2 Hydroxy 5 Iodopyridine

2-Hydroxy-5-iodopyridine is one of the organic compounds and has important uses in many fields.
First, in the field of medicinal chemistry, this compound is often used as a key intermediate. During drug synthesis, its unique structure can participate in a variety of chemical reactions, and after clever transformation, it can construct a complex molecular structure with specific pharmacological activities. For example, in the synthesis of some antibacterial drugs, the iodine atom and hydroxyl group of 2-hydroxy-5-iodopyridine can be substituted and condensed with other reagents, introducing suitable functional groups, giving the drug the ability to specifically bind to bacterial targets, thus exerting antibacterial effect.
Second, in the field of materials science, it has also attracted much attention. Due to the presence of hydroxyl groups and iodine atoms, the surface properties of materials can be modified. For example, when introduced into polymer materials, hydroxyl groups can enhance the hydrophilicity of the material, and iodine atoms may affect the electrical or optical properties of the material. In this way, 2-hydroxy-5-iodopyridine can be used to prepare polymer materials with special properties, such as materials with good hydrophilicity and specific electrical conductivity or optical properties, which may have applications in electronic devices, optical sensors, etc.
Third, in the field of organic synthetic chemistry, it is an important starting material for the construction of complex pyridine derivatives. Chemists can expand the chemical structure around the pyridine ring by selectively reacting its hydroxyl groups with iodine atoms, and realize the synthesis of various functionalized pyridine compounds. This synthetic strategy is conducive to the creation of new organic compounds and contributes to the development of organic synthetic chemistry.
In summary, 2-hydroxy-5-iodopyridine plays an important role in many fields such as drug, materials and organic synthesis, and has made great contributions to the development of related fields.

The physical properties of 2-hydroxy-5-iodopyridine are very important and are related to many practical applications. This substance is usually in a solid state and is stable at room temperature and pressure. Its melting point is a specific value, which is of great significance for determining its purity and the change of state under specific conditions. To accurately know the melting point, it needs to be determined by professional experiments, which may vary slightly due to different experimental conditions.
Looking at its solubility, it shows a certain solubility in common organic solvents such as ethanol and acetone. However, in water, the solubility is relatively limited. This solubility characteristic has a significant impact on the chemical synthesis and separation and purification process. In organic synthesis, a suitable reaction solvent can be selected according to its solubility to promote the smooth progress of the reaction.
The color state of 2-hydroxy-5-iodopyridine also needs attention. Under normal conditions, it is mostly white to light yellow powder or crystalline solid. The color and shape may change due to the presence of impurities or different preparation methods. If it contains impurities, the color or darker, the shape may also change.
Its density is also one of the key physical properties. Although the exact density value needs to be accurately measured, this value is of great significance for material calculation and process design. In chemical production, the material dosage and volume can be accurately calculated according to its density to ensure the accuracy of the production process.
In addition, the stability of 2-hydroxy-5-iodopyridine is also worthy of attention. It is relatively stable in conventional environments, but it may be exposed to extreme conditions such as high temperature, strong acid, and strong alkali, or chemical reactions may occur, resulting in structural and property changes. Therefore, when storing and using, avoid contact with such substances, and choose a suitable environment for proper storage.

The synthesis of 2-hydroxy-5-iodine pyridine is an important topic in the field of organic synthesis. In the past, many researchers have worked hard on this and explored several paths.
One of them is to use 2-hydroxy pyridine as the starting material. This compound can be first halogenated to introduce halogen atoms into a specific position in the pyridine ring. To obtain 5-iodine substituted products, suitable iodizing reagents can be selected, such as iodine elemental substance combined with suitable oxidizing agent, or higher activity organic iodine reagent. When reacting, attention should be paid to the regulation of reaction conditions, such as temperature, solvent and catalyst selection. A mild polar solvent, such as dichloromethane or N, N-dimethylformamide, with an appropriate amount of catalyst, such as copper salt or palladium salt, can promote the precise addition of iodine atoms to the 5 position of the pyridine ring, and the hydroxyl group can be prevented from unnecessary reactions during the halogenation process by protecting the group strategy. After the halogenation is completed, the protecting group is removed to obtain 2-hydroxy-5-iodine pyridine.
Second, the target molecule can also be constructed from pyridine derivatives through multi-step reactions. If 2-alkoxy pyridine is used as the starting material, the pyridine ring is first introduced into the iodine atom by electrophilic substitution reaction, and then the synthesis is achieved by selectively removing the alkoxy group and converting it into the hydroxyl group. In this process, the electrophilic substitution step needs to precisely control the reaction check point, and the iodine atom can be guided into the 5 position by electronic effects and steric resistance factors. The reaction of removing the alkoxy group and converting it into the hydroxyl group can be selected according to the appropriate hydrolysis conditions of different alkoxy groups, such as acidic or basic hydrolysis, or the reaction path mediated by specific metal reagents to achieve the synthesis of the target product.
Furthermore, the cross-coupling reaction catalyzed by transition metals is also an effective strategy. Iodine-containing reagents and pyridine derivatives are selected to achieve the formation of carbon-iodine bonds under the action of transition metal catalysts such as palladium and nickel. This method requires careful design of the substrate structure, so that the reaction check point of pyridine derivatives has a suitable electron cloud density and space environment, so that the cross-coupling reaction can be carried out efficiently. At the same time, the choice of ligands is also critical, and suitable ligands can enhance the activity and selectivity of the catalyst, improve the reaction yield and the purity of the target product.

2-Hydroxy-5-iodopyridine is an organic compound. When storing and transporting, the following matters should be paid attention to:
First, the storage environment must be dry and cool. This compound is prone to deterioration due to moisture, and high temperature will also affect its stability. Therefore, it should be stored in a well-ventilated dry warehouse with a temperature of 15-30 degrees Celsius. If the environment is humid, water molecules may interact with hydroxyl groups such as 2-hydroxy-5-iodopyridine to change its chemical structure; if the temperature is too high, chemical reactions such as decomposition may be triggered.
Second, sealing measures need to be taken. If 2-hydroxy-5-iodopyridine is exposed to air, or reacts with gases such as oxygen and carbon dioxide. For example, the hydroxyl group may be oxidized, thereby reducing the quality of the product. Therefore, it should be stored in a sealed container and sealed in time after use.
Third, avoid violent vibration and collision during transportation. Because it is a solid crystalline substance, violent vibration or collision may cause damage to the package, expose it to the external environment, and cause danger due to friction heat generation. Therefore, it should be properly fixed during transportation and protected by soft cushioning materials.
Fourth, be sure to store and transport it separately from oxidants, acids, bases and other substances. The chemical properties of 2-hydroxy-5-iodopyridine are lively. Contact or chemical reaction with these substances can even cause serious accidents such as combustion and explosion.
Fifth, storage and transportation places should be equipped with corresponding fire protection and leakage emergency treatment equipment. In the event of a leak, it is necessary to quickly isolate the leaked contaminated area and restrict personnel from entering and leaving. Emergency personnel should wear dust masks (full masks) and gas suits. Collect them in a dry, clean, covered container with a clean shovel and transfer them to a safe place. In the event of a fire, a suitable extinguishing agent should be selected to extinguish the fire according to the fire situation.

2-Hydroxy-5-iodopyridine is also an organic compound. As for its market price, it is difficult to determine. The change in price is influenced by various factors.
First, the trend of supply and demand is the key. If at a certain time, many companies compete for this product for use in pharmaceuticals, scientific research, etc., and the output is limited, the price will increase. On the contrary, if there are few applicants, the supply will exceed the demand, and the price may drop.
Second, the price of raw materials also affects. The production of this compound requires specific raw materials. If raw materials are scarce and the price is high, the cost of 2-hydroxy-5-iodopyridine will increase, and the price will also rise.
Third, the difficulty of preparation and the simplicity of the process are related to the cost. If the preparation method is complicated, delicate equipment and multiple processes are required, the cost will be high, and the price will follow.
Fourth, the state of market competition cannot be ignored. If there are many producers competing with each other, it is to occupy the market, or there may be a price reduction; if there are few players, the trend of monopoly will gradually become established, and the price may be high.
According to the past market conditions, the price may vary from time to time, fluctuating between a few yuan per gram and tens of yuan. However, today is different from the past, and the market conditions are unpredictable. To know the exact price, you need to consult the chemical raw material supplier or check the latest market conditions of the chemical product trading platform in order to obtain the actual price.