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What are the chemical properties of 2-chloro-4- [3-iodo-1- (1-methylethyl) -1h-pyrazol-4-yl] -pyrimidine
2-Chloro-4- [3-iodine-1- (1-methylethyl) -1H-pyrazole-4-yl] -pyrimidine, this is an organic compound with unique chemical properties. The following is analyzed according to its structure:
- ** Physical properties **: Its normal appearance, melting point, boiling point, solubility, etc., often depend on intermolecular forces and functional groups. Contains chlorine, iodine and halogen atoms, or cause them to have a certain polarity, solubility in polar solvents or better than in non-polar solvents. However, the specific value must be determined experimentally, and it is difficult to predict accurately theoretically due to its complex structure.
- ** Chemical properties **:
- ** Halogen atom reactivity **: Both the 2-position chlorine atom and the 3-position iodine atom have high reactivity. Chlorine atoms can undergo nucleophilic substitution reactions, such as with nucleophiles such as sodium alcohol and amines. Chlorine atoms are replaced by corresponding groups to form new C-O or C-N bonds. Due to the electron-absorbing properties of halogen atoms, the connected carbon atoms are partially positively charged and vulnerable to attack by nucleophilic reagents. Although the reactivity of iodine atoms is slightly weaker than that of chlorine atoms, they can also participate in specific nucleophilic substitution or coupling reactions, such as the Ullman reaction, which can react with active hydrogen-containing compounds or metal-organic reagents.
- ** Reactivity of pyrazole ring **: 1- (1-methylethyl) -1H-pyrazole-4-yl moiety, pyrazole ring is aromatic and has high stability. However, the nitrogen atom on the ring has lone pair electrons and can participate in the reaction as an electron donor, such as reacting with acids to form salts, or coordinating with metal ions to form complexes. At the same time, the 3-iodine atom on the pyrazole ring can participate in the functional group conversion reaction related to the pyrazole ring, such as the reverse reaction of iodization reaction under suitable conditions to realize the removal or substitution of iodine atoms to modify the pyrazole ring structure.
- ** Reactivity of pyrimidine ring **: The pyrimidine ring is also aromatic, and the nitrogen atom on the ring also affects its reactivity. The pyrimidine ring can undergo electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The reaction check point is affected by the electronic effect of the substituent on the ring. In this compound, the electrophilic substitution reaction may selectively occur at a specific location of the pyrimidine ring due to the electronic effect of 2-chlorine atom and 4- [3-iodine-1- (1-methylethyl) -1H-pyrazole-4-yl]. In addition, pyrimidine cyclic nitrogen atoms can coordinate with metal ions or other Lewis acids, altering the chemical properties and reactivity of compounds.
What is the main use of 2-chloro-4- [3-iodo-1- (1-methylethyl) -1h-pyrazol-4-yl] -pyrimidine?
2-Chloro-4- [3-iodine-1- (1-methylethyl) -1H-pyrazole-4-yl] -pyrimidine, an organic compound. Its main use involves the field of pharmaceutical chemistry and organic synthesis.
In medicinal chemistry, such compounds are often used as potential pharmaceutical intermediates. The structure of Geiinpyrazole and pyrimidine is common in many bioactive molecules. Pyrazole rings have various biological activities, such as anti-inflammatory, antibacterial, and anti-tumor. Pyrimidine rings are also widely found in nucleic acids, vitamins, and many pharmaceutical molecules. In this compound, the two are connected, and chlorine and iodine substituents are added, or they are endowed with unique pharmacological properties. Researchers can use it as a starting material to modify and optimize the structure through various chemical reactions to develop new drugs with specific biological activities and curative effects.
In the field of organic synthesis, it is a key intermediate and can be used to construct more complex organic molecular structures. Because it contains active halogen atoms, such as chlorine and iodine, it can participate in nucleophilic substitution, coupling reactions, etc. By selecting suitable reaction conditions and reagents, chemists can react with various organic reagents, introduce different functional groups or structural fragments, and expand the complexity and diversity of molecules to meet the needs of different fields for special structural organic compounds.
In summary, 2-chloro-4- [3-iodine-1- (1-methylethyl) -1H-pyrazole-4-yl] -pyrimidine is of great value in the field of pharmaceutical research and development and organic synthesis, providing a key foundation for the creation of new drugs and the synthesis of complex organic molecules.
What are the synthesis methods of 2-chloro-4- [3-iodo-1- (1-methylethyl) -1h-pyrazol-4-yl] -pyrimidine
To obtain the synthesis method of 2-chloro-4- [3-iodine-1- (1-methylethyl) -1H-pyrazole-4-yl] -pyrimidine, the following method can be used.
First, the pyrazole ring needs to be constructed from suitable starting materials. 1 - (1 - methylethyl) hydrazine is selected as one of the starting materials, and it reacts with a suitable β-dicarbonyl compound under acidic or basic catalytic conditions to form 1 - (1 - methylethyl) -1H -pyrazole-3,4 -dicarboxylate. This reaction is like the beginning of building a pavilion, and the reaction temperature, time and material ratio need to be carefully controlled. If the temperature is too high or the time is too long, it may cause a cluster of side reactions; if the ratio is improper, the yield will be damaged.
Then, an ester group in 1- (1-methylethyl) -1H-pyrazole-3,4-dicarboxylic acid ester is selectively hydrolyzed, and then converted into a halide, such as by reacting with an iodizing reagent to introduce iodine atoms, to obtain 3-iodine-1- (1-methylethyl) -1H-pyrazole-4-carboxylic acid halide. In this step, a suitable iodizing reagent should be selected, and attention should be paid to the influence of the reaction environment on the iodine substitution reaction.
At the same time, another step should be taken to synthesize the pyrimidine ring part. Using 2-chloro-4-halogenated pyrimidine as raw material and reacting with nucleophilic reagents containing suitable substituents, intermediates connected to the target product pyrimidine ring were prepared. In this step, factors such as the activity of the nucleophilic reagent and the polarity of the reaction solvent all affect the success or failure of the reaction and the purity of the product.
Finally, 3-iodine-1- (1-methylethyl) -1H-pyrazole-4-carboxylic acid halide and pyrimidine ring intermediates are condensed in a suitable solvent in the presence of a suitable base. The strength of the base, the solubility and reactivity of the solvent are also crucial in this step. After the reaction is completed, the pure 2-chloro-4- [3-iodine-1- (1-methylethyl) -1H-pyrazole-4-yl] -pyrimidine product can be obtained by separation and purification methods, such as column chromatography, recrystallization, etc. Each step of the reaction requires careful operation like ancient craftsmen carved utensils to obtain satisfactory results.
In which fields is 2-chloro-4- [3-iodo-1- (1-methylethyl) -1h-pyrazol-4-yl] -pyrimidine used?
2-Chloro-4- [3-iodine-1- (1-methylethyl) -1H-pyrazole-4-yl] -pyrimidine, this compound has considerable applications in medicine, pesticides and other fields.
In the field of medicine, it may be a key intermediate for innovative drug development. Due to the unique structure of the compound, it may be able to specifically act on specific targets in organisms. For example, for some disease-related enzymes or receptors, after rational chemical modification, this compound can precisely bind to it and regulate abnormal biochemical processes in organisms, and is expected to become a new type of drug for the treatment of cancer, inflammation and other diseases. In the field of cancer treatment, it may inhibit the growth and spread of cancer cells by interfering with the targets related to the proliferation signaling pathway of cancer cells; in the field of inflammation treatment, it may regulate the release of inflammation-related cytokines and reduce the inflammatory response.
In the field of pesticides, the compound also has potential application value. With its unique mechanism of action against insects and plant pathogens, it may be developed as a new type of pesticide. For example, targeting specific pests' nervous system or digestive system targets, it interferes with the normal physiological functions of pests and plays an efficient insecticidal role; targeting plant pathogens, it may inhibit key physiological processes such as cell wall synthesis and nucleic acid metabolism, and achieve disease control, and has a small impact on the environment, which is in line with the needs of modern green agriculture development
In addition, in the field of materials science, this compound may be used in the preparation of some functional materials due to its unique electronic structure and chemical properties. For example, in the field of organic optoelectronic materials, or the optoelectronic properties of materials can be adjusted, providing new ideas for the research and development of new optoelectronic materials.
In summary, 2-chloro-4- [3-iodine-1- (1-methylethyl) -1H-pyrazole-4-yl] -pyrimidine has shown broad application prospects in many important fields. With the deepening of research, it is expected to bring new breakthroughs to the development of various fields.
What is the market outlook for 2-chloro-4- [3-iodo-1- (1-methylethyl) -1h-pyrazol-4-yl] -pyrimidine?
2-Chloro-4- [3-iodine-1- (1-methylethyl) -1H-pyrazole-4-yl] -pyrimidine, this compound is used in the field of medicine and chemical industry. The prospect is like the dawn of the morning, but the first glimmer contains infinite possibilities.
Looking at the current market, it is still emerging. In the field of scientific research, because of its unique chemical structure, it is like a mysterious rune, which has attracted researchers to explore the mysteries. It may be a key link in the path of innovative drug development, giving hope for conquering difficult diseases. For example, in the field of anti-tumor drug research and development, researchers hope to use its structural characteristics to build a bridge to precisely connect with tumor cell targets, in order to achieve high-efficiency and low-toxicity curative effects.
However, the road ahead for its market is also full of thorns. The complexity of the synthetic process is like a rugged and dangerous path, and the cost of raw materials is high, such as roadblocks, hindering the pace of large-scale production. And the market awareness is still shallow, it seems to be hidden in the fog, and downstream companies are not fully aware of its performance and application advantages.
To expand the market, multiple efforts are required. Developers should strive to optimize the synthesis process, overcome obstacles, and reduce costs; at the same time, strengthen publicity and promotion, dispel the fog, and enable more companies to gain insight into its potential. In this way, 2-chloro-4 - [3-iodine-1 - (1-methylethyl) -1H-pyrazole-4-yl] -pyrimidine is expected to bloom in the market, shining like a pearl.