2 Bromo 5 Iodo Phenol

2-Bromo-5-iodophenol, which is the product of the naming of organic compounds. In terms of its name, "2-bromo" means the carbon atom connected to the hydroxyl group (the characteristic group of phenol) on the phenyl ring. It is the No. 1 carbon, counted clockwise or counterclockwise, with bromine atoms connected at the No. 2 carbon position; "5-iodine" indicates that there are iodine atoms connected at the No. 5 carbon position.
The naming of organic compounds has always been based on rules. Following the "Nomenclature Principles of Organic Chemistry", for phenolic compounds, phenol is often used as the parent, and the positions and names of other substituents are indicated one by one. In this compound, both bromine and iodine are substituents, which are precisely named 2-bromo-5-iodophenol according to their position on the benzene ring. This naming can accurately convey the structural information of the compound, so that chemists can understand its molecular structure by name when communicating and researching, and then gain insight into its possible chemical properties and reaction characteristics. This naming convention is like a universal language in the field of chemistry, followed by chemical researchers around the world, which greatly facilitates academic communication and scientific inheritance.

2-Bromo-5-iodo-phenol, Chinese name 2-bromo-5-iodophenol, has important uses in multiple domains.
In the field of synthesis, it can be used as a key ingredient in the synthesis of specific compounds. Since the bromine-iodine atom of the compound is an active functional group, it can be used by the general reaction, such as nuclear substitution, etc., to build the molecular skeleton of the compound with other molecules. For example, it can be used to synthesize novel molecules with antibacterial, antiviral or anticancer activities through careful reverse coupling.
In the field of materials science, 2-bromo-5-iodophenol also exhibits a certain application value. Due to the presence of phenolic groups in the molecule, it can be reacted to polymers, and is introduced into polymer materials. In this way, polymer materials may be given special properties, such as increasing the resistance and oxidation resistance of the material, or modifying its light properties. For example, in the synthesis of some photoinduced materials, the introduction of 2-bromo-5-iodophenol as a component is expected to control the light wave efficiency of the material.
In chemical research, 2-bromo-5-iodophenol is often used as a model compound to explore the rationale of chemical reactions. Due to the presence of bromine, iodine and phenol groups in its molecules with different activities, it can be used as an ideal research image to help researchers in-depth understanding of the reaction activities, properties and mutual effects of different functional groups under various reactions, and to provide a basis for the development of synthetic methods.

2-Bromo-5-iodo-phenol is an organic compound composed of bromine and iodine atoms replacing hydrogen atoms at specific positions in the phenol ring. This compound has the following physical properties:
1. ** Appearance properties **: At room temperature, it is mostly white to light yellow crystalline powder with fine texture. Due to the intermolecular forces, the molecules are arranged in an orderly manner and are in an aggregated state of powder. Its color is derived from the absorption and reflection characteristics of bromine and iodine atoms to light.
2. ** Melting boiling point **: The melting point is about 120-125 ° C, and the boiling point is about 300 ° C. The melting point is relatively high, due to the existence of hydrogen bonds and van der Waals forces between molecules. Among them, phenolic hydroxyl groups can form hydrogen bonds and enhance the binding force between molecules. Higher energy is required to destroy, causing the melting point to rise; higher boiling point also requires a lot of energy to destroy the strong interaction between molecules.
3. ** Solubility **: Slightly soluble in water, soluble in organic solvents such as ethanol, ether, and chloroform. Slightly soluble in water, due to strong hydrogen bonds between water molecules, although 2-bromo-5-iodo-phenol has phenolic hydroxyl groups, it can form hydrogen bonds with water, but the introduction of bromine and iodine atoms causes the molecular polarity to decrease and the interaction force with water is weak; while it is soluble in organic solvents, because it matches the forces between organic solvent molecules, it follows the principle of "similar miscibility".
4. ** Density **: The density is higher than that of water, about 2.3 - 2.5 g/cm ³. Due to the large relative atomic weight of bromine and iodine atoms, the molecular weight increases, and the unit volume mass is greater than that of water.
5. ** Odor **: It has a special organic halide odor, pungent and irritating, originating from the stimulation of the olfactory receptors by the structure of bromine, iodine atoms and benzene rings.

2-Bromo-5-iodo-phenol is also an organic compound. Its molecules contain bromine (Br), iodine (I) and phenolic hydroxyl (-OH) on the phenyl ring. The chemical properties of this compound are quite unique because of the functional groups it contains.
First, the phenolic hydroxyl group, which is weakly acidic, can interact with bases such as sodium hydroxide (NaOH) to form phenolic salts and water. This is the general property of phenolic compounds. Because the lone pair electrons of the oxygen atom in the phenolic hydroxyl group form a conjugated system with the benzene ring, the polarity of the hydrogen-oxygen bond is enhanced, and the hydrogen atom is more easily dissociated and acidic.
On the halogen atom, bromine and iodine. Under appropriate conditions, nucleophilic substitution reactions can occur. For example, with nucleophilic reagents such as sodium alcohol, ammonia, etc., halogen atoms can be replaced to form corresponding substitution products. The mechanism of this reaction is that the nucleophilic reagent attacks the carbon atom connected to the halogen atom, and the halogen atom leaves with a pair of electrons.
Furthermore, the presence of benzene rings allows the compound to undergo aromatic electrophilic substitution reactions. Because benzene rings are electron-rich, they are vulnerable to attack by electrophilic reagents. Common electrophilic substitution reactions such as nitrification, sulfonation, etc. In the nitrification reaction, mixed acids (a mixture of concentrated nitric acid and concentrated sulfuric acid) are used as electrophilic reagents to attack the benzene ring and generate nitro
In addition, due to the high electronegativity of bromine and iodine atoms, the electron cloud density distribution of the benzene ring is affected, which in turn affects the acidity of the phenolic hydroxyl group and the activity and positional selectivity of the electrophilic substitution reaction on the benzene ring. The interaction between the phenolic hydroxyl group of the ortho-para-localized group and the halogen atom of the meta-localized group makes the regioselectivity of the reaction more complex.
In conclusion, 2-bromo-5-iodo-phenol presents a rich and diverse chemical properties due to the interaction of the phenolic hydroxyl group, the halogen atom and the benzene ring, which is of great significance in the field of organic synthesis and chemical research.

There are various methods for synthesizing 2-bromo-5-iodo-phenol. One method is to start with phenol, iodize it first, and then brominate it. The iodization of phenol can be used under mild conditions with iodine and appropriate oxidants, such as hydrogen peroxide or nitric acid. This reaction allows the iodine atom to be selected into the ring of phenol and bonded in the para or ortho position. The product to be iodized is obtained, and then brominated. During bromination, brominating agents such as carbon tetrachloride solution of bromine or N-bromosuccinimide (NBS) are commonly used. Among them, NBS is often preferred because of its milder reaction, which can avoid the risk of over-bromination.
Another method can be used to protect phenols first, and then introduce iodine and bromine in sequence. The protection of phenols is often done by forming ethers or esters. After protection, iodizing agents and brominating agents are used successively, and finally the protection group is removed to obtain the target product.
Furthermore, metal-catalyzed reactions can be used. For example, palladium-catalyzed cross-coupling reactions, phenols are first derived into suitable halogenated aromatics or borates, and then reacted with iodide and bromide in the presence of palladium catalysts, ligands and bases to form 2-bromo-5-iodo-phenol. Each of these methods has its own advantages and disadvantages, and the synthesizer needs to follow the factors such as the availability of raw materials, the difficulty of reaction, and the high or low yield.