2 Iodo 4 5 Difluoroaniline
Iodobenzene

2 Iodo 4 5 Difluoroaniline

Fengxi Chemical

Specifications

HS Code

306456

Packing & Storage
Packing 100g of 2 - iodo - 4,5 - difluoroaniline packaged in a sealed, chemical - resistant bottle.
Storage 2 - iodo - 4,5 - difluoroaniline should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container to prevent moisture absorption and vapor leakage. Label the storage container clearly to avoid misidentification, and ensure it is in a location inaccessible to unauthorized personnel.
Shipping 2 - iodo - 4,5 - difluoroaniline is a chemical. Shipping should follow strict regulations. It must be properly packaged in corrosion - resistant containers. Label with hazard warnings, and use carriers approved for transporting such chemicals.
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2-iodo-4,5-difluoroaniline 2-iodo-4,5-difluoroaniline 2-iodo-4,5-difluoroaniline
General Information
Frequently Asked Questions
What are the main uses of 2-iodine-4,5-difluoroaniline?
Second, its main users are laxative, liver-clearing fire, and chancre.
Second, the taste is bitter and cold, and it enters the big body and the liver. The power under the body is strong and fierce, and it can be improved and improved. If a person is dry in the middle, and the stool can't be stuffed, use this stool to make dry shit go down, and the organs can be improved. Gu Yun: "The sex is good, and the dry shit is good, so that the organs can be used."
And its ability to clear the liver and fire is also effective. If there is fire in the liver, it can cause pain and red eyes, irritability and irritability. The second one can directly break the liver, so that the evil fire can be vented. For example, in the "Words of Materia Medica", it can "cure the liver and relieve the fire". As soon as the fire of the liver is cleared, the disease will be self-relieving.
To the chancre, it is also the second one. The small chancre, mostly due to the lack of food, the spleen and stomach are affected, and it can be used at the same time. It can not only be used to remove the cause, but also to manage the spleen and stomach, to help the effect of transformation, so that the chancre can be eliminated. In the past, people used the combination of strengthening the spleen to treat small malnourishment, and it was effective.
However, the nature of bitterness and cold is very strong, so it should be used with caution. Those who are cold in the spleen and stomach must not be cast, for fear of cutting in the middle, causing the spleen to become even more weak, and the birth will be low. Even if it is low, it will stop while the disease is middle, and it cannot be low, so as not to be correct.
What are the synthesis methods of 2-iodine-4,5-difluoroaniline?
The synthesis methods of 2-butanol and 4,5-divinylpyridine are as follows:
1. Nucleophilic substitution reaction with halogenated hydrocarbons as raw materials
Take an appropriate amount of halobutane, such as 2-bromobutane, and place it in a reactor. Add an appropriate amount of basic substances, such as potassium carbonate, to provide an alkaline environment. Then 4,5-divinylpyridine is slowly added dropwise to the reaction system, and a phase transfer catalyst, such as tetrabutylammonium bromide, is added at the same time to promote the reaction between the two phases. At the appropriate temperature, generally 60-80 ° C, stir the reaction for several hours. The halogen atom in the halobutane is nucleophilically substituted by the nitrogen atom in 4,5-divinylpyridine to form an intermediate of 2-butanol-4,5-divinylpyridine, which is then hydrolyzed under acidic conditions to obtain the target product. The reaction mechanism is that the carbon-halogen bond of the halogenated hydrocarbon has a certain polarity, and the halogen atom is easily attacked and left by the nucleophilic reagent. The nitrogen atom in 4,5-divinylpyridine has a lone pair electron and undergoes a substitution reaction as a nucleophilic reagent.
2. Dehydration-addition reaction with alcohol as raw material
Mix 2-butanol with an appropriate amount of concentrated sulfuric acid, heat it to 140-170 ° C, and dehydrate to form butene. After the butene is separated from the reaction system, it is passed into the reaction vessel containing 4,5-divinylpyridine, and an appropriate amount of Lewis acid catalyst, such as aluminum trichloride, is added. At a suitable temperature, about 40-60 ° C, butene is added to 4,5-divinylpyridine. In this process, the hydroxyl group of the alcohol is dehydrated under the action of concentrated sulfuric acid to form a carbon-carbon double bond, and butene is added to the double bond in 4,5-divinylpyridine as an electrophilic reagent, thereby forming a new carbon-carbon bond and obtaining the target product.
3. Transition metal-catalyzed coupling reaction
In the reaction vessel, add 2-butanol-derived organometallic reagents, such as butyllithium reagent, and 4,5-divinylpyridine. Add an appropriate amount of transition metal catalysts, such as palladium catalysts (such as tetra (triphenylphosphine) palladium (0)), and add ligands, such as tri-tert-butylphosphine. Under the protection of inert gas, such as nitrogen or argon, the reaction is carried out at room temperature to about 50 ° C. The transition metal catalyst first forms an intermediate with organometallic reagents and 4,5-divinylpyridine, and realizes the coupling of carbon-carbon bonds through oxidative addition, metal transfer and reduction elimination to generate the target product. This method has high selectivity and relatively mild reaction conditions, but the catalyst cost is high.
What are the physical properties of 2-iodine-4,5-difluoroaniline?
2-% E7% A2% 98 refers to 4,5-diethyl ether-based naphthol, which is an organic compound. Its physical properties are complex and detailed as follows:
Looking at its properties, at room temperature, 4,5-diethyl ether-based naphthol is mostly white to pale yellow crystalline powder. This state is quite common in many organic compounds, due to the intermolecular forces and arrangements. Its microscopic molecules are arranged in an orderly manner, and macroscopically it takes on the shape of a powder. This property is also easy to store and use.
When it comes to melting points, the melting point of 4,5-diethyl ether-based naphthol is within a specific range. The melting point is also the critical temperature at which a substance changes from a solid state to a liquid state. The specific melting point reflects the stability of its molecular structure and the strength of its interaction forces. When the external temperature reaches this melting point, the molecule is energized enough to break through the lattice binding, and then melts from the solid state to the liquid state. This property is of great significance in the experimental operation of material purification and identification, and can be determined by the melting point to distinguish its purity and authenticity.
As for solubility, 4,5-diethyl ether-based naphthol has good solubility in organic solvents, such as ethanol, ether, etc. The molecular structure of organic solvents is similar to that of 4,5-diethyl ether-based naphthol. According to the principle of "similar miscibility", the two easily interact to form a uniform dispersion system. However, the solubility in water is not good, because water is a polar molecule, and the polarity difference between it and 4,5-diethyl ether-based naphthol is large, and the interaction force is weak, so it is difficult to dissolve. This difference in solubility can be exploited for separation purposes in the separation and purification steps of products in organic synthesis.
In addition, the density of 4,5-diethyl ether-based naphthol is also an important physical property. Density represents the mass of a unit volume of material and reflects the molecular compactness. The specific density helps to accurately measure and control the dosage in chemical production and experimental operations to ensure that the reaction proceeds as expected.
In summary, the physical properties of 4,5-diethyl ether-based naphthol, whether it is its properties, melting point, solubility or density, are closely related to its molecular structure, and are of great significance in scientific research, industrial production and other fields, providing a key basis for related operations and research.
What is the market price of 2-iodine-4,5-difluoroaniline?
Today I have asked what the market price of Iris Erjiang is. Iris Fu Erjiang was born in the Second River Basin of Shudi. Its flowers are graceful, its color is like blue and purple clouds, and its leaves are as tall and straight as green swords. It is popular with everyone, so it has its price in the city.
Looking at the market of various cities, the price varies according to the quality of the products and the time. The good ones have lush flowers and leaves, fresh color and subtle aroma, and their price is high; the second one is slightly inferior.
In the season when flowers bloom, there is a large supply in the city, and the price may be slightly flat. The price of each plant is about tens to hundreds of dollars. If it is a pot plant, add refined soil and elegant pots, and the price will increase again, or more than a thousand dollars.
In the event of a disaster, or excessive harvesting makes its quantity thin, the price will rise. And if the officials and nobles are good for a while and compete to buy, they can also make the price go up. Therefore, if you want to know the exact price, you should consider the supply and demand of the market, the season of the time, and the quality of the goods.
What are the precautions for storing and transporting 2-iodine-4,5-difluoroaniline?
2-% E7% A2% 98-4 5-%E4%BA%8C%E6%B0%9F%E8%8B%AF%E8%83%BA, both of which are precious materials, and should be paid more attention to when they are stored.
The first words are stored, 2-% E7% A2% 98-4. Sex likes to be dry, and must not be exposed to light, nor should it be exposed to tidal places. Because of its composition, it is easy to cause damage and loss of resistance when it encounters high tides and tides. It can be used in ceramic jars and glass jars to prevent the material from being exposed to the air and causing it to oxidize. 5-%E4%BA%8C%E6%B0%9F%E8%8B%AF%E8%83%BA need to pay special attention to prevent moth. This material has a special taste and is easy to attract. Therefore, it can be accompanied by prickly ash, peel and other things with special taste to achieve the effect of burning. And the same system needs to be placed in the atmosphere of the dry, regular inspection, if there is mildew or moth, it will be dealt with immediately.
To the environment, 2-% E7% A2% 98-4 is moving, and it will be used as a good, because of its weakness or fragility, if it is shocked or collided, it may be broken, and the shadow effect will be affected. The environment of the tool part also needs to be controlled to keep the dry, and it can be used to absorb the dry. On the way 5-%E4%BA%8C%E6%B0%9F%E8%8B%AF%E8%83%BA, in addition to paying attention to shock-proof and moisture-proof, it should also pay attention to the smell. Because its own taste is easily affected by external shadows, if other things with strong taste are the same, it may cause confusion and affect its quality. Moreover, the quality of the product should be kept short, and the quality of the product should be guaranteed due to external factors. Therefore, the quality of the product should be preserved.