As a leading (2-Fluoro-4-Iodopyridin-3-Yl)Methanol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
(2-fluoro-4-iodopyridin-3-yl) What are the main uses of methanol?
(2-Fluoro-4-iodopyridine-3-yl) methanol, which is an important intermediate in the field of organic synthesis. In the field of medicinal chemistry, its use is quite critical.
The unique structure of the geinpyridine ring and the atoms of fluorine and iodine endows (2-fluoro-4-iodopyridine-3-yl) methanol with special reactivity. First, it can be used to construct more complex drug molecular structures. For example, by means of its methanol group condensation reaction with other compounds containing active functional groups, the carbon chain is increased, and a novel skeleton is constructed to develop drugs with specific pharmacological activities. Second, the fluorine and iodine atoms on the pyridine ring can participate in many nucleophilic substitution or metal-catalyzed coupling reactions due to the strong electronegativity of fluorine atoms and the characteristics of iodine atoms prone to substitution reactions, thereby introducing various pharmacoactive groups to optimize the activity, selectivity and pharmacokinetic properties of drugs.
In the field of materials science, (2-fluoro-4-iodopyridine-3-yl) methanol is also used. Due to its structural designability, it may be used as a functional monomer to participate in the synthesis of polymer materials. After polymerization, its structural units are introduced into the main chain or side chain of the polymer to endow the material with special optical and electrical properties, such as the preparation of organic light-emitting materials with specific light-emitting properties, or the improvement of carrier transport properties of semiconductor materials.
In summary, (2-fluoro-4-iodopyridine-3-yl) methanol has shown important application value in the fields of medicine and materials due to its unique structure, providing a rich material basis and structural diversity for the research and development of related fields.
(2-fluoro-4-iodopyridin-3-yl) What are the synthesis methods of methanol
There are several ways to prepare (2-fluoro-4-iodopyridine-3-yl) methanol. First, it can be started from a suitable pyridine derivative. First, take a pyridine containing the corresponding substituent, such as 2-fluoro-4-iodopyridine, which introduces hydroxymethyl groups at the 3rd position of the pyridine ring. This can be achieved by nucleophilic substitution reaction. Choose a suitable nucleophilic reagent, such as a negative ion or equivalent of hydroxymethyl group, and make it react with a suitable leaving group on the pyridine ring. If there is a suitable leaving group such as a halogen atom or a sulfonate group at the third position of the pyridine ring, the nucleophilic reagent attacks this check point and replaces the leaving group to generate (2-fluoro-4-iodopyridine-3-yl) methanol.
Second, it can be prepared by metal-organic reagents. First prepare metal-organic compounds containing 2-fluoro-4-iodopyridine, such as Grignard reagents or lithium reagents. The corresponding Grignard reagents can be obtained by reacting magnesium with 2-fluoro-4-iodopyridine in anhydrous ether solvents. Subsequently, the Grignard reagent is reacted with formaldehyde or a suitable formaldehyde equivalent, and the target product (2-fluoro-4-iodopyridine-3-yl) methanol can be obtained through a hydrolysis step.
Furthermore, redox strategies may be employed. If a suitable pyridine derivative exists, it has groups at the 3rd position that can be reduced to hydroxymethyl groups, such as aldehyde groups, carboxyl groups or their derivatives. First, the 3 position of 2-fluoro-4-iodopyridine is modified to an aldehyde group, which can be achieved by specific oxidation or substitution reactions. Then, the aldehyde group is reduced to hydroxymethyl group with suitable reducing agents, such as sodium borohydride, lithium aluminum hydride, etc., to obtain (2-fluoro-4-iodopyridine-3-yl) methanol. The choice of specific synthesis path needs to consider many factors such as the availability of starting materials, the difficulty of reaction conditions, the yield and selectivity.
(2-fluoro-4-iodopyridin-3-yl) What are the physical properties of methanol
(2-Fluoro-4-iodopyridine-3-yl) methanol, this is an organic compound. Its physical properties are unique, let me tell them one by one.
Looking at its properties, under room temperature and pressure, it is likely to be a white to pale yellow solid. This is a common color state of many organic compounds with similar structures, due to the arrangement of atoms in the molecule and the distribution of electron clouds.
When it comes to the melting point, the melting point is usually relatively high. Due to the existence of various forces between molecules, such as van der Waals force, and the large electronegativity of atoms such as fluorine and iodine, the molecules can produce a certain polarity, which in turn enhances the attraction between molecules and increases the melting point. However, the exact value still needs to be determined accurately according to the experiment. The boiling point is also within a certain range due to the intermolecular force, and it is also affected by factors such as the surrounding ambient air pressure.
In terms of solubility, because it contains hydroxyl groups, it has a certain hydrophilicity and may have a certain solubility in some polar solvents, such as water, methanol, and ethanol. However, the existence of pyridine rings and halogen atoms in the molecule makes it more soluble in non-polar solvents, such as n-hexane and toluene.
The density is higher than that of water, or because the atomic weight of iodine atoms in the molecule is larger. This is the characteristic of many organic compounds containing heavy atoms.
Its appearance may be crystalline, and the crystal form may vary due to different crystallization conditions. The physical properties of this compound have a profound impact on its application in organic synthesis, medicinal chemistry and other fields. During synthesis, the appropriate reaction conditions and separation and purification methods need to be selected according to its melting point, solubility and other properties; in drug development, its solubility and stability are related to drug absorption, distribution and other in vivo processes.
(2-fluoro-4-iodopyridin-3-yl) What are the chemical properties of methanol
(2-Fluoro-4-iodopyridine-3-yl) methanol, this is an organic compound. Its physical and chemical properties are unique and of great significance to the field of organic synthetic chemistry.
Looking at its physical properties, under room temperature and pressure, (2-fluoro-4-iodopyridine-3-yl) methanol may be in a solid state, due to the presence of halogen atoms such as fluorine and iodine, and the intermolecular force is enhanced. As for the melting point, it is relatively high due to the introduction of fluorine and iodine atoms. And the compound may have a certain solubility in organic solvents such as dichloromethane and chloroform, but its solubility in water may be limited. After all, its molecular polarity is not enough to form extensive hydrogen bonds with water molecules.
When it comes to chemical properties, methanol-CH 2O OH is very active. It can participate in many chemical reactions, such as oxidation reactions. Under the action of suitable oxidants, methanol groups can be converted into aldehyde-CHO and even carboxyl-COOH. It can also be esterified with carboxylic acids to form corresponding ester compounds. This reaction is quite common in the preparation of organic synthetic esters.
The pyridine ring also affects its chemical properties. The pyridine ring is aromatic and the nitrogen atom is highly electronegative, which makes the electron cloud of the pyridine ring uneven. The substitution of 2-position fluorine atom and 4-position iodine atom changes the electron cloud density on the variable ring and affects the activity of electrophilic substitution and nucleophilic substitution. Generally speaking, fluorine atoms have a strong electron-sucking induction effect, which decreases the electron cloud density of pyridine rings and weakens the activity of electrophilic substitution. Although iodine atoms have electron-sucking induction effect, due to their large atomic radius, they have a certain electron conjugation effect, which has a complex effect on the electron cloud density of pyridine rings. On the whole, the pyridine ring part of (2-fluoro-4-iodopyridine-3-yl) methanol can undergo nucleophilic substitution reaction, and the halogen atom can be replaced by nucleophilic reagents to form new carbon-heteroatom bonds, which provides the possibility for organic synthesis of new pyridine derivatives.
(2-fluoro-4-iodopyridin-3-yl) What is the price range of methanol in the market?
The market price of (2-fluoro-4-iodopyridine-3-yl) methanol varies according to market conditions, quality and purchase quantity.
Looking at past market conditions, its price fluctuates quite a lot. If it is purchased in small quantities, its price may be high. The preparation method of this compound is more complex, and the requirements for raw materials and processes are also harsh, resulting in high production costs. This is one of the reasons for the high price.
If the purchase quantity is quite large, the cost may be slightly reduced by the effect of scale. And the trend of market supply and demand is also the main reason for pricing. If there are many applicants, and the supply is limited, the price must rise; if the supply exceeds the demand, the price may decline.
Those who are commonly seen in the market, the price may be between tens and hundreds of gold per gram. However, the exact price must be carefully checked by the current suppliers' offers, and the quality provided by each supplier is different, and the price will also change accordingly. Or due to the different control of purity and impurities, the price varies. To know the exact price, you should consult all suppliers in the market in detail before you can get an accurate number.