2 Bromo 6 Iodo 3 Methoxypyridine

2-Bromo-6-iodine-3-methoxypyridine is a crucial compound in the field of organic synthesis. It has a wide range of main uses. In the field of medicinal chemistry, it can be used as a key intermediate to construct drug molecules with specific biological activities. Due to its unique structure, it can participate in a variety of chemical reactions. After ingenious design, it can achieve precise modification of drug molecular structures to achieve desired pharmacological effects.
It also has important applications in the field of materials science. With its special chemical properties, it can participate in the preparation of organic materials with special properties, such as photoelectric materials. In this field, the bromine, iodine and methoxy groups in its structure can have a significant impact on the electronic transport and optical properties of materials, and then meet the strict requirements of material properties in different application scenarios.
In the research and development of pesticides, 2-bromo-6-iodine-3-methoxy pyridine also plays an important role. It can be used as an important starting material for the synthesis of new pesticides. Through a series of reactions, pesticide molecular structures with high insecticidal, bactericidal or herbicidal activities can be constructed to help agricultural production, improve crop yield and quality, and resist the invasion of diseases and pests. In conclusion, 2-bromo-6-iodine-3-methoxypyridine, with its unique chemical structure, has shown great application potential in many fields such as drugs, materials, and pesticides, providing an indispensable material foundation and key support for the development of related fields.

The method for preparing 2-bromo-6-iodine-3-methoxypyridine has the following common paths.
First, 3-methoxypyridine can be started. First, under suitable reaction conditions, such as N-bromosuccinimide (NBS), under suitable reaction conditions, such as inert solvents, heating or lighting, the specific position on the pyridine ring is brominated to obtain 2-bromo-3-methoxypyridine. Then iodine atoms are introduced, and iodization reagents, such as cuprous iodide (CuI), are often used to react with corresponding ligands and bases in appropriate solvents to induce iodine atoms to replace hydrogen at specific positions, thereby obtaining the target product 2-bromo-6-iodine-3-methoxypyridine. The key to this path lies in the position selectivity of the bromination step and the control of the conditions of the subsequent iodization reaction.
Second, 2-bromo-3-hydroxypyridine is used as the raw material. First, the hydroxyl group is converted into methoxy group by the interaction of methylation reagents, such as dimethyl sulfate ((CH < unk >) 2O SO <) with a base, to obtain 2-bromo-3-methoxy pyridine. Then iodization is carried out. Iodine elemental substance (I < unk >) can be used in combination with appropriate oxidants and bases. After a series of reaction processes, iodine atoms are introduced into the 6 position of the pyridine ring, and the final target product is obtained. During this process, the methylation reaction needs to pay attention to the degree of reaction to avoid side reactions such as excessive methylation. The iodization step also needs to optimize the reaction conditions to improve the yield and selectivity.
Third, if pyridine is used as the starting material, methoxy, bromine and iodine atoms need to be introduced in Pyridine is first methoxylated, such as reacting with methoxylating reagents under strong alkaline conditions to obtain 3-methoxylpyridine. Subsequent steps can refer to the synthesis path starting from 3-methoxylpyridine, first brominated and then iodized. However, this path has many steps, and each step needs to be carefully controlled to ensure the yield and purity of each step of the reaction, otherwise it will easily lead to problems such as low total yield and difficulty in product separation.
All synthesis methods have their own advantages and disadvantages, and the appropriate synthesis route should be reasonably selected according to the actual situation, such as the availability of raw materials, cost, and requirements for product purity and yield.

2 - bromo - 6 - iodo - 3 - methoxypyridine is an organic compound with unique physical properties, as detailed below:
- ** Appearance Properties **: This compound is usually solid, but its exact appearance may vary depending on purity and preparation method. Generally speaking, pure or white to light yellow crystalline powder, under normal light and environmental conditions, the appearance is relatively stable.
- ** Melting Boiling Point **: The melting point is related to the intermolecular force and lattice energy. 2 - bromo - 6 - iodo - 3 - methoxypyridine contains halogen atoms such as bromine and iodine, as well as methoxy groups, which enhance the intermolecular force. Therefore, its melting point may be in a certain range, and the specific value has been determined experimentally, which is roughly around [X] ° C. The boiling point is affected by molecular weight and intermolecular forces. The compound has a large molecular weight, and there are dipole-dipole interactions between molecules, etc., resulting in a higher boiling point. It is estimated that it is around [Y] ° C. Under this boiling point condition, the molecule is energized enough to overcome the intermolecular forces and vaporize.
- ** Solubility **: From the molecular structure analysis, the pyridine ring has a certain polarity, and the methoxy group is also a polar group. The presence of bromine and iodine atoms affects the overall polarity of the molecule. In polar solvents, such as methanol and ethanol, there is a certain solubility because of the formation of hydrogen bonds or dipole-dipole interactions between molecules of compounds. However, in non-polar solvents such as n-hexane, the solubility is very small due to the mismatch of intermolecular forces.
- ** Density **: Density is closely related to molecular weight and molecular packing. 2-bromo-6-iodo-3-methoxypyridine contains heavy atoms of bromine and iodine, which increases the molecular weight, and the molecular structure determines the way it accumulates in the solid state, resulting in a relatively high density, about [Z] g/cm ³.
- ** Stability **: In terms of chemical stability, although the pyridine ring has certain aromaticity and stability, bromine and iodine atoms can participate in nucleophilic substitution and other reactions. Under specific conditions, such as the presence of strong alkalinity or nucleophilic reagents, halogen atoms may be substituted. Methoxy groups are relatively stable, but under extreme conditions such as strong acids, reactions such as dissociation of methyl groups may occur. At the same time, environmental factors such as light and high temperature may also affect its stability, and reactions such as intramolecular rearrangement may be triggered at high temperatures.

2-Bromo-6-iodine-3-methoxypyridine is an organic compound with unique chemical properties and is worth studying.
First, the presence of its halogen atoms, bromine and iodine, endows this compound with significant reactivity. Both bromine and iodine are halogen elements, and halogen atoms often act as leaving groups in organic reactions. Therefore, 2-bromo-6-iodine-3-methoxypyridine is prone to nucleophilic substitution reactions. Nucleophiles can attack carbon atoms attached to halogen atoms, and halogen atoms leave to form new organic compounds. For example, if an alcohol nucleophilic reagent is reacted with it, the oxygen atom of the alcohol will attack nucleophilically, and the bromine or iodine will leave, which can form ether compounds. This reaction has a wide range of uses in organic synthesis and can construct various complex organic molecular structures.
Furthermore, the presence of methoxy groups also affects its chemical properties. Methoxy groups are the power supply groups, which can increase the electron cloud density on the pyridine ring. This electronic effect makes the pyridine ring more prone to electrophilic substitution reactions, and the electrophilic reagents are more inclined to attack the positions with higher electron cloud density on the pyridine ring. Compared with the unsubstituted pyridine, the electrophilic substitution reactivity of 2-bromo-6-iodine-3-methoxy pyridine may be changed, and the reaction check point may show specific selectivity due to the interaction of methoxy and halogen atoms.
In addition, the pyridine ring itself has a certain alkalinity. Due to the presence of lone pair electrons on the nitrogen atom of the pyridine, protons can be accepted. However, the substitution of the halogen atom with the methoxy group may affect its alkalinity. The electron-withdrawing action of the halogen atom competes with the electron-donating action of the methoxy group, which ultimately affects the ability of the pyridine ring nitrogen atom to bind to the proton, resulting in a change in the alkalinity of the compound The chemical properties of 2-bromo-6-iodine-3-methoxy pyridine are rich and diverse, and the interaction between halogen atoms and methoxy groups makes it exhibit unique reactivity and selectivity in the field of organic synthesis, providing an important synthetic building block for organic chemists to construct novel compound structures.

At present, it is difficult to determine the price range of 2-bromo-6-iodo-3-methoxypyridine in the market. The change in its price is related to many ends.
First, the price of raw materials has a great impact. If the price of the raw materials for making this product increases, the price of the finished product will also rise; conversely, if the price of raw materials decreases, the price may also decrease.
Second, the preparation method is also the key. If a new method is developed, the consumption of its preparation can be reduced and the cost can be reduced, and the price may be reduced; however, if the preparation is difficult and requires more material resources and manpower, the price will be high.
Third, the supply and demand of the city determines the price. If there are many applicants, but there are few suppliers, the price will be high; if the supply exceeds the demand, the price may decline.
Fourth, the difference in origin also has an impact. Different places have different prices due to different taxes, transportation and other fees.
Looking at similar fine chemicals in the market, such halogenated and heterocyclic compounds, if the purity is ordinary, the price per gram may be in the tens of yuan. However, if you want high purity, or more than 100 yuan per gram, or even higher prices, it is unknown.
In short, if you want to know the price, you can obtain a more accurate price by carefully examining the market conditions and consulting the chemical raw material suppliers.