2 Ethoxy 3 Iodopyridine

2-Ethoxy-3-iodopyridine is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
In the field of pharmaceutical chemistry, it can be used as a starting material. After a series of chemical reactions, many bioactive compounds can be prepared, or it can lay the foundation for new drug development. Due to its unique structure, the introduction of ethoxy and iodine atoms endows compounds with specific chemical and physical properties, which is conducive to interaction with biological targets.
In materials science, it may also emerge. It can be used to participate in reactions to construct materials with special properties, such as optoelectronic materials. Due to its structural characteristics, which may affect the electronic transport and optical properties of materials, it has potential application value in organic Light Emitting Diodes, solar cells and other fields.
In addition, in the field of fine chemicals, 2-ethoxy-3-iodopyridine can be used to synthesize special chemicals and additives. With its unique chemical properties, it can optimize product performance, such as improving the adhesion of coatings and enhancing the stability of plastics. In conclusion, 2-ethoxy-3-iodopyridine, with its unique structure, has important uses in many fields such as organic synthesis, medicinal chemistry, materials science, and fine chemistry. It provides key starting materials and intermediates for many research and applications, and promotes the development of related fields.

To prepare 2-ethoxy-3-iodopyridine, there are three methods.
First, 3-iodopyridine is used as the starting material. First, the nitrogen atom on the pyridine ring is deprotonated at a strong base to enhance its nucleophilicity. Then, when it meets bromoethane, the two undergo a nucleophilic substitution reaction. In this process, the ethyl group of bromoethane is attacked by the nucleophilic attack of the nitrogen atom, and the bromine ion leaves, so 2-ethoxy-3-iodopyridine is obtained. This reaction needs to be in an anhydrous environment, such as in a dry tetrahydrofuran, catalyzed by a strong base such as sodium hydride, and the temperature control is moderate. Good results can be obtained.
Second, take 2-hydroxy-3-iodopyridine as the starting material. First, it is mixed with ethanol, and a strong acid such as concentrated sulfuric acid is used as the catalyst to carry out an esterification reaction. The hydroxy group is combined with the ethoxy group of ethanol, and the water molecule is removed to obtain 2-ethoxy-3-iodopyridine. However, this reaction is reversible, and it is necessary to try to remove the generated water or increase the amount of ethanol to promote the equilibrium right shift and improve the yield.
Third, take pyridine as the starting material, iodide it first, and introduce iodine atoms at the 3rd position of the pyridine ring. Then react with 3-iodopyridine with an ethoxylating agent, such as sodium ethanol. The ethoxy group of sodium ethanol, nucleophilic attack on the second position of 3-iodopyridine, and the iodine ions leave to obtain the target product. This reaction condition needs to be mild, otherwise it is easy to cause side reactions such as ring opening of the pyridine ring.
All these methods have their own advantages and disadvantages. When implemented, the choice should be weighed according to many factors such as the availability of raw materials, the difficulty of reaction, and the high and low yield.

2-Ethoxy-3-iodopyridine is also an organic compound. It has unique physical properties, which are related to material morphology, melting boiling point, solubility, etc., and is crucial in the field of organic synthesis.
First of all, its appearance, at room temperature and pressure, 2-ethoxy-3-iodopyridine is mostly in a liquid state, clear and transparent, like a mirror, or a white to light yellow solid, with a fine texture. This appearance characteristic can help chemists identify it in experiments.
As for the melting point, according to relevant chemical records, it is about [X] ° C, and it gradually melts when heated, turning into a flowing state. The boiling point also has a fixed number, about [X] ℃. When the temperature rises to Si, the substance changes from liquid to gaseous and diffuses in space. This melting boiling point data is the key basis for the separation and purification of compounds. Chemists can use distillation to make 2-ethoxy-3-iodopyridine escape from the mixture according to its boiling point difference, and achieve the purpose of purification.
In terms of solubility, 2-ethoxy-3-iodopyridine is soluble in many organic solvents, such as ethanol, ether, etc. In ethanol, the two are like water emulsion, and they quickly dissolve each other to form a uniform solution. This solubility property makes it easy to find a suitable reaction medium for 2-ethoxy-3-iodopyridine in organic reactions and promote the progress of the reaction. Due to its solubility, the reactant molecules can be fully contacted, the probability of collision is greatly increased, and the reaction rate is also accelerated.
In addition, the density of 2-ethoxy-3-iodopyridine cannot be ignored. Its density is about [X] g/cm ³, which is lighter or heavier than water, depending on its distribution in the mixed system. In some liquid-liquid separation operations, the difference in density becomes a key factor in separation. Chemists can use liquid separation funnels and other devices to layer 2-ethoxy-3-iodopyridine with other liquids to achieve separation.
The physical properties of 2-ethoxy-3-iodopyridine are the cornerstone of organic synthesis, chemical analysis and other fields. Chemists use their skills to explore the mysteries of matter, create novel compounds, and promote the vigorous development of chemistry.

2-Ethoxy-3-iodopyridine, this is an organic compound. Looking at its structure, the presence of the pyridine ring gives it unique chemical properties. The pyridine ring is aromatic, and the nitrogen atom on the ring has lone pairs of electrons, which makes the compound weakly basic.
As far as ethoxy is concerned, it is a power supply group, which can affect the electron cloud density of the pyridine ring through induction and conjugation effects. In this way, the electron cloud density at a specific position on the ring changes. During the electrophilic substitution reaction, the ethoxy group will guide the reaction towards a specific position, which is the localization effect. Usually, the power supply group increases the electron cloud density of the ortho and para-position of the benzene ring, so the electrophilic substitution is easy to occur in the ortho and para-position
Although iodine atoms have electron-sucking induction effects, they have weak electron-donor conjugation effects. Overall consideration, its effect on the electron cloud density of the pyridine ring is more complex, but the whole also has a significant effect on the activity and selectivity of electrophilic substitution reactions.
In chemical reactions, 2-ethoxy-3-iodine pyridine can participate in many organic reactions. For example, iodine atoms can be used as leaving groups to participate in nucleophilic substitution reactions. The activity of halogen atoms makes them vulnerable to attack by nucleophiles, thereby realizing the conversion of functional groups. The nitrogen atom of the pyridine ring can be used as a nucleophilic check point to react with the electrophilic reagent to form new carbon-nitrogen bonds or other chemical bonds, and then derive various organic compounds with novel structures, which are of great application value in the field of organic synthesis.
In addition, the physical properties of the compound cannot be ignored. Its solubility or specific laws due to the hydrophilic interaction of ethoxy groups with the hydrophobicity of the pyridine ring and iodine atoms, and the solubility varies in different organic solvents. This property is crucial in separation, purification and reaction medium selection. Physical constants such as melting point and boiling point are also determined by their intermolecular forces, including van der Waals forces, hydrogen bonds, etc. These properties are of great significance to the setting of storage, transportation and practical application conditions of compounds.

I do not know the exact price range of 2-ethoxy-3-iodopyridine in the market. The price of this compound is susceptible to many factors, such as purity, supply, purchase volume and market supply and demand.
In terms of purity, high purity, due to the difficulty of preparation and high cost, so the price is high; low purity, the cost is reduced and the price is also low. Supply sources also have an impact. Different manufacturers or suppliers have different pricing due to differences in technology and cost control.
Purchase volume is also critical. Large purchases, due to economies of scale, suppliers may give discounts, and the unit price drops; small purchases, the unit price tends to rise. Market supply and demand more influence the price. If demand exceeds supply, the price will rise; if supply exceeds demand, the price may fall.
To know the exact price range, you can consult chemical product suppliers, browse chemical product trading platforms, or check industry reports through the channels described in Tiangong Kaiwu. These channels may be able to obtain an approximate market price in the near future to help you know its price range.