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What is the chemical structure of 2 '-deoxy-5-iodouridine 3', 5 '-diacetate?
2% 27 - deoxy - 5 - iodouridine + 3% 27% 2C5% 27 - diacetate is also a compound of the chemical formula C < unk > H < unk > < unk > IN < unk > O < unk >. The molecule contains a pyrimidine, which is the basic framework of the pyrimidine group. The 5 - iodinuridine part is substituted with an iodine atom at position 5 of the pyrimidine, and an oxy-ribosyl group at position 2. The ribosyl group is N-glycoside.
Furthermore, at positions 3% 27 and 5% 27, there are monoacetate groups. The presence of this diacetate group has a significant impact on the properties of the compound. Its introduction into the lipid solubility of the enhancing molecule also affects its solubility and chemical reactivity in different solubilities.
The delicate nature of this compound makes it valuable in the field of multi-biological and chemical research. For example, in the study of antiviral compounds, because of its similarity to natural nucleotides, it can dry the synthesis of viral nucleic acids, so it has antiviral properties. Its special chemical properties also provide interesting research images for synthesizers, which can be used to explore new synthetic methods and antiviral systems.
What are the main uses of 2 '-deoxy-5-iodouridine 3', 5 '-diacetate
2% 27-deoxy-5-iodouridine + 3% 27% 2C5% 27-diacetate, that is, 2 '-deoxy-5-iodouridine-3', 5 '-diacetate, is an organic compound. Its main uses are quite extensive, and it has many applications in the field of medical chemistry.
In the process of drug development, it is often used as a key intermediate for antiviral drugs. Due to its structural characteristics, it can participate in the process of viral nucleic acid synthesis, and interfere with the replication of viruses through specific reactions, thus providing an important cornerstone for the creation of antiviral agents. For example, in the study of some DNA virus infections, this compound can hinder the normal synthesis and transmission of viral genetic materials through its unique chemical mechanism, and then it is expected to become an effective pharmaceutical ingredient against such virus infections.
In the field of biochemical research, 2 '-deoxy-5-iodouridine-3', 5 '-diacetate also plays an important role. Because it can mimic nucleic acid constituent units, it is often used to explore biochemical processes such as nucleic acid metabolism pathways and cell proliferation mechanisms. By observing the changes in cell uptake, metabolism and subsequent cell physiological activities of the compound, researchers can gain in-depth insights into the complex physiological mechanisms related to nucleic acids in cells, providing a foundation for basic research in life science.
Furthermore, in the field of organic synthesis, this compound is often an important starting material for the synthesis of more complex nucleoside analogs or bioactive molecules due to its unique structure and reactivity. With the exquisite skills of organic synthesis, structural modification and derivatization, a series of compounds with novel biological activities or unique functions can be created to meet the needs of medicine, agriculture, materials and other fields.
What is the synthesis method of 2 '-deoxy-5-iodouridine 3', 5 '-diacetate
The synthesis of 2% 27-deoxy-5-iodouridine-3% 27,5% 27-diacetate is a key research point in the field of organic synthesis. Its synthesis path requires many delicate chemical steps and techniques to achieve.
First, 5-iodouracil should be used as the starting material. This raw material can be reacted with a suitable protecting group reagent to protect the specific hydroxyl group of uracil from unnecessary participation in subsequent reactions and cause the reaction path to deviate. For example, an acetylating reagent can be used to acetylate the 3% 27 and 5% 27 hydroxyl groups of uracil to form the corresponding acetate protective structure. This step of the reaction often needs to be carried out in a suitable organic solvent, such as dichloromethane, and the reaction system needs to maintain a specific pH and temperature. Generally, under mild heating conditions, the catalyst amount of base or acid is used as the catalyst to promote the efficient advancement of the reaction.
Second, after the introduction of the protective group, the protected 5-iodouracil is reacted with the deoxyribose derivative. This reaction is the core step in the construction of the 2% 27-deoxyribonucleoside structure. Usually, higher active deoxyribose derivatives are selected, such as those with appropriate leaving groups. During the reaction, the specific position of the deoxyribose derivative is connected to 5-iodouracil by means of the nucleophilic substitution reaction mechanism. The success of this step is highly dependent on the precise regulation of reaction conditions, such as reaction temperature, reaction time, and molar ratio of the reactants. Generally speaking, the reaction can occur smoothly under the protective atmosphere of anhydrous and oxygen-free inert gas and catalyzed by a specific metal catalyst to generate the target 2% 27-deoxy-5-iodouridine-3% 27,5% 27-diacetate precursor.
Furthermore, after the precursor is generated, the protective group needs to be removed. This step aims to restore the original hydroxyl structure of 2% 27-deoxy-5-iodouridine, while retaining the 3% 27,5% 27-diacetate structure. Specific deprotective reagents can be selected to selectively remove protective groups under mild reaction conditions without affecting the integrity of other structures. Finally, through fine separation and purification steps, such as column chromatography, recrystallization, etc., high-purity 2% 27-deoxy-5-iodouridine-3% 27,5% 27-diacetate products can be obtained.
Overall, the synthesis method, each step is interconnected, and the selection of reaction conditions and reagents requires strict requirements. Only careful operation can successfully prepare this important organic compound.
How stable is 2 '-deoxy-5-iodouridine 3', 5 '-diacetate?
2% 27 - deoxy - 5 - iodouridine 3% 27,5% 27 - diacetate is a kind of organic compound. Its stability is related to many aspects, and it varies under different environmental conditions.
This compound is not stable when exposed to light. Light can cause electron excitation in its molecular structure, causing chemical bond breakage or rearrangement, thereby promoting decomposition reactions. If left in light for a long time, its composition may change, reducing its purity and efficacy.
Temperature is also a key factor affecting its stability. High temperature will intensify molecular motion, enhance the collision frequency and energy between molecules, and accelerate the chemical reaction process. If the temperature is too high, 2% 27-deoxy-5-iodouridine 3% 27,5% 27-diacetate may deteriorate due to thermal decomposition, its chemical structure will be damaged, and its original properties will be lost.
Humidity also plays a role in its stability. When the ambient humidity is too high, water molecules may participate in its chemical reactions, or act as a reaction medium to accelerate reactions such as hydrolysis, resulting in structural changes of compounds and affecting their stability.
When storing and using 2% 27-deoxy-5-iodouridine 3% 27,5% 27-diacetate, every effort should be made to avoid light and place it in a low temperature and dry place. In this way, it can effectively maintain its stability, ensure that it functions normally in related applications, and avoid deviations in experiments or production due to stability issues.
2 '-deoxy-5-iodouridine 3', 5 '-diacetate in the market price range
I don't know the price range of 2 '-deoxy-5-iodouridine 3', 5 '-diacetate in the market. The price of various products in the market often changes due to many reasons, such as origin, quality, supply and demand, season and merchant's pricing. For details, please consult a pharmaceutical store, chemical material supplier, or on a business information platform or industry website. In this way, you can get a close price range. And this product may involve special controls. When buying and selling, you must abide by relevant laws and procedures to prevent violations.