2 Fluoro 4 Iodo

2-Fluoro-4-iodo (2-fluoro-4-iodo) is widely used in the field of modern chemistry.
The first step in organic synthesis. In the art of organic synthesis, it is often used as a key building block. Because of its fluorine and iodine diatoms, fluorine atoms have unique electronic effects, which can change the physical and chemical properties of compounds, such as improving fat solubility and enhancing metabolic stability. Iodine atoms are highly active and prone to many chemical reactions, such as nucleophilic substitution reactions. With this property, 2-fluoro-4-iodo can be replaced by nucleophiles, meet with many nucleophiles, and generate a series of new organic compounds, paving the way for the creation of novel drugs and functional materials.
Furthermore, in the context of drug research and development, it also plays a pivotal role. Medicinal chemists regard it as a carrier of potential active groups. After clever splicing, it is integrated into the molecular structure of the drug, and the properties of fluorine and iodine atoms are used to optimize the pharmacokinetic properties of the drug. Or make it easier for the drug to penetrate the biofilm and reach the target of action; or prolong the retention time of the drug in the body, enhance the efficacy, and contribute to the creation of new drugs to overcome difficult diseases.
In addition, in the field of materials science, 2-fluoro-4-iodo is also useful. It can participate in the synthesis of special functional materials, such as optoelectronic materials. Its unique atomic structure may endow materials with special optoelectronic properties, such as adjusting the energy band structure of materials, which in turn affects their luminescence, conductivity and other properties. It has emerged in the fields of organic Light Emitting Diodes and solar cells, helping to improve and innovate the properties of related materials.

2-Fluorine-4-iodine has unique physical properties. Its color is almost colorless and transparent, and it is mostly liquid under normal circumstances. It looks like smart water, but its properties are quite different from water.
Regarding its boiling point, due to the intermolecular force, the influence of fluorine and iodine atoms makes its boiling point different from common hydrocarbons. Fluorine atoms have strong electronegativity, iodine atoms have a large relative atomic mass, causing complex intermolecular forces, and the boiling point is in a specific range. Specifically, it is higher than similar halogen-free compounds, but the exact value needs to be determined by precise experiments.
Its melting point is also affected by halogen atoms. Fluorine and iodine atoms in the molecular structure change the lattice energy, resulting in a special melting point. Usually, at low temperatures, this substance can condense into a solid state, like crystal clear ice, but the texture may be different from ice.
In terms of density, due to the relatively large atomic mass of fluorine and iodine atoms, their density is greater than that of common organic liquids. If placed in water, it can be seen that it sinks at the bottom of the water, like a treasure hidden in the bottom of the water.
In terms of solubility, 2-fluoro-4-iodine has good solubility in organic solvents, such as common ether, acetone, etc., which can be fused with, just like the joy of fish water. However, it has little solubility in water, because it is an organic compound, the force between it and water molecules is small, and it is difficult to form a uniform mixed system.
In addition, the refractive index of this substance also has characteristics. When light passes through, the molecular structure acts on the light, and the light is refracted. Its refractive index can be used as an important physical constant for identifying this substance, providing a key basis for identifying objects and identifying objects.

2-Fluorine-4-iodine This substance has unique chemical properties, which are attributed to the characteristics of fluorine and iodine atoms. Fluorine, the first of the halogen elements, has extremely strong electronegativity and a very small atomic radius. Iodine is also a halogen group. Although its electronegativity is inferior to that of fluorine, the atomic radius is quite large.
First, the influence of fluorine atoms. Because of its high electronegativity, in the 2-fluorine-4-iodine molecule, it has a huge attractive force on the electron cloud, causing the electron cloud to be biased towards the fluorine atom. This polarization effect makes the charge distribution in the molecule uneven, which then affects the polarity of the molecule. And fluorine atoms reduce the density of the electron cloud of carbon atoms connected to them. In nucleophilic substitution reactions, this carbon atom is more vulnerable to nucleophilic reagents. For example, if there are nucleophilic reagents such as hydroxyl negative ions, or they can interact with the carbon atom, substitution occurs, and fluorine atoms leave.
Look at the iodine atom again. Its atomic radius is large, and the outer electron cloud is loose. In chemical reactions, iodine atoms are more easily deformed and can be highly polarized. This property makes 2-fluoro-4-iodine atoms easy to become a reaction check point in some reactions. In case of electrophilic reagents, the electron cloud of iodine atoms may attract electrophilic reagents and initiate a reaction. At the same time, the iodine-carbon bond is relatively weak and easy to break. Under certain conditions, iodine atoms can be separated from molecules and participate in subsequent reactions.
In addition, the physical properties of 2-fluoro-4-iodine are also affected by fluorine and iodine. Due to the polarity of the molecule, it may have better solubility in polar solvents, but not in non-polar solvents. And due to the existence of fluorine and iodine atoms, the physical parameters such as boiling point and melting point of this substance are also different from similar compounds without these two atoms. Its chemical properties are complex, and the interaction of fluorine and iodine atoms jointly determines its performance in various chemical reactions.

To prepare 2-fluoro-4-iodine, you can follow the following method. First take a suitable aromatic hydrocarbon substrate, which should contain a check point that can be introduced into fluorine and iodine through substitution reaction.
The first fluorine atom can often be introduced by nucleophilic substitution. Select a suitable fluorine-containing reagent, such as potassium fluoride, etc., under specific reaction conditions, so that the fluorine atom replaces the predetermined hydrogen atom on the substrate. The reaction needs to be carried out in a suitable solvent, such as dimethyl sulfoxide (DMSO), etc. This solvent can help the reactants to dissolve and promote the reaction. And the reaction temperature needs to be precisely controlled, or in the state of heating and reflux, to promote the fluorination reaction to occur smoothly.
After the fluorine atom is successfully introduced, the iodine atom is introduced again. At this time, the strategy of electrophilic substitution reaction can be selected. Use iodine elemental substance or other suitable iodine-containing reagents with appropriate catalysts, such as copper salts. In a specific reaction environment, such as adding an appropriate amount of ligands to enhance the activity of the catalyst, adjusting the pH of the reaction, so that the iodine atom replaces the hydrogen atom in the appropriate position with the fluorine atom on the substrate to obtain the target product of 2-fluoro-4-iodine.
During the reaction, attention should be paid to the selectivity and yield of each step of the reaction. After each step of the reaction, impurities are removed by suitable separation and purification methods, such as column chromatography, recrystallization, etc., to ensure the purity of the product and provide pure raw materials for the next reaction, so that 2-fluoro-4-iodine can be efficiently and with high purity.

I am not sure about the market price range of 2-fluoro-4-iodine. The price of this compound depends on many factors, and it is difficult to generalize.
First, the difficulty of preparation affects the price. If the preparation requires complicated steps, rare raw materials or special conditions, the cost will be high, and the price will also rise. For example, high-precision purification or a specific catalyst is required, and this catalyst is rare and expensive, which will increase the cost significantly.
Second, the relationship between market demand and supply is the key. If the demand is strong and the supply is limited, such as for cutting-edge pharmaceutical research and development, the demand suddenly rises and the production scale is not expanded, the price will rise; on the contrary, if the demand is low and the supply is sufficient, the price will decline.
Third, the purity has a great impact on the price. High purity 2-fluoro-4-iodine is difficult to purify and meets high-end scientific research or special industrial needs, and the price is much higher than that of low purity.
Fourth, the price varies from different purchase channels. Purchased from well-known chemical reagent suppliers, the price may be higher than ordinary channels due to factors such as brand reputation and quality assurance; when purchasing in large quantities, the supplier may give discounts due to economies of scale.
For the exact price range, please consult chemical reagent suppliers, chemical product trading platforms, or refer to relevant industry reports for more accurate price information.