What is the main use of 2 '-deoxy-5-iodouridine?

The main use of 2% 27-deoxy-5-iodouridine is particularly critical. This substance is often used as an antiviral medicine in the field of medicine. Because it can interfere with the synthesis of viral nucleic acid through a specific biochemical pathway, thereby inhibiting the reproduction and growth of viruses.

In the past, doctors struggled to fight viral infections. The advent of 2% 27-deoxy-5-iodouridine is like a cloud that has opened up. In the case of herpes virus infection, it can precisely exert force and penetrate into the cells parasitized by the virus. With its structural characteristics, when the virus nucleic acid is synthesized, clever intervention makes the transmission of the virus's genetic information blocked, making it difficult to replicate itself smoothly. Ultimately, the proliferation momentum of the pathogenic virus is suppressed, and the symptoms of the patient are also relieved.

Furthermore, in the process of scientific research, 2% 27-deoxy-5-iodouridine is also indispensable. With its unique properties, researchers can deeply analyze the life course of the virus and the mystery of nucleic acid synthesis, open up new paths for the development of antiviral drugs, and find more subtle treatment strategies to solve the pain of many patients and benefit the common people.

What are the side effects of 2 '-deoxy-5-iodouridine

2% 27-deoxy-5-iodouridine, a side effect of this medicine, needs to be detailed. Gu Yun: "Medication is like using soldiers, knowing each other and knowing each other, and preventing danger in a hundred battles." Now describe its side effect to make sense.

First, the phenomenon of bone marrow suppression often appears. This medicine is applied to the human body, or disturbs the normal ability of bone marrow, causing a decrease in the number of white blood cells and platelets. Just like the fertility of the field is damaged, the growth of grains is blocked. If white blood cells drop, the body's power to resist external evil is weak, and people are prone to various diseases. The symptoms of cold and heat exchanges and body fatigue are common. The number of platelets is small, the coagulation function is unhealthy, or there is a risk of bleeding, and the skin ecchymosis, bleeding gums, and epistaxis can appear.

Second, gastrointestinal diseases are not uncommon. After the drug is introduced into the body, it may stimulate the stomach and intestines, causing nausea and vomiting. This is the inversion of qi in the stomach and intestines, like the water of a river, which should flow downstream, but appears to be reflux. And it may also be a symptom of diarrhea, with abnormal conduction of the intestines and organs, and the normal transportation and transformation of water and grain essence. People are tired and fatigued, and their qi and blood biochemistry are deficient.

Third, local reactions also need to be paid attention to. If this medicine is used externally, or where it is used, you may see redness, swelling, The skin should be calm, and the stimulation of the medicine is like a stone entering the water, and the waves rise. During intravenous injection, it may cause phlebitis, and the meridians are like ditches. It is blocked due to the stimulation of the medicine, and local pain and cord-like induration can occur.

Fourth, other side effects should not be ignored. Such as the nervous system, or the feeling of dizziness and headache, the brain is disturbed, and the sun does not rise. The reproductive system, or has an impact on reproductive cells, in people of childbearing age, it is related to the reproduction of children, so it must be observed.

When taking medicine, doctors should carefully review the patient's condition, weigh the pros and cons, such as a good general using soldiers, and plan carefully, so that the medicine can do its best and reduce the harm of side effects.

What is the mechanism of action of 2 '-deoxy-5-iodouridine?

2% 27-deoxy-5-iodouridine, the mechanism of action of this substance, is involved in the field of biochemical pharmacology. It plays a unique role in the process of cell metabolism.

covers the proliferation of cells, which requires the synthesis of nucleic acids. 2% 27-deoxy-5-iodouridine structural natural nucleoside can enter the cell metabolic pathway. When cells perform DNA synthesis, this compound can replace thymidine nucleoside and incorporate into the DNA chain.

Such substitution causes abnormal DNA structure. Because its chemical structure is different from that of natural nucleosides, its incorporation changes the physical and chemical properties of DNA and affects the interaction between DNA and related proteins.

Furthermore, the formation of this abnormal DNA interferes with the normal replication and transcription of DNA. During replication, DNA polymerase misidentifies 2% 27-deoxy-5-iodouridine as a normal substrate and integrates it into the new synthetic strand, causing strand extension to be blocked or mispaired, resulting in defects in the structure and function of progeny DNA.

During transcription, RNA synthesized from abnormal DNA as a template also makes errors, affecting protein synthesis and ultimately inhibiting cell proliferation. In particular, rapidly proliferating cells, such as tumor cells, have an even greater impact on them, which is why 2% 27-deoxy-5-iodouridine can be used for anti-tumor and other related therapies, with the construction of abnormal DNA, to prevent the excessive reproduction of cells, to achieve the purpose of treatment.

2 '-deoxy-5-iodouridine used in the treatment of which diseases

2% 27-deoxy-5-iodouridine is a medicinal compound. It is widely used in the treatment of various diseases.

In the treatment of diseases caused by viruses, this compound is quite effective. It can block the synthesis of the nucleic acid of the virus and achieve the purpose of controlling the virus. Such as diseases caused by the herpes virus, 2% 27-deoxy-5-iodouridine can be applied to herpes infections of the skin and mucous membranes. With its ability to enter infected cells, it is phosphorylated to form an active triphosphate, which is combined with the DNA polymerase of the virus, inhibits its activity, and is incorporated into the DNA of the virus, causing the extension of the DNA chain to be blocked, and the replication of the virus is then inhibited.

In the field of tumor treatment, 2% 27-deoxy-5-iodouridine is also useful. Tumor cells proliferate rapidly and require a large amount of nucleic acid for their division. This compound can be incorporated into the DNA of tumor cells like normal nucleotides, disrupting their replication and transcription processes, and inhibiting the growth of tumor cells. In some solid tumors, such as head and neck tumors, breast cancer, etc., it can be seen occasionally in the chemotherapy regimen. It is often combined with other drugs to increase its anti-cancer effect.

When using this drug, you should also pay attention to its side effects. Or cause local irritation, such as skin redness and swelling, pain, etc.; when applied to the whole body, there may be bone marrow suppression, resulting in a decrease in the number of white blood cells and platelets, reducing the body's resistance. Therefore, doctors must weigh its advantages and disadvantages, and determine the appropriate dosage and usage according to the specific conditions of the patient, so as to ensure the effectiveness of treatment and reduce the harm of side effects.

What are the pharmacokinetic characteristics of 2 '-deoxy-5-iodouridine

2 '-Deoxy-5' -iodouridine, the pharmacokinetic characteristics of this drug are quite critical, and it is related to the efficacy and safety of the drug. After oral administration, it is rapidly absorbed through the gastrointestinal tract and enters the blood circulation. Some drugs are combined with plasma proteins and are widely distributed in the body, reaching many tissues and organs.

The metabolism of this drug in the body is complicated. Some of them are chemically converted through the action of liver enzymes to generate metabolites. Its metabolites may be active or inactive, depending on the specific transformation situation.

Drugs and their metabolites are mainly excreted from the body through the kidneys. Traces of original drugs and metabolites can be detected in urine. The elimination half-life of this drug is relatively stable, about [X] hours. From this, it can be seen that the clearance rate of the drug in the body can provide an important basis for setting the dose and interval of the drug.

After administration, the change of blood drug concentration shows a certain pattern. In the initial stage, the blood drug concentration rises rapidly, and after reaching the peak, it gradually decreases. The peak value and peak time of blood drug concentration are affected by factors such as administration dose and dosage form. Different dosage forms, such as tablets and capsules, have different dissolution rates, resulting in different drug absorption rates, which in turn affect the change of blood drug concentration. Mastering the pharmacokinetic characteristics of this drug can provide a solid theoretical basis for rational clinical use, in order to achieve the best therapeutic effect and reduce the occurrence of adverse reactions.