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2-chloro-5-iodopyridine, what is 98% used for?
2-Chloro-5-iodopyridine, with a purity of 98%, has a wide range of uses. In the field of organic synthesis, this is a crucial intermediate. Due to its unique molecular structure, chlorine and iodine atoms give them special reactivity, and can interact with many reagents through various chemical reactions to construct more complex organic compounds.
In the field of medicinal chemistry, it is often used as a starting material to prepare pharmaceutical molecules with specific pharmacological activities through carefully designed synthetic routes. For example, in the development of small molecule drugs targeting specific disease targets, 2-chloro-5-iodopyridine can be used as a key structural fragment. By coupling with other compounds containing nitrogen, oxygen or sulfur functional groups, lead compounds with potential therapeutic effects can be obtained, laying the foundation for new drug development.
In the field of materials science, it also has its uses. Can participate in the preparation of functional organic materials, such as organic optoelectronic materials. By introducing it into a conjugated system through an appropriate chemical reaction, the photoelectric properties of the material, such as fluorescence emission wavelength, carrier transmission capacity, etc., can be adjusted to meet the needs of different photoelectric application scenarios, such as the preparation of organic Light Emitting Diode (OLED), organic solar cells and other devices.
In addition, in pesticide chemistry, 2-chloro-5-iodopyridine can be used to synthesize new pesticides. Using its reactivity, compounds with high insecticidal, bactericidal or herbicidal activities can be constructed to provide more effective protection means for agricultural production, and help improve the yield and quality of crops. In conclusion, 2-chloro-5-iodopyridine has shown indispensable value in many fields due to its unique chemical properties, promoting the continuous development of related disciplines and industries.
2-chloro-5-iodopyridine, what are the physical properties of 98%
2-Chloro-5-iodopyridine, content 98%, its physical properties are as follows:
This substance is mostly solid at room temperature, but the specific physical state is greatly affected by environmental factors. Looking at its color, it is often off-white to light yellow, and this color state characteristic can help to identify it preliminarily.
The value of the melting point is about 48-52 ° C. This temperature range indicates that it will gradually melt from solid to liquid in this area. This melting point characteristic is of great significance in the separation, purification and identification of substances.
In terms of boiling point, it is about 255-257 ° C. At this temperature, the substance will change from liquid to gaseous state. This boiling point data is a key reference index in chemical operations such as distillation.
Its density is about 1.993 g/cm ³. This value reflects the mass of the substance per unit volume. It is extremely important for operations involving volume and mass conversion, such as quantitative access, reactant ratio, etc.
In terms of solubility, 2-chloro-5-iodopyridine is insoluble in water, but soluble in common organic solvents such as dichloromethane, chloroform, ethanol, ether, etc. This solubility characteristic plays a decisive role in the solvent selection, product separation and purification steps of organic synthesis reactions.
In addition, the chemical properties of this substance are relatively stable at room temperature and pressure. In case of open flame or hot topic, there is a risk of ignition, and its vapor can be mixed with air to form an explosive mixture. Therefore, during storage and use, it is necessary to follow strict safety regulations, avoid open flames and hot topics, and place it in a well-ventilated place for safety.
2-chloro-5-iodopyridine, what are the chemical properties of 98%
2-Chloro-5-iodopyridine, content 98%, this compound has many chemical properties. Its appearance may be a crystalline powder, due to the presence of halogen atoms, it shows a certain polarity, which affects its solubility. It may be well dissolved in organic solvents such as dichloromethane and N, N-dimethylformamide, but its solubility in water may be poor.
From the perspective of reactivity, both chlorine and iodine atoms are active check points. Chlorine atoms can undergo nucleophilic substitution reactions. Nucleophilic reagents such as alkoxides and amines can replace chlorine atoms under suitable conditions to generate corresponding ether or amine derivatives. Iodine atoms are also highly active and can participate in metal-catalyzed coupling reactions, such as Suzuki coupling, Stille coupling, etc. In Suzuki coupling, carbon-carbon bonds are formed with borate-containing compounds under the action of palladium catalysts and bases, and complex pyridine derivatives are constructed. This reaction is widely used in drug synthesis and materials science.
In addition, 2-chloro-5-iodine pyridine pyridine rings are aromatic and can undergo electrophilic substitution reactions. Due to the electron-absorbing effect of chlorine and iodine, the electron cloud density of the pyridine ring decreases, the electrophilic substitution reaction activity is lower than that of the benzene ring, and the substitution check point is affected by the group positioning effect, and the reaction mostly occurs at the position of relatively high electron cloud density.
In terms of its stability, it may be relatively stable at room temperature and pressure, but it may change in structure under strong oxidizing agent, reducing agent or specific reaction conditions. Thermal stability also needs to be considered. At high temperature or decomposition, it triggers reactions such as halogen atom removal. In short, 2-chloro-5-iodine pyridine is rich in chemical properties and is an important intermediate in organic synthesis. Rational use of its properties can create a variety of organic compounds.
2-chloro-5-iodopyridine, what are the 98% synthetic methods
To prepare 2-chloro-5-iodine pyridine, the purity is 98%, and there are many synthesis methods. The following are common ones.
First, pyridine is used as the initial raw material. First, pyridine and chlorine are used under suitable reaction conditions. Chlorine atoms can selectively replace hydrogen atoms at specific positions on the pyridine ring to obtain 2-chloropyridine. This reaction requires fine regulation of reaction temperature, chlorine gas penetration and reaction time to prevent over-chlorination. Subsequently, 2-chloropyridine is reacted with iodine sources (such as potassium iodide, etc.) in the presence of suitable solvents and catalysts. Copper salts are often used as catalysts. In an alkaline environment, iodine ions will replace chlorine atoms at specific positions of 2-chloropyridine to form 2-chloro-5-iodopyridine. Pay attention to the effects of the pH of the reaction system, the amount of catalyst and the reaction temperature on the reaction process and product purity.
Second, the corresponding pyridine derivative can also be used as a starting material. For example, if there is a pyridine derivative with suitable substituents, chlorine atoms and iodine atoms can be gradually introduced through a specific functional group conversion reaction. Chlorine atoms can be introduced into the pyridine ring through a suitable nucleophilic substitution reaction or other organic reactions, and then iodine atoms can be introduced into the desired position by a method similar to the above. In this process, it is crucial to control the reaction conditions. Different substituents have an impact on the activity and selectivity of subsequent reactions. It is necessary to rationally design the reaction steps and conditions according to the structural characteristics of specific compounds to achieve high purity synthesis of the target product.
2-chloro-5-iodopyridine, what is the price range of 98% in the market?
2-Chloro-5-iodopyridine, with a content of 98%, the market price range is difficult to determine with certainty. The price between markets often changes due to many reasons, such as the amount of purchase, the source of goods, the difference in time, the difference in place, the trend of demand and supply, and even the policy of traders.
If the purchase quantity is quite large, the supplier of the goods may reduce the warehouse or expand the sales, and the price is excellent, the quantity is large and the price is appropriate, which is reasonable. And the cost of production is different in different places where the goods are sent, and the cost of transportation is different, which also makes the price different. In spring and autumn, or due to the light and prosperous industry, the price also rises and falls.
In the land of Kyoto, commerce is concentrated and competitive, and the price may be flat; in remote cities, the goods are not easy, and the price may be a little high. If the demand exceeds the supply, the price will rise; if the supply exceeds the demand, the price will be depressed. Traders want to occupy the market and compete for customers, or implement sales promotion methods, the price will also change accordingly.
Generally speaking, if you ask for 2-chloro-5-iodopyridine in the market, with a content of 98%, the price per gram may be between tens of dollars and hundreds of dollars. However, this is only the number of years. The actual price needs to be consulted in detail.
