2 Bromo 4 Iodo Pyridine

2-Bromo-4-iodopyridine is one of the organic compounds. Its chemical properties are unique and have attracted much attention in the field of organic synthesis.
In this compound, both bromine (Br) and iodine (I) are halogen elements attached to the pyridine ring. The presence of halogen atoms endows it with active chemical activity. Bromine and iodine atoms can change the electron cloud distribution of the pyridine ring due to their high electronegativity, thereby affecting their reactive properties.
For nucleophilic substitution reactions, 2-bromo-4-iodopyridine exhibits special properties. Because bromine and iodine atoms can be used as leaving groups, they are easily replaced when encountering nucleophiles. However, the leaving ability of bromine and iodine is different. The iodine atom is relatively large, and the bond energy of its C-I bond is smaller than that of the C-Br bond, so the iodine atom is more likely to leave. Under appropriate conditions, the nucleophilic reagent preferentially attacks the carbon atom connected to iodine, resulting in a nucleophilic substitution reaction.
In the redox reaction, 2-bromo-4-iodine pyridine also exhibits. The pyridine ring has a certain electron conjugation system, and the presence of halogen atoms can affect its redox Under the action of suitable oxidizing or reducing agents, the pyridine ring or halogen atom itself can undergo oxidation or reduction changes.
In addition, its reaction with metal-organic reagents is also interesting. Metal-organic reagents such as Grignard reagents can react with 2-bromo-4-iodopyridine to form new carbon-carbon bonds or carbon-heteroatomic bonds, which are important reaction pathways in the process of constructing complex organic molecular structures.
In conclusion, 2-bromo-4-iodopyridine is a valuable synthetic intermediate in the field of organic synthetic chemistry due to its unique chemical structure and rich and active chemical properties. It can be used to construct various organic compounds through various reaction paths.

To prepare 2-bromo-4-iodopyridine, there are two methods. The first method is halogenation. The first method is to use pyridine as the base. The nitrogen of the pyridine ring is basic and can be salted with acids. In a suitable solvent, such as glacial acetic acid, a brominating agent such as bromine or N-bromosuccinimide (NBS), at a suitable temperature and in the presence of a catalyst, the bromine atom is substituted for the hydrogen at a specific position on the pyridine ring. After bromination, iodization is performed. 2-bromo-4-iodopyridine is obtained by substituting the iodine atom for the hydrogen at a specific position in the presence of an oxidizing agent such as hydrogen peroxide or periodic acid.
The second method is the participation of metal-organic reagents. First, pyridine is reacted with an appropriate metal reagent, such as butyl lithium, to form a lithiated pyridine intermediate. This intermediate has strong nucleophilic properties and can react with brominated reagents to introduce bromine atoms. Then, it is reacted with iodine-containing reagents. Iodine or iodine elementals are commonly used. Under suitable conditions, iodine atoms are attached to the pyridine ring, and the final product is 2-bromo-4-iodine pyridine. The two methods have their own advantages and disadvantages. The raw materials for halogenation are commonly available, but the reaction selectivity may need to be fine-tuned. Although the metal-organic reagent method can precisely control the substitution position, the metal reagents are more active, and the operation needs to be careful, and the reaction conditions are strict.

2-Bromo-4-iodo-pyridine is an important intermediate in organic synthesis and is widely used in many fields such as medicinal chemistry, materials science, and pesticide research and development.
In the field of medicinal chemistry, its role is extraordinary. Due to the presence of bromine and iodine atoms in its structure, it endows the molecule with unique reactivity and properties, and can participate in various chemical reactions to construct complex drug molecular structures. In the process of many drug development, this is used as a starting material and modified by specific chemical reactions to synthesize compounds with specific biological activities for disease treatment. For example, in the development of anti-tumor drugs, with the help of the structural properties of 2-bromo-4-iodo-pyridine, drug molecules that can precisely act on specific targets of tumor cells can be designed and synthesized to inhibit the growth and spread of tumor cells.
In the field of materials science, it also plays a key role. It can be used as a key building block for the synthesis of functional materials. Because it contains bromine and iodine, it can affect the electronic structure and physical properties of materials. For example, in the synthesis of organic optoelectronic materials, the introduction of this compound can adjust the light absorption and charge transport properties of materials, and then be used in the fabrication of organic Light Emitting Diodes (OLEDs), solar cells and other devices to improve the photoelectric conversion efficiency and stability of devices.
In the field of pesticide research and development, 2-bromo-4-iodo-pyridine has a wide range of uses. It can be converted into compounds with insecticidal, bactericidal or herbicidal activities through chemical reactions. Due to the significant impact of bromine and iodine atoms on biological activities, pesticides synthesized on this basis may have higher biological activity and selectivity, which can effectively control crop diseases and pests, and reduce the impact on the environment and non-target organisms, meeting the needs of modern agriculture for high-efficiency and low-toxicity pesticides.

The market price of 2-bromo-4-iodopyridine often varies with time and place, quality, supply and demand. In Guanfu's past "Tiangong Kaiwu", the price of all things is affected by various factors, and the same is true for this chemical product.
In the market, if the quality is high, the preparation is excellent, and when the demand is strong, the price may be high. When the supply is abundant and the demand is weak, the price may decline.
If you want to know the detailed price, you should visit the chemical raw material trading market and chemical reagent suppliers. There may be real-time quotations there for reference by merchants. On the Internet, the chemical product trading platform may also list its price, but it is necessary to carefully review the authenticity and timeliness of its information.
Furthermore, whether to purchase in bulk or not also affects its price. block trade, or get a preferential price due to a large quantity; if you buy sporadically, the price may be slightly higher. And different regions, due to differences in transportation costs and taxes, the price is also different. In short, in order to know the market price of 2-bromo-4-iodopyridine, it is necessary to visit multiple parties and comprehensively consider various factors to obtain a more accurate price.

2-Bromo-4-iodo-pyridine is an organic compound, and its storage conditions are quite important, which is related to the stability and quality of this compound.
This substance should be stored in a cool, dry and well-ventilated place. A cool environment can inhibit its chemical reaction caused by excessive temperature. Due to high temperature, the activity of the compound is often greatly increased, or adverse reactions such as decomposition and polymerization are initiated, which will damage its purity and structure. A dry place is also indispensable, because moisture can react with many organic compounds or act as a catalyst to speed up the reaction process. 2-bromo-4-iodo-pyridine is deteriorated when it encounters water or undergoes reactions such as hydrolysis. Good ventilation can disperse harmful gases that may be generated in time, and avoid danger caused by excessive local concentration.
Furthermore, keep away from fires and heat sources. This compound is flammable, and it is easy to burn in case of open flames and hot topics, and may even explode, endangering the safety of the storage environment.
When storing, it should also be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to the chemical properties of 2-bromo-4-iodo-pyridine, when it comes into contact with the above substances, it is prone to violent chemical reactions, or serious consequences such as fire and explosion.
Packaging should also not be ignored. Choose suitable packaging materials to ensure good sealing to prevent leakage. Commonly used packaging materials include glass bottles, plastic bottles, etc. However, it is necessary to choose according to the specific situation. If the storage capacity is large, also pay attention to the material and pressure resistance of the container to ensure the safety of the storage process.
Follow the above storage conditions to effectively ensure the quality and stability of 2-bromo-4-iodo-pyridine and reduce safety risks.