2 Chloro 1 Fluoro 4 Iodobenzene
Iodobenzene

2-Chloro-1-Fluoro-4-Iodobenzene

Fengxi Chemical

Specifications

HS Code

726717

Chemical Formula C6H3ClFI
Molecular Weight 260.44
Appearance Liquid (usually)
Boiling Point Data may vary, around high-boiling range
Melting Point Data may vary
Density Data may vary
Solubility In Water Low solubility
Solubility In Organic Solvents Soluble in common organic solvents
Vapor Pressure Low vapor pressure
Stability Stable under normal conditions, may react with strong oxidants
Hazard Class Toxic, harmful to environment (classification may vary)
Chemical Formula C6H3ClFI
Molecular Weight 256.44
Appearance Liquid (usually)
Boiling Point Data needed
Melting Point Data needed
Density Data needed
Solubility In Water Insoluble (expected, being an organic halogen - benzene derivative)
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Vapor Pressure Data needed
Flash Point Data needed

As an accredited 2-Chloro-1-Fluoro-4-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 - gram vial of 2 - chloro - 1 - fluoro - 4 - iodobenzene, tightly sealed for safety.
Storage 2 - chloro - 1 - fluoro - 4 - iodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container made of a suitable material, such as glass or certain plastics, to prevent leakage and evaporation. Label the container clearly for easy identification and to ensure proper handling.
Shipping 2 - chloro - 1 - fluoro - 4 - iodobenzene is a hazardous chemical. It should be shipped in accordance with strict regulations, using appropriate packaging to prevent leakage. Transport is via approved carriers, following safety protocols for such substances.
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2-Chloro-1-Fluoro-4-Iodobenzene
General Information
Historical Development
2-Chloro-1-fluoro-4-iodobenzene is also an organic compound. The beginning of its research can be traced back to the past. At that time, the art of chemistry was not as refined as it is today, but all the sages were already interested in this thing. At the beginning, the path of exploration was bumpy, and it was as difficult to make this thing as reaching the sky.
After several generations of research, the method gradually became clear. Scholars of the past, after years and years, have been searching for the wonderful way to synthesize it in bottles and cans. Either because the raw materials are rare, or because the reactions are complicated, every step forward is difficult.
With unremitting efforts, it is finally successful. With the passage of time, the synthesis method has become better and the yield has gradually increased. From the initial occasional discovery to the current large-scale preparation, the development of this compound is really a chapter in the evolution of chemistry. From ignorance and exploration to mastery, this is the crystallization of the wisdom and sweat of predecessors.
Product Overview
There is a substance today called 2-chloro-1-fluoro-4-iodobenzene. It is an organic halogenated aromatic hydrocarbon. In the molecular structure, above the benzene ring, chlorine atoms, fluorine atoms and iodine atoms are arranged in an orderly manner.
This substance has unique properties. At room temperature, it is often in a liquid or solid state, depending on specific environmental conditions. Its physical properties, such as melting point and boiling point, are determined by the interaction between atoms and the force between molecules. In terms of chemical properties, halogenated aromatics have full characteristics and can participate in many chemical reactions, such as nucleophilic substitution reactions. Halogen atoms can be replaced by other nucleophilic groups, and then various new compounds can be derived.
2-chloro-1-fluoro-4-iodobenzene is widely used in the field of organic synthesis. It can be used as a key intermediate to help synthesize a variety of complex organic compounds. It has its place in medicine, materials science and other fields, and contributes unique value to scientific research and industrial production.
Physical & Chemical Properties
2 - Chloro - 1 - Fluoro - 4 - Iodobenzene is also an organic compound. Its physical and chemical properties are worth exploring. Looking at its physical properties, it may be liquid at room temperature, colored or transparent and has a slightly special taste. Its boiling point, melting point, etc. are the keys to characterizing its physical properties. As for chemistry, the presence of halogen atoms makes it reactive. Chlorine, fluorine, and iodine atoms can initiate various chemical reactions under different reaction conditions, such as nucleophilic substitution. Chemists often use this property to synthesize more complex organic molecules. The study of its properties is of great help in the field of organic synthesis. It can expand the way of chemical synthesis and promote the research and development of new materials. It is an important object of chemical research.
Technical Specifications & Labeling
Today there is a product called 2-chloro-1-fluoro-4-iodobenzene. The method of making it is related to technical specifications and identification (product parameters), which is the focus of my research.
To make this product, the first thing is to clarify the purity of the raw materials and the accuracy of the amount. All kinds of raw materials, according to a certain rule. When reacting, the control of temperature and pressure is of paramount importance. If the temperature is high, it is easy to mess, and if the temperature is low, it is difficult to respond. The same is true for pressure, and if it is not appropriate, it will not work.
As for the identification (product parameters), the color, taste and state of this product need to be detailed. Its purity is certain, and the geometry of impurities is also the key. These technical specifications and logos (product parameters) are related to the quality of the product and its effectiveness. We should strictly abide by its regulations to achieve excellent products and live up to our research and development.
Preparation Method
To prepare 2-chloro-1-fluoro-4-iodobenzene, the raw materials and production process, reaction steps and catalytic mechanism are very critical.
The selection of raw materials should be based on suitable compounds containing chlorine, fluorine and iodine. If fluorobenzene is used as the starting material, chlorine atoms can be introduced through chlorination reaction to obtain chlorofluorobenzene; this step requires the selection of suitable chlorinating agents, such as chlorine gas, under the action of suitable catalysts such as ferric chloride, temperature control can be carried out to improve the yield.
Then, the iodization reaction of chlorofluorobenzene is carried out. Select the appropriate iodizing reagent, such as the mixture of iodine elemental substance and potassium iodide, under the catalysis of catalysts such as copper salts, through specific reaction steps, the iodine atom precisely replaces the hydrogen atom at the target position, and finally obtains 2-chloro-1-fluoro-4-iodobenzene. During the reaction process, careful regulation of temperature, time, and the proportion of reactants to ensure that the reaction is efficient and directional is the key to improving the purity and yield of the product.
Chemical Reactions & Modifications
Nowadays, there is a chemical substance, named 2-chloro-1-fluoro-4-iodobenzene. In the study of chemistry, its reaction and modification are very important.
To observe the reaction of this substance, it is often necessary to clarify its characteristics. Its chlorine, fluorine and iodine atoms are each active, and can trigger different reactions under different conditions. In case of nucleophiles, chlorine or iodine atoms, or as leaving groups, cause substitution reactions. This change is related to the strength of the reagent, the temperature of the reaction, the properties of the solvent, etc.
Regarding its modification, chemists try to change its structure to obtain new properties. Or introduce other functional groups to change its physical and chemical properties. Or adjust its spatial configuration, affecting its biological activity, solubility, etc.
In order to seek the best conditions for the reaction and modification of this substance, chemists have always used rigorous methods to observe its phenomena and measure its data. At the microscopic level, understand the mechanism of its reaction and find a good strategy for modification. This unremitting exploration is expected to add new results to the field of chemistry and promote the progress of related technologies.
Synonyms & Product Names
2-Chloro-1-fluoro-4-iodobenzene, the synonyms and trade names of this substance should be detailed.
In the field of chemistry, synonyms refer to different names of the same substance. 2-chloro-1-fluoro-4-iodobenzene, or have other names, but all refer to this specific compound. Its structure is unique, and the atoms of chlorine, fluorine, and iodine are in specific positions in the benzene ring, resulting in their unique chemical properties.
As for trade names, they may have different names due to different uses and markets. In the scientific research reagent market, merchants recognize their quality and characteristics, or give unique trade names to distinguish them from their own kind. These trade names are designed to help users understand their advantages and applicability.
Although synonyms are different from trade names, they all refer to the substance 2-chloro-1-fluoro-4-iodobenzene. We chemical researchers need to know their various names in order to research and apply them accurately and avoid confusion.
Safety & Operational Standards
2-Chloro-1-fluoro-4-iodobenzene - Safety and Handling Specifications
Fu 2-chloro-1-fluoro-4-iodobenzene is an important substance in chemical research. During its experimental operation and use, safety regulations are of paramount importance.
#1. Storage Method
This substance should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent accidents. It should be stored separately from oxidants and alkalis, and must not be mixed. Because mixed storage can easily cause chemical reactions, resulting in safety concerns. The storage area should be equipped with suitable materials to contain leaks for emergencies.
#2. Rules of Operation
When operating, the experimenter must wear appropriate protective equipment. Protective clothing is required to protect the body; protective gloves are worn to avoid contact with the skin; safety glasses are worn to ensure the safety of the eyes. The operation should be carried out in a fume hood, which can effectively remove volatile gases and prevent them from accumulating in the experimental space, endangering the health of the experimenter.
If a leak occurs accidentally, the personnel in the leaked contaminated area should be quickly evacuated to a safe area and quarantined to strictly restrict access. Emergency responders must wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Do not allow leaks to come into contact with combustible substances. In the event of a small amount of leakage, it can be absorbed by sand, vermiculite or other inert materials. In the event of a large amount of leakage, build an embankment or dig a pit to contain it, transfer it to a tanker or special collector with a pump, and recycle or transport it to a waste treatment site for disposal.
#3. Emergency treatment
If the skin comes into contact, immediately remove the contaminated clothing, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical attention. If the eyes come into contact, lift the eyelids, rinse with flowing water or normal saline, and seek medical attention in time. If inhaled, quickly leave the scene to a fresh place to keep the respiratory tract unobstructed, such as breathing difficulties, give oxygen, stop breathing and heartbeat, immediately carry out cardiopulmonary resuscitation, and seek medical attention.
In short, in the research and use of 2-chloro-1-fluoro-4-iodobenzene, strict adherence to safety and operating standards can ensure the smooth operation of the experiment and the safety of personnel.
Application Area
Fu 2-chloro-1-fluoro-4-iodobenzene is also an organic compound. It is widely used in the field of chemical medicine.
In pharmaceutical research and development, this compound can be used as an intermediate. With its unique structure, it can react with other reagents to make specific drugs. Such as anti-cancer drugs, or drugs for neurological diseases, all rely on its participation in the synthesis process.
In the genus of materials science, it also has its uses. After special treatment, it can be made into a material with specific properties, or increase the stability of the material, or change its conductivity. It has potential applications in electronic components and other fields.
In organic synthetic chemistry, 2-chloro-1-fluoro-4-iodobenzene is an important building block. Chemists can design delicate reaction paths according to its structural characteristics to build complex organic molecules, expand the boundaries of organic chemistry, and provide a solid foundation for the development of many fields.
Research & Development
Today there is a thing called 2 - Chloro - 1 - Fluoro - 4 - Iodobenzene. As a researcher, we explore the way of its research and progress.
This compound has a unique structure, with chlorine, fluorine and iodine atoms co-attached to the benzene ring. At the beginning of the research, analyze its physicochemical properties, and observe its state in different media and conditions. Its reactivity is the key to the investigation, and it is related to the possibility of many organic synthesis.
If you want to enter this product, the first method is created. The method of improving the synthesis is to seek a high-efficiency and pure way, reduce costs and increase production. Furthermore, find its new use, and explore its unique effects in fields such as medicine and materials. With time, or can create a new situation for all industries, this is the wish of our generation of researchers, unremitting research, hope to promote its progress, for the world to use.
Toxicity Research
2-Chloro-1-fluoro-4-iodobenzene is also a chemical substance. Yu is a researcher of chemical substances and often studies the toxicity of various substances. The toxicity of this 2-chloro-1-fluoro-4-iodobenzene is of great importance.
Looking at its molecular structure, the atoms of chlorine, fluorine and iodine exist. Such halogen atoms may affect their chemical activity and toxicity. In the environment, they may participate in various reactions due to their chemical properties, which in turn affects the ecology.
Experiments show that it may have different degrees of influence on organisms. Or disturb the normal metabolism of cells and cause abnormal physiological functions. However, the toxicity is indeed still to be studied by many methods, such as cell experiments, animal experiments, etc., to analyze its dose-effect relationship in detail, to clarify its toxicity mechanism in different biological systems, and to provide a solid basis for its safe use and environmental control.
Future Prospects
In the future, 2 - Chloro - 1 - Fluoro - 4 - Iodobenzene is the most important. This compound has special characteristics and the possibility of containing.
In today's field of transformation, new materials are in high demand for new research. 2 - Chloro - 1 - Fluoro - 4 - Iodobenzene may be a synthetic raw material due to its special atomic arrangement. With its starting materials, it may be able to produce a wide range of bioactive molecules, and it may be able to generate new special effects.
Furthermore, in the field of materials, its characteristics may enable the development of high-performance functional materials, which can be used in multi-frontier fields such as electronics and light, and promote the development of science and technology.
There may be a new way forward, but with the heart of exploration, unremitting research, 2 - Chloro - 1 - Fluoro - 4 - Iodobenzene will surely be able to expand its color in the future, and lead to a new journey in the field of technology.
Historical Development
2-Chloro-1-fluoro-4-iodobenzene is also an organic compound. Tracing back to its origin, chemists in the past studied the field of organic synthesis. At the beginning, the synthesis method was not perfect, but scholars were determined to persevere and unremitting exploration.
In the past, organic chemistry was flourishing, and many people studied the preparation of halogenated aromatics. After years of trial and error, many wonderful methods have gradually emerged. Prepare this 2-chloro-1-fluoro-4-iodobenzene, or through the ingenuity of halogenation reaction, introduce chlorine, fluorine and iodine atoms based on benzene.
Although the conditions were difficult at that time, the chemists used their wisdom and perseverance to improve the process and increase the yield. From the initial exploration to the gradual maturity of the method, the synthesis process of 2-chloro-1-fluoro-4-iodobenzene has improved day by day. Its application in medicine, materials and other fields has also gradually expanded, becoming an important member of chemical research and industrial production, laying the foundation for future scientific and technological progress.
Product Overview
Today there is a substance called 2-chloro-1-fluoro-4-iodobenzene. Its shape is also a genus of organohalogenated aromatic hydrocarbons. Looking at its structure, on the benzene ring, the three atoms of chlorine, fluorine and iodine are arranged in an orderly manner.
This compound has a wide range of uses in the field of organic synthesis. It can be used as a key intermediate to participate in the construction of various complex organic molecules. With the active properties of halogen atoms, various functional groups can be introduced into the benzene ring, thus opening the way to synthesize various compounds.
The method of preparation often relies on organic halogenation. Starting with suitable benzene derivatives, chlorine, fluorine and iodine atoms are precisely introduced through the action of halogenated reagents to achieve the desired structure. However, when preparing, the reaction conditions, such as temperature, reagent ratio, and catalyst selection, need to be carefully controlled to obtain high-purity products.
2-chloro-1-fluoro-4-iodobenzene is of great value in organic chemistry research and industrial production, and is also a cornerstone material for organic synthesis.
Physical & Chemical Properties
2-Chloro-1-Fluoro-4-Iodobenzene is an organic compound, and its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, this substance may be in a liquid state, with a specific color, taste and shape. Its boiling point and melting point determine its physical state changes, which have a great impact on storage and use. The density is related to its floating and sinking in liquids. In terms of chemical properties, due to the presence of halogen atoms such as chlorine, fluorine, and iodine, the chemical activity is considerable. Chlorine atoms change the density of electron clouds in the benzene ring, which is prone to electrophilic substitution reactions; fluorine atoms have strong electronegativity, which affects molecular polarity and stability; iodine atoms are relatively active and can participate in substitution, addition and other reactions under certain conditions. All kinds of physical and chemical properties are widely used in organic synthesis, material science and other fields, and are the key raw materials for the preparation of special structural and functional
Technical Specifications & Labeling
Today there is a product called 2 - Chloro - 1 - Fluoro - 4 - Iodobenzene. To clarify its technical specifications and identification (product parameters), you should pay close attention.
The preparation of this product requires precise methods. All raw materials must be properly proportioned and the operation should also follow the procedures. In the reactor, control its temperature and pressure, so that the products can react smoothly, and its pure product can be obtained.
The product parameters involved in its labeling are crucial. Such as the number of purity and the amount of impurities, all need to be clearly identified in the label. And its shape, color and taste should also be remembered. In this way, the user can see at a glance, know its characteristics, and make good use of it.
Based on technical specifications, accurate identification is essential, and both are used to ensure that this product is suitable for the requirements and on the right track.
Preparation Method
Now to prepare 2-chloro-1-fluoro-4-iodobenzene, the method is as follows:
In terms of raw materials, fluorobenzene and the like need to be prepared. The first reaction step of the preparation method starts with fluorobenzene, and first encounters with chlorinated reagents. Under suitable temperature, pressure and catalytic conditions, a substitution reaction is carried out to make chlorine into the benzene ring to obtain 1-chloro-4-fluorobenzene.
Second, take 1-chloro-4-fluorobenzene and the iodine substitution reagent, according to a specific process, through the reaction of iodine into the benzene ring, then obtain 2-chloro-1-fluoro-4-iodobenzene.
In this process, temperature control, pressure control and catalytic mechanisms are essential. Temperature control is precise, and the reaction can be carried out in sequence, avoiding side reactions; pressure control is appropriate, and the reaction equilibrium is shifted; the catalytic mechanism is well set up, which can increase the reaction rate, reduce energy consumption, and yield, so as to obtain a good method for this product.
Chemical Reactions & Modifications
The rise of modern chemistry, exploring the principle of changes in various substances. For 2 - Chloro - 1 - Fluoro - 4 - Iodobenzene, its chemical reaction and modification are quite important to scholars.
Looking at its reaction, the properties of halogenated aromatics make the atoms of chlorine, fluorine and iodine above the benzene ring, or there is a nucleophilic substitution. In case of nucleophilic reagents, iodine atoms are often replaced by reagents first because of their high activity. This is a common reaction path.
As for modification, chemical means can be used to change its structure to obtain novelty. Or introduce other groups to change the electron cloud density of the benzene ring, and then change its chemical activity and physical properties. Or take advantage of external conditions such as light and heat to promote its isomerization and obtain different properties.
Chemists should study the mechanism in detail to understand the wonders of its reaction and modification, which are used in the chemical and pharmaceutical industries to increase its efficiency and extend its use. It is beneficial to the progress of science and technology.
Synonyms & Product Names
2-Chloro-1-fluoro-4-iodobenzene has the same name and the trade name
Fu 2-chloro-1-fluoro-4-iodobenzene, one of the chemical substances. In the academic community and the industry, its same name and trade name refer to each other, which cannot be ignored.
The same name depends on the chemical naming rules. This substance is named 2-chloro-1-fluoro-4-iodobenzene according to its atomic composition and connection method. This is common in the academic community, so that scholars can communicate accurately and correctly.
As for the product name, it varies according to the marketing and product characteristics of the merchant. Or highlight its purity, or emphasize its use, each has its own ingenuity. However, whether it is the same name or the product name, it is to identify the substance, which helps to distinguish and recognize. In the study of scholars, it is necessary to clarify their different titles in order to accurately quote them, which is correct for academic and practice.
Safety & Operational Standards
2-Chloro-1-fluoro-4-iodobenzene is also a chemical research product. It is related to safety and operating standards, and it is of paramount importance.
When preparing, all kinds of materials must be precisely measured. When handled in a well-ventilated place, it prevents the accumulation of toxic gases and harms people. The utensils used must be clean and intact, so as not to mix impurities and cause the product to be impure.
When operating, follow the procedures. The degree of heating must be carefully controlled, and the reactants may cause decomposition or explosion. When stirring, the rate should be uniform to make the reaction uniform. And do not touch objects with your hands, you must take them with instruments to prevent skin damage.
When storing, choose a cool, dry, and dark corner. Store it in a sealed container to prevent it from contacting air and water vapor and causing qualitative change. The logo is clear, remember its name, sex, and danger, so that people can see it and know it, so as not to misuse it.
In case of an accident, such as a leak, quickly evacuate everyone and prohibit fireworks. Small leaks should be covered with sand, collected and discarded in a proper place; large leaks should be reported to the official as soon as possible and listened to his command.
All in all, the safety and operating standards of 2-chloro-1-fluoro-4-iodobenzene should not be ignored throughout the chemical research process. Only by obeying them can we ensure that everything goes smoothly and people are safe.
Application Area
2-Chloro-1-fluoro-4-iodobenzene, this compound is useful in various fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help create special new drugs to treat various diseases. In the field of materials science, through delicate chemical modification, it can lay the foundation for the synthesis of new functional materials, endowing materials with specific electrical and optical properties. In the field of organic synthesis, chemists use its unique structure and reactivity to build a multi-component organic structure. Its value in many practical fields is like a shining star, illuminating the way forward for chemical research and application, and contributing to human well-being and technological progress.
Research & Development
The rise of modern chemistry, the study of matter and the search for Japanese essence. Today there is a thing called 2-Chloro-1-Fluoro-4-Iodobenzene. Our generation studied it to clarify its properties, explore its uses, and promote its development.
At first, the structure of chlorine, fluorine, and iodine atoms is connected to the benzene ring, and this unique structure gives it specific chemical activity. After various experiments, observe its reaction under different conditions. When encountering nucleophiles, halogen atoms on the benzene ring are easily replaced. This reaction mechanism is complex, which is the key to revealing its essence.
We also explore its physical properties, such as melting point, solubility, etc., which are of great significance in the selection, separation and purification of solvents in organic synthesis. It has great potential in the field of medicinal chemistry, or can be used as an intermediate to create new drugs and fight various diseases.
We should make unremitting efforts to deepen our understanding of 2-Chloro-1-Fluoro-4-Iodobenzene, expand its application, and promote progress in the field of chemistry for the benefit of the world.
Toxicity Research
Since modern times, chemical refinement has resulted in the emergence of various compounds. Today, there is 2-Chloro-1-Fluoro-4-Iodobenzene, and our generation takes toxicological research as the service to observe its properties in detail.
Looking at its structure, halogen atoms are combined with benzene rings, chlorine, fluorine and iodine coexist. Halogenated aromatic hydrocarbons are mostly toxic, or they can interfere with the biochemical path in organisms. It enters the organism, or interacts with macromolecules such as proteins and nucleic acids, causing changes in its structure and function.
After various experiments, using animals as models, observe the impact of 2-Chloro-1-Fluoro-4-Iodobenzene. It may damage the function of the liver and kidney, and the biochemical indicators are abnormal; or it may disturb nerve conduction and cause perverse behavior. However, the study of toxicology still needs to be in-depth, and the details of dose, time course, and metabolism need to be carefully examined to get the whole picture, which is the basis for protection and application.
Future Prospects
Husband 2 - Chloro - 1 - Fluoro - 4 - Iodobenzene, the thing of transformation is also. Today's characteristics are special, or it can be used for the opposite of general transformation. Before it is developed, it can be expected to be researched in the future, or it can be used for special effects to solve the pain of disease. Or it can be used for the development of materials, to help the development of new materials, so that the utensils are more efficient and convenient to use. In the process of synthesis, or in the process of synthesis, the method of synthesis is more and more exquisite. Our researchers, study the properties of this product, explore its capabilities, and hope to open up new territories that have not been transformed and benefit the world.
Where to Buy 2-Chloro-1-Fluoro-4-Iodobenzene in China?
As a trusted 2-Chloro-1-Fluoro-4-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-Chloro-1-Fluoro-4-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemistry of 2-chloro-1-fluoro-4-iodobenzene?
2-Chloro-1-fluoro-4-iodobenzene is also an organic compound. Its chemical properties are worth exploring.
In this compound, the presence of chlorine, fluorine and iodine halogen atoms endows it with unique properties. Halogen atoms have strong electronegativity, which causes changes in the electron cloud density distribution of benzene rings. From the perspective of electrophilic substitution reaction, halogen atoms are adjacent and para-localized groups. However, due to their strong electronegativity and a certain electron-absorbing induction effect, the reactivity is slightly different from that of benzene.
In nucleophilic substitution reactions, halogen atoms can be replaced by nucleophilic reagents. Although the fluorine atom has the strongest electronegativity, its C-F bond energy is large, and the substitution reaction is difficult to occur; the C-Cl and C-I bonds between chlorine and iodine atoms are relatively weak, and they are more susceptible to nucleophilic attack and substitution.
And because it contains a variety of halogen atoms, it can participate in the halogen atom exchange reaction. The reactivity of different halogen atoms is different, and the replacement of halogen atoms can be achieved under suitable conditions to obtain the desired compound.
Furthermore, 2-chloro-1-fluoro-4-iodobenzene can be used as a synthetic intermediate. After many reactions, various organic compounds with special functions can be derived, which have potential applications in medicine, pesticides, materials and other fields. The study of its chemical properties is of great significance to the development of organic synthetic chemistry.
What are the main uses of 2-chloro-1-fluoro-4-iodobenzene?
2-Chloro-1-fluoro-4-iodobenzene is also an organic compound. It has a wide range of uses and is often a key intermediate in the synthesis of drugs in the field of medicinal chemistry. Due to its unique molecular structure and active halogen atoms, it can undergo various chemical reactions to construct complex drug molecular structures, providing the possibility for the creation of new drugs.
It is also useful in the field of materials science. It can participate in the synthesis of organic materials with special functions, such as photoelectric materials. Its structural properties may endow materials with unique optical and electrical properties, and it is used in organic Light Emitting Diodes (OLEDs), organic solar cells and other devices to improve their performance. < Br >
In organic synthetic chemistry, it is an important synthetic building block. Through nucleophilic substitution, coupling reactions, etc., it reacts with many organic reagents to form carbon-carbon bonds and carbon-heteroatomic bonds, expand the complexity of molecules, prepare various organic compounds, and enrich the strategies and paths of organic synthesis.
Furthermore, in the field of pesticide chemistry, it may be an important raw material for the synthesis of new pesticides. After rational design and modification, the synthesized derivatives may have unique biological activities, showing efficient control effects on pests, diseases, etc., and contributing to the prevention and control of pests and diseases in agricultural production. Overall, 2-chloro-1-fluoro-4-iodobenzene is of great value in many fields, promoting the development of related disciplines and industries.
What are 2-chloro-1-fluoro-4-iodobenzene synthesis methods?
There are several common methods for preparing 2-chloro-1-fluoro-4-iodobenzene.
First, the halogenated aromatics are used as the starting material and the nucleophilic substitution reaction is achieved. First, take the halogenated benzene containing a suitable substituent, such as p-chlorofluorobenzene, and react with the iodizing reagent. The iodizing reagent can be selected from potassium iodide, sodium iodide, etc., in a suitable solvent, add a catalyst, such as a copper salt or a palladium salt catalyst, heat and stir to make the halogen exchange reaction occur, and then generate 2-chloro-1-fluoro-4-iodobenzene. In this reaction, the choice of solvent is quite critical. Commonly used are N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), etc., because of their good solubility to both reactants and catalysts, which is conducive to the reaction.
Second, starting from aryl boronic acid derivatives. First, aryl boronic acid containing specific substituents, such as 2-chloro-1-fluorophenylboronic acid, is prepared, and then reacted with iodide reagents under suitable conditions. The iodide reagent can use N-iodosuccinimide (NIS), etc., and react in organic solvents such as tetrahydrofuran (THF) or dichloromethane in the presence of bases. The role of the base is to activate the aryl boric acid, which prompts it to couple with the iodide reagent to form the target product 2-chloro-1-fluoro-4-iodobenzene.
Third, it is prepared by diazotization. First, aniline derivatives containing suitable substituents, such as 2-chloro-1-fluoro-4-aminobenzene, are converted into diazotically salts by diazotization. The diazotization reaction is usually formed at low temperature in the presence of inorganic acids such as hydrochloric acid or sulfuric acid and sodium nitrite. Then, the diazonium salt is reacted with iodizing reagents such as potassium iodide, and the diazonium group is replaced by an iodine atom to obtain 2-chloro-1-fluoro-4-iodobenzene. This process requires strict control of the reaction temperature to prevent the decomposition of the diazonium salt and affect the yield of the product.
All these methods have advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product, and choose the optimal method.
2-chloro-1-fluoro-4-iodobenzene What are the precautions during storage and transportation?
2-Chloro-1-fluoro-4-iodobenzene is one of the organic compounds. During storage and transportation, many matters must be paid attention to.
Bear the brunt, and the storage place must be cool and dry. This substance is afraid of moisture. If it is placed in a humid place, it is easy to deteriorate, or cause chemical reactions, which will damage its quality. And it is not appropriate for the temperature to be too high. High temperature may increase its volatilization, or even cause dangerous reactions. Therefore, it is crucial to choose a place with good ventilation and constant temperature.
Furthermore, it needs to be isolated from oxidants, strong bases and other substances when storing. 2-Chloro-1-fluoro-4-iodobenzene is chemically active, encounters with oxidants, or reacts violently, with the risk of fire and explosion; comes into contact with strong alkalis, or causes chemical reactions, changing its chemical structure and affecting use.
When transporting, the packaging must be solid and reliable. Select suitable packaging materials to prevent package damage due to vibration and collision during transportation, resulting in leakage. Leakage not only pollutes the environment, but also poses a threat to the safety of transporters.
At the same time, transportation vehicles need to be equipped with necessary emergency treatment equipment. In case of leakage, measures can be taken in time to reduce the harm. Transport personnel should also receive professional training and be familiar with the characteristics of this substance and emergency treatment methods to ensure the safety of transportation.
2-chloro-1-fluoro-4-iodobenzene impact on the environment and human health
2-Chloro-1-fluoro-4-iodobenzene is a genus of organohalogenated aromatic hydrocarbons. Its impact on the environment and human health cannot be ignored.
In the environment, 2-chloro-1-fluoro-4-iodobenzene is quite stable and difficult to degrade naturally. If released into the atmosphere, it can be transported over a long distance, causing contamination in a wider area. Its entry into water bodies will pollute water sources and cause great harm to aquatic organisms. Because of its fat solubility, it is easy to accumulate in aquatic organisms, and is transmitted and amplified through the food chain, endangering high-rise organisms. In soil, it can inhibit soil microbial activities, disturb soil ecological balance, and reduce soil fertility.
As for human health, this compound may enter the body through breathing, diet, skin contact, etc. It has potential neurotoxicity, or damages the nervous system, causes dizziness, headache, fatigue, memory loss, etc. Long-term exposure or increases the risk of neurodegenerative diseases. And there is a risk of reproductive toxicity, or affects the reproductive system, causing decreased reproductive capacity and abnormal fetal development. And because it is a halogenated aromatic hydrocarbon, or carcinogenic, long-term exposure can increase the chance of cancer.
Therefore, the use, production and discharge of 2-chloro-1-fluoro-4-iodobenzene should be strictly regulated, and effective prevention and control measures should be taken to reduce its harm to the environment and human health.