2 Bromo 3 Iodo 5 Methoxypyridine

2-Bromo-3-iodine-5-methoxy pyridine is a key intermediate in the field of organic synthesis. It has a wide range of uses, especially in the field of medicinal chemistry.
In the process of drug development, this compound is often the cornerstone of the construction of specific bioactive molecules. Due to the unique combination of bromine, iodine and methoxy in its structure, it endows molecules with diverse reactive activity check points. Bromine and iodine atoms can participate in nucleophilic substitution reactions, metal-catalyzed coupling reactions, etc., such as Suzuki coupling and Heck coupling reactions. With these reactions, different functional groups can be introduced into the molecular structure, thereby expanding the complexity and diversity of molecules, and laying the foundation for the creation of new drugs.
For example, in the synthesis path of some antibacterial drugs, 2-bromo-3-iodine-5-methoxypyridine can be used as a starting material to generate pyridine derivatives with antibacterial activity by nucleophilic substitution reaction with specific amine compounds. Or when anti-tumor drugs are developed, complex molecular structures with targeted inhibitory effects on tumor cells can be constructed through metal-catalyzed coupling reactions with aryl-containing reagents.
In addition, this compound also shows potential application value in the field of materials science. Due to its unique electronic structure and reactivity, it may participate in the preparation of organic materials with special photoelectric properties. For example, by introducing it into a conjugated polymer system through rational molecular design and reaction, it is expected to regulate the electrical and optical properties of materials, such as fluorescence emission and charge transport, and then be applied to the development of organic Light Emitting Diodes (OLEDs), organic solar cells and other devices.

2-Bromo-3-iodo-5-methoxypyridine is an organic compound with specific physical properties. It is mostly solid at room temperature. Due to the presence of moderate intermolecular forces, the molecules are arranged in an orderly manner.
Looking at its melting point, due to the presence of bromine, iodine, and methoxy groups, the intermolecular forces are changed, and the melting point is different from that of general pyridine derivatives. These substituents increase the intermolecular attraction and cause the melting point to increase. The specific melting point value needs to be accurately determined by experiments.
In terms of boiling point, it is also affected by intermolecular forces. The relative atomic mass of bromine and iodine atoms is large, which enhances the intermolecular dispersion force. Methoxy groups cause their boiling point to rise through induction effects and hydrogen bonds, and more energy is required to overcome intermolecular forces during heating to achieve gasification.
In terms of solubility, the compound has a certain solubility in polar solvents such as methanol and ethanol due to its polar methoxy group. However, bromine and iodine atoms increase the non-polar part of the molecule, making it limited in solubility in water. In organic solvents such as dichloromethane and chloroform, the solubility will be higher than that of water due to the similar principle of miscibility.
Appearance is often white to light yellow solid, which is related to the absorption and reflection of light by the molecular structure. The π-electron conjugate system and substituents in its structure affect the absorption of light of different wavelengths, resulting in this appearance.
The density is dominated by the molecular weight and the degree of molecular packing compactness. The atomic weight of bromine and iodine is large, resulting in an increase in molecular weight. If the molecules are packed tightly, their density will be higher than that of common organic solvents. The physical properties of this compound are of great significance for its application in the fields of organic synthesis and medicinal chemistry, and help researchers to select methods for separation, purification and use in specific reactions.

To prepare 2-bromo-3-iodine-5-methoxypyridine, there are several synthesis methods as follows.
First, it can be started from 5-methoxypyridine. Under suitable conditions, such as bromine (Br ²), under suitable conditions, such as in the presence of suitable solvents and catalysts, 5-methoxypyridine is brominated, so that the bromine atom replaces the hydrogen atom at a specific position on the pyridine ring to obtain 2-bromo-5-methoxypyridine. Then, an iodizing reagent, such as iodine (I ²) and an appropriate iodization accelerator, is used to replace the hydrogen in the obtained product with an iodine atom to obtain 2-bromo-3-iodine-5-methoxypyridine. In this process, the choice of solvent is very critical, such as the choice of halogenated hydrocarbon solvents such as dichloromethane and chloroform, or polar aprotic solvents such as acetonitrile, which can help the reaction proceed smoothly. In terms of catalysts, iron powder can be used during bromination, and a suitable metal salt catalyst can be selected during iodization to improve the reaction efficiency.
Second, 3-iodine-5-methoxypyridine can also be used. It is brominated with a brominating agent to precisely control the reaction conditions, such as temperature and reaction time, so that the bromine atom replaces the hydrogen atom at a specific position in the pyridine ring, and finally obtains the target product. This path also requires attention to the regulation of the reaction conditions to ensure that the bromine atom is accurately connected to the desired position.
Or start with other suitable pyridine derivatives and gradually introduce functional groups such as bromine, iodine and methoxy group through multi-step reaction. For example, the pyridine derivative containing methoxy group and other convertible functional groups is first constructed, and then the convertible functional group is sequentially converted into bromine atom and iodine atom through a suitable reaction, so as to achieve the purpose of synthesizing 2-bromo-3-iodine-5-methoxy pyridine. This strategy requires careful planning of each step of the reaction to ensure that the yield and selectivity of each step are good, and the reaction conditions of each step need to be adapted to each other, so as not to affect the subsequent reaction.
All synthesis methods require careful control of the reaction conditions, accurate allocation of the proportion of reactants, and attention to the purification and characterization of intermediates in order to efficiently and high-quality synthesis of 2-bromo-3-iodine-5-methoxy pyridine.

2-Bromo-3-iodo-5-methoxypyridine is an organic compound. When storing and transporting it, the following things should be paid attention to.
The first storage environment. This compound should be placed in a cool, dry and well-ventilated place. Because of the cool environment, it can be avoided from changing its properties due to excessive temperature. If it is exposed to high temperature, it may cause reactions such as decomposition, which will damage its purity and quality. Drying is also key. Moisture may react with the compound and cause it to deteriorate. In case of water vapor, or hydrolysis, the structure will be changed. Good ventilation can prevent the accumulation of harmful gases and ensure the safety of the storage environment.
Second words The importance of packaging. It must be filled in a suitable container, and the seal must be tight. Containers made of commonly used glass or specific plastic materials are not easy to interact with compounds because of their stable chemical properties. Strict sealing can prevent the intrusion of air and water vapor to ensure the stability of their chemical properties. If the packaging is not good, air enters the interior, or causes reactions such as oxidation, which affects the quality of the compound.
As for transportation, there are also many points to pay attention to. During transportation, shock and collision prevention are extremely important. This compound may be damaged due to violent vibration or collision, causing leakage. Once leaked, it will not only damage the goods, but also endanger the transportation personnel and the surrounding environment. And the transportation temperature needs to be strictly controlled. According to its characteristics, a suitable temperature range should be maintained to prevent changes in the properties of the compound due to temperature fluctuations.
In addition, transportation and storage personnel should be familiar with the characteristics and hazards of this compound. In case of emergencies, such as leakage, fire, etc., they can quickly take appropriate measures according to their nature to reduce the hazard. In short, the storage and transportation of 2-bromo-3-iodo-5-methoxypyridine requires multiple attention to the environment, packaging, transportation conditions and personnel awareness to ensure its safety and quality.

2-Bromo-3-iodine-5-methoxypyridine, the price of this product in the market is difficult to determine. The price of this product often varies due to many factors, such as the state of supply and demand, the method of preparation, the level of quality, the amount of purchase, and even the competitive situation of the market.
If there is a lot of demand and the supply is scarce, the price will rise; on the contrary, the supply will exceed the demand, and the price will drop. The method of preparation is also critical. If there is a simple and low-cost method, the price may be easier. The quality of the product also affects the price. Those with high purity and few impurities often have higher prices than those with inferior products.
The amount purchased is related to the price. If you buy in large quantities, merchants may give discounts to promote transactions, and the price may be lower; if you buy in small quantities, the price may be relatively high. The market competition situation is also important. Where the competition is intense, merchants may lower their prices to attract buyers in order to compete for market share.
Looking at the past market, the price of such chemicals fluctuated a lot. There was a high purity of 2-bromo-3-iodine-5-methoxy pyridine. Due to the complex production process and the sudden increase in demand, the price was once high. Later, new production methods came out, the cost fell, the supply increased, and the price also gradually declined.
If you want to know the current market price, you must consult chemical product suppliers, chemical trading platforms, or people in related industries. They can provide accurate prices based on real-time market conditions.