2 Bromo 4 Iodobenzenamine

2-Bromo-4-iodoaniline, this is the name of an organic compound. In terms of its name, "aniline" is based on a phenylcyclomethylamine group. "2-bromo" means that there is a bromine atom substituted at the second carbon position of the benzene ring; "4-iodine" means that there is an iodine atom substituted at the fourth carbon position of the benzene ring.
The naming of organic compounds is always fixed. The naming of this compound is first called "aniline" according to the parent structure, and then the substituent is indicated according to the position. Following such rules, the naming is clear and accurate, so that the academic community can identify and communicate with chemical substances without confusion.
2-Bromo-4-iodoaniline, in the field of organic synthesis, or because of its unique structure and specific reactivity and application. Its bromine and iodine atoms can be used as reaction check points and participate in many organic reactions, such as nucleophilic substitution, coupling reactions, etc. Chemists can use this to construct more complex organic molecules for drug development, materials science and other aspects to meet various practical needs.

2-Bromo-4-iodobenzenamine, Chinese name 2-bromo-4-iodobenzenamine, is an organic compound, which is widely used in the field of chemical research and organic synthesis. Its physical properties are complex, and are described in detail as follows:
- ** Appearance properties **: Under normal temperature and pressure, 2-bromo-4-iodobenzenamine often takes the form of a white-like to light yellow crystalline powder. This form is conducive to observation and processing, and is easy to weigh and transfer in laboratory operations. It is relatively stable, and it is not easy to change its properties due to morphological changes during storage.
- ** Melting boiling point **: The melting point is about 105-109 ° C. The boiling point varies depending on the ambient pressure. Under standard atmospheric pressure, the boiling point is higher. The melting point is in this range, indicating that the intermolecular force is moderate. When heated, it reaches a specific temperature, the lattice structure is destroyed, and the substance changes from solid to liquid. A higher boiling point means that more energy is required to overcome the intermolecular force and vaporize it.
- ** Solubility **: 2-Bromo-4-iodoaniline is slightly soluble in water, but easily soluble in organic solvents such as ethanol, ether, dichloromethane, etc. This characteristic is determined by its molecular structure. It contains benzene ring, amino group and halogen atom. The benzene ring and halogen atom are lipophilic. The amino group has a certain polarity, but the overall lipophilic effect is dominant. Therefore, it has good solubility in organic solvents, while water is a polar solvent. It interacts weakly with it and has poor solubility.
- ** Density **: The density is greater than that of water, and the specific value will vary slightly due to purity and measurement conditions. The density is greater than that of water, which determines that it will sink to the bottom when mixed with water. This property is crucial in separation operations or reaction systems involving stratification, and separation schemes can be designed accordingly.
- ** Stability **: At room temperature, 2-bromo-4-iodoaniline is relatively stable. In case of open flame, hot topic or contact with strong oxidants, there is a risk of combustion and explosion. Because it contains halogen atoms and amino groups, it can participate in a variety of chemical reactions under specific conditions, change the molecular structure and affect the stability. When storing and using, be sure to avoid contact with such dangerous substances and conditions to ensure safety.

2-Bromo-4-iodobenzenamine, or 2-bromo-4-iodobenzenamine, is one of the organic compounds. Its chemical properties are quite rich, as follows:
1. ** Basic **: This compound contains an amino group (-NH ²), and the nitrogen atom in the amino group has a lone pair of electrons and can accept protons, so it is alkaline. In case of strong acid, it can react with it to form salts. For example, when it encounters hydrochloric acid, the amino nitrogen atom will combine with hydrogen ions to form the corresponding ammonium salt. This reaction is actually a process of acid-base neutralization.
2. ** Nucleophilic Substitution Reaction **: Its amino group is a nucleophilic reagent, and under suitable conditions, it can participate in the nucleophilic substitution reaction. For example, when it encounters halogenated hydrocarbons, the nitrogen atom of the amino group will attack the carbon atom connected to the halogen in the halogenated hydrocarbon, and the halogen atom will leave as a leaving group, resulting in the formation of new organic compounds. This reaction is widely used in the field of organic synthesis and can be used to construct more complex organic molecular structures.
3. ** Halogen Atom Reaction **: The compound molecule contains both bromine (Br) and iodine (I) halogen atoms. The halogen atom has a certain polarity due to its high electronegativity, which causes the carbon-halogen bond connected Under specific reagents and reaction conditions, the carbon-halogen bond can be broken, and then the substitution reaction can be initiated. For example, under the action of nucleophiles, bromine atoms or iodine atoms can be replaced by other groups, which provides the possibility for the introduction of different functional groups in organic synthesis.
4. ** Benzene ring reaction **: As an aniline compound, the benzene ring is affected by the amino group, and the electron cloud density changes. The amino group is an electron-supplying group, which can increase the electron cloud density of the benzene ring o and the para-position, so the benzene ring is more prone to electrophilic substitution reactions. Common electrophilic substitution reactions such as nitrification, sulfonation reaction, halogenation reaction, etc. Under suitable conditions, the electrophilic reagents are prone to attack the adjacent and para-position of the benzene ring and generate corresponding substitution products.
5. ** Oxidation reaction **: The amino group is relatively active and easy to be oxidized. When exposed to strong oxidants, the amino group may be oxidized to nitro (-NO 2O), or other oxidation reactions may occur, resulting in changes in the structure and properties of the compound. Some oxidants may even cause damage to the structure of the benzene ring. This oxidation reaction needs to be carefully controlled in organic synthesis and analysis to avoid unnecessary by-products.
In short, the various chemical properties of 2-bromo-4-iodoaniline make it useful in organic synthesis, pharmaceutical chemistry and other fields. Through rational utilization of these properties, many organic compounds with specific functions and structures can be prepared.

The common synthesis methods of 2-bromo-4-iodoaniline generally include the following.
First, halogenated aromatic hydrocarbons are used as starting materials. First, halogenated benzene containing suitable substituents is taken, and after halogenation, bromine atoms and iodine atoms are introduced at specific positions to obtain 2-bromo-4-iodohalobenzene. Then, the halogenated benzene is combined with ammonia or amine compounds under suitable reaction conditions, such as high temperature, high pressure and the presence of catalysts. A nucleophilic substitution reaction is carried out, and the halogen atom is replaced by an amino group to obtain 2-bromo-4-iodoaniline. This process requires attention to the precise control of reaction conditions, and the choice of catalyst is also crucial, which can significantly affect the reaction rate and yield.
Second, nitroaromatic hydrocarbons are used as the starting material. First, nitrobenzene containing the corresponding substituents is prepared, and 2-bromo-4-iodonitrobenzene is obtained by halogenation. After that, the nitro group is reduced to an amino group. The commonly used reducing agents include iron filings and hydrochloric acid, hydrogen and metal catalysts. The reduction reaction needs to be carried out under a suitable solvent and reaction temperature to ensure a smooth and efficient reaction to obtain the target product 2-bromo-4-iodoaniline.
Third, through diazotization. First, aniline derivatives containing appropriate substituents are converted into diazonium salts through diazotization reaction. Then under the action of specific reagents, the diazonium groups are replaced by bromine atoms and iodine atoms to form 2-bromo-4-iodohalobenzene. Finally, 2-bromo-4-iodoaniline is prepared by nucleophilic substitution with ammonia or amines. In this path, the conditions of diazotization are very critical, and the stability of diazonium salts is poor, so follow-up reactions need to be carried out in time.
Each method of synthesis has its own advantages and disadvantages. In practical application, it is necessary to choose carefully according to many factors such as the availability of raw materials, the difficulty of reaction, cost and yield.

2-Bromo-4-iodobenzenamine, Chinese name 2-bromo-4-iodoaniline, this compound has applications in many fields such as medicine, materials science and organic synthesis.
In the field of medicine, because the bromine and iodine atoms in the structure can enhance the lipophilic properties of molecules, change their biological activities and pharmacological properties, and are often used as key intermediates for the synthesis of antibacterial, anti-cancer and other drugs. For example, in the development of some antibacterial drugs, 2-bromo-4-iodoaniline is connected to a specific structure through multi-step reaction to enhance the ability of drugs to bind to bacterial targets and improve antibacterial effect.
In the field of materials science, it can participate in the synthesis of materials with special photoelectric properties. The aniline structure endows the material with a certain conjugate system, and the bromine and iodine atoms are introduced into the electron cloud distribution of the material to adjust its optical and electrical properties. For example, when preparing organic Light Emitting Diode (OLED) materials, 2-bromo-4-iodoaniline participates in the construction of luminous layer structure, which improves the luminous efficiency and color purity of the material.
In the field of organic synthesis, 2-bromo-4-iodoaniline, as an important aromatic amine intermediate, can utilize the activity of amino and halogen atoms to construct complex organic molecular structures through nucleophilic substitution, coupling and other reactions. For example, through the Ullmann reaction, amino groups and halogen atoms can participate in the reaction, connect different aryl groups or alkyl groups, expand the molecular framework, and synthesize organic compounds with diverse structures, providing rich raw materials and strategies for organic synthetic chemistry.