2 Amino 5 Iodobenzoic Cid

2-Amino-5-iodobenzoic acid (2-amino-5-iodobenzoic acid) is a crucial raw material in organic synthesis, and it has a wide range of uses in many fields. Let me tell you one by one.
In the field of pharmaceutical chemistry, this compound is a key intermediate. Pharmaceutical development aims to create safe and effective drugs, and 2-amino-5-iodobenzoic acid can participate in the construction of many drug molecules. For example, it can be used as a starting material to combine with other compounds with specific structures through a series of fine chemical reactions, and then synthesize molecules with specific pharmacological activities. In the synthesis of some antimicrobial drugs, 2-amino-5-iodobenzoic acid plays an important role. With its unique chemical structure, it gives the final drug the ability to inhibit or kill specific bacteria, providing help for human resistance to bacterial infections.
In the field of materials science, 2-amino-5-iodobenzoic acid also has extraordinary performance. With the development of science and technology, the demand for special performance materials is increasing day by day. This compound can be used to prepare materials with special optical or electrical properties. Through ingenious chemical modification and polymerization, it is introduced into the structure of polymer materials, which can change the electron cloud distribution of materials, thereby affecting their optical absorption and emission characteristics, so that materials in the field of optoelectronics, such as organic Light Emitting Diode (OLED) or light sensors, show unique application potential, and promote the development and innovation of new optoelectronic materials.
In the field of dye chemistry, 2-amino-5-iodobenzoic acid is also an indispensable ingredient. The function of dyes is to give substances rich colors, and their chemical structure has a profound impact on the presentation and stability of colors. 2-Amino-5-iodobenzoic acid can be used as an important module for the synthesis of new dyes due to its amino and carboxyl reactive groups, as well as the special electronic effects of iodine atoms. With the help of reasonable molecular design and synthesis methods, the compound can be used to construct dyes with bright colors, good light resistance and washable properties, meeting the needs of high-quality dyes in textile, printing and other industries.

2-Amino-5-iodobenzoic acid (2-amino-5-iodobenzoic acid) is an organic compound with unique physical properties.
Its properties are mostly crystalline, the appearance is often white to light yellow solid, the texture is fine, and the powder or crystal morphology varies according to the preparation and treatment conditions. The melting point of this compound is quite high. Due to the presence of hydrogen bonds and van der Waals forces between molecules, high energy is required to break the lattice to cause it to melt. Usually the melting point is in a specific temperature range, and the specific value depends on the purity and determination method.
In terms of solubility, its solubility in water is limited, because its molecules contain benzene rings, amino groups and carboxyl groups. Although carboxyl groups and amino groups can form hydrogen bonds with water, the hydrophobicity of the benzene ring is large, and the overall solubility in water is reduced. However, it is soluble in some organic solvents, such as dichloromethane, ethanol, ether, etc. In these solvents, the solubility varies due to the interaction between the solvent and the solute. For example, in ethanol, because it can form hydrogen bonds with ethanol hydroxyl groups, the solubility is relatively better.
The density of 2-amino-5-iodobenzoic acid is greater than that of water, and it will sink when placed in water. In addition, it has certain stability, but under extreme conditions such as strong acid, strong base or high temperature, the molecular structure will change and chemical reactions will occur, such as the reaction of carboxyl groups with bases to form salts, and the reaction of amino groups with acids to form ammonium salts. And because it contains iodine atoms, under specific conditions, iodine atoms can participate in substitution reactions, etc., showing special chemical activities.

2-Amino-5-iodobenzoic acid (2-amino-5-iodobenzoic acid) is an organic compound with unique chemical properties and is widely used in the field of organic synthesis.
This compound is acidic because it contains a carboxyl group (-COOH). The oxygen atom in the carboxyl group has strong electronegativity, and the hydrogen-oxygen bond electron cloud is biased towards oxygen, so that hydrogen is easily dissociated in the form of protons, so it can be neutralized with bases. For example, when reacting with sodium hydroxide (NaOH), hydrogen and hydroxide in the carboxyl group combine to form water, resulting in the corresponding carboxylate and water. The reaction formula is: 2-amino-5-iodobenzoic acid + NaOH → 2-amino-5-iodobenzoate + H2O O.
Its amino group (-NH2O) is basic, and the nitrogen atom has a lone pair of electrons, which can accept protons and can react with acids. For example, when reacted with hydrochloric acid (HCl), the amino group binds protons to form an ammonium salt. The reaction formula is: 2-amino-5-iodobenzoic acid + HCl → [2-amino-5-iodobenzoic acid · H 🥰] Cl.
The benzene ring of 2-amino-5-iodobenzoic acid has aromatic properties and can undergo electrophilic substitution reactions. Iodine atoms, amino groups and carboxyl groups will affect the electron cloud density distribution of the benzene ring. The carboxyl group is an electron-withdrawing group, which reduces the electron cloud density of the benzene ring, and the amino group is a donator group, which can increase the electron cloud density of the benzene ring. Under the combined action of the two, the electrophilic substitution reaction mainly occurs in the amino ortho and For example, when nitrification is carried out, the nitro group (-NO 2O) mainly enters the amino ortho and para-position to form the corresponding nitro substituent.
Its carboxyl group can undergo esterification reaction. Under the action of acid catalysis and alcohol, the hydroxyl group in the carboxyl group is replaced by the alkoxy group of the alcohol to form an ester. Taking the reaction with methanol (CH 🥰 OH) as an example, under the catalysis of concentrated sulfuric acid, 2-amino-5-iodobenzoic acid methyl ester and water are generated. The reaction formula is: 2-amino-5-iodobenzoic acid + CH 🥰 OH (concentrated sulfuric acid, Delta) 2-amino-5-iodobenzoic acid methyl ester + H 🥰 O. Amino groups can participate in many reactions, such as reaction with acyl halide and acid anhydride, amino hydrogen is replaced by acyl groups to form amide bonds, which is a common method for preparing amide compounds.

The synthesis of 2-amino-5-iodobenzoic acid (2-amino-5-iodobenzoic acid) is an important issue in organic synthesis. There are many methods, each has its advantages and disadvantages, and the best one should be followed, which needs to be reviewed in detail.
First, benzoic acid derivatives can be used as starting materials. The iodine atom is introduced into the benzene ring of benzoic acid first, which can be achieved by electrophilic substitution reaction. Appropriate iodine substitution reagents, such as iodine elementals, interact with oxidants to introduce iodine atoms at specific positions in the benzene ring to generate 5-iodobenzoic acid derivatives. Subsequently, amino groups are introduced. The nitro group can be introduced into the benzene ring by nitration reaction, and then the nitro group can be converted into an amino group by reduction means, such as iron powder and hydrochloric acid, to obtain 2-amino-5-iodobenzoic acid. This path step is relatively clear, but the reaction conditions of each step need to be precisely controlled to ensure the selectivity and yield of the reaction.
Second, aniline derivatives can also be used as starters. First, the benzene ring of aniline is iodized to make the iodine atom connect to the appropriate position. Then the carboxyl group is introduced through the carboxylation reaction. There are various carboxylation methods, such as the Grignard reagent method, which uses halogenated benzene (already containing iodine and amino groups) to make Grignard reagents, and then interacts with carbon dioxide to obtain carboxyl groups after acidification, and then obtains the target product. This approach requires attention to the protection of amino groups during the reaction to prevent side reactions under the reaction conditions, which affects the purity and yield of the product.
Or consider the coupling reaction catalyzed by transition metals. Using iodine-containing aromatic derivatives and compounds containing amino groups and carboxyl precursors, under the action of transition metal catalysts such as palladium catalysts, the formation of carbon-carbon or carbon-heteroatomic bonds can be achieved, and the target molecular structure can be directly constructed. Such methods often have the advantages of high efficiency and good selectivity, but the catalyst cost is higher, and the reaction equipment and operation requirements are also more stringent.
All synthesis methods have their own advantages, and it is difficult to generalize which one is the best. Experimenters should weigh the advantages and disadvantages according to their own experimental conditions, availability of raw materials, purity and yield requirements of the target product, and carefully choose the appropriate synthesis path to achieve twice the result with half the effort.

I have a question today, what is the price range of 2-amino-5-iodobenzoic acid in the market. However, I have searched all over the classics, but I have not found this specific price.
This 2-amino-5-iodobenzoic acid is an organic compound. Its price often changes due to many reasons. One is purity. If the purity is high, the price will be expensive; if it is low, the price will be slightly cheaper. The second is yield. If the output of this product is abundant and the supply exceeds the demand, the price may fall; if the output is scarce and the supply exceeds the demand, the price will rise. The third is supply and demand. If the market demands a lot, the price will rise; if the demand is few, the price may fall.
And the origin is far and near, and the transportation fee is also related to its price. If it is shipped from a distance, if it costs more, the price will be high; if it is produced nearby, if it costs less, the price will be low.
Although there is no exact price, it is common sense to infer that in the chemical reagent market, it may vary depending on the use, specification and brand. Common specifications, low purity, the price per gram may be a few yuan to tens of yuan; high purity, the price per gram may be hundreds or even hundreds of yuan.
The above are all speculative numbers, and the actual price shall be subject to the quotations of various merchants in the market.