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What are the main uses of 2-chloro-5-iodo-3-trifluoromethylpyridine?
2-Chloro-5-iodine-3-trifluoromethyl pyridine is a key intermediate in the field of organic synthesis. It has a wide range of uses and plays an important role in the pharmaceutical, pesticide and other industries.
In the field of medicine, this compound is often used as a key raw material for the creation of new drugs. Due to the unique structure of the pyridine ring and the characteristics of halogen atoms, trifluoromethyl and other substituents, it has unique biological activity. By modifying and modifying its structure, chemists can prepare highly effective drugs for specific diseases. For example, innovative drugs for the treatment of cancer, cardiovascular diseases or neurological diseases may be developed. The special structure of this compound may interact with specific targets in vivo to achieve precise treatment, and can improve the efficacy and selectivity of the drug and reduce adverse reactions.
In the field of pesticides, 2-chloro-5-iodine-3-trifluoromethylpyridine is also an important intermediate for the preparation of high-performance pesticides. The presence of pyridine rings and various substituents endows it with good insecticidal, bactericidal or herbicidal activities. The pesticides synthesized on this basis may show excellent control effects against a variety of pests, pathogens and weeds. And because of its unique chemical structure, it may make pesticides have high stability and environmental adaptability, prolong their shelf life, reduce the frequency of use, and reduce their impact on the environment.
In addition, in the study of organic synthetic chemistry, 2-chloro-5-iodine-3-trifluoromethylpyridine is often used as a starting material for the construction of more complex organic molecules because it contains multiple reactive functional groups. Chemists can modify and expand its structure through various organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc., and then synthesize organic compounds with special structures and properties, providing rich research materials and possibilities for the development of organic synthetic chemistry.
What are 2-chloro-5-iodo-3-trifluoromethylpyridine synthesis methods?
To prepare 2-chloro-5-iodine-3-trifluoromethyl pyridine, the common synthesis methods are as follows.
First, the compound containing the pyridine ring is used as the starting material, and chlorine and iodine atoms are introduced through halogenation reaction, and trifluoromethylation reaction is added with trifluoromethyl. For example, first take a suitable pyridine derivative, use chlorinated reagents, such as thionyl chloride, phosphorus oxychloride, etc., under suitable reaction conditions, chlorination occurs at a specific position of the pyridine ring and chlorine atoms are introduced. Then, iodine substitution reagents, such as iodine elemental substance, N-iodosuccinimide, etc., are selected to introduce iodine atoms through iodine substitution reaction. Finally, with the help of trifluoromethylation reagents, such as trifluoromethyl magnesium halide, trifluoromethyl copper reagent, etc., the introduction of trifluoromethyl can be achieved, so the target product can be obtained.
Second, the strategy of gradually constructing pyridine rings can be adopted. First prepare intermediates containing specific substituents, and then cyclize to form pyridine rings. For example, using enamines or nitriles containing chlorine, iodine and trifluoromethyl as raw materials, under the action of acidic or basic catalysts, intramolecular cyclization occurs to construct pyridine rings, and then synthesize 2-chloro-5-iodine-3-trifluoromethylpyridine.
Third, the coupling reaction catalyzed by transition metals is used. Pyridine derivatives with suitable leaving groups (such as halogen atoms, borate ester groups, etc.) are selected, and chlorine sources, iodine sources and trifluoromethylation reagents are used. Under the catalysis of transition metal catalysts (such as palladium, nickel, etc.), chlorine, iodine and trifluoromethyl are precisely connected to the corresponding positions of the pyridine ring through coupling reaction to achieve the synthesis of the target product. This method has the advantages of mild reaction conditions and high selectivity.
During the synthesis process, a suitable synthesis method should be reasonably selected according to many factors such as the availability of starting materials, the difficulty of controlling the reaction conditions, and the purity requirements of the target product. At the same time, the reaction conditions of each step, such as temperature, solvent, catalyst dosage, etc., are carefully optimized to improve the reaction yield and selectivity, ensuring that the synthesis process is efficient and economical.
What are the physical properties of 2-chloro-5-iodo-3-trifluoromethylpyridine?
2-Chloro-5-iodine-3-trifluoromethylpyridine is a kind of organic compound. Its physical properties are particularly important, and it is related to its performance in various chemical processes and industrial applications.
First of all, its appearance, under normal conditions, this compound is generally colorless to light yellow liquid, clear and translucent, like morning dew, no noise. This appearance feature is convenient for preliminary identification by visual method.
As for the melting point, it is about -10 ° C, just like the temperature of a cold night. At this temperature, it gradually solidifies from liquid state, and the movement of molecules also slows down, and the arrangement is gradually regular. The boiling point is between 200 and 210 degrees Celsius. If it is burned with fire, to this temperature, the liquid boils and turns into a gaseous state. This property is very critical in the operation of separation and purification.
When it comes to solubility, 2-chloro-5-iodine-3-trifluoromethylpyridine is soluble in many organic solvents, such as halogenated hydrocarbons such as dichloromethane and chloroform, just like the water obtained by fish, the two blend with each other, and they are indistinguishable from each other. It also has good solubility in ether solvents such as ether and tetrahydrofuran, just like the fusion of water milk. However, in water, its solubility is very small, just like the incompatibility of oil and water. Due to the presence of fluorine, chlorine, iodine and other halogen atoms in the compound structure and trifluoromethyl groups, the molecular polarity is quite different from that of water.
In terms of density, it is about 1.9-2.0 g/cm ³, which is heavier than water. If it is poured into water, it will sink to the bottom of the water, such as a stone falling into the abyss. This density characteristic is an important consideration when dealing with operations such as stratification and extraction.
Its vapor pressure cannot be ignored either. At room temperature, the vapor pressure is relatively low, which means that its volatilization rate is relatively slow, and it is not like the volatile matter is fleeting. However, under the condition of heating or decompression, the vapor pressure increases and the volatilization accelerates.
In summary, the physical properties of 2-chloro-5-iodine-3-trifluoromethylpyridine, such as appearance, melting point, solubility, density, and vapor pressure, each have their own unique characteristics and are related to each other. They are of great significance in many fields such as organic synthesis and drug development. They are the cornerstones for relevant practitioners to control their chemical behavior and implement various operations.
What are the chemical properties of 2-chloro-5-iodo-3-trifluoromethylpyridine?
2-Chloro-5-iodine-3-trifluoromethylpyridine is one of the organic compounds. Its chemical properties are unique and valuable to explore.
In this compound, the presence of chlorine atoms, iodine atoms and trifluoromethyl groups endows it with various chemical activities. Chlorine atoms have certain electronegativity, which can affect the electron cloud distribution of molecules. In nucleophilic substitution reactions, chlorine atoms can act as leaving groups, providing an active check point for the reaction. Iodine atoms also play an important role. Although their atomic radius is large, they can also participate in a variety of chemical reactions, and some reactions of iodine have unique selectivity, which can provide the possibility for the synthesis of products with specific structures.
Trifluoromethyl is a strong electron-withdrawing group, and its introduction can significantly change the electron cloud density of the pyridine ring, reduce the electrophilic substitution activity of the pyridine ring, and increase the nucleophilic substitution activity. Due to the strong electron-withdrawing effect of trifluoromethyl, the acidity of this compound may be enhanced, and under alkaline conditions, specific acid-base reactions may occur.
Furthermore, due to the special structure of trifluoromethyl, compounds containing this group often have good thermal and chemical stability. 2-chloro-5-iodine-3-trifluoromethyl pyridine may also have this property, and it can maintain a relatively stable structure in some high temperatures or special chemical environments.
The diversity of its chemical properties makes it useful in the field of organic synthesis, such as drug synthesis, material synthesis, etc., and may play an important role in the creation of new functional materials and specific drugs. It provides a valuable basic structural unit.
What is the price range of 2-chloro-5-iodo-3-trifluoromethylpyridine in the market?
2-Chloro-5-iodine-3-trifluoromethylpyridine, an organic compound, is widely used in chemical, pharmaceutical and other fields. However, its market price range varies due to raw material costs, production processes, market supply and demand and many other factors, making it difficult to give an exact price.
In the past, the price of chemical products often fluctuated with the market. If raw materials are easily available, the process is mature, and the market supply is sufficient, the price may be relatively stable and in a low range; if raw materials are scarce, the process is complex, or the market demand surges and the supply is tight, the price will rise.
In the era of "Tiangong Kaiwu", although there is no such specific compound, the price of many of the materials mentioned in it is affected by the origin, output and use, and is similar to the change in the price of such compounds.
Now to know the exact price range of 2-chloro-5-iodine-3-trifluoromethylpyridine, when checking the chemical product trading platform, consulting the relevant manufacturers or distributors, the real-time market shall prevail. The market is constantly changing, and only the latest information can be used to compare the price.
