2-hydroxy-5-iodo-benzaldehyde

2-Hydroxy-5-iodobenzaldehyde is an organic compound. It has a wide range of uses in the field of medicine and can be used as a key intermediate in drug synthesis. Due to the specific chemical structure and activity of this compound, it can introduce specific functional groups into drug molecules, which can affect the pharmacological activity and target of drugs. When synthesizing drugs with antibacterial and anti-inflammatory effects, 2-hydroxy-5-iodobenzaldehyde can play an indispensable role.
In the field of materials science, it can be used to prepare functional materials. For example, by reacting with other compounds, materials with unique optical and electrical properties can be constructed, or used in organic Light Emitting Diodes (OLEDs), sensors and other devices to impart specific responsiveness and functional characteristics to materials.
In the field of organic synthesis, 2-hydroxy-5-iodobenzaldehyde is an extremely important starting material. Because its aldehyde group, hydroxyl group and iodine atom can participate in many organic reactions, such as condensation reaction, oxidation-reduction reaction, etc., it can derive a variety of organic compounds, providing a rich material basis for the research and development of organic synthesis chemistry, and helping scientists to create more novel and functional organic molecules.

To prepare 2-hydroxy-5-iodobenzaldehyde, the following methods can be used.
First, use 2-hydroxy benzaldehyde as the starting material. First, it reacts with iodine in the presence of appropriate solvents and catalysts. Glacial acetic acid is often used as the solvent, and appropriate amounts of potassium iodide and hydrogen peroxide are used as catalytic aids. In this environment, iodine atoms can selectively replace hydrogen atoms at specific positions on the benzene ring. After fine regulation of reaction conditions, such as temperature, reactant ratio, and reaction time, the iodine atom is preferentially placed in the fifth position of the 2-hydroxy benzaldehyde benzene ring, and then 2-hydroxy-5-iodobenzaldehyde is obtained. The reaction mechanism is electrophilic substitution. The aldehyde group and the hydroxyl group are ortho-para-sites, and the positioning effect of the hydroxyl group is strong, which guides the iodine atom to be substituted at the hydroxy para-site, that is, the 5 position.
Second, it can be started from 2-methoxybenzaldehyde. First, it reacts with iodine in a system similar to the above catalyst to obtain 2-methoxy-5-iodobenzaldehyde, and then goes through the demethylation step. Often treated with boron tribromide and other reagents to remove the methoxy group and convert it into a hydroxyl group, thereby obtaining the target product 2-hydroxy-5-iodobenzaldehyde. In this path, the methoxy group is also an ortho-para-locator, and the dominant iodine atom is substituted at the 5th position. The demethylation reaction requires strict temperature control and reaction process to prevent overreaction from affecting the purity and yield of the product.
Or, starting with the corresponding phenolic compound, introducing the aldehyde precursor through acylation, then iodizing, and then oxidizing it appropriately, 2-hydroxy-5-iodobenzaldehyde can also be obtained. However, each method needs to be carefully controlled at all stages of the reaction, from the purity of the raw material, the reaction conditions to the separation and purification of the product, each step is related to the quality and yield of the product.

2-Hydroxy-5-iodobenzaldehyde, this is an organic compound. Its physical properties are quite important and are related to many chemical applications.
Looking at its appearance, under room temperature and pressure, 2-hydroxy-5-iodobenzaldehyde is often in a solid state, mostly white to light yellow crystalline powder. This form is conducive to storage and transportation, because it is relatively stable, it is not easy to flow or evaporate at will.
The melting point is crucial for the identification and purification of this compound. Its melting point is about a certain range, and the specific value varies slightly according to the experimental conditions. Generally speaking, the melting point can help chemists determine the purity of the substance. If the purity is high, the melting point range is relatively narrow and close to the theoretical value; if it contains impurities, the melting point is reduced and the range is wider.
In terms of solubility, 2-hydroxy-5-iodobenzaldehyde has acceptable solubility in organic solvents. For example, in common organic solvents such as ethanol and ether, it can be dissolved to a certain extent. However, in water, its solubility is poor, because although there are hydroxyl groups in the molecular structure of the compound that can form hydrogen bonds with water, the presence of iodine atoms and benzene rings enhances the overall hydrophobicity, so it is difficult to dissolve in water. This solubility characteristic has a great influence on the chemical synthesis and separation process, and chemists can choose suitable solvents for reaction and purification.
In addition, 2-hydroxy-5-iodobenzaldehyde has a certain degree of volatility, but it is relatively weak. In a conventional environment, its volatilization rate is slow, but if it is in a high temperature or well-ventilated environment, the volatilization will be accelerated. This requires that environmental factors should be taken into account when storing and using it to avoid losses due to volatilization or environmental pollution.
Density is also one of its physical properties. Although the value is relatively fixed, the density data can help chemists design a reasonable process when it comes to mixing and separating substances. For example, in the liquid-liquid extraction process, different components can be effectively separated according to the density difference.
In summary, the physical properties of 2-hydroxy-5-iodobenzaldehyde, such as appearance, melting point, solubility, volatility, and density, are interrelated and affect its application and treatment in the chemical field. Chemists need to consider in detail in order to better use this compound.

2-Hydroxy-5-iodobenzaldehyde, this is an organic compound with unique chemical properties.
It has an aldehyde group, and the aldehyde group is active, and can participate in many reactions. If it can react with weak oxidants, such as Torun's reagent, the aldehyde group is oxidized to carboxyl groups to precipitate silver mirrors. This is a silver mirror reaction, often used as an aldehyde group test method. It can also react with Feilin's reagent to form a brick red precipitate, which is also a characteristic reaction of aldehyde groups.
The hydroxyl group in this compound can exhibit some of the properties of alcohols. It can react with active metals, such as sodium, to replace hydrogen. Under appropriate conditions, an esterification reaction can also occur, and an ester compound can be formed by reacting with carboxylic acids.
The structure of its benzene ring also affects its properties. The benzene ring has a certain stability and can undergo substitution reactions. Because the hydroxyl group and the aldehyde group are ortho-para-sites, new substituents are easy to enter the ortho-sites or para-sites of the benzene ring. The presence of iodine atoms at position 5 makes the reactivity and substitution position unique.
In addition, the halogen atom iodine can participate in reactions such as nucleophilic substitution. Under specific reagents and conditions, the iodine atom can be replaced by other groups to realize the structural transformation and derivatization of compounds.
In summary, 2-hydroxy-5-iodobenzaldehyde exhibits rich and diverse chemical properties due to the synergistic action of aldehyde, hydroxyl, iodine atoms and benzene ring, and has important application potential in organic synthesis and other fields.

The price of Wuguan Market varies with supply and demand over time and place. It is not easy to determine the price of 2-hydroxy-5-iodobenzaldehyde. This compound may be involved in the fields of fine chemical and pharmaceutical research and development, and its price is often affected by factors such as raw materials, process, purity, and batch size.
If the raw materials are difficult to obtain, the preparation process is complicated, or the purity requirements are extremely high, the price will be high. If there are many buyers, and the output is limited, the price should also rise; conversely, if the raw materials are abundant, the process is mature, and the market supply is abundant, the price may be leveled.
However, as far as I know, the price of such fine chemicals per gram in the ordinary chemical reagent market may range from tens to hundreds of yuan. If purchased in bulk, the unit price may be slightly reduced due to the scale effect. However, this is only a rough estimate. To get an accurate price, you need to consult chemical raw material suppliers, reagent dealers, or check the recent transaction price on the chemical trading platform before you can be sure.