2 Fluoro 3 Iodo 5 Methylpyridine

2-Fluoro-3-iodine-5-methylpyridine, this substance has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate and participates in the synthesis of many drugs. Because of its special structure, it endows the synthesized drugs with unique activities and properties. For example, the preparation of some antibacterial drugs, with the help of their structural properties, enhances the inhibition and killing ability of drugs against specific bacteria, or improves the pharmacokinetic properties of drug absorption, distribution, and metabolism in vivo.
In the field of materials science, it also has its own uses. It can be used to create special functional materials, such as organic semiconductor materials. The presence of atoms such as fluorine and iodine in its molecular structure can regulate the electrical and optical properties of materials, laying the foundation for the preparation of high-performance organic Light Emitting Diodes (OLEDs), organic field effect transistors (OFETs) and other materials, and improving material carrier transport efficiency, luminous efficiency and other performance indicators.
In addition, in the field of pesticide chemistry, it is also an important synthetic raw material. Pesticides synthesized on the basis of it may have high insecticidal and bactericidal activities, and due to structural specificity, have little impact on the environment, meet the needs of modern green pesticide development, and help sustainable agricultural development. Overall, 2-fluoro-3-iodine-5-methylpyridine has important uses in many chemical-related fields, promoting technological innovation and development in various fields.

There are several ways to synthesize 2-fluoro-3-iodine-5-methylpyridine. First, fluorine and iodine atoms can be introduced by halogenation from suitable pyridine derivatives. If 5-methylpyridine is used as a base, a specific fluorination reagent is used to introduce fluorine atoms into the second position of the pyridine ring under suitable reaction conditions. Fluorination reagents, or Selectfluor, etc. are commonly used. Then, iodine atoms are introduced into the third position through iodization reaction. The iodization reaction can be carried out with iodine elemental substance and appropriate oxidants, such as hydrogen peroxide or nitric acid, in a suitable solvent and temperature.
Second, it can also be achieved by coupling reaction catalyzed by transition metals. The target product is obtained by coupling reaction between fluorine-containing pyridine derivatives and iodine-containing reagents under the action of transition metal catalysts such as palladium catalysts. In this process, suitable ligands need to be selected to improve the activity and selectivity of the reaction. Commonly used ligands include tri-tert-butylphosphine, etc. The solvent of the reaction also needs to be considered. Common organic solvents, such as N, N-dimethylformamide, toluene, etc., may be applicable.
Furthermore, a strategy for the gradual construction of pyridine rings can be designed. First, a methyl-containing pyridine ring is constructed by multi-step reaction with suitable organic raw materials, and then fluorine and iodine atoms are introduced successively at specific locations. This strategy requires meticulous planning of reaction steps and conditions to ensure the smooth progress of each step of the reaction and the purity of the product. For example, the pyridine ring skeleton is first constructed by condensation reaction of raw materials such as aldehyde, ketone and ammonia, and then halogen atoms are introduced in turn. When synthesizing this compound, the control of reaction conditions is crucial, and the temperature, reaction time, and proportion of reactants will all affect the yield and selectivity of the reaction. And after each step of the reaction, it is often necessary to separate and purify the operation, such as column chromatography, recrystallization, etc., to obtain a pure product.

2-Fluoro-3-iodine-5-methylpyridine, this is an organic compound with unique physical properties. It is mostly liquid at room temperature, and it solidifies due to moderate intermolecular forces without strong associations or lattice structures. Looking at its color, it is often nearly colorless or very light yellow, and it is more colorless when it is high in purity. Because the molecular structure does not contain a large number of conjugated systems, it does not strongly absorb visible light.
It has a special smell, which is difficult to describe accurately. It is not odorous and pungent, but it has a unique smell of organic heterocyclic compounds. It can be heard in organic synthesis laboratories or related industrial environments.
The boiling point of 2-fluoro-3-iodine-5-methylpyridine is specific, depending on the intermolecular force. It contains atoms such as fluorine and iodine. The relative molecular weight is large, the intermolecular van der Waals force is enhanced, and the boiling point is higher, about 180-220 ° C, depending on the purity and measurement conditions. Its melting point is affected by molecular regularity and interaction, which is relatively low, or between -20-0 ° C, indicating that it can be a solid state at low temperatures.
The compound has a density greater than that of water. When mixed with water, it will sink to the bottom of the water, and its unit volume mass will increase due to the halogen atoms in the molecule. In terms of solubility, it has good solubility in common organic solvents such as dichloromethane, chloroform, and toluene. Due to the principle of "similar miscibility", its organic structure is similar to that of organic solvents; but it has poor solubility in water because it is an organic heterocycle with limited polarity and weak interaction with water.
In addition, 2-fluoro-3-iodine-5-methyl pyridine has a certain volatility. Although the boiling point is high, some molecules can escape into the air in an open environment or when heated. Pay attention to ventilation during operation to ensure safety.

2-Fluoro-3-iodine-5-methylpyridine is an organic compound of great importance in the field of organic synthesis. Its chemical properties are unique, mainly due to the structure of fluorine atoms, iodine atoms, methyl groups and pyridine rings in the molecule.
As far as nucleophilic substitution is concerned, this compound exhibits special activity due to the presence of fluorine atoms and iodine atoms. The iodine atom is relatively large and moderately electronegative, making it a good leaving group. Under suitable conditions for nucleophilic reagents and reactions, iodine atoms are easily replaced by nucleophilic reagents, and then novel organic compounds can be formed. For example, when alkoxy groups are used as nucleophilic reagents, nucleophilic substitution reactions can occur, and iodine atoms are replaced by alkox
Fluorine atoms have extremely high electronegativity, which will significantly reduce the electron cloud density of the pyridine ring, making the electrophilic substitution reaction on the pyridine ring more difficult. However, under certain conditions, the carbon atoms in the adjacent and para-position of the fluorine atom may still undergo electrophilic substitution reactions due to the relatively high electron cloud density. Moreover, fluorine atoms also affect the physical properties of molecules, which can enhance the lipid solubility of compounds and change their boiling point and melting point properties. The presence of
methyl groups will affect the distribution of the electron cloud in the pyridine ring. It is a donator group, which can increase the electron cloud density of the pyridine ring and have a certain activation effect on the electrophilic substitution reaction. In some reactions, methyl groups can be oxidized, for example, under the action of suitable oxidizing agents, methyl groups can be oxidized to carboxyl groups.
In addition, the pyridine ring in 2-fluoro-3-iodine-5-methylpyridine contains basic nitrogen atoms, which can react with acids to form corresponding salts. This property can be used in organic synthesis to separate and purify the compound, or to modify its physical properties by forming salts to suit specific reaction needs.
In organic synthesis, 2-fluoro-3-iodine-5-methylpyridine is often used as a key intermediate for the synthesis of more complex organic compounds due to its chemical properties. It has broad application prospects in many fields such as medicinal chemistry and materials science.

I think this 2-fluoro-3-iodo-5-methylpyridine is one of the organic compounds. However, it is difficult to determine the market price range. The price of this product is affected by many factors, such as difficulty in preparation, raw material cost, market supply and demand, and production scale.
If the preparation is difficult, it needs to be made with rare raw materials or through complex processes, and its price will be high. On the contrary, if the preparation is convenient, the raw materials are easy to obtain, and the price should be close to the people.
Market supply and demand are also key. If the demand for this product in the fields of medicine, materials, etc. increases greatly, but the supply is limited, the price will rise. If the demand is weak and the supply is abundant, the price may decline.
As for the production scale, large-scale production can often reduce the unit cost and make the price more competitive. Small-scale production is more expensive, and the selling price will also increase accordingly.
Although I do not have the exact price range, it is common sense to infer that if the preparation is moderate and the supply and demand are balanced, the price per gram may be between tens of yuan and hundreds of yuan. If the preparation is extremely difficult or the demand is strong and the supply is scarce, the price per gram may exceed 1,000 yuan. If the preparation is easy and the supply is sufficient, the price per gram may be reduced to a few yuan. This is all speculation, and the actual price still needs to be carefully checked through channels such as chemical product trading platforms and supplier quotations to obtain an accurate number.