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What is the main use of 2 '-fluoro-5-iodo-2' -deoxyuridine?
2% 27 - fluoro - 5 - iodo - 2% 27 - deoxyuridine, the Chinese name is often fluoroiodine deoxyuridine. This drug is mainly used for tumor-related treatment and research.
In today's medical system, the disease of tumors is very harmful. Fluoroiodine deoxyuridine has unique pharmacological properties and can inhibit the proliferation of tumor cells. The reason is that the structure of this substance is similar to deoxyuridine and can be mixed into the DNA synthesis process of tumor cells. Tumor cells proliferate rapidly, and the demand for raw materials for DNA synthesis is very urgent, so fluoroiodine deoxyuridine takes advantage of it. Once incorporated, it is like a foreign body embedded, disrupting the normal structure and function of DNA, making it difficult for tumor cells to replicate and divide in sequence, and the potential for proliferation is blocked.
In the field of tumor research, fluoroiodine deoxyuridine is also a powerful tool. Researchers often use it to label tumor cells and observe the growth, migration and invasion pathways of tumor cells by virtue of their special properties. In this way, it is possible to deeply explore the pathogenesis of tumors and provide key clues for finding better treatment methods. Therefore, fluoroiodine deoxyuridine plays a pivotal role in the treatment and research of tumors, just like a sharp blade in the hands of doctors, contributing extraordinary power to conquering tumor problems.
What is the mechanism of action of 2 '-fluoro-5-iodo-2' -deoxyuridine?
2% 27-fluoro-5-iodo-2% 27-deoxyuridine (FIAU) is a special nucleoside analogue. Its mechanism of action is quite complex and delicate.
This drug can mimic natural nucleosides. With its affinity with related transporters, it is ingested by cells like a "dark warehouse". Once it enters the cell, it is like a "disguise sneak in", phosphorylated under the action of kinases, and turned into an active form. This active form is like a "Trojan horse" and quietly mixed into the DNA synthesis process.
In the key process of DNA synthesis, the active material formed by FIAU can combine with DNA polymerase, which is like plugging foreign matter into the "running gear" of the enzyme and hindering the incorporation of normal nucleotides. In this way, the extension of the DNA chain seems to be blocked halfway and forced to terminate. Not only that, after its incorporation into DNA, the DNA structure will be eroded like a pillar of a building, and the stability will drop sharply, which will then destroy the normal function of DNA. It is like a building that is unstable and difficult to function normally.
FIAU also affects the activities of many enzymes related to DNA synthesis and repair. These enzymes are originally the "guardians" that maintain the stability of the cellular genome, but FIAU makes their "combat effectiveness" weakened or dysfunctional. Such multiple effects eventually led to cell proliferation inhibition and even apoptosis, just like the enemy army breaking through the defense line and the cell "city" falling.
What are the side effects of 2 '-fluoro-5-iodo-2' -deoxyuridine?
2% 27 - fluoro - 5 - iodo - 2% 27 - deoxyuridine is fluorouridine. Although this substance has healing power, it also has various side effects.
First, it has a considerable impact on the gastrointestinal organs. It often causes nausea and vomiting. This is the drug entering the gastrointestinal tract, disturbing its and descending ability, and the stomach qi is reversed. And it is easy to cause diarrhea, because the drug damages the function of gastrointestinal transportation, the water and grain essence cannot be transferred normally, and the bet is diarrhea. What's more, the gastrointestinal mucosa is damaged, which can cause ulcers and bleeding, endangering health.
Second, the hematopoietic ability of the bone marrow is also inhibited. It can reduce the production of white blood cells, platelets and other blood cells. White blood cells, the body's defense against external evil, reduce their number, the body is prone to invasion by external evil, suffering from various infections. Platelets are related to blood coagulation, and their number is reduced. A slight bump can easily cause bleeding, such as skin ecchymosis, bleeding gums, etc.
Third, it is also unfavorable to liver and kidney functions. The liver is an important detoxification and metabolic organ of the human body, and the kidneys are responsible for excretion. This drug may cause liver enzymes to increase, affecting the normal metabolism and detoxification of the liver; in the kidney, it may damage its ability to filter and reabsorb, causing the excretion of metabolic wastes in the body to be blocked, accumulating in the body, poisoning the body.
Fourth, the skin and hair are also affected. It can cause erythema and itching of the skin, which can be caused by allergic or inflammatory reactions of the skin caused by the drug. Hair loss is nourishing, and it is common to see hair loss, which damages the appearance of the human face.
Fifth, the nervous system is also not immune. Patients may feel headache and dizziness, because the drug affects the flow of qi and blood in the brain and nerve conduction. What's more, it can cause mental abnormalities, disturb the gods, and affect the patient's mental thinking.
Those who use this drug should carefully weigh its advantages and disadvantages and closely monitor it to prevent all side effects.
What are the applicable populations of 2 '-fluoro-5-iodo-2' -deoxyuridine?
2% 27-fluoro-5-iodo-2% 27-deoxyuridine, the Chinese name is often fluoroiodine deoxyuridine, and the application population of this drug is quite specific. According to ancient medical theory, most people who suffer from specific diseases may be suitable.
In the case of tumor diseases, if it is a part of the malignant tumor patients with vigorous proliferation, it can be considered for use. Because fluoroiodine deoxyuridine can be incorporated into the DNA of tumor cells, thereby hindering their synthesis and proliferation, just like the ancient art of war to "disturb its source and cut off its path", so that the growth of tumor cells is hindered. For example, some solid tumors, whose cells divide rapidly and are more sensitive to drugs, may be suitable for such patients.
Furthermore, in some cases of viral infection, if the virus replicates actively, it may also be applied. This medicine can interfere with the synthesis of viral DNA and inhibit the proliferation of the virus, just like defending against foreign enemies in the way of invasion.
However, when using the medicine, it is necessary to carefully check the patient's body shape. For the elderly and weak, the qi and blood are deficient, and the function of the organs is gradually declining. The dosage and course of treatment need to be reduced, so as not to damage the righteousness of the medicine. Young children, with delicate organs and insufficient qi and blood, need to be carefully weighed and should not be used rashly.
Doctors should use drugs like good generals, evaluate the situation, carefully observe the individual differences of patients, and use precise drugs to avoid harm.
Does 2 '-fluoro-5-iodo-2' -deoxyuridine interact with other drugs?
2% 27-fluoro-5-iodo-2% 27-deoxyuridine (fluorouridine analogue, often abbreviated as FIAU), may interact with other drugs. This drug is a nucleoside analogue, and its metabolism and pharmacological pathway in the body are complex. When used in combination with other drugs, many aspects must be taken into account.
The path of drug metabolism, FIAU is metabolized through the action of enzymes in the body. If used with drugs that affect the activity of such enzymes, it may cause changes in FIAU metabolism. If taken in combination with agents that induce specific liver drug enzymes, the enzyme activity will increase, the metabolic rate of FIAU will decrease, and the blood drug concentration will decrease, and the drug efficacy may not meet expectations. On the contrary, if co-administration with drugs that inhibit this enzyme, FIAU metabolism will slow down, blood concentration will build up, or the risk of adverse reactions will increase.
Furthermore, consider the target of drug action. FIAU acts on specific targets of viruses or cells to exert its effect. If other drugs also target this check point, or act nearby, the two may compete and combine, and the drug effects will interfere with each other. It is difficult to predict whether they are synergistic or antagonistic. For example, if antiviral drugs with similar effects are administered together, although they may be synergistic in antiviral effect, they may also decrease due to target competition.
In addition, FIAU has a wide range of effects on the body's physiological system. It may involve important organs such as liver and kidney. If used with drugs that harm the liver or kidneys, the burden on the organs will increase sharply. If taken with hepatotoxic agents, the risk of liver damage will increase sharply, which can cause transaminase liters, or even the risk of liver failure.
In summary, when 2% 27 - fluoro - 5 - iodo - 2% 27 - deoxyuridine is used in combination with other drugs, it may exist due to various factors such as metabolism, target and organ influence. When taking medication, doctors must carefully review the characteristics of the drug, the patient's condition, and weigh the pros and cons to achieve the purpose of safe and effective medication.