2 Fluoro 5 Iodobenzoic Acid

2-Fluoro-5-iodobenzoic acid (2-fluoro-5-iodobenzoic acid) has a wide range of uses and is often a key intermediate in the field of pharmaceutical synthesis. Due to its unique structure, the introduction of fluorine and iodine atoms imparts different physical and chemical properties and biological activities to the compound. Based on this, various drugs such as antibacterial, anti-inflammatory and anti-tumor can be prepared. With its special structure, it interacts with targets in vivo to achieve the effect of treating diseases.
In the field of materials science, it also has important functions. It can be integrated into polymer materials through specific chemical reactions to improve the properties of materials, such as enhancing the stability, corrosion resistance and optical properties of materials. Due to the high electronegativity of fluorine atoms, intermolecular forces can be enhanced, while iodine atoms can affect the electron cloud distribution of materials under specific conditions, thus optimizing material properties.
In the field of organic synthetic chemistry, 2-fluoro-5-iodobenzoic acid is an important starting material for the construction of complex organic molecules. With the different reactivity of carboxyl groups, fluorine atoms and iodine atoms, organic compounds with diverse structures can be constructed through various organic reactions, such as esterification reactions, nucleophilic substitution reactions, coupling reactions, etc., providing a rich material basis and research direction for the development of organic synthetic chemistry.

2-Fluoro-5-iodobenzoic acid is an organic compound with specific physical properties. It is solid at room temperature, which is due to the strong interaction between molecules, resulting in its stable existence in the solid state. Melting point and boiling point are of great significance for the identification and separation of substances. It is unfortunate that I have not obtained these two data, which are different due to different literature reports or differences in purity and determination methods.
Looking at its solubility, this compound may be better than water in organic solvents. Organic solvents such as ethanol, ether, dichloromethane, etc. are soluble due to interactions such as van der Waals force and hydrogen bonds with the compound molecules. Water is a polar strong solvent. Although 2-fluoro-5-iodobenzoic acid contains carboxyl groups, it can form hydrogen bonds with water. However, the presence of fluorine and iodine atoms enhances the hydrophobicity of the molecule, resulting in poor solubility in water.
Again, I have not obtained the exact value of its density. However, it can be inferred that because the molecule contains iodine atoms, the relative weight of iodine atoms is large, which increases the molecular weight, so its density may be greater than that of common organic solvents. If extraction and other operations are carried out, this property can be used as a reference.
In addition, its appearance may be white to light yellow solid, and the formation of color is due to factors such as electron transitions in the molecular structure. This color feature can be used as a basis for the initial identification of compounds. The physical properties of 2-fluoro-5-iodobenzoic acid are of great significance in the fields of organic synthesis and medicinal chemistry. For example, in synthetic reactions, solubility affects the choice of reaction medium; melting point and boiling point help purify and separate products; density is also an important consideration in liquid-liquid separation operations.

The synthesis method of 2-fluorobenzoic acid has been known for a long time, and it has undergone several changes. It is now selected and described.
First, 2-fluorobenzoic acid is used as the starting material, which is a common starting material. First, 2-fluorobenzoic acid is introduced into an activating group under appropriate reaction conditions to make the benzene ring more prone to electrophilic substitution. Then, an iodine source, such as potassium iodide, is combined with an appropriate oxidizing agent in a suitable solvent to carry out the iodization reaction. In this process, the reaction temperature, time and the ratio of reactants need to be precisely controlled. If the temperature is too high, the side reactions will increase; if the temperature is too low, the reaction rate will be slow. After this step, 2-fluoro-5-iodobenzoic acid can be obtained.
Second, 5-iodo2-nitrobenzoic acid can also be used as a raw material. The nitro group is first reduced, and a suitable reducing agent can be used, such as the system of iron powder and hydrochloric acid, or catalytic hydrogenation, etc., to convert the nitro group into an amino group. Then, through diazotization reaction, sodium nitrite interacts with inorganic acid to form a diazo salt, and then through hydrolysis reaction, using water as a reagent, under specific conditions, the diazo group is converted into a carboxyl group to obtain the target product 2-fluoro-5-iodobenzoic acid. Although this route is slightly complicated, the reaction conditions of each step are relatively mild and easy to control.
Third, you can also start from 2-fluoro-5-iodobenzaldehyde. With suitable oxidizing agents, such as potassium permanganate, potassium dichromate, etc., the aldehyde group is oxidized to a carboxyl group in a basic or acidic environment. This oxidation process requires attention to the choice of reaction conditions. Too acidic or too basic may affect the purity and yield of the product.
All the above synthesis methods have their own advantages and disadvantages. In practical application, when considering the availability of raw materials, the difficulty of reaction conditions, and the purity and yield of the product, the choice is made.

There are 2-fluoro-5-iodobenzoic acid in the market today, what is the price? We can simulate the ancient saying and literary style of "Tiangong Kaiwu" to answer it.
The price of various items in the city often varies due to many reasons. For 2-fluoro-5-iodobenzoic acid, the price is mainly related to the state of supply and demand. If there are many applicants for this item, and there are few suppliers, the price will be high; on the contrary, if the supply exceeds the demand, the price will decline.
Furthermore, the difficulty of its production is also related to the price. If the preparation method is complicated, requires concentrate and good workmanship, and is time-consuming and labor-intensive, the cost will be high, and the price will be higher. In addition, the difference in purity also has a great impact on the price. For high purity, the preparation is more difficult, and the price must be higher than for low purity.
And the distance of the place of origin and the cost of transportation are also variables of the price. Produced in distant places, with the labor and cost of transportation, the price may be higher than that of nearby real estate.
According to the current common form, 2-fluoro-5-iodobenzoic acid, if it is ordinary purity, the price per gram may be between tens and hundreds of yuan; if it is high purity, the price per gram may exceed 100 yuan, or even hundreds of yuan. However, this is only a rough number, and the market conditions are ever-changing. The actual price must be consulted with the supplier in detail to determine the exact number.

2-Fluoro-5-iodobenzoic acid is one of the organic compounds. Its storage conditions are quite important, which is related to the stability and quality of this substance.
This compound should be placed in a cool, dry and well-ventilated place. In a cool environment, it can avoid decomposition or other chemical reactions caused by excessive temperature. High temperature often promotes molecular activity, making the structure volatile and damaging its chemical properties. Dry places are also indispensable. Due to moisture or moisture, it can cause hydrolysis or other reactions with water, which in turn affects the purity and quality. If placed in a humid environment, moisture may interact with certain groups in the compound, causing it to deteriorate.
Furthermore, keep away from fire and heat sources. Because it may be flammable or in contact with fire sources, it is easy to cause violent reactions, endangering safety. And should be stored separately from oxidizing agents, reducing agents, etc. Cover substances of different chemical properties in contact with each other, or chemical reactions, and even cause dangerous accidents such as explosion and combustion.
When storing, also ensure that the package is well sealed. Sealing can prevent external factors such as air and moisture from invading and maintain its chemical stability. If the package is damaged, external substances are easy to enter and interact with compounds, causing their properties to change.
During the use process, strict operating procedures must also be followed. After use, the packaging should be sealed and placed in the specified storage environment to ensure that 2-fluoro-5-iodobenzoic acid is always in good storage condition without losing its inherent chemical properties and application value.