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What is the Chinese name of 2-bromo-4-iodo-1-methylbenzene?
2-Bromo-4-iodine-1-methylbenzene, which is the result of the naming of organic compounds. According to the naming rules of organic compounds, for aromatic hydrocarbon derivatives, the parent is first established as benzene, and then the naming is based on the position and type of substituents.
In this compound, methyl ($- CH_3 $), bromine atom ($-Br $), iodine atom ($-I $) are all substituents of the benzene ring. With the benzene ring as the parent body, the carbon atom attached to the methyl group is designated as No. 1 carbon. According to the principle of the lowest position, the carbon of the bromine atom in the adjacent position with the methyl group is No. 2 carbon, and the carbon of the opposite iodine atom is No. 4 carbon. Therefore, it was named 2-bromo-4-iodine-1-methylbenzene.
This nomenclature follows the nomenclature of the International Union of Pure and Applied Chemistry (IUPAC) to ensure that the naming of organic compounds is accurate and unique. It is of great significance to the exchange and research in the field of chemistry, so that chemists in different regions can know the structure of compounds with this nomenclature.
What are the main uses of 2-bromo-4-iodo-1-methylbenzene?
2-Bromo-4-iodo-1-methylbenzene, Chinese name 2-bromo-4-iodo-1-methylbenzene, is an organic compound. Its main uses probably have the following numbers.
First, in the field of organic synthesis, it is often used as a key intermediate. Bromine, iodine and methyl are connected to the phenyl ring, each with unique reactivity. Bromine and iodine atoms can undergo many reactions, such as nucleophilic substitution reactions, which can interact with various nucleophilic reagents to introduce other functional groups, and then build more complex organic molecules. Taking Grignard's reagent as an example, after 2-bromo-4-iodine-1-methylbenzene reacts with magnesium to form the corresponding Grignard reagent, it can react with carbonyl compounds to grow carbon chains, which is quite commonly used in the synthesis of alcohols with specific structures.
Second, in the field of pharmaceutical chemistry, it also has important value. Its structure can be modified and modified to meet the needs of specific drug targets. The core skeleton of many drug molecules is often derived from similar structures. By functionalizing it, it is expected to develop new drugs with specific pharmacological activities.
Third, in the field of materials science, it may also emerge. After appropriate chemical modification, it can be introduced into polymer materials to endow the materials with unique properties. For example, it can improve the optical and electrical properties of the materials, and show potential application prospects in organic optoelectronic materials.
Fourth, in dye chemistry, 2-bromo-4-iodine-1-methyl benzene can be used as the starting material for the synthesis of new dyes. Through subsequent reactions, a conjugated system can be constructed to endow the dyes with specific colors and dyeing properties, providing the possibility for innovative development of the dye industry.
What are the physical properties of 2-bromo-4-iodo-1-methylbenzene?
2-Bromo-4-iodine-1-methylbenzene is a kind of organic compound. Looking at its physical properties, it is mostly liquid at room temperature, with a clear and transparent color and a special smell. Its boiling point is about [X] ° C, which is determined by the intermolecular force. The relative atomic weight of bromine and iodine atoms in the molecule is relatively large, resulting in the increase of the intermolecular force, and the boiling point is also increased. The melting point is about [X] ° C, which is affected by its crystal structure and intermolecular interactions.
The density of this substance is greater than that of water, so when placed in water, it must sink to the bottom. Its solubility is quite special, and it is extremely difficult to dissolve in water, because water molecules are polar molecules, and 2-bromo-4-iodine-1-methylbenzene is a non-polar molecule. According to the principle of "similar miscibility", the two are insoluble. However, in organic solvents, such as ethanol, ether, benzene, etc., it has good solubility, because organic solvents are mostly non-polar or weakly polar, and are similar in structure to 2-bromo-4-iodine-1-methylbenzene.
In addition, 2-bromo-4-iodine-1-methylbenzene is volatile. Although it evaporates more slowly than water, it will evaporate over time in an open environment. Its vapor is heavier than air and easily accumulates in low places.
The physical properties of 2-bromo-4-iodine-1-methylbenzene are of great significance in the fields of chemical industry and organic synthesis, and are related to its separation, purification, storage and application.
What are the chemical properties of 2-bromo-4-iodo-1-methylbenzene?
2-Bromo-4-iodine-1-methylbenzene is an organic compound with interesting chemical properties. Because its structure contains bromine, iodine and methyl groups, it has specific reactivity.
First talk about the properties of halogenated hydrocarbons. Bromine and iodine atoms are highly active and can participate in nucleophilic substitution reactions. Take the action of bases in alcohol solutions as an example, bromine or iodine atoms can be replaced by nucleophilic reagents. In the case of sodium hydroxide alcohol solution, the hydroxyl group of the nucleophilic reagent can attack the carbon atom containing halogen atoms, and the halogen atoms leave to form corresponding substitution products. This reaction is a classical nucleophilic substitution, which follows a specific reaction mechanism and has strict requirements on reaction conditions, such as temperature and alkali concentration.
Furthermore, the presence of methyl also affects its properties. Methyl as the donator group can increase the electron cloud density of the benzene ring, which in turn makes the benzene ring more prone to electrophilic substitution. Taking the nitrification reaction as an example, the reactivity of 2-bromo-4-iodine-1-methyl benzene is higher than that of benzene, and due to the positioning effect of methyl, the electrophilic reagents are more inclined to attack the neighboring and para-sites of methyl. However, bromine and iodine atoms are electron-withdrawing groups, which weaken the electron cloud density of the benzene ring, affecting the activity and localization of electrophilic substitution reactions to a certain extent. The electronic effects are intertwined and quite complex.
In addition, 2-bromo-4-iodine-1-methylbenzene may also participate in metal-catalyzed reactions. Under the action of transition metal catalysts, bromine and iodine atoms can participate in coupling reactions to form carbon-carbon bonds or carbon-heteroatomic bonds, which are widely used in the field of organic synthesis and can be used to synthesize complex organic molecular structures. In short, its chemical properties are rich and diverse, and it is of great significance in many fields such as organic synthesis.
What are the preparation methods of 2-bromo-4-iodo-1-methylbenzene?
2-Bromo-4-iodo-1-methylbenzene is an organic compound, and there are many preparation methods, which are described in detail below.
First, toluene is used as the starting material. First, toluene is substituted with bromine under appropriate conditions. This reaction can be carried out under the catalysis of light or Lewis acid. For example, when catalyzed by iron powder, toluene reacts with bromine. The o-and para-hydrogen atoms of methyl are easily replaced by bromine atoms to form a mixture of o-bromotoluene and p-bromotoluene. After separation and purification, p-bromotoluene can be obtained. Subsequently, p-bromotoluene is then iodized with iodine. This iodization reaction usually needs to be carried out under a specific catalyst and mild reaction conditions before iodine atoms can be introduced into the ortho-position of bromine atoms on the benzene ring to obtain 2-bromo-4-iodo-1-methylbenzene.
Second, 1-methyl-4-iodo-benzene is used as the starting material. Under suitable reaction conditions, 1-methyl-4-iodo-benzene is brominated with the bromine source. The reaction can improve the selectivity and efficiency of the reaction with the help of suitable catalysts. For example, a specific metal catalyst is selected to precisely replace the bromine atom in the ortho-position of the iodine atom, thereby obtaining the target product 2-bromo-4-iodo-1-methylbenzene.
Third, it can also be prepared by the Grignard reagent method. First, the Grignard reagent is prepared from a suitable halogenated aromatic hydrocarbon, and then the Grignard reagent is reacted with the corresponding halogenated alkane or halogenated aromatic hydrocarbon under specific conditions. For example, after preparing Grignard reagent with p-bromoiodobenzene and reacting with methyl halides in anhydrous ether and other solvents, methyl groups can be introduced into the benzene ring to obtain 2-bromo-4-iodo-1-methylbenzene. However, this method requires strict control of the reaction conditions to ensure that the reaction is carried out in an anhydrous and anaerobic environment to avoid the failure of Grignard reagent.
The above preparation methods have their own advantages and disadvantages. In practical applications, the most suitable preparation path should be selected based on the availability of raw materials, the difficulty of controlling the reaction conditions, and the production cost.