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2-chloro-3-iodopyridine, what is the main use of 98 +%
2-Chloro-3-iodopyridine, 98 +% This substance has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. Geinpyridine ring structure has unique stability and reactivity, and chlorine and iodine atoms can participate in a variety of chemical reactions. Such as nucleophilic substitution, chlorine or iodine atoms can be replaced by other functional groups, thereby constructing complex drug molecules, which are of great significance in the development of antibacterial and anti-tumor drugs.
In the field of materials science, 2-chloro-3-iodopyridine can be used to prepare special functional materials. By reacting with specific reagents, the pyridine structure is introduced to impart special properties such as light, electricity, and magnetism to the material. For example, the preparation of organic optoelectronic materials may have applications in the fields of Light Emitting Diode and solar cells.
In organic synthetic chemistry, it is an important starting material for the construction of more complex pyridine derivatives. With the different reactivity of chlorine and iodine atoms, the reaction can be carried out in a specific order to accurately construct the target molecular structure, enrich the strategies and paths of organic synthesis, and promote the research progress of organic chemistry.
2-chloro-3-iodopyridine, what are the physical properties of 98 +%
2-Chloro-3-iodopyridine, content 98 +%, its physical properties are as follows:
This substance is mostly solid at room temperature, and it may be white to off-white crystalline powder with fine and uniform quality. Its melting point is about a certain range, but the exact value varies depending on the measurement conditions, roughly in the melting point range of common organic compounds. This property is crucial for material identification and purity judgment.
When it comes to solubility, in polar organic solvents such as ethanol and acetone, 2-chloro-3-iodopyridine exhibits a certain solubility, due to the principle of "similar miscibility", its molecular structure is compatible with polar solvents, and the intermolecular force makes the two blend. In water, its solubility is poor. Water is a strong polar solvent, and the molecular polarity of 2-chloro-3-iodopyridine is relatively weak, so it is difficult to dissolve.
Its density is also an important physical property. Although the exact value is not detailed, it is speculated that the density should be greater than that of water based on similar chlorine and iodine heterocyclic compounds. This property is of great significance for studies involving liquid-liquid separation or the distribution of substances in mixed systems.
In addition, 2-chloro-3-iodopyridine is volatile to a certain extent, but the degree of volatilization is low. At room temperature and pressure, its volatilization rate is slow, but in high temperature or decompression environments, the volatilization rate may increase. Its vapor pressure is relatively small, reflecting the strong intermolecular forces and the greater difficulty of gas escape systems.
In summary, the physical properties of 2-chloro-3-iodopyridine, such as appearance, melting point, solubility, density, volatility, etc., lay the foundation for its application in organic synthesis, drug development, and other fields. Researchers can choose suitable reaction conditions and separation and purification methods accordingly.
2-chloro-3-iodopyridine, what is the 98 +% synthesis method?
To prepare 2-chloro-3-iodopyridine (purity above 98%), the following synthesis method can be followed.
The starting material is pyridine, because of its six-element nitrogen-containing heterocyclic structure, which is the skeleton basis of the target product. The pyridine is first chlorinated to introduce chlorine atoms. This step is usually achieved with chlorine gas or chlorine-containing reagents under appropriate catalyst and reaction conditions. If chlorine is used as the chlorine source, chlorine can replace the hydrogen atom on the pyridine ring when catalyzed by light or Lewis acid (such as aluminum trichloride). It is necessary to pay attention to the control of the reaction conditions. Due to the different activity of hydrogen at different positions on the pyridine ring, by adjusting the catalyst, temperature and the proportion of reactants, the chlorine atom is preferentially substituted over the 2-position to obtain 2-chloropyridine.
2-chloropyridine is obtained, and then the iodine substitution reaction is performed to introduce the iodine atom. This step can be done by a combination of iodizing reagents, such as iodine elemental substance and an appropriate oxidizing agent. Common oxidizing agents such as hydrogen peroxide or potassium persulfate, etc. In suitable solvents (such as dichloromethane, N, N-dimethylformamide, etc.), the oxidizing agent oxidizes iodine ions to active In the reaction, the polarity of the solvent, the reaction temperature and time have a great influence on the position and yield of iodine substitution. Through precise regulation, the iodine atom is substituted at the 3rd position, and then 2-chloro-3-iodopyridine is obtained.
After the reaction is completed, the product often contains impurities, which must be separated and purified. The product can be extracted with a suitable organic solvent by extraction method first, and the impurities can be preliminarily separated. Then, column chromatography is used to select the appropriate stationary phase (such as silica gel) and the mobile phase. According to the difference in the distribution coefficient between the product and the impurities in the stationary phase and the mobile phase, the two are separated to obtain high-purity 2-chloro-3-i Throughout the synthesis process, the precise control of reaction conditions at each step and the timely monitoring of the product are crucial, which are related to the yield and purity of the target product.
2-chloro-3-iodopyridine, 98 +% What to pay attention to when storing
2-Chloro-3-iodopyridine, content 98 +%. When this substance is stored, you should pay attention to everything. Cover because of its nature, it is related to the importance of survival.
First, avoid the disaster of water and fire. Water and fire are the great enemy of all things. This chemical substance is either flammable or interacts with water, causing danger. Therefore, it should be placed in a place away from water and fire, and it is fireproof and subject to water immersion.
Second, the temperature and humidity need to be adjusted. If the temperature is high, the substance is variable, or its quality is affected, or its properties are changed; the wet weight is not good, or it causes deliquescence, which impairs its purity. It should be stored in a cool and dry place to maintain its stability.
Furthermore, sealing is essential. When exposed to air, it comes into contact with oxygen, carbon dioxide and other gases, or starts to react and deteriorate. It must be stored in a sealed device to prevent air disturbance.
Also, store it in categories, and do not mix with other things. Chemical things, each with its own characteristics, mix or cause unwanted changes, and are dangerous. According to its chemistry, classify and store, and keep it safe.
and place it, when clearly marked. Write down its name, content, shelf life, etc., for easy reference, and prevent misuse, to avoid errors.
To sum up, pay attention, then 2-chloro-3-iodopyridine can be properly stored to protect its quality and avoid its risks.
2-chloro-3-iodopyridine, what is the market price range of 98 +%?
2-Chloro-3-iodopyridine, 98 +%, the market price range will vary due to many factors.
The market in Guanfu City, the source of raw materials, the difficulty of making, and the amount of demand all affect the price. If you find this product in the market, the price varies depending on the purchase quantity. If you buy it in small quantities, the price per gram may reach tens of gold. Due to small transactions, the cost and transportation costs are all concentrated in small quantities, so the price is high. If it is for industrial use, if you buy it in bulk, the price may be slightly reduced, but the price per kilogram may also be thousands of gold.
Its raw materials are not easy to harvest, the synthesis method is fine and complex, and professional techniques and specific agents are required, which all lead to rising costs and high prices. And those who seek it, either for the needs of scientific research or for the needs of pharmaceuticals, are critical to their use, and their prices are also stable.
Furthermore, the market changes are unpredictable. Sometimes raw materials are abundant, the supply exceeds the demand, and the price may drop; sometimes there is a shortage of supply, the demand exceeds the supply, and the price rises. And in different places, due to the difference in tax and the convenience of logistics, the price also varies. In summary, the price of 2-chloro-3-iodopyridine, 98 +%, is tens of gold per gram in small quantities and thousands of gold per kilogram in batches, but it does not fluctuate with market factors.
