2 Fluoro 3 Iodo 5 Picoline

2-Fluoro-3-iodine-5-methylpyridine is widely used in the field of organic synthesis. Its primary use is as a pharmaceutical intermediate. It contains special atoms such as fluorine and iodine, which can endow drugs with unique physical and chemical properties and biological activities. Through delicate organic reactions, it can be turned into drug molecules with complex structures and excellent activity, which is of great significance in the process of developing new drugs such as antibacterial and anti-cancer.
In addition, it also plays an important role in the creation of pesticides. With its special structure, pesticide varieties with high killing power against pests and environmental friendliness can be derived. Targeted pesticides can be designed and synthesized according to the physiological characteristics of specific pests, which can not only improve the control effect, but also reduce the impact on non-target organisms.
At the same time, in the field of materials science, 2-fluoro-3-iodine-5-methylpyridine has also emerged. It can be used as a key building block for the construction of functional materials. It can be connected to polymer systems through chemical reactions to endow materials with excellent properties such as photoelectric properties and thermal stability, and plays a unique role in the research and development and preparation of organic photoelectric materials and high-performance polymer materials.
To sum up, 2-fluoro-3-iodine-5-methylpyridine, with its unique structure, has important applications in many fields such as medicine, pesticides and materials science, promoting technological progress and innovation in related fields.

The synthesis of 2-fluoro-3-iodine-5-methylpyridine has attracted much attention in the field of organic synthesis. Several common methods are described in detail below.
First, 5-methylpyridine is used as the starting material. The iodization reaction of 5-methylpyridine is carried out first. In this process, it is crucial to select a suitable iodizing reagent. Common iodizing reagents such as iodine elemental substance combined with suitable oxidizing agent can iodize the third position of the pyridine ring to generate 3-iodine-5-methylpyridine. Then, the obtained product is fluorinated, and nucleophilic fluorination reagents can be selected. Under specific reaction conditions, fluorination in 2 positions is achieved, and the final product is 2-fluoro-3-iodine-5-methylpyridine. This route step is relatively clear, but the precise control of each step of the reaction conditions is extremely important, such as reaction temperature, reaction time, and the dosage ratio of reagents, which will have a significant impact on the yield and selectivity of the reaction.
Second, other compounds containing fluorine, iodine, and pyridine structures can also be used to achieve the synthesis of the target product through suitable functional group transformation. For example, to find a pyridine derivative whose structure already contains some of the target substituents, only the remaining substituents need to be introduced one by one through a specific reaction. This method requires careful design and screening of the structure of the starting material, and the subsequent functional group conversion reaction also requires a high degree of chemical selectivity and stereoselectivity to ensure high purity of 2-fluoro-3-iodine-5-methylpyridine.
Third, the coupling reaction catalyzed by transition metals is also a feasible way. First, a substrate containing a pyridine ring with a suitable leaving group is prepared, and then it is coupled with fluorine-containing and iodine-containing reagents in sequence under the action of transition metal catalysts. The choice of transition metal catalysts such as palladium and nickel and the choice of ligands has a great impact on the activity and selectivity of the reaction. By precisely regulating the reaction conditions, such as temperature, solvent and type of base, the reaction can be carried out smoothly, and the efficient synthesis of 2-fluoro-3-iodine-5-methylpyridine can be achieved.
All the above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as the availability of raw materials, the cost of reaction, yield and purity requirements, and choose the most suitable method.

2-Fluoro-3-iodine-5-methylpyridine, this substance is also important in its physical properties and is related to many practical uses.
First of all, its appearance, at room temperature, 2-fluoro-3-iodine-5-methylpyridine is often colorless to light yellow liquid, and the appearance is clear, such as clear oil, and the luster is restrained. This appearance feature can be an important basis for identifying and preliminarily judging its state.
Second on its melting point and boiling point. The melting point is the temperature at which a substance changes from a solid state to a liquid state. However, according to the ancient books, the melting point of 2-fluoro-3-iodine-5-methylpyridine is quite low, and it is difficult to form a solid state under normal ambient temperatures. As for the boiling point, it is in a certain temperature range, and this temperature causes it to change from liquid to gaseous state. The characteristics of the boiling point are a key guide when separating and purifying this compound. For example, by distillation, temperature control to near the boiling point can separate it from impurities and achieve the purpose of purification.
Furthermore, density is also an important physical property. 2-Fluoro-3-iodine-5-methylpyridine has a higher density than water. If it is mixed with water, it can be seen that it sinks to the bottom of the water, such as stone entering water. This characteristic is used in operations such as liquid-liquid separation, which can be used as a convenient method.
In terms of solubility, 2-fluoro-3-iodine-5-methylpyridine is soluble in a variety of organic solvents, such as ethanol and ether. Organic solvents, such as ethanol, are mild in nature. When they are soluble with 2-fluoro-3-iodine-5-methylpyridine, the two are like water emulsion and blend without any hindrance. This solubility, in organic synthesis reactions, can provide a suitable environment for the reaction, so that the reactants can be fully contacted
In addition, its vapor pressure cannot be ignored. Although the vapor pressure is not very high under normal conditions, it gradually increases with the rise of temperature. The change of vapor pressure depends on its existence in the gas phase. It needs to be carefully considered in the ventilation and storage of chemical production to prevent gas accumulation and cause safety risks.

2-Fluoro-3-iodine-5-methylpyridine is an organic compound with unique chemical properties. It exhibits different reactivity due to the structure of fluorine, iodine and methylpyridine.
Fluorine atoms have high electronegativity, which can strengthen molecular polarity and affect intermolecular forces. In chemical reactions, it can make molecules more prone to nucleophilic substitution reactions. Because of its strong electronegativity, it can attract electron clouds, causing changes in the density of ortho or para-electron clouds, making nucleophiles more prone to attack.
Iodine atoms are relatively large, and their C-I bond energy is weak and easy to break. This property makes the iodine atom of 2-fluoro-3-iodine-5-methylpyridine easily replaced by other groups under certain conditions, participating in various organic synthesis reactions, such as the Ullman reaction, to construct new carbon-carbon or carbon-heteroatom bonds.
Furthermore, methyl pyridine partially confers alkalinity to the molecule. The nitrogen atom of the pyridine ring has a lone pair of electrons, which can accept protons and is weakly basic. This alkaline property allows the compound to react with acids to form corresponding salts. And the presence of methyl groups changes the distribution of molecular electron clouds and affects the reactivity of the pyridine ring.
In the field of organic synthesis, 2-fluoro-3-iodine-5-methylpyridine is often used as a key intermediate due to the above properties. With the characteristics of its various groups, complex organic molecular structures can be constructed through various chemical reactions, providing important starting materials for the research and production of pharmaceutical chemistry, materials science and other fields to synthesize compounds with specific biological activities or material properties.

I look at your question, but I am inquiring about 2-fluoro-3-iodine-5-methylpyridine in the market price range. Sadly, the price of this compound varies due to many factors, and it is difficult to determine the exact number.
First, suppliers are different, and their costs and business strategies are different, resulting in different prices. Well-known large factories, due to their excellent brands and quality control, the price may be slightly higher; emerging small factories, in order to expand the market, the price may be close to the people.
Second, the quantity is also the key to the price. Bulk procurement, due to economies of scale, unit costs are reduced, suppliers often give discounts, and unit prices are low; small purchases, cost sharing is high, and prices are high.
Third, market supply and demand determine the price. If the demand is strong and the supply is tight, the price will rise; conversely, if the demand is weak and the supply is sufficient, the price may drop.
Fourth, the difficulty of preparation and the cost of raw materials also affect the price. If the synthesis of this compound is complex and the raw materials are expensive, the price will be high.
Although it is difficult to determine the price range, if you want to know, you can consult chemical malls, reagent suppliers, or refer to the prices of similar compounds to estimate the price. You can also ask industry insiders in industry forums and communities to learn from their experience to get an approximate price.