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What are the chemical properties of 2-hydroxy-4-methyl-5-iodopyridine?
2-Hydroxy-4-methyl-5-iodopyridine is an organic compound with unique chemical properties. In its structure, hydroxyl groups, methyl groups and iodine atoms coexist in pyridine rings and interact, giving it various chemical activities.
As far as acidity is concerned, hydroxyl hydrogen atoms can be dissociated, making the compound somewhat acidic. Under specific conditions, hydroxyl groups are prone to participate in the substitution reaction. The oxygen atom of the hydroxyl group can act as a nucleophilic reagent due to its lone pair of electrons, and react with electrophilic reagents to form new chemical bonds. The existence of
methyl groups has an impact on the distribution of molecular electron clouds and the spatial structure. It has a electron-inducing effect, which can change the electron cloud density of the pyridine ring and affect the reactivity and selectivity of the compound. Generally speaking, the electron cloud density of the adjacent and para-sites of the pyridine ring is relatively increased by the action of the methyl-donator, which is conducive to the occurrence of electrophilic substitution reactions at these locations.
Iodine atoms introduce a larger atomic radius and a stronger electron-sucking induction effect for this compound. Although the nitrogen atom of the pyridine ring has electron-sucking properties, the addition of iodine atoms further enhances the molecular polarity. The iodine atom also makes the compound have unique reactivity. Due to the relatively low C-I bond energy, under suitable conditions, the iodine atom is easy to leave and participate in nucleophilic substitution, coupling and other reactions, such as Ullman reaction, Suzuki reaction, etc., providing the possibility for the construction of complex organic molecular structures.
In addition, 2-hydroxy-4-methyl-5-iodopyridine contains multiple reactive functional groups and can participate in various types of organic reactions. It has potential application value in the field of organic synthesis. It can be used as an intermediate for the synthesis of drugs, natural products and functional materials.
What are the common synthetic methods of 2-hydroxy-4-methyl-5-iodopyridine?
2-Hydroxy-4-methyl-5-iodopyridine is also an organic compound. Its common synthesis methods are about the following numbers.
First, 2-hydroxy-4-methyl pyridine is used as the starting material. Shilling it with appropriate iodine substitution reagents, such as iodine element ($I_ {2} $) and oxidants, such as hydrogen peroxide ($H_ {2} O_ {2} $) or potassium persulfate ($K_ {2} S_ {2} O_ {8} $), etc., in a suitable solvent, such as acetic acid ($CH_ {3} COOH $), under heating conditions. In this process, the oxidizing agent can induce the iodine element to produce an electrophilic iodine cation ($I ^{+}$）， and then react with the 5-position of 2-hydroxy-4-methylpyridine to obtain the target product 2-hydroxy-4-methyl-5-iodopyridine.
Second, it can be started from 4-methyl-2-methoxypyridine. It is first reacted with iodine substitutes, such as copper iodide ($CuI $) and ligands, such as 1,10-phenanthroline ($phen $), under basic conditions, such as potassium carbonate ($K_ {2} CO_ {3} $), in a suitable organic solvent, such as $N, N $-dimethylformamide ($DMF $), to introduce the iodine atom into the 5-position. Subsequently, treated with an acid, such as hydrochloric acid ($HCl $), the methoxy group is hydrolyzed to a hydroxyl group, resulting in 2-hydroxy-4-methyl-5-iodopyridine.
Third, pyridine derivatives can also be used as starters and obtained through multi-step reactions. First, methyl groups and protected hydroxyl groups are introduced into the pyridine ring, then iodine atoms are introduced through halogenation reaction, and finally the protective groups are deprotected to obtain the target compound. The choice of reaction conditions and reagents needs to be carefully determined according to the specific reaction path to achieve the purpose of efficient synthesis.
In what areas is 2-hydroxy-4-methyl-5-iodopyridine applied?
2-Hydroxy-4-methyl-5-iodopyridine, this compound is useful in many fields. In the field of medicine, it can be a key intermediate for the creation of new drugs. Gainpyridine ring structure is common in many drug molecules, and the introduction of hydroxyl, methyl and iodine atoms endows the compound with unique chemical activity and spatial structure, which can act on specific biological targets, or participate in the process of drug metabolism, helping to develop antibacterial, antiviral, anti-tumor and other drugs.
In the field of materials science, it also has its uses. It can participate in the synthesis of materials with special optoelectronic properties. For example, through a specific reaction, it becomes a part of a conjugated polymer, giving the material unique properties of light absorption, emission or charge transport, which is used in the preparation of organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices.
Furthermore, in the field of organic synthetic chemistry, it is an extremely important synthetic building block. Because different functional groups in the molecule can undergo a variety of chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to construct more complex organic molecular structures, providing a powerful tool for organic synthetic chemists to explore new reaction paths and expand the compound library.
In the field of agricultural chemistry, it may be used to develop new pesticides. With its unique chemical structure, it can inhibit or kill some pests and pathogens, and has higher selectivity and lower environmental toxicity than traditional pesticides, which helps the development of green agriculture. In short, 2-hydroxy-4-methyl-5-iodopyridine has great potential application value in many fields, which needs to be deeply explored and explored by scientists.
What are the physical properties of 2-hydroxy-4-methyl-5-iodopyridine?
2-Hydroxy-4-methyl-5-iodopyridine, this is an organic compound with specific physical properties. Its properties are mostly solid at room temperature, but due to the characteristics of substituents, it may also be oily liquids.
Looking at its melting point, due to the influence of hydrogen bonds and substituents in the molecule, the melting point or a specific range. Hydroxyl groups can cause hydrogen bonds to form between molecules, which increases the melting point; methyl groups are the power supply groups, which have an impact on the intermolecular force; iodine atoms have a large mass, which also affects the accumulation and melting point of molecules.
In terms of boiling point, due to factors such as hydrogen bonds and molecular weight, the boiling point is higher. Intermolecular hydrogen bonds make molecules bond tightly, requiring more energy to vaporize; iodine atoms increase molecular weight and intermolecular van der Waals force, which also increases the boiling point.
In terms of solubility, it has different solubility in organic solvents. Because it contains polar hydroxyl groups, it has certain solubility to some polar organic solvents such as methanol, ethanol, dichloromethane, etc. Hydroxyl groups can form hydrogen bonds with polar solvents, which is conducive to solubility; while methyl and iodine atoms affect the overall polarity of molecules, or cause poor solubility in non-polar solvents.
Appearance may be white to light yellow solid or powder, which is related to its molecular structure and crystal structure. Molecular arrangement and light absorption and scattering characteristics determine its appearance and color. The physical properties of 2-hydroxy-4-methyl-5-iodopyridine are determined by its unique molecular structure. Each substituent interacts and exhibits specific properties in terms of melting point, boiling point, solubility and appearance.
What is the market price of 2-hydroxy-4-methyl-5-iodopyridine?
The price of 2-hydroxy-4-methyl-5-iodopyridine is known to everyone in today's market. However, its price cannot be generalized, due to many reasons, its price fluctuates.
First, the price of raw materials is the key reason. If the raw materials required for its preparation are high and dilute, the production cost of this compound will increase, and its market price will also rise. On the contrary, if the raw materials are abundant and cheap, the price may drop slightly.
Second, the preparation method and process also affect its price. If the method is complicated, requires delicate equipment and many man-hours, and the yield is not ideal, the cost will be high and the price will be difficult to lower. However, if there are new and clever methods that can simplify the process and increase the yield, there may be room for price reduction.
Furthermore, the supply and demand of the market is the most important element. If at some time, the demand for 2-hydroxy-4-methyl-5-iodopyridine from various industries is surging, and the supply is not sufficient, the price will rise. On the contrary, if the supply exceeds the demand, the manufacturer may have to reduce the price to compete for the market in order to sell its goods.
In addition, the difference between regions is also related to the price. In places with abundant materials and convenient transportation, the transportation and transaction fees may be low, and the price is relatively stable. And in remote places, due to logistics and other fees, the price may be slightly higher.
As for the exact market price, it is difficult to determine. Or you need to consult the chemical raw material suppliers widely to compare their prices; or refer to the platform for chemical product trading, and look at its recent transaction price, in order to understand the price of 2-hydroxy-4-methyl-5-iodopyridine in the market.
