2-Bromo-4-Fluoroiodobenzene

Fengxi Chemical

Specifications

HS Code	606887
Chemical Formula	C6H3BrFI
Molecular Weight	302.897 g/mol
Appearance	Typically a colorless to light - colored liquid or solid
Melting Point	Data may vary, but generally in a range related to its structure
Density	Higher than water due to heavy halogens
Solubility In Water	Low, as it is an organic halide
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform
Reactivity	Reactive towards nucleophiles due to the presence of halogens

As an accredited 2-Bromo-4-Fluoroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 2 - bromo - 4 - fluoroiodobenzene packaged in a sealed glass bottle.
Storage	2 - bromo - 4 - fluoroiodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store it in a tightly sealed container, preferably made of glass or a suitable chemical - resistant material. Label the container clearly. This helps prevent decomposition, potential reactions, and ensures safety during storage.
Shipping	2 - bromo - 4 - fluoroiodobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict chemical shipping regulations, ensuring safe transport to prevent any leakage and potential hazards during transit.

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General Information

Historical Development

In the field of chemistry, we often study all kinds of substances, and today there is 2-Bromo-4-Fluoroiodobenzene. In the past, when chemistry was at its dawn, all the sages thought hard to explore the properties of substances. At that time, the understanding of halogenated aromatics was still shallow. However, with the passage of time, scholars have worked tirelessly. At the beginning, only simple halogenates could be obtained, and the process was also simple. After gradual improvement, the reaction conditions were controlled and improved, and the complex halogenated aromatics 2-Bromo-4-Fluoroiodobenzene were obtained. The synthesis method, from simple to complex, from preliminary attempts to precise preparation of reaction materials, temperatures, and catalysts, condensed the wisdom of predecessors at every step. Looking at its historical evolution, it is like a stream converging into a river, moving from ignorance to clarity, laying the foundation for subsequent chemical research and application, and gradually showing its importance in many fields such as organic synthesis.

Product Overview

Today there is a substance called 2 - Bromo - 4 - Fluoroiodobenzene. Its shape is also characteristic of halogenated aromatics. Looking at its structure, bromine (Bromo), fluorine (Fluoro) and iodo atoms are sequentially connected to the benzene ring, each in a specific position.
This substance has a wide range of uses and is often a key intermediate in the field of organic synthesis. With its active chemical properties, it can introduce various functional groups through various reactions, such as nucleophilic substitution, etc., to construct complex organic molecules.
The preparation method requires the selection of suitable raw materials and conditions according to chemical principles. Or start with a derivative of benzene, go through a series of steps such as halogenation, and fine regulation to obtain this product. Its yield and purity are related to the precise determination of reaction conditions and operation.
This substance is of great value in chemical research and industrial production, contributing to the development of organic synthesis and assisting progress in many fields.

Physical & Chemical Properties

2 - Bromo - 4 - Fluoroiodobenzene is an organic compound with unique physicochemical properties. Its appearance may be colorless to light yellow liquid, and it has certain volatility at room temperature and pressure.
From the perspective of chemical properties, halogen atoms such as bromine (Br), fluorine (F) and iodine (I) in this compound endow it with active chemical activity. Bromine and iodine atoms can participate in nucleophilic substitution reactions. Fluorine atoms have strong electronegativity, which affects the distribution of molecular electron clouds, thereby changing their reactivity and selectivity.
In terms of physical properties, their boiling point and melting point are affected by intermolecular forces and relative molecular weights. Due to the presence of halogen atoms, molecular polarity is enhanced, and intermolecular forces are increased, so the boiling point or compounds with similar structures are higher. Its solubility or polarity has a certain solubility in polar organic solvents, but little solubility in water. These physicochemical properties make 2-Bromo-4-Fluoroiodobenzene have important application value in the field of organic synthesis.

Technical Specifications & Labeling

Today there is a product, name 2 - Bromo - 4 - Fluoroiodobenzene. In the technical specifications and identification (product parameters) of the product, we should carefully observe it.
Its quality must be pure, and impurities should not disturb its properties. Looking at its shape, it should have a specific color and state, in line with the established standards. To measure its chemistry, all parameters must comply with the regulations, such as melting point, boiling point, solubility, etc. It should not be ignored. Its logo is also heavy, and the product parameters should be clearly marked, including ingredients, purity, production date, etc., so that those who see it know the details.
When preparing, the process must be fine, and it should be carried out according to the technical specifications to ensure that the product always has a stable quality. The inspection process should be rigorous and correct to ensure that it conforms to the product parameters shown in the label. In this way, high-quality 2-Bromo-4-Fluoroiodobenzene can be obtained for all needs.

Preparation Method

To prepare 2 - Bromo - 4 - Fluoroiodobenzene, the raw materials and production process are the key. First, take an appropriate amount of fluorobenzene, take a brominating reagent such as liquid bromine, and react with a catalyst such as iron powder to obtain 4 - fluorobromobenzene. This step requires moderate temperature control and does not cause side reactions to occur.
Then, 4 - fluorobromobenzene and iodine sources, such as potassium iodide, in a specific solvent, such as N, N - dimethylformamide, under the catalysis of copper salts, through substitution reaction to produce the target product. During the reaction process, the degree of reaction should be constantly measured and the conditions should be adjusted at the appropriate time. After the
reaction is completed, the high-purity product is obtained through extraction, distillation, recrystallization and other purification steps. Equipment selection is also important, the material needs to be corrosion-resistant, and the temperature control and stirring device should be accurate to ensure a smooth reaction and improve yield and purity.

Chemical Reactions & Modifications

2 - Bromo - 4 - Fluoroiodobenzene is an important compound in organic synthesis. Its chemical reaction and modification are related to research in many chemical fields.
In the past, to obtain this compound, it often went through a complex and multi-step reaction. The initial raw materials need to be precisely selected and pretreated, and the control of the reaction conditions is also very critical. At that time, the yield and purity were difficult to achieve the ideal.
However, today is different from the past, and the chemical technology is becoming more and more exquisite. The use of new catalysts can greatly optimize the reaction path. If a special metal complex is used as a catalyst, the activation energy can be reduced, so that the reaction can be carried out efficiently under milder conditions. Not only the yield is significantly improved, but the purity is also guaranteed.
Modification of this compound, or the introduction of specific functional groups to give it new characteristics. For example, by adding nitrogen-containing heterocycles through specific reactions, its electron cloud distribution can be improved, showing unique photoelectric properties in the field of material chemistry. The refinement of this chemical reaction and modification paves the way for the application of 2-Bromo-4-Fluoroiodobenzene in more fields.

Synonyms & Product Names

Today there is a thing called 2 - Bromo - 4 - Fluoroiodobenzene. It is quite useful in the field of chemistry. The name of this substance, although it is a foreign logo, is known to everyone in the industry.
Looking at its synonymous name, it may be found from its chemical structure and properties. In the language of Wuhuaxia, I also hope to have an appropriate title. Because there are many chemical substances, the names may vary from place to place, but it is precise and clear, so that everyone in the industry can understand its meaning.
As for the name of the product, it should be concise and able to highlight its characteristics. This 2 - Bromo - 4 - Fluoroiodobenzene can be appropriately named according to its use and characteristics. In this way, it is conducive to its circulation in the market, and it is also convenient for all parties to communicate and discuss, so that everyone can understand the function and value of this thing.

Safety & Operational Standards

2 - Bromo - 4 - Fluoroiodobenzene is safe, and the operator
of 2 - Bromo - 4 - Fluoroiodobenzene is also a chemical. Its safety and operation are essential.
First, it is safe. This thing is dangerous. Be careful when touching. If, skin, touch it, quickly, rinse with plenty of water, then with fat soap, and wash it finely. If, if there is any discomfort, quickly, ask a doctor for diagnosis and treatment. If, into the eyes, rinse immediately with normal saline or water, and, no, rub, and then seek medical attention. Inhalation, dangerous, also, not, suddenly. Appropriate operation, in a well-ventilated and well-ventilated place, if, aspiration, speed, to a place with fresh air, keep breathing smooth, illness, severe, urgent call, rescue.
Times, on the operating specifications. Before the experiment, be familiar with it, instrument, use. Measure, take this thing, when, use a precise device, such as pipette, tube, titration tube, etc. When dissolving, choose a suitable solvent to beware of abnormal reactions. During the reaction process, strictly control the temperature and pressure. Use a thermometer to measure the temperature, and adjust the heating or cooling as needed. The control of pressure depends on the accuracy of the instrument, and do not exceed the limit.
When storing, it is advisable to store in a cool, dry, ventilated place away from light. Keep away from fire and heat sources, and do not coexist with strong, oxidizing agents, strong, reducing agents, etc., to prevent explosion and combustion.
In short, operation 2 - Bromo - 4 - Fluoroiodobenzene, safety first, standardized operation, in order to avoid danger and achieve the purpose of verification.

Application Area

2 - Bromo - 4 - Fluoroiodobenzene is an exquisite chemical substance with a wide range of application fields and profound meaning. In the field of pharmaceutical synthesis, this substance is often a key intermediate. Through exquisite chemical reactions, specific functional groups can be introduced to help create new drugs with excellent curative effect and precise targeting.
In the field of materials science, it also shows extraordinary functions. After clever design and synthesis, materials with unique photoelectric properties can be prepared. If applied to advanced display technology, it can improve the clarity and color saturation of the display effect.
Furthermore, in the field of organic synthetic chemistry, 2 - Bromo - 4 - Fluoroiodobenzene offers the possibility to construct complex organic molecular structures. Its unique chemical activity allows chemists to build diverse molecular structures through various reaction pathways, opening up new frontiers for the development of organic chemistry.

Research & Development

Today, there is a thing named 2 - Bromo - 4 - Fluoroiodobenzene, which is very important in our chemical research. We are dedicated to its research and development, hoping to clarify its properties and explore its uses.
We observe its structure in detail, observe the structure of its molecules, and understand the connection of its atoms. After repeated experiments, we study its physical properties, such as the point of melting and boiling, the dissolution. Also study the chemical properties, and observe its changes in various reactions.
Want to use it widely in the field of synthesis, explore its potential as a raw material, and hope to create new products with unique properties to meet the needs of all parties. In various fields such as pharmaceutical research and development, material creation, etc., it is expected to shine.
Although the research road is difficult, we uphold the heart of research and move forward unremittingly. With the research and development of 2-Bromo-4-Fluoroiodobenzene, we have made achievements and contributed to the progress of chemistry.

Toxicity Research

Today there is a thing called 2 - Bromo - 4 - Fluoroiodobenzene. I am a chemical researcher, and I have been studying its toxicity for a long time.
The toxicity of this thing is related to living things. It can be harmful if it enters the body through the mouth and nose, or touches the skin. After entering the body, it may disturb the function of the internal organs and disrupt the flow of qi and blood. Looking at the experiments, small animals often show a listless state when they touch it, their diet is reduced, and even their lives are endangered.
The source of its toxicity is due to the unique molecular structure and strong activity. It is easy to respond to the biochemical substances in the body, breaking the stability of cells and bad physiological order. Although we try our best to find out, there are still unknowns. In the future, it will be necessary to study it carefully and find out the full extent of its toxicity, so as to ensure the safety of all beings and prevent it from developing.

Future Prospects

Now 2 - Bromo - 4 - Fluoroiodobenzene is still in the field of chemistry. Although our current knowledge is limited, we look to the future as researchers, and its potential is shining.
This compound has an exquisite structure and unique atomic arrangement. It may be able to open up new paths in organic synthesis. It is expected that in the future, with advanced scientific research, it will be able to develop efficient synthesis methods based on its characteristics, and it will make a name for itself in the field of drug creation and material innovation.
It is also expected to show its skills in the field of electronic materials. With its halogen atomic properties, it may be able to optimize the electrical properties of materials, upgrade electronic devices, and inject new flow. In time, with the deepening of research, more mysteries will be unlocked, a new chapter of future chemical development will be drawn, the door to exploration of unknown fields will be opened, and the path of scientific and technological progress will leave a strong impression.

Where to Buy 2-Bromo-4-Fluoroiodobenzene in China?

As a trusted 2-Bromo-4-Fluoroiodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 2-Bromo-4-Fluoroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemistry of 2-bromo-4-fluoroiodobenzene?

2-Bromo-4-fluoroiodobenzene is one of the organohalogenated aromatic hydrocarbons. Its chemical properties are unique, and it is related to many organic compounds. It is a key raw material in the field of organic synthesis.
In this compound, bromine, fluorine and iodine atoms are highly electronegative, and can exhibit different activities in chemical reactions. Bromine atoms are relatively large, and the electron cloud is relatively loose. In nucleophilic substitution reactions, they are easily replaced by nucleophiles. For example, in case of strong nucleophiles, such as sodium alcohol, bromine atoms will be replaced by alkoxy groups, resulting in corresponding ether compounds.
Although fluorine atoms are small, they are extremely electronegative, which will reduce the electron cloud density of the benzene ring, making the electrophilic substitution reaction on the benzene ring more challenging. However, it can enhance the molecular polarity and has a great impact on the physical properties of compounds, such as boiling point and solubility.
The carbon-iodine bond energy of the iodine atom is relatively small, and it is prone to fracture. In some reactions, it can be used as a leaving group to participate in free radical reactions or nucleophilic substitution reactions. For example, under appropriate conditions, it can react with metal reagents to form organometallic compounds, which can be used to construct carbon-carbon bonds.
2-Bromo-4-fluoroiodobenzene is widely used in drug synthesis, materials science and other fields due to its existence of multiple halogen atoms and active chemical properties. It can be used as an intermediate to build more complex organic molecules.

What are the common synthetic methods of 2-bromo-4-fluoroiodobenzene?

The common synthesis methods of 2-bromo-4-fluoroiodobenzene are as follows.
First, the halogenation reaction path. Using benzene as the starting material, bromine atoms and fluorine atoms are first introduced. Benzene can be placed in a specific reaction environment, and a suitable catalyst, such as iron or iron salt, can react with bromine to replace the hydrogen atom on the benzene ring to form bromobenzene. Subsequently, by means of specific electrophilic substitution reaction conditions, fluorine atoms are introduced to generate 2-bromo-4-fluorobenzene. On this basis, 2-bromo-4-fluorobenzene is iodized with an iodine source, such as iodine, in the presence of an appropriate oxidant, such as hydrogen peroxide or nitric acid, to achieve the purpose of generating 2-bromo-4-fluoroiodobenzene.
Second, through the metal-organic chemical path. Aromatic halogenates containing bromine and fluorine, such as 2-bromo-4-fluorobenzene, can be prepared first. React this halogen with a metal reagent, such as magnesium, to form Grignard reagents. Grignard's reagent has high activity and can react with iodine-substituted reagents such as iodomethane or iodine elemental substance, thereby introducing iodine atoms into the benzene ring to successfully synthesize 2-bromo-4-fluoroiodobenzene. Alternatively, the coupling reaction catalyzed by palladium is used to realize the coupling of carbon-carbon bonds with 2-bromo-4-fluorophenylboronic acid and iodoaromatic hydrocarbons. Under the catalysis of palladium catalysts such as tetra (triphenylphosphine) palladium, the synthesis of 2-bromo-4-fluoroiodobenzene is achieved.
Third, the synthesis method of protecting group strategy is selected. If there are other groups to be protected on the benzene ring to prevent it from being affected in the reaction, a suitable protective group needs to be introduced first. After the bromine, fluorine and iodine atoms are introduced in sequence and the reaction is completed, the protective group is removed. For example, if there are easily reactive groups such as hydroxyl groups on the benzene ring, it can be protected with protective groups such as silicon ethers first, and then the halogenation or metal-organic reaction steps are followed to finally remove the protective group and obtain pure 2-bromo-4-fluoroiodobenzene.

2-bromo-4-fluoroiodobenzene in what areas

2-Bromo-4-fluoroiodobenzene is widely used in the field of organic synthesis. First, it can be used as a building block for the construction of complex aromatic compounds. It covers the halogen atoms in its molecule and has different activities. It can perform nucleophilic substitution and metal-catalyzed coupling reactions according to different reaction conditions to form new carbon-carbon or carbon-heteroatom bonds. Therefore, it is a key raw material for the synthesis of aromatic compounds with special structures and properties.
It also has important applications in medicinal chemistry. The design and synthesis of drug molecules often require the introduction of specific functional groups to modulate the activity and pharmacokinetic properties. The halogen atom of 2-bromo-4-fluoroiodobenzene can be precisely integrated into the target drug molecule through various reactions, optimizing its ability to bind to the target, improving the efficacy of the drug, and reducing toxic and side effects.
Furthermore, in the field of materials science, it can be used to prepare organic optoelectronic materials. Through organic synthesis, it is introduced into the conjugate system to regulate the electronic structure and optical properties of the material to produce materials with specific luminous and conductive properties, which are used in organic Light Emitting Diodes, solar cells and other devices.
In the field of pesticide chemistry, halogen-containing organic compounds prepared from this raw material often have good biological activity. The properties of halogen atoms can be used to enhance the effect of pesticides on target organisms, achieve high-efficiency insecticidal, bactericidal or weeding effects, and provide important starting materials for pesticide creation.
In summary, 2-bromo-4-fluoroiodobenzene plays an indispensable role in organic synthesis, pharmaceutical chemistry, materials science, pesticide chemistry and other fields, and promotes the development of various fields.

What are the physical properties of 2-bromo-4-fluoroiodobenzene?

2-Bromo-4-fluoroiodobenzene is one of the organic compounds. Its physical properties are quite unique, let me come one by one.
Looking at its properties, at room temperature, 2-bromo-4-fluoroiodobenzene is mostly in a liquid state, with a pure substance. It has a certain fluidity and is as agile as a spring. Its color is often nearly colorless, clear and transparent, as if intangible, but it does have a physical existence.
As for its smell, it has a special aromatic charm. Although this aroma is not rich and pungent, it is also unique. It can be distinguished from the smell category of organic compounds.
When it comes to the melting point, the melting point value is relatively low, so that the substance is in a liquid state at a temperature slightly higher than normal temperature. The boiling point is affected by factors such as intermolecular forces and is within a specific range. This specific melting point data is a key reference for the separation, purification and practical application of the substance.
In terms of solubility, 2-bromo-4-fluoroiodobenzene exhibits good solubility in organic solvents, such as common ethanol, ether, etc., and can be fused with organic solvents to form a homogeneous mixed system. However, in water, its solubility is very small, and the two seem to be distinct and difficult to blend. This solubility characteristic is derived from the lipophilic and hydrophobic properties of its molecular structure.
In terms of density, 2-bromo-4-fluoroiodobenzene is larger than water. If it is placed in the same container as water, it can be seen that it sinks in the bottom of the water, just like a pearl sinking in the abyss. This density characteristic is also one of the important characteristics in the process of separation and identification of substances.
In summary, the physical properties of 2-bromo-4-fluoroiodobenzene vary from character, odor, melting point, solubility to density, which are all the characteristics of its unique chemical identity. It is of great significance in the research and practical application field of organic chemistry.

What are 2-bromo-4-fluoroiodobenzene storage conditions?

2-Bromo-4-fluoroiodobenzene is an organic compound. Its storage conditions are quite critical, related to the stability and safety of this substance.
The first to bear the brunt, it needs to be placed in a cool place. Because the temperature is too high, it is easy to cause this compound to undergo chemical reactions, or to cause decomposition and deterioration. On hot days, the sun is hanging high, if exposed to this substance, it will still be hot to cook oil, and it will be dangerous. Therefore, it is necessary to choose a cool place and keep the temperature constant in a lower area, so as to keep it stable.
Second, a dry environment is indispensable. Water and wet gas are often the medium for chemical reactions. If the environment is humid and the water vapor is dense, this material may react with water, causing its structure to change and losing its original nature. For example, if a boat travels in water, the erosion of water can cause the boat body to decay. In order to store it, it must be dry to prevent the disturbance of water vapor.
Furthermore, this material should be sealed and stored. All components in the air, such as oxygen, carbon dioxide, etc., may react with 2-bromo-4-fluoroiodobenzene. Sealed, it can block the air. If you build a strong city to defend against enemies, it should be protected from external intrusion.
When stored, it should also be kept away from fire sources and oxidants. If the source of fire can cause it to burn, under a raging fire, this substance will turn into powder, and may cause the risk of explosion; if the oxidant encounters 2-bromo-4-fluoroiodobenzene, if dry wood encounters fire, it is easy to trigger a violent chemical reaction, endangering safety.
As for the storage container, it is also necessary to choose carefully. Glass or specific plastic materials should be used. Glass is stable in nature and does not react easily with 2-bromo-4-fluoroiodobenzene; specific plastic materials also have good chemical resistance, which can ensure that this substance is safe in it.
In general, the storage of 2-bromo-4-fluoroiodobenzene should be cool, dry, sealed, away from fire and oxidants, and choose a suitable container, so that it can be stored for a long time without losing its properties.