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What is the main use of 2-chloro-4-iodo-6- (trifluoromethyl) pyridine?
2-Chloro-4-iodine-6- (trifluoromethyl) pyridine is an important category of organic compounds. It has a wide range of uses and is often a key intermediate in the synthesis of specific drugs in the field of medicinal chemistry. Taking the creation of antibacterial drugs as an example, this compound can introduce key functional groups through specific reaction steps to construct molecular structures with unique antibacterial activities, which can help the research and development of new antibacterial drugs and provide a possible path to deal with the problem of drug-resistant bacterial infections.
In the field of pesticide chemistry, it also plays a key role. It can be used as a starting material for the synthesis of high-efficiency and low-toxicity pesticides. After chemical modification and transformation, pesticides are given high selectivity and strong inhibitory ability against specific pests or diseases, which can help sustainable agricultural development, improve crop yield and quality, and reduce adverse effects on the environment.
Furthermore, in the field of materials science, due to its unique chemical structure and fluorine atomic properties, it can participate in the synthesis of functional materials. For example, in the preparation of organic optoelectronic materials, the introduction of this compound can optimize the electronic transmission performance and stability of materials, provide novel material options for the development of new optoelectronic devices, such as organic Light Emitting Diode (OLED), solar cells, etc., and promote the progress of materials science and related industries. In conclusion, 2-chloro-4-iodine-6-trifluoromethyl pyridine has important application value in many fields, and is an indispensable substance for the research of organic synthetic chemistry and the development of related industries.
What are the synthesis methods of 2-chloro-4-iodo-6- (trifluoromethyl) pyridine
To prepare 2-chloro-4-iodine-6- (trifluoromethyl) pyridine, the following methods can be used.
First, the compound containing the parent nucleus of pyridine is used as the starting material to introduce chlorine and iodine atoms by halogenation reaction, and trifluoromethyl atoms are introduced simultaneously or successively. For example, take 6- (trifluoromethyl) pyridine first, and after properly protecting the specific position, react with suitable chlorination reagents such as thionyl chloride and phosphorus oxychloride at the second position of the pyridine ring to obtain 2-chloro-6- (trifluoromethyl) pyridine. Subsequently, the product is iodized at the 4-position, selected iodine sources such as iodine elemental substance, N-iodosuccinimide (NIS), and combined with suitable catalysts, such as copper salts, under appropriate reaction conditions, the introduction of 4-position iodine atoms can be achieved, and the final product 2-chloro-4-iodine-6 - (trifluoromethyl) pyridine.
Second, to start with the strategy of constructing the pyridine ring. Select a suitable precursor compound to construct the pyridine ring through a multi-step reaction, and introduce chlorine, iodine and trifluoromethyl during or after the construction of the ring is completed. For example, nitrile compounds with appropriate substituents and carbonyl-containing compounds are used as starting materials to form pyridine rings through cyclization under basic conditions, and then chlorine, iodine and trifluoromethyl are gradually introduced according to the reactivity and localization effect of each substituent. First introduce more reactive substituents, such as trifluoromethyl, which can be introduced by nucleophilic substitution or electrophilic substitution. Then, by controlling the reaction conditions and selecting specific reagents, chlorine and iodine atoms are introduced at suitable positions.
Third, the coupling reaction catalyzed by transition metals can also be used. If there are substrates containing partial substituents on the pyridine ring, such as 2-chloro-6- (trifluoromethyl) pyridine halides, a palladium-catalyzed coupling reaction can be used to react with iodine reagents to achieve the introduction of 4 iodine atoms. Such coupling reaction conditions are mild and highly selective, which is helpful to improve the yield and purity of the target product. In each reaction process, attention should be paid to the precise control of reaction conditions, such as temperature, pH, reaction time, etc., and the separation and purification method should be reasonably selected according to the product characteristics and reaction steps to obtain high purity 2-chloro-4-iodine-6- (trifluoromethyl) pyridine.
What are the physical properties of 2-chloro-4-iodo-6- (trifluoromethyl) pyridine
2-Chloro-4-iodine-6- (trifluoromethyl) pyridine is an important compound in organic chemistry. Its physical properties are particularly critical and have a great impact on chemical, pharmaceutical research and development and other fields.
The appearance of the first word is usually white to light yellow crystalline powder, which is easy to store and use, and is more convenient for operation in many chemical reactions.
When it comes to the melting point, the melting point of this compound is moderate, about [X] ° C. The exact value of the melting point is of great significance for the identification of the purity of the compound. If the purity is high, the melting point range is narrow and approaches the theoretical value; if it contains impurities, the melting point is reduced and the melting range is widened. This property allows chemists to precisely control its purity and ensure the reliability of experiments and production.
The boiling point is also an important physical property, and its boiling point is about [X] ° C. The characteristics of boiling point play a significant role in the separation and purification of compounds. By distillation and other means, using the difference in boiling point, it can be effectively separated from the mixture to obtain high-purity products.
In terms of solubility, 2-chloro-4-iodine-6 - (trifluoromethyl) pyridine is soluble in some organic solvents, such as dichloromethane, chloroform, etc. The good solubility of organic solvents provides convenience for its participation in organic synthesis reactions. Because many organic reactions are carried out in solution, suitable solvents can fully contact the reactants, accelerate the reaction process, and improve the reaction efficiency.
In addition, its density is about [X] g/cm ³, and the physical property of density is indispensable when it comes to the measurement of substances and the ratio of reaction systems. Accurate density data helps chemists to accurately calculate the amount of reactants, ensure that the reaction proceeds according to the expected stoichiometric ratio, and then optimize the reaction results.
The physical properties of 2-chloro-4-iodine-6- (trifluoromethyl) pyridine are important in many fields such as organic synthesis and drug research and development, and are of great significance to promoting related scientific research and industrial production development.
What are the chemical properties of 2-chloro-4-iodo-6- (trifluoromethyl) pyridine
2-Chloro-4-iodine-6- (trifluoromethyl) pyridine is one of the organic compounds. Its chemical properties are unique and valuable to explore.
In this compound, functional groups such as chlorine, iodine and trifluoromethyl give it specificity. Chlorine atoms have certain electronegativity, which can affect the electron cloud distribution of molecules, and then play a role in their reactivity. In nucleophilic substitution reactions, chlorine atoms can act as leaving groups, opening pathways for the reaction.
Iodine atoms are relatively large, and their existence also affects the spatial structure and electronic properties of molecules. The introduction of iodine atoms may enhance the lipid solubility of molecules and exhibit unique chemical behaviors in some reactions.
Trifluoromethyl is a strong electron-absorbing group, which significantly affects the electron cloud density of the pyridine ring, causing the electron cloud of the pyridine ring to shift to the trifluoromethyl group, which makes the electrophilic substitution reaction on the pyridine ring change. Generally speaking, the electrophilic substitution is more likely to occur in the position where the electron cloud density is relatively high. And the strong electron-absorbing property of trifluoromethyl may enhance the stability of the compound.
In addition, 2-chloro-4-iodine-6- (trifluoromethyl) pyridine may have potential applications in the fields of medicine, pesticides and other fields because it contains multiple halogen atoms and special groups, or has certain biological activities. It may be able to participate in various organic synthesis reactions, and through appropriate reaction conditions, modify and modify the molecular structure to meet the needs of different fields.
In short, 2-chloro-4-iodine-6 - (trifluoromethyl) pyridine has rich and diverse chemical properties, and its special structure determines that it has important research and application significance in many fields of organic chemistry.
What is the price range of 2-chloro-4-iodo-6- (trifluoromethyl) pyridine in the market?
The price of 2-chloro-4-iodo-6- (trifluoromethyl) pyridine in Wuguanfu City is difficult to determine, and there are many reasons. The preparation of this compound also requires exquisite skills, and the price of raw materials, the preparation method, and the supply and demand of the market all affect its price.
If the raw materials are of high quality and wide sources, the price may be slightly flat; however, if they are rare and difficult to find, the price will rise. If the preparation method is good, the yield will be high, and the impurities will be less, the cost may drop, and the price will follow; if the technique is poor and the consumption is high, the price will be high.
And the supply and demand of the market, the demand is prosperous and the supply is small, and the price must go up; if the supply exceeds the demand, the price will fall. There is competition in the market, and various merchants compete to sell, and the price may become cheaper; if there is only one company, the price cannot be suppressed.
Therefore, the price is about the same, or it ranges from tens to hundreds of gold per gram. If you buy it in small quantities, it will be used for laboratory research, and the price may be slightly higher; if you ask for it in batches, it will be industrially prepared, and the price may be negotiated. However, this is only a rough estimate. The actual price should be subject to the quotations of various merchants in the market. If you consult the chemical material suppliers, you can get a definite