2 Bromo 5 Iodobenzyl Alcohol

2-Bromo-5-iodobenzyl Alcohol is one of the organic compounds. In its molecular structure, there are bromine atoms at two positions above the benzene ring, iodine atoms at five positions, and benzyl groups are connected with hydroxyl groups. This compound has unique chemical properties.
In terms of its reactivity, the presence of hydroxyl groups makes the compound nucleophilic. Hydroxyl hydrogen is acidic and can react with strong bases to form corresponding alkoxides. For example, in the case of sodium hydroxide, hydroxyl hydrogen can be replaced by sodium to form a sodium salt.
Furthermore, the bromine and iodine atoms on the benzene ring can participate in nucleophilic substitution reactions due to the characteristics of halogen atoms. Under appropriate conditions, such as the presence of nucleophiles, suitable temperature and solvent environment, bromine or iodine atoms can be replaced by other groups. Taking cyanyl as an example, under suitable conditions, cyanide negative ions can act as nucleophiles to attack the halogen atoms on the benzene ring and realize the reaction of halogen atoms being replaced by cyanyl groups.
The benzyl part of this compound, because its α-hydrogen has a certain activity, can be oxidized under the action of specific reagents. For example, with a suitable oxidizing agent, α-hydrogen can be oxidized to form a corresponding carbonyl compound.
In addition, due to the conjugated system of benzene ring, 2-bromo-5-iodobenzyl Alcohol has certain stability, but it also gives it the possibility of specific reactions under light, heat and other conditions. For example, under light conditions, halogen atoms may undergo photolysis reactions to generate free radicals, which in turn trigger a series of free radical reactions.
In short, 2-bromo-5-iodobenzyl Alcohol has many applications and research values in organic synthesis and other fields due to its unique molecular structure.

2 - bromo - 5 - iodobenzyl Alcohol is one of the organic compounds. Its physical properties are quite impressive, let me explain in detail for you.
In terms of its appearance, at room temperature, 2 - bromo - 5 - iodobenzyl Alcohol is often in the form of a colorless to light yellow liquid, which is clear and textured. The smell of this substance also has its own unique characteristics. It emits a special fragrance. Although it is not pungent, you can feel the uniqueness of its breath when you smell it carefully, as if it carries subtle information about the organic world.
When it comes to the melting point, the melting point of this compound is about [specific value] ° C. This temperature limit is similar to the turning point between its solid and liquid states. When the ambient temperature rises above the melting point, it gradually melts from the solid state to the liquid state, showing a flowing state. As for the boiling point, it is about [specific value] ° C. At this temperature, the liquid vaporizes sharply, turns into a gaseous state, and escapes into space. The characteristics of such a melting boiling point are of crucial significance in many aspects such as the separation, purification and application of substances.
In terms of solubility, 2-bromo-5-iodobenzyl Alcohol exhibits good solubility in organic solvents such as ethanol and ether. This is due to the specific interaction between the molecular structure and the organic solvent molecules, such as van der Waals force, hydrogen bond, etc., which makes the two easy to blend with each other and mix into one. However, in water, its solubility is relatively limited, which is due to the difference between the polarity of water and the molecular polarity of the compound, making it difficult for the two to fully dissolve each other.
Density is also one of its important physical properties. The density of 2-bromo-5-iodobenzyl Alcohol is about [specific value] g/cm ³, which is slightly larger than that of water. This density characteristic plays a non-negligible role in the process of liquid-liquid separation or the distribution of substances in the system.
To sum up, the physical properties of 2-bromo-5-iodobenzyl Alcohol, such as appearance, odor, melting point, solubility, and density, together constitute its unique physical properties and provide a solid foundation for its application in many fields such as organic synthesis and drug development.

To prepare 2-bromo-5-iodobenzyl alcohol, the following ancient method can be used.
Take 2-bromo-5-iodobenzoic acid as the starting material. This acid is reacted with lithium aluminum hydride (LiAlH) in a suitable anhydrous organic solvent, such as anhydrous ethyl ether, at a low temperature and nitrogen protected environment. Lithium aluminum hydride is a strong reducing agent, and the carboxyl group (-COOH) can be reduced to hydroxymethyl (-CH 2O OH) to obtain the target product 2-bromo-5-iodobenzyl alcohol. In this reaction, the ratio of lithium-aluminum hydride to 2-bromo-5-iodobenzoic acid needs to be precisely prepared. Usually, lithium-aluminum hydride should be slightly excessive to ensure complete reaction. At the time of reaction, lithium-aluminum hydride should be added slowly to prevent the reaction from being too violent. After the reaction is completed, the excess lithium-aluminum hydride is carefully quenched with dilute acid, and then the product is purified by extraction, drying, and column chromatography.
Or it can be started from 2-bromo-5-iodobenzyl bromide. React 2-bromo-5-iodobenzyl bromide with ulotropine (hexamethylenetramine) in an appropriate solvent to form a quaternary ammonium salt. Then the quaternary ammonium salt is treated with dilute acid to hydrolyze it to produce 2-bromo-5-iodobenzyl alcohol. In this process, the choice of solvent is very critical, and the commonly used solvents are acetonitrile. The reaction conditions of urotropine with 2-bromo-5-iodobenzyl bromide should be mild, and the temperature should not be too high, otherwise side reactions may occur. The hydrolysis step also needs to control the concentration of acid and the reaction time to complete the hydrolysis and avoid further damage to the product. After this series of operations, pure 2-bromo-5-iodobenzyl alcohol can be obtained.

2-Bromo-5-iodobenzyl alcohol, which has a wide range of uses, is mostly used as a key intermediate in organic synthesis in the field of medicinal chemistry. The halogen atom activity of bromine and iodine in the genome molecule is quite high, and it can borrow nucleophilic substitution, coupling and other reactions to ingeniously construct complex drug molecules. For example, the creation of anti-cancer and antibacterial drugs often relies on this as the starting material. After multiple steps of delicate reactions, it reaches the expected molecular structure, and then has unique biological activity.
In the field of materials science, it also has extraordinary performance. It can participate in the synthesis of specific functional materials, and the reaction of bromine, iodine and other groups endows materials with novel optoelectronic properties. For example, when preparing organic optoelectronic materials, based on this, with appropriate chemical modification, the materials can have excellent light absorption and charge transport capabilities, revealing potential application value in cutting-edge fields such as organic Light Emitting Diodes and solar cells.
Furthermore, in the field of fine chemicals, it is also an important member. It can be used to produce high-end fragrances, dyes and other fine chemicals. Through precise chemical reactions, it is used as a substrate to build specific structural units, giving products a unique aroma or bright color, meeting the strict requirements of the high-end market for the quality and performance of fine chemicals. Therefore, 2-bromo-5-iodobenzyl alcohol plays an indispensable role in many important fields and has made outstanding contributions to promoting technological innovation and development in related industries.

2 - bromo - 5 - iodobenzyl Alcohol is also an organic chemical substance. When handling this substance, it is safe to the most serious, and many things need to be paid attention to.
First protective gear. Wear appropriate protective clothing, which can prevent this substance from coming into contact with the skin and protect the skin from it. Also wear protective gloves. The material should be chemically resistant to prevent this substance from penetrating into the gloves and hurting the hands. Eye protection is indispensable. Protective glasses or masks can protect the eyes from sputtering injuries from this substance.
Ventilated environment is also key. It is suitable for well-ventilated operation, preferably in a fume hood. In this way, the volatile steam of this thing can be discharged in time to prevent the steam from accumulating in the air, being absorbed by breathing, and damaging the respiratory tract. If there is no fume hood, it is also necessary to ensure that the site is well ventilated, and windows and exhaust fans can be opened.
Furthermore, when handling this thing, the action should be steady and careful. Because of its chemical activity, improper operation or danger. When measuring and transferring this thing, the utensils used should be clean and dry to prevent impurities from reacting with it. And do not make this thing similar to open flames or hot topics, because it may be flammable or risk decomposition by heat, causing fire or explosion.
Storage of this thing is also important. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. It is very important to keep it sealed to prevent it from reacting with air and moisture and deteriorating, and to prevent its volatilization from increasing the concentration in the air.
Dispose of the waste of this material in accordance with relevant regulations. It should not be dumped at will, but should be collected in a centralized manner and handed over to a professional organization for treatment according to the method of chemical waste disposal, so as not to pollute the environment.
In short, when operating 2-bromo-5-iodobenzyl Alcohol, you need to pay attention to protection, ventilation, operation, storage, waste disposal, etc., in order to ensure safety and avoid danger.