is in short supply, the price will rise. On the contrary, if the supply exceeds the demand, the price may drop.
Furthermore, the difficulty of preparation also affects its price. The synthesis of 2-amino-5-iodobenzoic acid may require complicated steps, expensive reagents and specific conditions, and the price will be high if the cost is high. If the preparation process is optimized, the cost will drop, and the price will also fall.
Looking at the past data of the chemical raw material trading platform, the price of this product can range from a few yuan per gram to more than 100 yuan. When purchasing in bulk, there may be discounts for large quantities. However, the chemical market is fickle, and the price often varies from time to time. In order to know the real-time price, you can obtain accurate prices by consulting chemical raw material suppliers, browsing professional trading platforms or chemical information websites.

2-Amino-5-iodobenzoic acid (2-amino-5-iodobenzoic acid) is an organic compound. Its storage conditions are quite important, which is related to the stability and quality of this compound.
This compound should be stored in a cool, dry and well-ventilated place. Cover a cool environment to reduce the risk of decomposition or deterioration due to excessive temperature. If the temperature is high, the molecular movement will intensify, which will easily lead to chemical reactions and damage its structure and properties. Dry conditions are also indispensable, because moisture can easily cause the compound to absorb moisture or cause adverse reactions such as hydrolysis, which will reduce its purity. As for the well-ventilated, it can disperse the volatile gas that may accumulate and avoid potential danger and quality deterioration.
Furthermore, it should be stored in isolation from oxidants, acids, bases and other substances. This is due to the chemical properties of 2-amino-5-iodobenzoic acid, which may react violently with the above-mentioned substances. Oxidants have strong oxidizing properties, or react with some groups in the compound, causing its structure to change; acids and bases may also react with acids and bases, destroying their original chemical structure and affecting their chemical activity and purity.
In terms of packaging, suitable materials should be selected. Usually a sealed container is used to prevent the intrusion of outside air, moisture, etc. High-quality packaging materials, when they have good barrier properties, can effectively block the influence of environmental factors on the compound and ensure its stability during storage. In this way, 2-amino-5-iodobenzoic acid can be properly preserved to maintain its good chemical properties and quality.