2-Chloro-5-Iodopyridine-3-Carboxylic Acid

2-Chloro-5-iodopyridine-3-carboxylic acid, which has a wide range of uses. In the field of medicinal chemistry, it can be called an important organic synthesis intermediate. Due to its unique chemical structure, it can participate in many key chemical reactions, thereby assisting in the synthesis of a wide variety of pharmaceutical active ingredients.
For example, in the research and development of antibacterial drugs, with its structural characteristics, it can effectively build a molecular skeleton with antibacterial activity, laying the foundation for the development of new antibacterial drugs. It can also play a key role in the exploration of anti-tumor drugs, or it can be combined with other active groups through specific reactions to prepare compounds with targeted inhibitory effects on tumor cells.
In the field of materials science, it also has its uses. Or it can be used as a synthetic raw material for functional materials, giving the material special properties. For example, in the synthesis of optoelectronic materials, the material is endowed with unique optical or electrical properties by its structure, and then applied to new display technologies or optoelectronic devices.
In the field of pesticide chemistry, it is also indispensable. It can be used as an important intermediate for the synthesis of efficient and low-toxicity pesticides. Through ingenious design of reactions, pesticide products with efficient killing effect on pests and low impact on the environment can be prepared to meet the needs of modern agriculture for green and environmentally friendly pesticides.
In summary, 2-chloro-5-iodopyridine-3-carboxylic acids have important uses in many fields such as medicine, materials, and pesticides, and are of great significance for promoting the development of related fields.

To prepare 2-chloro-5-iodopyridine-3-carboxylic acid, the method of organic synthesis is often followed. The methods vary, and the following are common methods.
First, pyridine-3-carboxylic acid is used as the starting material. Before in a suitable solvent, under specific reaction conditions, chlorine reagents such as thionyl chloride and phosphorus oxychloride are used to carry out chlorination reaction, and chlorine atoms are introduced into the second position of the pyridine ring to obtain 2-chloropyridine-3-carboxylic acid. Subsequently, a suitable iodine substitution reagent, such as N-iodosuccinimide (NIS), is selected, and 2-chloropyridine-3-carboxylic acid is iodized at 5 positions in a suitable catalyst and reaction environment, and the final target product is 2-chloro-5-iodopyridine-3-carboxylic acid.
Second, 2-chloropyridine can also be used as the starting material. Carboxylation is carried out first, and carboxyl groups are introduced at 3 positions. This step can be achieved by the Grignard reagent method or palladium-catalyzed carbonylation. After obtaining 2-chloropyridine-3-carboxylic acid, 2-chloro-5-iodopyridine-3-carboxylic acid was prepared by introducing iodine atom at the 5th position with iodine substitution reagent as above.
Third, starting from 5-iodopyridine-3-carboxylic acid, chlorine atom was introduced at the 2nd position through chlorination reaction. In this process, according to the reactivity and selectivity, the chlorination reagent and reaction conditions were reasonably selected, and the target compound could also be successfully synthesized.
Each method has its advantages and disadvantages, and it is necessary to comprehensively weigh the availability of raw materials, the difficulty of reaction, the level of yield and cost to choose the most suitable synthesis path.

2-Chloro-5-iodopyridine-3-carboxylic acid, this is an organic compound. Its physical properties are quite important and are related to many fields of chemical applications.
Looking at its morphology, under room temperature and pressure, it is mostly in a solid state. Due to the existence of various forces between molecules, such as van der Waals forces and hydrogen bonds, the molecules are arranged in an orderly manner to form a solid state structure.
The melting point is a key parameter for considering the properties of this compound. After experimental determination, its melting point is within a certain range, and this value reflects the firmness of the bonding between molecules. A higher melting point means that the intermolecular forces are strong, and more energy is required to disintegrate its lattice structure and turn it into a liquid state.
Solubility is also an important physical property. In common organic solvents, such as ethanol and acetone, their solubility varies. In polar organic solvents, because the compound molecules have a certain polarity, they can form hydrogen bonds or dipole-dipole interactions with polar solvent molecules, so they exhibit a certain solubility. However, in non-polar solvents, such as n-hexane, due to the large difference between polar and non-polar solvents, the interaction force is weak, and the solubility is very low.
Furthermore, its density cannot be ignored. The density value indicates the mass of the substance per unit volume, and this property has a significant impact when mixed with other substances or carried out separation operations. By accurately measuring the density, it can help to determine the purity of the compound and its behavior in a specific system.
In addition, the color and odor of the compound also belong to the category of physical properties. Usually, its color may be colorless to light yellow, and the odor is relatively weak. Although these properties are not of quantitative significance like melting point and solubility, they play an important role in practical operation and identification.
In short, the physical properties of 2-chloro-5-iodopyridine-3-carboxylic acids, such as morphology, melting point, solubility, density, color and odor, are of crucial value for their application and research in many fields such as organic synthesis and drug development.

2-Chloro-5-iodopyridine-3-carboxylic acid, this is an organic compound with many unique chemical properties.
First, the acidity is significant. Its molecule contains a carboxyl group (-COOH). Under suitable conditions, the carboxyl group can be dissociated from hydrogen ions (H 🥰), showing acidity. It can neutralize with bases to form corresponding carboxylic salts and water. For example, react with sodium hydroxide (NaOH) to form 2-chloro-5-iodopyridine-3-carboxylate sodium and water. This acidic property can be used in organic synthesis to adjust the pH of the reaction system, or as an intermediate to participate in salt-forming reactions to change the solubility and stability of compounds.
Second, the halogenated group is active. The compound contains two halogen atoms of chlorine (Cl) and iodine (I), and the halogen atom endows it with higher reactivity. In the nucleophilic substitution reaction, the halogen atom is easily replaced by the nucleophilic reagent. For example, under suitable nucleophilic reagents and reaction conditions, the chlorine atom or iodine atom can be replaced by hydroxyl (-OH), amino (-NH ²), etc., to construct more complex pyridine derivatives. This property makes 2-chloro-5-iodopyridine-3-carboxylic acid an important raw material for organic synthesis, which is used to create functional compounds such as drugs and pesticides.
Third, the conjugate system is stable. The pyridine ring forms a conjugated system, which imparts certain stability to the compound. However, the conjugated system can also participate in the electron transfer process, affecting the spectral properties and reactivity of the compound. For example, in photochemical reactions or redox reactions involving electron transfer, the conjugated system can play a role, making the compound exhibit a unique reaction path and product.
Fourth, a variety of organic reactions can occur. In addition to the above nucleophilic substitution and neutralization reactions, it can also participate in esterification reactions. Carboxyl groups react with alcohols under the action of catalysts to form corresponding ester compounds. This reaction is widely used in the field of fragrance and drug synthesis. At the same time, the halogen atom on the pyridine ring can participate in metal-catalyzed coupling reactions, such as Suzuki coupling, Stille coupling, etc., to realize the construction of carbon-carbon bonds of pyridine derivatives, greatly expanding its application in organic synthesis.
In short, 2-chloro-5-iodopyridine-3-carboxylic acids play an important role in the field of organic chemistry due to their acidity, halogenated group activity, conjugated system and diverse reactivity, providing a key starting point and path for the synthesis of many organic compounds.

Fu 2-chloro-5-iodopyridine-3-carboxylic acid is also an organic compound. It is not easy to know its market price range. The price often varies due to many factors, such as the price of raw materials, the difficulty of synthesis, the situation of supply and demand, and the competition in the market.
Looking at the market in the past, the price of these fine chemicals may vary due to differences in production processes. If complicated steps and rare raw materials are required to be prepared, the price must be high. However, there are also those whose prices fall due to the expansion of production scale and technological innovation.
In the past, in the chemical product market, the price of similar halogenated heterocyclic carboxylic acid compounds fluctuated greatly due to the type, location and other substituents of halogen atoms. In terms of pyridine carboxylic acid compounds containing chlorine and iodine, the price may range from a few yuan per gram to several hundred yuan. If the quality is high and the purity is extremely high, it may be more expensive for high-end pharmaceutical research and development or special fine chemical fields.
However, today, the specific price range of 2-chloro-5-iodine pyridine-3-carboxylic acid is difficult to determine. To obtain an accurate price, it is necessary to consult chemical raw material suppliers and chemical trading platforms, and carefully examine the current market conditions in order to obtain an approximate price range.