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What are the chemical properties of 2-fluoro-6-iodoanisole?
2-Fluoro-6-iodoanisole is a member of the family of organic compounds. This compound has unique chemical properties and has a wide range of uses in the field of organic synthesis.
Let's talk about its physical properties first. At room temperature, 2-fluoro-6-iodoanisole is mostly liquid and has a specific odor and color. Its boiling point and melting point are influenced by intermolecular forces. The introduction of fluorine and iodine atoms changes the intermolecular forces, and the boiling point and melting point are also different. Due to the large relative atomic weight of iodine atoms, the molecular weight increases, and the van der Waals force is enhanced, the boiling point may be increased.
In terms of chemical properties, fluorine, iodine and methoxy groups in this compound give it active chemical activity. The iodine atom has high activity and is easy to participate in the nucleophilic substitution reaction. When the nucleophilic reagent attacks, the iodine atom is easy to leave and is replaced by the nucleophilic group, thereby forming a new carbon-heteroatom bond, which lays the foundation for the synthesis of complex organic molecules. For example, when reacting with sodium alcohol, the iodine atom can be replaced by an alkoxy group to form ether compounds.
The fluorine atom has a large electronegativity, which can change the electron cloud density of the benzene ring, which affects the activity and regioselectivity of the electrophilic substitution reaction on the benzene ring. Due to its electron-absorbing induction effect, the electron cloud density of the benzene ring is reduced, and the activity of the electrophilic substitution reaction is slightly reduced, but the substitu
Methoxy group acts as the power supply group, which is opposite to the fluorine atom. It increases the electron cloud density of the benzene ring, improves the activity of the electrophilic substitution reaction of the benzene ring, and guides the electrophilic reagents into the ortho and para-methoxy group. In the electrophilic substitution reaction, the methoxy group interacts with the fluorine and iodine atoms to determine the reaction check point and difficulty.
In addition, 2-fluoro-6-iodoanisole can also participate in the metal catalytic coupling reaction. Under the action of metal catalysts such as palladium and nickel, it reacts with reagents containing alkenyl groups and aryl halides to form carbon-carbon bonds. It is widely used in drug synthesis, materials science and other fields to help construct complex organic molecules with specific
What are 2-fluoro-6-iodoanisole synthesis methods?
The synthesis of 2-fluoro-6-iodoanisole often involves several paths. First, it can be obtained by starting with 2-fluoro-6-iodophenol and methylating the phenolic hydroxyl group. In this process, dimethyl sulfate or iodomethane are used as methylating reagents. In the presence of alkaline environments such as potassium carbonate or sodium hydroxide, the two react to form the target product. Specifically, place 2-fluoro-6-iodophenol and an appropriate amount of potassium carbonate in a suitable organic solvent, such as N, N-dimethylformamide (DMF) or acetone, stir well, heat up to an appropriate temperature, add dimethyl sulfate or iodomethane dropwise, and continue the reaction. After the reaction is completed, it can be purified by extraction, washing, drying and column chromatography to obtain pure 2-fluoro-6-iodoanisole.
Second, it can be started from 2-fluoro-6-nitroanisole. First, 2-fluoro-6-nitroanisole is reduced to 2-fluoro-6-aminoanisole with a suitable reducing agent, such as iron filings and hydrochloric acid or hydrogen and palladium carbon catalysts. Subsequently, the target product is synthesized by diazotization and iodization. That is, 2-fluoro-6-aminoanisole is reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt, and then potassium iodide is added. The diazonium group is replaced by an iodine atom to obtain 2-fluoro-6-iodoanisole. The subsequent purification steps are also required to remove impurities.
Or it is synthesized by iodization reaction starting from 2-fluoroanisole. With a suitable iodine source, such as iodine elemental or N-iodosuccinimide (NIS), in the presence of a catalyst, such as ferric trichloride or concentrated sulfuric acid, react with 2-fluoroanisole, and iodine atoms are selectively introduced into the 6-position of the phenyl ring. After the reaction is completed, the product is purified by post-treatment.
These methods have their own advantages and disadvantages. In the actual synthesis, the choice needs to be weighed according to factors such as raw material availability, cost and reaction conditions, in order to achieve the purpose of efficient synthesis of 2-fluoro-6-iodoanisole.
In what areas is 2-fluoro-6-iodoanisole applied?
2-Fluoro-6-iodoanisole is useful in many fields.
In the field of medicinal chemistry, this compound can be used as an important synthetic intermediate. Due to its structure containing fluorine, iodine and other halogen atoms, it has unique chemical and biological activities. Chemists can use it as a starting material through various reactions, modify and splice to produce a variety of molecules with special pharmacological activities. Or when developing antibacterial, anti-tumor and other drugs, it is refined chemically transformed to integrate it into the molecular structure of the drug to optimize the drug's drug formation, such as improving the affinity of the drug to the target, enhancing the metabolic stability of the drug, etc., to help create new drugs with high efficiency and low toxicity.
In the field of materials science, 2-fluoro-6-iodoanisole also has its work. In view of the influence of halogen atoms on the distribution of molecular electron clouds and molecular interactions, it can be introduced into the structure of polymers or organic materials. This may modify the electrical and optical properties of the material. For example, in organic optoelectronic materials, the introduction of this compound, or the energy band structure of the material can be adjusted to optimize its charge transport performance, is expected to be used in the preparation of high-performance organic Light Emitting Diode (OLED), organic solar cells and other optoelectronic devices to improve the efficiency and stability of the device.
In the field of organic synthesis chemistry, 2-fluoro-6-iodoanisole provides a variety of reaction check points for organic synthesis due to the difference in the activity of fluorine and iodine atoms. Chemists can use the characteristics of selective halogenation reactions to selectively activate fluorine or iodine atoms according to different needs, perform nucleophilic substitution, coupling and other reactions to construct complex organic molecular structures, providing rich strategies and possibilities for the synthesis of novel organic compounds, and promoting the development and innovation of organic synthesis chemistry.
What is the market price of 2-fluoro-6-iodoanisole?
2-Fluoro-6-iodoanisole is a fine chemical in organic chemistry. Its market price is difficult to hide, because it is affected by many factors.
First, the difficulty of preparation has a great impact on the price. To make 2-fluoro-6-iodoanisole, a multi-step organic synthesis reaction is required. The choice of raw materials and the control of reaction conditions are all key. If the synthesis route is lengthy and the yield of each step is not high, or special reaction equipment and conditions are required, such as low temperature, high pressure, or the use of expensive catalysts, the preparation cost will be high, and the market price will also rise.
Second, the market supply and demand relationship is also an important determinant of price. If the chemical is in strong demand in the fields of medicine and materials, but the supply is relatively insufficient, if the number of producers is limited or limited in production capacity, it cannot meet the market demand, the price will rise. On the contrary, if the market demand is low, the producers may reduce the price to promote sales.
Third, the fluctuation of raw material prices will also affect the price of 2-fluoro-6-iodoanisole. If the price of fluoride, iodide and other raw materials required for the preparation of this chemical changes due to factors such as resource scarcity, market monopoly, or international situation, the price of the final product will fluctuate.
Fourth, the purity and quality grade of the product are also related to the price. In some high-end application scenarios, such as pharmaceutical research and development, the purity of chemicals is extremely high, requiring more than 99% or even higher. Such high-purity products will naturally be higher than ordinary purity products due to the complex purification process and increased cost.
According to past market conditions, the price of 2-fluoro-6-iodoanisole may range from tens to hundreds of yuan per gram. However, this is only a general range. The actual price depends on the current market conditions and specific negotiations with suppliers. When purchasers make inquiries, they can obtain the best procurement plan by considering factors such as product quality, delivery time, and after-sales services, rather than just focusing on price.
What are 2-fluoro-6-iodoanisole storage conditions?
2-Fluoro-6-iodoanisole is one of the organic compounds. Its storage conditions are very critical, which is related to the stability and quality of this compound.
This compound should be stored in a cool place. Because the temperature is too high, or the molecular activity is enhanced, it triggers a chemical reaction and causes it to deteriorate. A cool environment can keep the molecule in a relatively stable state and slow down possible changes.
And it should be placed in a dry place. Water is often the medium for many chemical reactions. If the environment is humid, water can participate in the reaction, or hydrolyze 2-fluoro-6-iodoanisole, or cause other side reactions, which will damage its purity and properties.
It should also be stored in a well-ventilated place. If the space is closed, once this substance evaporates and steam accumulates, it may not only affect its own properties, but also pose a safety risk. Good ventilation can disperse the volatile gas in time to ensure environmental safety.
Furthermore, it should be kept away from fire sources and oxidants. 2-Fluoro-6-iodoanisole may be flammable, and it is easy to cause fire in case of fire sources; and oxidants can react violently with the like, endangering storage safety.
In addition, storage containers are also careful. Containers with good sealing performance are required to prevent air, moisture, etc. from invading. And the container material should not react with 2-fluoro-6-iodoanisole to ensure the stability of the material.
In this way, follow the cool, dry, ventilated, away from fire sources and oxidants, and choose suitable storage conditions such as containers to properly store 2-fluoro-6-iodoanisole, so that its properties and quality can be maintained.