2 Bromo 3 Iodopyridine

2-Bromo-3-iodopyridine is an organic compound with the structure of halogenated pyridine. Its chemical properties are unique and worthy of investigation.
First, its halogen atoms (bromine and iodine) are active and can initiate nucleophilic substitution reactions. Taking alcohols as an example, under the catalysis of bases, hydroxyl nucleophiles can attack the carbon attached to the halogen atom on the pyridine ring, and the halogen atom leaves to form corresponding substitution products. In this reaction, the tendency of the halogen atom to leave is affected by the distribution of the electron cloud in the pyridine ring, and the nitrogen atom in the pyridine ring has an electron-absorbing effect, which makes the carbon attached to the halogen atom more positive, which is conducive to the attack of nucleophiles.
Furthermore, 2-bromo-3-iodopyridine can participate in metal-catalyzed coupling reactions. For example, under palladium catalysis, Suzuki coupling reaction can occur with borate esters. In this reaction, palladium catalysts activate halogen atoms and borate esters, promoting the coupling of the two, forming new carbon-carbon bonds, and constructing more complex organic molecular structures. The reaction conditions are mild and highly selective, and it is widely used in the field of organic synthesis.
In addition, because the pyridine ring is basic, 2-bromo-3-iodopyridine can react with acids to form salts. The nitrogen atom of the pyridine ring can accept protons and form pyridine salts. This property plays an important role in regulating the solubility and stability of compounds. For example, the formed pyridine salts have better solubility in water, which is conducive to related reactions or applications in aqueous systems.
At the same time, the halogen atoms of 2-bromo-3-iodopyridine can be reduced. Under the action of appropriate reducing agents, bromine and iodine atoms can be reduced to hydrogen atoms, which can change the substituents on the pyridine ring. This reduction reaction provides an effective way to adjust the structure and properties of compounds, which is helpful for the synthesis of organic compounds with specific structures and functions. In conclusion, 2-bromo-3-iodopyridine is rich in chemical properties due to the presence of halogen atoms and pyridine rings, and has broad application prospects in organic synthesis, medicinal chemistry and other fields.

2-Bromo-3-iodopyridine is an important compound in organic synthesis. Its common synthesis methods are as follows:
Pyridine is first used as the starting material. Pyridine is also a nitrogen-containing heterocyclic compound with an aromatic ring structure. First, pyridine undergoes an electrophilic substitution reaction with bromine. In this reaction, the nitrogen atom of pyridine changes the electron cloud density distribution of the aromatic ring, making it easier for the electrophilic reagent bromine to attack specific positions in the pyridine ring. Usually in the presence of a suitable solvent such as dichloromethane and a catalyst such as iron tribromide, bromine preferentially replaces the 3-position hydrogen atom of the pyridine ring to generate 3-bromopyridine The mechanism of this step is electrophilic substitution. Bromine positive ions attack the pyridine ring. After passing through the intermediate, protons are removed to obtain 3-bromopyridine.
Then, 3-bromopyridine is reacted with iodine reagents. Commonly used iodine reagents such as cuprous iodide (CuI), and appropriate ligands such as 1,10-phenanthroline are added to react under basic conditions. In the reaction, iodine negative ions are catalyzed by copper through a series of electron transfer and nucleophilic substitution processes to replace the 3-position bromine atom in 3-bromopyridine to generate 2-bromo-3-iodopyridine. This step requires strict control of the reaction conditions, such as temperature, amount of base, and reaction time, to improve the yield and selectivity.
Another synthesis strategy is to use 2-amino-3-halopyridine as the starting material. The amino group of 2-amino-3-halopyridine is first denitrified to form a diazonium salt. Diazonium salts are active and can be introduced into iodine atoms through iodization. This diazotization process is often carried out in an acidic medium with sodium nitrite. After forming diazonium salts, they react with iodine sources such as potassium iodide, so that the diazonium group is replaced by iodine to obtain the target product 2-bromo-3-iodopyridine. The advantage of this route is that the substituent position can be precisely controlled, but the diazotization reaction needs to be handled carefully. Due to the instability of diazonium salts, it is easy to decompose and even explode.
In addition, there are also people who use pyridine derivatives as raw materials to construct target molecules through multi-step functional group transformation. However, such methods are a little more complicated, and the reaction sequence and conditions need to be carefully planned to avoid side reactions and ensure the final high purity of 2-bromo-3-iodopyridine.

2-Bromo-3-iodopyridine is an organic compound that has applications in many fields.
In the field of medicinal chemistry, this compound has a significant effect. Due to its unique structure, it can be used as a key intermediate for the creation of various drugs. Pyridine ring structure widely exists in many bioactive molecules. The introduction of bromine and iodine atoms can adjust the electronic properties and spatial structure of molecules, thereby enhancing the affinity and activity to specific biological targets. For example, when developing antibacterial drugs, through structural modification and derivatization of the compound, it is expected to obtain new antibacterial agents with high inhibitory activity against specific pathogens.
In the field of materials science, 2-bromo-3-iodopyridine also has important uses. It can participate in polymerization reactions to build polymer materials with special optoelectronic properties. The conjugate structure of pyridine rings and the presence of halogen atoms can affect the electron transport and optical absorption characteristics of materials, and can be applied to the preparation of optoelectronic devices such as organic Light Emitting Diode (OLED) and organic solar cells to improve the performance of devices.
In the field of organic synthetic chemistry, this compound is an extremely useful synthetic building block. Its halogen atoms can participate in a variety of classical organic reactions, such as Suzuki coupling reaction, Stille coupling reaction, etc. With the help of these reactions, various functional groups or carbon chains can be easily introduced into the pyridine ring to realize the construction of complex organic molecules, providing an effective way for the synthesis of organic compounds with specific structures and functions.

2-Bromo-3-iodopyridine is an organic compound with unique physical properties. It is a solid state at room temperature, and the melting boiling point has a great influence on its phase state and stability under specific conditions. The melting point is measured experimentally at about [X] ° C. At this temperature, the solid state turns to liquid state, reflecting the strength of intermolecular forces. The boiling point is about [X] ° C, reflecting the energy required for the molecule to overcome the interaction and turn into a gaseous state.
2-bromo-3-iodopyridine may be white to light yellow crystalline powder in appearance, and the color and morphology may vary depending on the purity and preparation method. It has different solubility in different solvents, and has a certain solubility in common organic solvents such as ethanol and dichloromethane. Due to the principle of similar miscibility, some structures of the compound interact with organic solvent molecules. However, the solubility in water is extremely low. Because it is an organic halide, its polarity is very different from that of water molecules, and it is not easy to form an effective interaction with water.
In addition, 2-bromo-3-iodopyridine has a certain density. The density data are meaningful for its distribution in the reaction system and the contact area involved in the reaction, indicating the mass of the substance per unit volume. At the same time, it may have a special odor. Although there are few relevant odor descriptions in the literature, it may have an irritating or special odor as a halogen-containing organic compound. This physical property requires attention during handling and storage to prevent adverse effects on the human body and the environment.

I think the "2-bromo-3-iodopyridine" you are asking about is one of the organic chemicals. As for its market price, it is difficult to determine. This is due to the changing price of the market, which often varies with many factors.
First, the state of supply and demand has a lot to do with it. If there are many applicants for this product, and there are few suppliers, the price will increase; if the supply exceeds the demand, the price will drop. Second, the difficulty of preparation is also the main reason. If the preparation method is complicated, the required raw materials are rare and expensive, or the preparation process is energy-intensive and labor-intensive, the cost will be high, and the price will also increase; if the preparation method is simple, the raw materials are easy to obtain and cheap, the price can be slightly lower. Third, competition in the market can also affect its price. Businesses compete to sell this product in order to compete for market share, or there is a price reduction strategy; if the market is monopolized, the price will be easy to control.
Furthermore, the difference in regions also makes the price different. In different places, the price or height varies depending on the transportation cost, tax policy, etc. Moreover, the fluctuation of the market and the change of raw material prices can make the price of "2-bromo-3-iodopyridine" high and low, which is difficult to be constant. Therefore, if you want to know the exact price, you must consult the chemical raw material market, merchants, or check relevant transaction information in real time.