2 Bromo 5 Iodopyridine

2-Bromo-5-iodopyridine, or 2-bromo-5-iodopyridine, has a wide range of uses and is particularly critical in the field of medicinal chemistry.
First, it plays a significant role in the creation of new drugs. In the process of many drug development, specific chemical structures need to be constructed to meet the needs of the target. The pyridine ring structure of 2-bromo-5-iodopyridine, together with bromine and iodine atoms, provides rich possibilities for drug molecular design. Bromine and iodine atoms can enhance the lipophilicity of molecules, improve the transmembrane transport ability of drugs, and can also optimize binding to targets through halogen bonding, thereby enhancing drug activity and selectivity. For example, the development of small molecule inhibitors for specific diseases may serve as a key intermediate. After a series of reactions, it precisely connects to the required functional groups and builds a molecular framework that works efficiently with the target.
Second, it also makes contributions to the field of materials science. In the preparation of organic optoelectronic materials, 2-bromo-5-iodopyridine can act as a structural unit. Pyridine rings endow materials with certain rigidity and conjugate properties, and bromine and iodine atoms can adjust the electron cloud distribution and energy level structure of materials. For example, preparing organic Light Emitting Diode (OLED) materials and introducing them into the molecular structure may regulate the luminous color, improve luminous efficiency and stability. Due to its special structure, different conjugated systems can be constructed by chemical modification to meet various photoelectric performance requirements.
Third, it is an important raw material in the field of organic synthetic chemistry. It can participate in many classical organic reactions, such as palladium-catalyzed cross-coupling reactions. In this reaction, bromine and iodine atoms can be coupled with organic reagents containing different functional groups respectively to realize the construction of carbon-carbon and carbon-heteroatom bonds, and help synthesize organic compounds with complex structures and specific functions. With this, organic chemists can efficiently build a diverse molecular skeleton and expand the variety and function of organic compounds.

To prepare 2-bromo-5-iodopyridine, there are various synthesis methods. First, pyridine is used as the starting material, and the second position of pyridine is first brominated to introduce bromine atoms. This bromination reaction can be selected from a suitable bromination reagent, such as liquid bromine, and accompanied by a suitable catalyst, such as iron powder. Under appropriate reaction conditions, such as heating, the reaction occurs to generate 2-bromo-pyridine.
Next, the iodization reaction of 2-bromo-pyridine is carried out. At this time, choose a suitable iodizing agent, such as potassium iodide, with a specific oxidizing agent, such as hydrogen peroxide, in a suitable solvent environment, such as dimethylformamide (DMF), control the reaction temperature and time, so that the 5-position of 2-bromopyridine is introduced into the iodine atom, and the final result is 2-bromopyridine.
Second, pyridine can also be iodized first to obtain 5-iodopyridine. In the iodization step, iodine and pyridine can be used under specific conditions to add an appropriate promoter, such as copper salt, to connect the iodine atom to the 5-position of pyridine. Then, the bromination reaction of 5-iodopyridine is carried out, and the commonly used brominating agent, such as N-bromosuccinimide (NBS), in the presence of a suitable initiator, such as benzoyl peroxide, in a suitable reaction solvent, such as carbon tetrachloride, heating the reaction, introducing bromine atoms at the second position of 5-iodopyridine, and the target product 2-bromo-5-iodopyridine can also be obtained.
All methods need to pay attention to the precise control of reaction conditions, such as temperature, reagent dosage, reaction time, etc., in order to improve the yield and purity of the product. During the reaction process, safety regulations for chemical experiments should be followed, and reactants and products should be properly disposed of to prevent the leakage of harmful substances and environmental pollution.

2-Bromo-5-iodopyridine is an organic compound, its physical properties are particularly important, and it has a wide range of uses in chemical and scientific research fields.
Looking at its properties, at room temperature, 2-bromo-5-iodopyridine is mostly in a solid state, and its structure is stabilized due to intermolecular forces. Its color is often white to light yellow. The formation of this color is related to the transition of electrons in the molecular structure, and the specific structure causes it to have a unique performance of light absorption and reflection.
When it comes to the melting point, it has been accurately determined to be about a specific temperature range. The level of melting point is closely related to the intermolecular forces. This compound has van der Waals forces and hydrogen bonds between molecules, which restrict each other, and requires specific energy to destroy the lattice structure and cause it to melt.
The boiling point is also a key physical property. Under a specific pressure environment, when it reaches the boiling point, the molecule obtains enough energy to overcome the attractive force between molecules, and changes from liquid to gaseous state. The value of boiling point reflects the strength of intermolecular forces and the relative mass of molecules. Those with large relative mass and strong intermolecular forces usually have higher boiling points.
In terms of solubility, 2-bromo-5-iodopyridine has a certain solubility in organic solvents such as dichloromethane and chloroform. Due to the principle of "similar phase dissolution", its organic molecular structure is similar to the molecular structure of organic solvents, and the molecules can form favorable interactions and promote dissolution. However, the solubility in water is very small. Because water is a polar molecule, the interaction with the non-polar part of the compound is weak, and it is difficult to break the original intermolecular force and dissolve.
Density is also one of its characteristics. The specific value of its density reflects the mass of the substance per unit volume and is related to the degree of molecular accumulation. Those who are closely packed have relatively large densities.
2-bromo-5-iodopyridine has the above physical properties and can be used as a key intermediate in organic synthesis, laying the foundation for many organic reactions and assisting researchers in creating a variety of organic compounds.

In today's world, it is not easy to know the price of 2-bromo-5-iodopyridine on the market. The price of this chemical substance often changes for many reasons.
First, the trend of supply and demand has a huge impact. If many workshops and research institutes are very eager for it, but there are few producers, the price will increase; on the contrary, if the supply exceeds the demand, the price will drop automatically.
Second, the cost of production is also the key. The price of raw materials, the complexity of preparation methods, and the consumption of manpower and material resources all affect its cost. Rare raw materials, complicated production methods, and time-consuming, the cost will be high, and the price will also be high.
Third, the origin is also related to the quality. Different origins may have different qualities due to differences in water, soil and technology. For high-quality products, the price is often higher than ordinary. And long-distance transportation, tariffs, freight, etc., also make the price different.
Then I checked "Tiangong Kaiwu" all over, but I didn't get the price of this product. Although "Tiangong Kaiwu" is detailed in all kinds of process products, there are times, but there was no such chemical product at that time. If you want to know its price today, you can consult the chemical market merchants, check the chemical product trading platform, or ask a special chemical raw material supplier to get a close real price.

2-Bromo-5-iodopyridine is an organic compound, and its storage conditions are very critical, which is related to the stability and quality of this compound. According to the traditional classical style of "Tiangong Kaiwu", this substance should be stored in a cool, dry and well-ventilated place.
A cool place can prevent its chemical properties from changing due to heat. High temperature can easily lead to chemical reactions, which can damage the structure of 2-bromo-5-iodopyridine and lose its inherent characteristics. Therefore, it is a good choice to choose a place with low room temperature and away from heat sources, such as direct sunlight, heating equipment, etc.
A dry environment is also indispensable. Moisture easily interacts with many compounds. If 2-bromo-5-iodopyridine encounters water vapor or reacts with hydrolysis, the purity will be reduced. Therefore, it is necessary to avoid moisture for storage. A desiccant can be used to absorb moisture and keep the environment dry.
Good ventilation can prevent the accumulation of harmful gases. If 2-bromo-5-iodopyridine decomposes or evaporates, the generated gas may be harmful. Good ventilation can cause the gas to escape, ensuring the safety of the storage environment and helping to maintain its chemical stability.
In addition, the container for storing 2-bromo-5-iodopyridine should also be carefully selected. Containers made of glass or specific plastic materials should be used. Such materials are chemically stable and do not easily react with 2-bromo-5-iodopyridine, ensuring that their quality is not affected by the material of the container. And the container must be well sealed to prevent the intrusion of air, water vapor, etc.
In general, 2-bromo-5-iodopyridine should be stored in a cool, dry, well-ventilated place in a suitable container to maintain its quality and stability for subsequent use.