As a leading 2-Chloro-5-Iodo-3-(Trifluoromethyl)Pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 2-chloro-5-iodo-3- (trifluoromethyl) pyridine?
2-Chloro-5-iodine-3- (trifluoromethyl) pyridine, this is an organic compound. Looking at its physical properties, it is mostly in a solid state at room temperature, and its melting and boiling point is related to the intermolecular force. The molecule contains chlorine, iodine, trifluoromethyl and other groups, which have strong polarity and large intermolecular force, resulting in a relatively high melting point.
When it comes to appearance, or white to light yellow crystalline powder, this is due to the halogen atoms and special groups contained, under the action of light, showing such color. In terms of solubility, due to its polar groups, it should have good solubility in polar organic solvents such as dichloromethane, N, N-dimethylformamide; however, in water, due to the polarity of water and the polar matching of the compound is limited, and the hydrophobic part of the compound is affected, the solubility may be low.
Furthermore, its density is also affected by the molecular structure and atomic weight. The atomic weight of chlorine and iodine atoms in the molecule is relatively large, and trifluoromethyl has a specific spatial structure and mass, so its density is relatively large, or greater than that of common organic solvents. As for volatility, due to the large intermolecular force, coupled with the high boiling point and weak volatility, it is difficult to evaporate into the air at room temperature and pressure.
In summary, the physical properties of 2-chloro-5-iodine-3- (trifluoromethyl) pyridine are determined by its unique molecular structure, and its application in organic synthesis and other fields is also closely related to its physical properties.
What are the chemical properties of 2-chloro-5-iodo-3- (trifluoromethyl) pyridine
2-Chloro-5-iodine-3- (trifluoromethyl) pyridine, an organic compound with unique chemical properties. Its chemical activity is quite significant and often varies due to the presence of chlorine, iodine and trifluoromethyl.
Let's talk about the chlorine atom first. It has a certain electronegativity. In chemical reactions, it can change the electron cloud density distribution of the pyridine ring. In this way, it affects the nucleophilic and electrophilic substitution reactions. The chlorine atom can be used as a leaving group to replace with the nucleophilic reagent to form new derivatives. For example, in reaction with sodium alcohol, chlorine is replaced by an alkoxy group to derive corresponding ethers.
Besides, iodine atoms, although iodine has a large atomic radius, its carbon-iodine bond energy is relatively small and it is easy to break. Under certain reaction conditions, iodine atoms can also be replaced by other groups, or participate in coupling reactions. For example, under the action of suitable catalysts with organic boric acid, Suzuki coupling reaction occurs to construct carbon-carbon bonds, which is an important means in organic synthesis.
And trifluoromethyl, because it contains three fluorine atoms, has strong electron absorption. This not only affects the electron cloud of the pyridine ring, but also enhances the fat solubility of the whole molecule. In pharmaceutical chemistry, the introduction of trifluoromethyl can often improve the biological activity, metabolic stability and membrane permeability of drug molecules. In chemical reactions, the electron cloud density of trifluoromethyl ortho or para-carbon atoms decreases, and electrophilic reagents are more likely to attack.
In addition, the compound has certain alkalinity due to the existence of pyridine rings. Pyridine nitrogen atoms can bind with protons or complex with metal ions, and have potential applications in catalysis and coordination chemistry. In organic synthesis, complex organic molecules can be synthesized through multi-step reactions by taking advantage of their alkalinity and the characteristics of each substituent. It is of great value in the fields of medicine, pesticides, and materials science.
What is the common synthesis method of 2-chloro-5-iodo-3- (trifluoromethyl) pyridine?
2-Chloro-5-iodine-3- (trifluoromethyl) pyridine is a common compound in organic synthesis. The synthesis method often follows a number of paths.
First, pyridine is used as the starting material and is prepared by a series of reactions such as halogenation and trifluoromethylation. First, under suitable reaction conditions, pyridine is halogenated with specific halogenating reagents such as chlorinating agents and iodizing agents, and chlorine atoms and iodine atoms are introduced at specific positions in the pyridine ring. This halogenation process requires fine regulation of reaction temperature, time, reagent ratio and other factors to achieve accurate substitution check points. Then, by means of trifluoromethylation reagents, such as trifluoromethyl halide or active reagents containing trifluoromethyl, under the action of appropriate catalysts, trifluoromethyl is introduced into the designated position of the pyridine ring to obtain the final target product.
Second, or from other pyridine derivatives containing specific substituents. For example, pyridine derivatives with trifluoromethyl are synthesized first, and then chlorine atoms and iodine atoms are introduced respectively through a selective halogenation step. In this process, the selectivity of the halogenation reaction is crucial. By selecting suitable halogenation reagents, reaction solvents and reaction conditions, such as light, heat, type and dosage of catalysts, etc., the substitution of chlorine atoms and iodine atoms at the desired position can be achieved to obtain 2-chloro-5-iodine-3- (trifluoromethyl) pyridine.
In addition, the synthesis strategy of transition metal catalysis can also be considered. Transition metal catalysts, such as palladium, copper and other metal complexes, can promote the coupling reaction between halogenated aromatics and nucleophiles containing trifluoromethyl groups. In the reaction system, halogenated pyridine derivatives are used as substrates and coupled with trifluoromethylating reagents under transition metal catalysis. At the same time, the activity and selectivity of metal catalysts may be enhanced by the synergistic effect of ligands, and then the target compounds can be synthesized efficiently. This method shows high synthesis efficiency and selectivity for the construction of pyridine compounds containing complex substituents, but the requirements for reaction conditions are also stricter, and the reaction parameters need to be carefully optimized to achieve the ideal synthesis effect.
In which fields is 2-chloro-5-iodo-3- (trifluoromethyl) pyridine used?
2-Chloro-5-iodine-3- (trifluoromethyl) pyridine is useful in various fields.
In the field of medicinal chemistry, this compound is often used as a key intermediate. Due to its unique structure, it contains groups such as chlorine, iodine and trifluoromethyl, which endow it with specific physical and chemical properties. It can be used as a starting material by organic synthesis, and complex molecular structures with biological activity can be constructed through various reactions, such as nucleophilic substitution and coupling reactions. Based on this, new drugs may be developed to target specific diseases and demonstrate therapeutic effects.
It also has potential uses in the field of materials science. Due to its fluorine-containing atoms, it can improve some properties of materials, such as chemical stability, thermal stability, etc. Or it can participate in the preparation of materials with special functions, such as those used in electronic devices and optical materials. This compound may be used as a functionalized monomer to polymerize to form polymer materials with special properties for specific electronic components to improve their performance and stability.
In the field of pesticide chemistry, compounds with such structures may be biologically active. The presence of chlorine, iodine atoms and trifluoromethyl may endow them with insecticidal, bactericidal or herbicidal properties. With appropriate modification and research and development, new pesticides with high efficiency, low toxicity and environmental friendliness may be developed to help agricultural pest control and improve crop yield and quality.
In summary, 2-chloro-5-iodine-3- (trifluoromethyl) pyridine has important applications in the fields of medicine, materials and pesticides, providing a key foundation for many scientific research and industrial development.
What is the market price range for 2-chloro-5-iodo-3- (trifluoromethyl) pyridine?
2-Chloro-5-iodine-3- (trifluoromethyl) pyridine, this substance is in the market, its price is uncertain, due to a variety of reasons.
First, the origin of the material is different. If the raw material required for its preparation is easy and sufficient, the price may be leveled; if the raw material is rare and difficult to find, or difficult to harvest and complex to make, the price will be high. If the origin of the raw material depends on changes, or is affected by the weather or policies, its supply and price will change, which also affects the price of 2-chloro-5-iodine-3- (trifluoromethyl) pyridine.
Second, the difference in the production method leads to different prices. The refined method can increase the yield, reduce energy consumption, reduce the cost, and the price may be low; if the method is clumsy and the consumption is huge and the production is small, the price will be high. And different workshops have different skills, which have an impact on quality and cost, and the price will also vary.
Third, the supply and demand of the city is related to the fluctuation of prices. If there is a strong demand for this product in the industry, but the supply is not enough, the price will rise; if you want less supply and more, the price will be depressed. For example, in the fields of medicine and chemical industry, the demand for it suddenly increases, but the production does not respond, and the price will rise; conversely, if the demand decreases and the production does not decrease, the price will fall.
Fourth, the operation and regulations of the business also affect the price. Large merchants can reduce the cost due to large regulations and wide channels, or obtain high-priced raw materials, and the price may be competitive; small merchants are on the contrary, the price may be higher.
In summary, the market price of 2-chloro-5-iodine-3 - (trifluoromethyl) pyridine is difficult to determine. To know the exact price, it is necessary to carefully investigate the raw materials, production methods, supply and demand, and the situation of merchants. Inquire about various vendors in the market, or you can approach their current prices.
