2-Bromo-1-Iodobenzene

Fengxi Chemical

Specifications

HS Code	195089
Chemical Formula	C6H4BrI
Molar Mass	282.804 g/mol
Appearance	Pale yellow to light brown liquid
Boiling Point	235 - 237 °C
Melting Point	−3 °C
Density	2.247 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ether, chloroform
Flash Point	105.8 °C
Refractive Index	1.654

As an accredited 2-Bromo-1-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	2 - bromo - 1 - iodobenzene packaged in 100 - gram bottles for secure storage.
Storage	2 - bromo - 1 - iodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions. Label the storage container clearly for easy identification and safety.
Shipping	2 - bromo - 1 - iodobenzene is shipped in well - sealed, corrosion - resistant containers. It's handled with care due to its chemical nature, following strict regulations for hazardous chemicals during transportation to ensure safety.

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General Information

Historical Development

2 - Bromo - 1 - Iodobenzene, an organic compound. The method of its preparation has evolved over the ages. At the beginning, the sages sought it with simplicity, but the effect was not good.
The science has advanced with each passing day, and the craftsmen and scholars have devoted themselves to studying new paths. Or change the conditions of the reaction, or explore the matching of materials. At first, the crude method was used, only a small amount was obtained, and other things were mixed. Later, it gradually became clear about its properties, improved skills, and the rate of reaction gradually increased, and the purity also increased.
In the past, the preparation was often hindered, the reaction was slow, and the product was impure. However, everyone worked tirelessly, using new agents to catalyze, adjust temperature and pressure, and then got the best method. Today's preparation can be precisely controlled to obtain this material to meet the needs of various industries, and it is of great use in the fields of medicine, materials, etc., which is also a sign of scientific progress.

Product Overview

About 2-bromo-1-iodobenzene
There is currently a product called 2-bromo-1-iodobenzene. It is an organic compound with a wide range of uses in various fields of chemistry.
Looking at its shape, it is a colorless to light yellow liquid under normal conditions, with a special odor. In its structure, bromine and iodine atoms on the benzene ring have one place each, giving it unique chemical properties.
In organic synthesis, 2-bromo-1-iodobenzene is an important intermediate. Due to the different activities of bromine and iodine, the reaction can be selectively initiated according to different reaction conditions. For example, under metal catalysis, it can be replaced with a variety of nucleophiles to build complex organic molecular structures, which is of great significance in drug synthesis, material research and development.
However, this substance also needs to be handled with caution. It is toxic and irritating. When operating, follow strict safety procedures, work in good ventilation, and wear protective equipment to prevent harm to human health. In short, 2-bromo-1-iodobenzene plays an important role in chemical research and industrial production, and rational use can promote scientific and technological progress.

Physical & Chemical Properties

2 - Bromo - 1 - Iodobenzene is an organic compound, and its physicochemical properties are of great importance. Looking at its physical properties, it is liquid at room temperature, with a clear color and a special odor. Its boiling point is quite high, due to intermolecular forces, reaching about several degrees Celsius. This property allows it to boil and gasify at specific temperature conditions. Furthermore, the density is greater than that of water, and it will sink to the bottom when thrown into water.
In terms of chemical properties, bromine and iodine atoms in this compound are quite active. The electron cloud distribution of the benzene ring is affected by it, making the benzene ring more prone to electrophilic substitution reactions. For example, it can react with electrophilic reagents to form different substitution products. And under appropriate conditions, bromine and iodine atoms can undergo substitution or elimination reactions, participate in many organic synthesis processes, and are widely used in the field of organic chemistry.

Technical Specifications & Labeling

2-Bromo-1-Iodobenzene, organic compounds are also. Its technical specifications and identification (product parameters) are crucial in chemical research. Looking at its color, it is often a colorless to light yellow liquid, which is recognizable to the naked eye. Its boiling point is about 240-245 ° C, and its melting point is close to -15 ° C. Such physical parameters are important indicators for identifying this substance.
Preparation method, often based on benzene, is formed by bromination and iodization. During the reaction, the temperature and the proportion of the reactants need to be strictly controlled. This is the technical specification to ensure the purity and yield of the product. Purity identification, commonly used chromatographic methods, such as high performance liquid chromatography, to measure the content of impurities, to ensure that the product meets the required standards. In this way, we can obtain 2-Bromo-1-Iodobenzene of good quality to meet the needs of various fields of chemical industry.

Preparation Method

This product of 2 - Bromo - 1 - Iodobenzene, its raw materials and production process, reaction steps and catalytic mechanism are the key.
First take benzene as the base material, contact the brominating agent with benzene, and obtain bromobenzene by electrophilic substitution. This step requires temperature control, speed, and catalyst selection to increase yield and control side effects. The corresponding formula is: $C_6H_6 + Br_2\ stackrel {FeBr_3} {\ longrightarrow} C_6H_5Br + HBr $.
Then, bromobenzene reacts with the iodine substitution reagent, and the reaction conditions, such as solvent properties, temperature, and time limit, are finely adjusted to form 2-Bromo-1-Iodobenzene. In this case, metal catalysis is used to promote the progress of the reaction and increase the purity of the product. Its catalytic mechanism is the complexation of metals and reagents, which reduces the energy barrier of the reaction and leads the reaction to go forward.
After the reaction is completed, the impurities are removed and the pure product is obtained by the separation and purification process. In this way, 2-Bromo-1-Iodobenzene can be refined to meet the needs of various chemical industries.

Chemical Reactions & Modifications

Chemical refinement in modern times, the wonderful changes in matter are amazing. This talk about the chemical reaction and modification of 2 - Bromo - 1 - Iodobenzene.
In various reactions, the activity of bromine and iodine has attracted chemists to study. The activity of bromine opens the way for nucleophilic substitution, allowing it to meet many nucleophilic reagents and obtain new compounds. Although iodine is slightly slower than bromine, it also has characteristics and can initiate unique reactions under specific conditions.
As for modification, chemists try to use subtle methods to adjust its structure and improve its properties. Or add a group to change its physical properties, such as melting point and solubility; or change its electron cloud distribution to change its chemical activity. This is to make it play an extraordinary role in materials, medicine and other fields. Although the road is long and long, the heart of a chemist, like the fire of flint, continues to explore the true meaning of chemical change, so that the potential of 2 - Bromo - 1 - Iodobenzene can be fully realized.

Synonyms & Product Names

Today there is a thing called 2 - Bromo - 1 - Iodobenzene. This is a chemical thing, and its synonyms and trade names are also something we have studied.
In the field of chemistry, there are many things in one place, which is not uncommon. 2 - Bromo - 1 - Iodobenzene, according to the rules of chemical nomenclature, its composition and structure are clarified. However, in the city, either because of convenience or because of vulgarity, it is also called differently.
When we study this substance, we must carefully investigate its synonyms. If we look for details, we should not leave any traces. Commodity names are related to commercial circulation, and they also need to be clarified. Knowing its name can be used to identify it in all situations, and it is of great benefit to research, production, and trade. Therefore, it is the priority of our chemical researchers to study the synonyms and trade names of 2-Bromo-1-Iodobenzene in detail.

Safety & Operational Standards

2 - Bromo - 1 - Iodobenzene Safety and Practice
2 - Bromo - 1 - Iodobenzene is a compound commonly used in chemical research. When used in research, it is essential to ensure safety and follow the practice.
#1. Safety Precautions
This substance has certain toxicity and can cause damage to the human body by contact or inhalation. When experimenting, be sure to wear appropriate protective equipment, such as gloves, goggles and lab clothes, to prevent skin contact and eye splashing. If you accidentally touch the skin, rinse with plenty of water immediately, and then seek medical attention according to the specific situation. If it splashes into the eyes, rinse with plenty of water quickly and seek medical attention as soon as possible.
In addition, its vapor is also dangerous, so the experimental operation should be carried out in a well-ventilated fume hood to avoid vapor accumulation and reduce the risk of inhalation.
#2. Operating instructions
When taking 2-Bromo-1-Iodobenzene, the action must be precise and cautious. Use clean and dry appliances to prevent impurities from mixing and affecting its quality and experimental results. During the measurement process, measure accurately according to the experimental requirements to avoid waste.
For storage, it should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Storage containers must be well sealed to prevent leakage and volatilization.
After the experiment is completed, the remaining 2 - Bromo - 1 - Iodobenzene should not be discarded at will, but should be properly disposed of in accordance with the laboratory waste disposal regulations to avoid pollution to the environment.
Follow the above safety and operation guidelines to ensure that when conducting research on 2 - Bromo - 1 - Iodobenzene, both the safety of the experimenter and the smooth conduct of the experiment are guaranteed.

Application Area

2 - Bromo - 1 - Iodobenzene is also an organic compound. Its application field is quite wide. In the field of drug synthesis, it can be used as a key intermediate. Due to the unique activity of halogen atoms on the benzene ring, it can be combined with various functional groups through many chemical reactions to build complex drug molecular structures.
In the field of materials science, it also has its uses. It can participate in polymerization reactions to prepare polymer materials with special properties, such as those with specific optoelectronic properties, for the manufacture of optoelectronic devices.
Furthermore, in the study of organic synthetic chemistry, it is often an important raw material. Chemists can create novel organic compounds through selective substitution and coupling of halogen atoms, which contribute to the development of organic synthetic chemistry. It is a widely used and important compound.

Research & Development

Today there is a product called 2 - Bromo - 1 - Iodobenzene. We have studied it chemically to explore the way of its research and creation. This compound has a special structure and has great potential in the field of organic synthesis.
At the beginning of the research, we tried hard to find a suitable method to make it. After repeated trials, we obtained various pathways. Or from benzene derivatives, by the method of halogenation, bromine and iodine are introduced to specific positions. However, the process is not smooth sailing, and it needs to be controlled by temperature, selected agents, and carried out cautiously.
And to obtain this product, re-study its properties. Looking at its physical properties, we know that its melting point and solubility are different in various solvents. Studying its chemical properties and exploring its ability to react with other things can be the basis for the creation of new things.
Today, 2 - Bromo - 1 - Iodobenzene is gradually showing its use in the fields of medicine and materials. We should continue to study it, expand its use, promote its development, and contribute to the progress of chemistry, so as to achieve its wonders and be used by the world.

Toxicity Research

There are many people who have studied poison in recent years. In 2 - Bromo - 1 - Iodobenzene, the toxicity of this substance is investigated. The husband 2 - Bromo - 1 - Iodobenzene has a different color and taste. After various tests, it can be known that the way it enters the body, either through the mouth and nose, or through the skin. After entering the body, it disturbs the transportation of qi and blood, and disrupts the ability of the viscera.
At first I feel tired and lethargic, and then my head is dizzy, and even the viscera is damaged and sick. And this thing is in the environment, and it also leaves a disaster. Over time, it gradually stains the water and soil, and the living things are harmed by it, and the ecological balance is chaotic.
Therefore, the study of its toxicity is not only to clarify that it is harmful to the human body, but also to protect the state of nature and protect the safety of all living beings. All researchers should devote their efforts to solving the recipe for poison, to stop the spread of its harm, and to live up to the original intention of researching poison, so as to restore the appearance of peace in the world.

Future Prospects

Husband 2 - Bromo - 1 - Iodobenzene, it is also a matter of transformation. As a person of transformation, we look forward to its undeveloped development, and our hearts are full of high hopes.
This compound is unique in nature and has extraordinary power in the field of synthesis. It can be used in the research of new materials to cure the pain of the world. Or in the field of materials, the manufacture of new materials provides the cornerstone.
Its synthesis method is more and more exquisite. With time, it will be more convenient, efficient and guaranteed. In this way, the cost can be reduced and the quantity can be increased. It is not a lie to use it in general.
I am diligent in my research and its secrets, so that this compound will not be widely used and benefit the world, which is not pleasant.

Where to Buy 2-Bromo-1-Iodobenzene in China?

As a trusted 2-Bromo-1-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 2-Bromo-1-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 2-bromo-1-iodobenzene?

2-Bromo-1-iodobenzene, Chinese name 2-bromo-1-iodobenzene, is an organic compound. Its physical properties are as follows:
Viewed at room temperature, it is a colorless to light yellow liquid. However, if left in the air for a long time or exposed to light, the color will gradually darken due to oxidation. This is due to the influence of bromine and iodine atoms in the molecule, coupled with the conjugated system of benzene rings, which cause light sensitivity and cause molecular structure changes and discoloration.
Smell, has a special odor. This odor originates from benzene rings and halogen atoms. Although it is difficult to describe accurately, it is unique and detectable.
Its melting point also has characteristics. The melting point is about -20 ° C, and the boiling point is about 248-250 ° C. The melting point is low because the intermolecular force is mainly van der Waals force. Although the halogen atom increases the polarity of the molecule, the plane structure of the benzene ring is restricted by tight accumulation, and the melting point is not high; the higher boiling point is due to the relatively large mass of the molecule, and the polar halogen atom enhances the intermolecular force, which requires more energy to make the molecule leave the liquid phase.
In terms of solubility, it is difficult to dissolve in water, because water is a strong polar solvent, and 2-bromo-1-iodobenzene is an organic molecule, the polarity is weak, and according to the principle of "similar miscibility", the two are insoluble. However, it is soluble in many organic solvents, such as ether, dichloromethane, carbon tetrachloride, etc. Because these organic solvents are close to its polarity < Br > The density is greater than that of water, about 2.36 g/cm ³. Due to the large relative atomic mass of bromine and iodine atoms, the molecular mass is large, and the molecular structure is compact. The unit volume mass is greater than that of water, and it will sink to the bottom in water.

What are the chemical properties of 2-bromo-1-iodobenzene?

2-Bromo-1-iodobenzene is an organic halogenated aromatic hydrocarbon with unique chemical properties. Its properties are as follows:
First, nucleophilic substitution reaction. Because of its halogen atom activity, in case of strong nucleophilic reagents, such as sodium alcohols, amines, etc., halogen atoms can be replaced by nucleophilic groups. Example Reacts with sodium alcohols to form corresponding ether compounds. Because the oxygen atom in the nucleophilic reagent is rich in electrons, it attacks the carbon site of the benzene cyclohalogen atom, and the halogen atom leaves in the form of negative ions, and then forms a new compound.
Second, metal-organic reaction. 2-bromo-1-iodobenzene can react with metal magnesium to form Grignard re Grignard reagents are extremely reactive and can react with many carbonyl-containing compounds, such as aldides and ketones, to form carbon-carbon bonds. They are a key step in organic synthesis, which can grow carbon chains and introduce various functional groups.
Third, electrophilic substitution reaction. The benzene ring has electron-rich properties and is vulnerable to attack by electrophilic reagents. Although the halogen atom is a blunt group, the ortho-site localization effect still exists. When encountering electrophilic reagents, such as mixed acid with nitric acid and sulfuric acid under specific conditions, the electrophilic reagent will attack the ortho-site of the benzene ring halogen atom and generate nitro substituents.
Fourth, eliminate the reaction. Under suitable conditions such as strong bases, 2-bromo-1-iodobenzene may be eliminated by hydrogen halide to form unsaturated bonds. This reaction requires specific bases and reaction conditions to form unsaturated aromatics containing carbon-carbon double bonds.
In short, 2-bromo-1-iodobenzene has rich chemical properties due to the conjugate structure of halogen atoms and benzene rings. It is widely used in the field of organic synthesis and can construct a variety of organic compounds through different reactions.

What are the applications of 2-bromo-1-iodobenzene in organic synthesis?

2-Bromo-1-iodobenzene, or 2-bromo-1-iodobenzene, is widely used in organic synthesis.
One of them can be used to construct carbon-carbon bonds. Through transition metal-catalyzed coupling reactions, such as Suzuki coupling reaction, Stille coupling reaction, and Negishi coupling reaction, 2-bromo-1-iodobenzene can react with different organometallic reagents to generate biphenyl compounds with diverse structures. Such biphenyl structures are widely found in many fields such as drugs and materials. For example, in drug development, some molecules with specific pharmacological activities have a core structure of biphenyl, and 2-bromo-1-iodobenzene can be prepared as a key starting material.
Second, it also has important applications in the construction of carbon-heteroatomic bonds. Through suitable reaction conditions, it can react with nucleophiles containing heteroatoms such as nitrogen, oxygen, and sulfur to form corresponding carbon-heteroatomic bonds. For example, by reacting with amines, nitrogen-containing aromatic compounds can be prepared, which have important uses in pesticides, dyes, and other industries. Some pesticide molecules contain such nitrogen-containing aromatic structures, which can enhance the toxicity of pesticides to pests and protect plants.
Furthermore, 2-bromo-1-iodobenzene can also be used as a starting material for the synthesis of polycyclic aromatic hydrocarbons. Through a series of cyclization reactions, polycyclic aromatic hydrocarbons with complex structures can be constructed. Such polycyclic aromatic hydrocarbons exhibit unique photoelectric properties in the field of materials science, such as organic semiconductor materials, which is of great significance for the development of new electronic devices.
To sum up, 2-bromo-1-iodobenzene plays an indispensable role in many fields of organic synthesis due to its unique chemical structure, providing important basic raw materials for the preparation of many organic compounds.

What are the methods of preparing 2-bromo-1-iodobenzene?

There are many ways to prepare 2-bromo-1-iodobenzene. First, benzene can be started from benzene, and first brominated, so that benzene and bromine can be formed under the action of suitable catalysts such as iron filings or iron tribromide. This reaction process is electrophilic substitution, bromine positive ions attack the benzene ring and replace hydrogen atoms. Then, bromobenzene is further iodized, and iodine and bromobenzene can be used under specific conditions. With the help of suitable catalysts and auxiliaries, iodine can be substituted for specific hydrogen in bromobenzene, and finally 2-bromo-1-iodobenzene can be obtained.
Second, it can be started from phenol. Phenol is first brominated, and bromine atoms will selectively enter the ortho and para-sites of phenolic hydroxyl groups. After controlling the reaction conditions and the amount of bromine, bromine can mainly enter the ortho-site to obtain o-bromophenol. Then the o-bromophenol is iodized, and the iodine atom replaces the hydrogen at the appropriate position in the o-bromophenol by using suitable iodizing reagents and reaction conditions, so as to obtain the target product 2-bromo-1-iodobenzene.
Third, the coupling reaction is carried out with halogenated aromatics as raw materials. 2-Bromo-1-iodobenzene can also be synthesized by selecting suitable brominated aromatics and iodized aromatics derivatives under the catalysis of transition metal catalysts such as palladium catalysts, and through the participation of suitable ligands and bases. This method requires precise control of the reaction conditions to improve the yield and selectivity of the product.

What safety precautions should be paid attention to when using 2-bromo-1-iodobenzene?

2-Bromo-1-iodobenzene is an organic compound. When using it, many safety matters need to be paid attention to.
First of all, this compound is toxic and can cause damage to the human body. During operation, be sure to wear appropriate protective equipment, such as laboratory clothes, gloves and goggles, to prevent skin contact and eye splashing. In case of inadvertent contact, rinse with plenty of water immediately and seek medical treatment according to the specific situation.
Second, 2-bromo-1-iodobenzene is a flammable substance. In case of open flame, hot topic or oxidant, there is a risk of ignition and explosion. Therefore, the place of use must be kept away from fire and heat sources, and avoid mixing with strong oxidants.
Furthermore, its volatility may cause vapor to diffuse in the air. The operation should be carried out in a well-ventilated place, preferably in a fume hood to prevent the inhalation of harmful vapors. If used in a confined space, it is necessary to ensure the normal operation of effective ventilation equipment.
In addition, 2-bromo-1-iodobenzene is chemically active and can react with a variety of substances. Before use, it is necessary to fully understand its chemical properties and reaction characteristics, and avoid contact with incompatible substances to prevent accidental reactions.
After use, the remaining 2-bromo-1-iodobenzene and related wastes should be properly disposed of in accordance with relevant regulations, and should not be dumped at will to prevent environmental pollution.
In conclusion, when using 2-bromo-1-iodobenzene, it is necessary to fully understand its toxicity, flammability, volatility and chemical activity characteristics, and strictly abide by safety operating procedures to ensure personal safety and environmental safety.